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This is a searchable collection of scientific photos, illustrations, and videos. The images and videos in this gallery are licensed under Creative Commons Attribution Non-Commercial ShareAlike 3.0. This license lets you remix, tweak, and build upon this work non-commercially, as long as you credit and license your new creations under identical terms.
Glowing glycans
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Sugars light up the cells in this jaw of a 3-day-old zebrafish embryo and highlight a scientific first: labeling and tracking the movements of sugar chains called glycans in a living organism. Carolyn Bertozzi, University of California, Berkeley View MediaCas9 protein involved in the CRISPR gene-editing technology
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In the gene-editing tool CRISPR, a small strand of RNA identifies a specific chunk of DNA. Janet Iwasa View MediaKinesin moves cellular cargo
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A protein called kinesin (blue) is in charge of moving cargo around inside cells and helping them divide. Charles Sindelar, Yale University View MediaHydra 02
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Hydra magnipapillata is an invertebrate animal used as a model organism to study developmental questions, for example the formation of the body axis. Hiroshi Shimizu, National Institute of Genetics in Mishima, Japan View MediaNeurons from human ES cells
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These neural precursor cells were derived from human embryonic stem cells. The neural cell bodies are stained red, and the nuclei are blue. Xianmin Zeng lab, Buck Institute for Age Research, via CIRM View MediaNucleolinus
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The nucleolinus is a cellular compartment that has been a lonely bystander in scientific endeavors. Mary Anne Alliegro, Marine Biological Laboratory View MediaBreast cancer cells change migration phenotypes
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Cancer cells can change their migration phenotype, which includes their shape and the way that they move to invade different tissues. Bo Sun, Oregon State University. View MediaMapping human genetic variation
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This map paints a colorful portrait of human genetic variation around the world. Noah Rosenberg and Martin Soave, University of Michigan View MediaWhite Poppy
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A white poppy. View cropped image of a poppy here 3423. Judy Coyle, Donald Danforth Plant Science Center View MediaTracking embryonic zebrafish cells
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To better understand cell movements in developing embryos, researchers isolated cells from early zebrafish embryos and grew them as clusters. Liliana Solnica-Krezel, Washington University School of Medicine in St. Louis. View MediaPathways – Bacteria vs. Viruses: What's the Difference?
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Learn about how bacteria and viruses differ, how they each can make you sick, and how they can or cannot be treated. National Institute of General Medical Sciences View MediaCoronavirus spike protein structure
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Coronaviruses are enveloped viruses responsible for 30 percent of mild respiratory infections and atypical deadly pneumonia in humans worldwide. Melody Campbell, UCSF View MediaNeural development
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Using techniques that took 4 years to design, a team of developmental biologists showed that certain proteins can direct the subdivision of fruit fly and chicken nervous system tissue into the regions Mieko Mizutani and Ethan Bier, University of California, San Diego, and Henk Roelink, University of Washington View MediaStretch detectors
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Muscles stretch and contract when we walk, and skin splits open and knits back together when we get a paper cut. Christopher Chen, University of Pennsylvania View MediaCircadian rhythm neurons in the fruit fly brain
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Some nerve cells (neurons) in the brain keep track of the daily cycle. This time-keeping mechanism, called the circadian clock, is found in all animals including us. Justin Blau, New York University View MediaSerum albumin structure 2
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Serum albumin (SA) is the most abundant protein in the blood plasma of mammals. SA has a characteristic heart-shape structure and is a highly versatile protein. Wladek Minor, University of Virginia View MediaCulex quinquefasciatus mosquito larva
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A mosquito larva with genes edited by CRISPR. The red-orange glow is a fluorescent protein used to track the edits. Valentino Gantz, University of California, San Diego. View MediaFocal adhesions
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Cells walk along body surfaces via tiny "feet," called focal adhesions, that connect with the extracellular matrix. Crabtree + Company View MediaA Growing Bacterial Biofilm
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A growing Vibrio cholerae (cholera) biofilm. Cholera bacteria form colonies called biofilms that enable them to resist antibiotic therapy within the body and other challenges to their growth. Jing Yan, Ph.D., and Bonnie Bassler, Ph.D., Department of Molecular Biology, Princeton University, Princeton, NJ. View MediaTransmission electron microscopy of coronary artery wall with elastin-rich ECM pseudocolored in light brown
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Elastin is a fibrous protein in the extracellular matrix (ECM). It is abundant in artery walls like the one shown here. As its name indicates, elastin confers elasticity. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View MediaBond types (with labels)
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Ionic and covalent bonds hold molecules, like sodium chloride and chlorine gas, together. Hydrogen bonds among molecules, notably involving water, also play an important role in biology. Crabtree + Company View MediaMicrotubule growth
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Map of microtubule growth rates. Rates are color coded. This is an example of NIH-supported research on single-cell analysis. Gaudenz Danuser, Harvard Medical School View MediaQuartered torso
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Cells function within organs and tissues, such as the lungs, heart, intestines, and kidney. Judith Stoffer View MediaHuman embryonic stem cells on feeder cells
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The nuclei stained green highlight human embryonic stem cells grown under controlled conditions in a laboratory. Blue represents the DNA of surrounding, supportive feeder cells. Julie Baker lab, Stanford University School of Medicine, via CIRM View MediaMycobacterium tuberculosis
