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Chromosome inside nucleus (with labels)
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The long, stringy DNA that makes up genes is spooled within chromosomes inside the nucleus of a cell. Crabtree + Company View Media
Myotonic dystrophy type 2 genetic defect
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Scientists revealed a detailed image of the genetic defect that causes myotonic dystrophy type 2 and used that information to design drug candidates to counteract the disease. Matthew Disney, Scripps Research Institute and Ilyas Yildirim, Northwestern University View Media
Secreted protein from Mycobacteria
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Model of a major secreted protein of unknown function, which is only found in mycobacteria, the class of bacteria that causes tuberculosis. Mycobacterium Tuberculosis Center, PSI View Media
Anti-tumor drug ecteinascidin 743 (ET-743), structure without hydrogens 04
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Ecteinascidin 743 (ET-743, brand name Yondelis), was discovered and isolated from a sea squirt, Ecteinascidia turbinata, by NIGMS grantee Kenneth Rinehart at the University of Illinois. Timothy Jamison, Massachusetts Institute of Technology View Media
Soft X-ray tomography of a pancreatic beta cell
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A color-coded, 3D model of a rat pancreatic β cell. This type of cell produces insulin, a hormone that helps regulate blood sugar. Carolyn Larabell, University of California, San Francisco. View Media
Thymidylate synthase complementing protein from Thermotoga maritime
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A model of thymidylate synthase complementing protein from Thermotoga maritime. Joint Center for Structural Genomics, PSI View Media
Dose response curves
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Dose-response curves determine how much of a drug (X-axis) causes a particular effect, or a side effect, in the body (Y-axis). Featured in Medicines By Design. Crabtree + Company View Media
Sheep hemoglobin crystal
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A crystal of sheep hemoglobin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Kappa opioid receptor
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The receptor is shown bound to an antagonist, JDTic. Raymond Stevens, The Scripps Research Institute View Media
Brain cells in the hippocampus
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Hippocampal cells in culture with a neuron in green, showing hundreds of the small protrusions known as dendritic spines. Shelley Halpain, UC San Diego View Media
Trp_RS - tryptophanyl tRNA-synthetase family of enzymes
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This image represents the structure of TrpRS, a novel member of the tryptophanyl tRNA-synthetase family of enzymes. View Media
G switch (with labels)
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The G switch allows our bodies to respond rapidly to hormones. G proteins act like relay batons to pass messages from circulating hormones into cells. Crabtree + Company View Media
Molecular view of glutamatergic synapse
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This illustration highlights spherical pre-synaptic vesicles that carry the neurotransmitter glutamate. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
Cytoscape network diagram 1
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Molecular biologists are increasingly relying on bioinformatics software to visualize molecular interaction networks and to integrate these networks with data such as gene expression profiles. Keiichiro Ono, Trey Ideker lab, University of California, San Diego View Media
Cell Nucleus and Lipid Droplets
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A cell nucleus (blue) surrounded by lipid droplets (yellow). James Olzmann, University of California, Berkeley View Media
Xenopus laevis embryos
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Xenopus laevis, the African clawed frog, has long been used as a model organism for studying embryonic development. The frog embryo on the left lacks the developmental factor Sizzled. Michael Klymkowsky, University of Colorado, Boulder View Media
tRNA splicing enzyme endonuclease in humans
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An NMR solution structure model of the transfer RNA splicing enzyme endonuclease in humans (subunit Sen15). This represents the first structure of a eukaryotic tRNA splicing endonuclease subunit. Center for Eukaryotic Structural Genomics, PSI View Media
Growing hair follicle stem cells
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Wound healing requires the action of stem cells. Hermann Steller, Rockefeller University View Media
Dengue virus membrane protein structure
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Dengue virus is a mosquito-borne illness that infects millions of people in the tropics and subtropics each year. Like many viruses, dengue is enclosed by a protective membrane. Hong Zhou, UCLA View Media
Group of Culex quinquefasciatus mosquito larvae
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Mosquito larvae with genes edited by CRISPR. Valentino Gantz, University of California, San Diego. View Media
Pores on the surface of the Hawaiian bobtail squid light organ
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The light organ (~0.5 mm across) of a juvenile Hawaiian bobtail squid, Euprymna scolopes, stained blue. Margaret J. McFall-Ngai, Carnegie Institution for Science/California Institute of Technology, and Edward G. Ruby, California Institute of Technology. View Media
Protein clumping in zinc-deficient yeast cells
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The green spots in this image are clumps of protein inside yeast cells that are deficient in both zinc and a protein called Tsa1 that prevents clumping. Colin MacDiarmid and David Eide, University of Wisconsin--Madison View Media
Cas9 protein involved in the CRISPR gene-editing technology
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In the gene-editing tool CRISPR, a small strand of RNA identifies a specific chunk of DNA. Janet Iwasa View Media
The nascent juvenile light organ of the Hawaiian bobtail squid
