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This is a searchable collection of scientific photos, illustrations, and videos. The images and videos in this gallery are licensed under Creative Commons Attribution Non-Commercial ShareAlike 3.0. This license lets you remix, tweak, and build upon this work non-commercially, as long as you credit and license your new creations under identical terms.

CRISPR

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RNA incorporated into the CRISPR surveillance complex is positioned to scan across foreign DNA. Cryo-EM density from a 3Å reconstruction is shown as a yellow mesh. NRAMM National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View Media

Dynamic cryo-EM model of the human transcription preinitiation complex

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Gene transcription is a process by which information encoded in DNA is transcribed into RNA. Eva Nogales, Berkeley Lab View Media

Mapping human genetic variation

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This map paints a colorful portrait of human genetic variation around the world. Noah Rosenberg and Martin Soave, University of Michigan View Media

Ubiquitin-fold modifier 1 from C. elegans

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Solution NMR structure of protein target WR41 (left) from C. elegans. Northeast Structural Genomics Consortium View Media

Microfluidic chip

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Microfluidic chips have many uses in biology labs. Jeff Hasty Lab, UC San Diego View Media

Microsporidia in roundworm 1

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Many disease-causing microbes manipulate their host’s metabolism and cells for their own ends. Keir Balla and Emily Troemel, University of California San Diego View Media

Human ES cells turn into insulin-producing cells

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Human embryonic stem cells were differentiated into cells like those found in the pancreas (blue), which give rise to insulin-producing cells (red). Eugene Brandon, ViaCyte, via CIRM View Media

How cilia do the wave

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Thin, hair-like biological structures called cilia are tiny but mighty. Zvonimir Dogic, Brandeis University View Media

Phagosome in macrophage cell

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A sensor particle being engulfed by a macrophage—an immune cell—and encapsuled in a compartment called a phagosome. The phagosome then fuses with lysosomes—another type of compartment. Yan Yu, Indiana University, Bloomington. View Media

Autofluorescent xanthophores in zebrafish skin

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Pigment cells are cells that give skin its color. David Parichy, University of Washington View Media

Hydra 05

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Hydra magnipapillata is an invertebrate animal used as a model organism to study developmental questions, for example the formation of the body axis. Hiroshi Shimizu, National Institute of Genetics in Mishima, Japan View Media

Cas9 protein involved in the CRISPR gene-editing technology

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In the gene-editing tool CRISPR, a small strand of RNA identifies a specific chunk of DNA. Janet Iwasa View Media

Floral pattern in a mixture of two bacterial species, Acinetobacter baylyi and Escherichia coli, grown on a semi-solid agar for 48 hours (photo 1)

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Floral pattern emerging as two bacterial species, motile Acinetobacter baylyi (red) and non-motile Escherichia coli (green), are grown together for 48 hours on 1% agar surface from a sma L. Xiong et al, eLife 2020;9: e48885 View Media

Mitochondria and endoplasmic reticulum

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A computer model shows how the endoplasmic reticulum is close to and almost wraps around mitochondria in the cell. The endoplasmic reticulum is lime green and the mitochondria are yellow. Bridget Wilson, University of New Mexico View Media

G switch

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The G switch allows our bodies to respond rapidly to hormones. See images 2537 and 2538 for labeled versions of this image. Crabtree + Company View Media

Map of protein structures 02

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A global "map of the protein structure universe" indicating the positions of specific proteins. Berkeley Structural Genomics Center, PSI View Media

Introns

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Genes are often interrupted by stretches of DNA (introns, blue) that do not contain instructions for making a protein. Crabtree + Company View Media

Lily mitosis 03

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A light microscope image of a cell from the endosperm of an African globe lily (Scadoxus katherinae). This is one frame of a time-lapse sequence that shows cell division in action. Andrew S. Bajer, University of Oregon, Eugene View Media

Structure of heme, top view

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Molecular model of the struture of heme. Heme is a small, flat molecule with an iron ion (dark red) at its center. Rachel Kramer Green, RCSB Protein Data Bank View Media

Dopaminergic neurons from ES cells

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Human embryonic stem cells differentiated into dopaminergic neurons, the type that degenerate in Parkinson's disease. Image courtesy of the California Institute for Regenerative Medicine. Jeannie Liu, Lab of Jan Nolta, University of California, Davis, via CIRM View Media

Structure of a key antigen protein involved with Hepatitis C Virus infection

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A three-dimensional representation of the structure of E2, a key antigen protein involved with hepatitis C virus infection. Mansun Law Associate Professor Department of Immunolgy and Microbial Science The Scripps Research Institute View Media

Nucleus and rough ER

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The nucleus contains the DNA of eukaryotic cells. Judith Stoffer View Media

3D reconstruction of the Golgi apparatus in a pancreas cell

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Researchers used cryo-electron tomography (cryo-ET) to capture images of a rat pancreas cell that were then compiled and color-coded to produce a 3D reconstruction. Xianjun Zhang, University of Southern California. View Media

Microtubules in African green monkey cells

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Microtubules in African green monkey cells. Microtubules are strong, hollow fibers that provide cells with structural support. Melike Lakadamyali, Perelman School of Medicine at the University of Pennsylvania. View Media

Protein kinases as cancer chemotherapy targets

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Protein kinases—enzymes that add phosphate groups to molecules—are cancer chemotherapy targets because they play significant roles in almost all aspects of cell function, are tightly regulated, and co Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media