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Mycobacterium tuberculosis, the bacterium that causes tuberculosis, has infected one-quarter of the world's population and causes more than one million deaths each year, according to the Reuben Peters, Iowa State University View MediaXenopus laevis egg
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Xenopus laevis, the African clawed frog, has long been used as a model organism for studying embryonic development. Michael Klymkowsky, University of Colorado, Boulder View MediaAnti-tumor drug ecteinascidin 743 (ET-743), structure without hydrogens 02
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Ecteinascidin 743 (ET-743, brand name Yondelis), was discovered and isolated from a sea squirt, Ecteinascidia turbinata, by NIGMS grantee Kenneth Rinehart at the University of Illinois. Timothy Jamison, Massachusetts Institute of Technology View MediaPlanting roots
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At the root tips of the mustard plant Arabidopsis thaliana (red), two proteins work together to control the uptake of water and nutrients. Philip Benfey, Duke University View MediaInduced stem cells from adult skin 01
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These cells are induced stem cells made from human adult skin cells that were genetically reprogrammed to mimic embryonic stem cells. James Thomson, University of Wisconsin-Madison View MediaTime-lapse video of floral pattern in a mixture of two bacterial species, Acinetobacter baylyi and Escherichia coli, grown on a semi-solid agar for 24 hours
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This time-lapse video shows the emergence of a flower-like pattern in a mixture of two bacterial species, motile Acinetobacter baylyi and non-motile Escherichia coli (green), that are gr L. Xiong et al, eLife 2020;9: e48885 View MediaCerebellum: the brain's locomotion control center
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The cerebellum of a mouse is shown here in cross-section. The cerebellum is the brain's locomotion control center. Thomas Deerinck, National Center for Microscopy and Imaging Research, University of California, San Diego View MediaActivation energy
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To become products, reactants must overcome an energy hill. See image 2526 for a labeled version of this illustration. Featured in The Chemistry of Health. Crabtree + Company View MediaCells frozen in time
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The fledgling field of X-ray microscopy lets researchers look inside whole cells rapidly frozen to capture their actions at that very moment. Here, a yeast cell buds before dividing into two. Carolyn Larabell, University of California, San Francisco, and the Lawrence Berkeley National Laboratory View MediaX-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 1
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View MediaBacteria working to eat
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Gram-negative bacteria perform molecular acrobatics just to eat. Because they're encased by two membranes, they must haul nutrients across both. Emad Tajkhorshid, University of Illinois at Urbana-Champaign View MediaNatcher Building 05
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NIGMS staff are located in the Natcher Building on the NIH campus. Alisa Machalek, National Institute of General Medical Sciences View MediaEarly life of a protein
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This illustration represents the early life of a protein—specifically, apomyoglobin—as it is synthesized by a ribosome and emerges from the ribosomal tunnel, which contains the newly formed protein's Silvia Cavagnero, University of Wisconsin, Madison View MediaDopaminergic neurons derived from mouse embryonic stem cells
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These neurons are derived from mouse embryonic stem cells. Red shows cells making a protein called TH that is characteristic of the neurons that degenerate in Parkinson's disease. Yaping Sun, lab of Su Guo, University of California, San Francisco, via CIRM View MediaSimulation of uncontrolled avian flu outbreak
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This video simulation shows what an uncontrolled outbreak of transmissible avian flu among people living in Thailand might look like. Neil M. Ferguson, Imperial College London View MediaLife of an AIDS virus
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HIV is a retrovirus, a type of virus that carries its genetic material not as DNA but as RNA. Crabtree + Company View MediaBlood clots show their flex
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Blood clots stop bleeding, but they also can cause heart attacks and strokes. Eric Lee, University of Illinois at Urbana-Champaign View MediaWound healing in process
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Wound healing requires the action of stem cells. Hermann Steller, Rockefeller University View MediaRNA polymerase
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RNA polymerase (purple) is a complex enzyme at the heart of transcription. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View MediaGolgi theories
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Two models for how material passes through the Golgi apparatus: the vesicular shuttle model and the cisternae maturation model. Judith Stoffer View MediaActive Site of E. coli response regulator PhoB
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Active site of E. coli response regulator PhoB. Ann Stock, Rutgers University View MediaInsulin and protein interact in pancreatic beta cells
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A large number of proteins interact with the hormone insulin as it is produced in and secreted from the beta cells of the pancreas. William E. Balch, The Scripps Research Institute View MediaFruit fly larvae brains showing tubulin
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Two fruit fly (Drosophila melanogaster) larvae brains with neurons expressing fluorescently tagged tubulin protein. Vladimir I. Gelfand, Feinberg School of Medicine, Northwestern University. View MediaRat Hippocampus
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This image of the hippocampus was taken with an ultra-widefield high-speed multiphoton laser microscope. Tom Deerinck, NCMIR View MediaNMR spectrometer
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This photo shows a Varian Unity Inova 900 MHz, 21.1 T standard bore magnet Nuclear Magnetic Resonnance (NMR) spectrometer. Center for Eukaryotic Structural Genomics View MediaBond types
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Ionic and covalent bonds hold molecules, like sodium chloride and chlorine gas, together. Hydrogen bonds among molecules, notably involving water, also play an important role in biology. Crabtree + Company View Media