Crab larva eye

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Colorized scanning electron micrographs progressively zoom in on the eye of a crab larva. In the higher-resolution frames, bacteria are visible on the eye. Tina Weatherby Carvalho, University of Hawaii at Manoa View Media

Calling Cards in a mouse brain

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The green spots in this mouse brain are cells labeled with Calling Cards, a technology that records molecular events in brain cells as they mature. Allen Yen, Lab of Joseph Dougherty, Washington University School of Medicine in St. Louis. View Media

Dengue virus membrane protein structure

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Dengue virus is a mosquito-borne illness that infects millions of people in the tropics and subtropics each year. Like many viruses, dengue is enclosed by a protective membrane. Hong Zhou, UCLA View Media

Hydra 01

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Hydra magnipapillata is an invertebrate animal used as a model organism to study developmental questions, for example the formation of the body axis. Hiroshi Shimizu, National Institute of Genetics in Mishima, Japan View Media

G switch (with labels)

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The G switch allows our bodies to respond rapidly to hormones. G proteins act like relay batons to pass messages from circulating hormones into cells. Crabtree + Company View Media

Soft X-ray tomography of a pancreatic beta cell

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A color-coded, 3D model of a rat pancreatic β cell. This type of cell produces insulin, a hormone that helps regulate blood sugar. Carolyn Larabell, University of California, San Francisco. View Media

Biofilm blocking fluid flow

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This time-lapse movie shows that bacterial communities called biofilms can create blockages that prevent fluid flow in devices such as stents and catheters over a period of about 56 hours. Bonnie Bassler, Princeton University View Media

Floral pattern in a mixture of two bacterial species, Acinetobacter baylyi and Escherichia coli, grown on a semi-solid agar for 24 hours

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Floral pattern emerging as two bacterial species, motile Acinetobacter baylyi and non-motile Escherichia coli (green), are grown together for 24 hours on 0.75% agar surface from a small L. Xiong et al, eLife 2020;9: e48885 View Media

Axolotl showing nervous system

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The head of an axolotl—a type of salamander—that has been genetically modified so that its developing nervous system glows purple and its Schwann cell nuclei appear light blue. Prayag Murawala, MDI Biological Laboratory and Hannover Medical School. View Media

Cell-like compartments from frog eggs 5

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Cell-like compartments that spontaneously emerged from scrambled frog eggs, with nuclei (blue) from frog sperm. Endoplasmic reticulum (red) and microtubules (green) are also visible. Xianrui Cheng, Stanford University School of Medicine. View Media

Mouse brain 1

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A mouse brain that was genetically modified so that subpopulations of its neurons glow. Prayag Murawala, MDI Biological Laboratory and Hannover Medical School. View Media

2-D NMR

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A two-dimensional NMR spectrum of a protein, in this case a 2D 1H-15N HSQC NMR spectrum of a 228 amino acid DNA/RNA-binding protein. Dr. Xiaolian Gao's laboratory at the University of Houston View Media

mDia1 antibody staining-01

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Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a complex process. Rong Li and Praveen Suraneni, Stowers Institute for Medical Research View Media

Seeing signaling protein activation in cells 04

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Cdc42, a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including motility, proliferation, apoptosis, and cell morphology. Klaus Hahn, University of North Carolina, Chapel Hill Medical School View Media

Sortase b from B. anthracis

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Structure of sortase b from the bacterium B. anthracis, which causes anthrax. Sortase b is an enzyme used to rob red blood cells of iron, which the bacteria need to survive. Midwest Center for Structural Genomics, PSI View Media

Cryo-electron microscopy of the dengue virus showing protective membrane and membrane proteins

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Dengue virus is a mosquito-borne illness that infects millions of people in the tropics and subtropics each year. Like many viruses, dengue is enclosed by a protective membrane. Hong Zhou, UCLA View Media

Nucleosome

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Like a strand of white pearls, DNA wraps around an assembly of special proteins called histones (colored) to form the nucleosome, a structure responsible for regulating genes and condensing DNA strand Karolin Luger, Colorado State University View Media

X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 7

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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View Media

Confocal microscopy image of two Drosophila ovarioles

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Ovarioles in female insects are tubes in which egg cells (called oocytes) form at one end and complete their development as they reach the other end of the tube. 2004 Olympus BioScapes Competition View Media

Lorsch Swearing In

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Jon Lorsch at his swearing in as NIGMS director in August 2013. Also shown are Francis Collins, NIH Director, and Judith Greenberg, former NIGMS Acting Director. View Media

Kinases

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Kinases are enzymes that add phosphate groups (red-yellow structures) to proteins (green), assigning the proteins a code. Crabtree + Company View Media

Precise development in the fruit fly embryo

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This 2-hour-old fly embryo already has a blueprint for its formation, and the process for following it is so precise that the difference of just a few key molecules can change the plans. Thomas Gregor, Princeton University View Media

Dimeric association of receptor-type tyrosine-protein phosphatase

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Model of the catalytic portion of an enzyme, receptor-type tyrosine-protein phosphatase from humans. The enzyme consists of two identical protein subunits, shown in blue and green. New York Structural GenomiX Research Consortium, PSI View Media

Cell-like compartments emerging from scrambled frog eggs 4

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Cell-like compartments that spontaneously emerged from scrambled frog eggs, with nuclei (blue) from frog sperm. Endoplasmic reticulum (red) and microtubules (green) are also visible. Xianrui Cheng, Stanford University School of Medicine. View Media

Simulation of controlled avian flu outbreak

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This video shows a controlled outbreak of transmissible avian flu among people living in Thailand. Neil M. Ferguson, Imperial College London View Media