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A light organ (~0.5 mm across) of a Hawaiian bobtail squid, Euprymna scolopes, with different tissues are stained various colors. Margaret J. McFall-Ngai, Carnegie Institution for Science/California Institute of Technology, and Edward G. Ruby, California Institute of Technology. View Media
Human embryonic stem cells on feeder cells
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The nuclei stained green highlight human embryonic stem cells grown under controlled conditions in a laboratory. Blue represents the DNA of surrounding, supportive feeder cells. Julie Baker lab, Stanford University School of Medicine, via CIRM View Media
Life in balance
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Mitosis creates cells, and apoptosis kills them. The processes often work together to keep us healthy. Judith Stoffer View Media
Fluorescent E. coli bacteria
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Bioengineers were able to coax bacteria to blink in unison on microfluidic chips. They called each blinking bacterial colony a biopixel. Thousands of fluorescent E. Jeff Hasty Lab, UC San Diego View Media
Mapping metabolic activity
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Like a map showing heavily traveled roads, this mathematical model of metabolic activity inside an E. coli cell shows the busiest pathway in white. Albert-László Barabási, University of Notre Dame View Media
CRISPR Illustration Frame 2
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This illustration shows, in simplified terms, how the CRISPR-Cas9 system can be used as a gene-editing tool. National Institute of General Medical Sciences. View Media
Protein map
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Network diagram showing a map of protein-protein interactions in a yeast (Saccharomyces cerevisiae) cell. This cluster includes 78 percent of the proteins in the yeast proteome. Hawoong Jeong, KAIST, Korea View Media
Worm sperm
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To develop a system for studying cell motility in unnatrual conditions -- a microscope slide instead of the body -- Tom Roberts and Katsuya Shimabukuro at Florida State University disassembled and rec Tom Roberts, Florida State University View Media
Chromatin in human fibroblast
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The nucleus of a human fibroblast cell with chromatin—a substance made up of DNA and proteins—shown in various colors. Melike Lakadamyali, Perelman School of Medicine at the University of Pennsylvania. View Media
Mouse Brain Cross Section
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The brain sections are treated with fluorescent antibodies specific to a particular protein and visualized using serial electron microscopy (SEM). Anton Maximov, The Scripps Research Institute, La Jolla, CA View Media
Cell division and cell death
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Two cells over a 2-hour period. The one on the bottom left goes through programmed cell death, also known as apoptosis. The one on the top right goes through cell division, also called mitosis. Dylan T. Burnette, Vanderbilt University School of Medicine. View Media
Pig trypsin crystal
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A crystal of pig trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Chang Shan
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For thousands of years, Chinese herbalists have treated malaria using Chang Shan, a root extract from a type of hydrangea that grows in Tibet and Nepal. Paul Schimmel Lab, Scripps Research Institute View Media
Mouse cerebellum close-up
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The cerebellum is the brain's locomotion control center. Every time you shoot a basketball, tie your shoe or chop an onion, your cerebellum fires into action. National Center for Microscopy and Imaging Research (NCMIR) View Media
Young squids
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Real-time movie of young squids. Michael Shribak, Marine Biological Laboratory/University of Chicago. View Media
Jack bean concanavalin A
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Crystals of jack bean concanavalin A protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Tiny points of light in a quantum dot
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This fingertip-shaped group of lights is a microscopic crystal called a quantum dot. About 10,000 times thinner than a sheet of paper, the dot radiates brilliant colors under ultraviolet light. Sandra Rosenthal and James McBride, Vanderbilt University, and Stephen Pennycook, Oak Ridge National Laboratory View Media
Bacterial cells migrating through the tissues of the squid light organ
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Vibrio fischeri cells (~ 2 mm), labeled with green fluorescent protein (GFP), passing through a very narrow bottleneck in the tissues (red) of the Hawaiian bobtail squid, Euprymna scolope Margaret J. McFall-Ngai, Carnegie Institution for Science/California Institute of Technology, and Edward G. Ruby, California Institute of Technology. View Media
Trajectories of labeled cell receptors
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Trajectories of single molecule labeled cell surface receptors. This is an example of NIH-supported research on single-cell analysis. Gaudenz Danuser, Harvard Medical School View Media
Disease-susceptible Arabidopsis leaf
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This is a magnified view of an Arabidopsis thaliana leaf after several days of infection with the pathogen Hyaloperonospora arabidopsidis. Jeff Dangl, University of North Carolina, Chapel Hill View Media
Induced stem cells from adult skin 03
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The human skin cells pictured contain genetic modifications that make them pluripotent, essentially equivalent to embryonic stem cells. James Thomson, University of Wisconsin-Madison View Media
Crane fly spermatocyte undergoing meiosis
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A crane fly spermatocyte during metaphase of meiosis-I, a step in the production of sperm. Michael Shribak, Marine Biological Laboratory/University of Chicago. View Media
GFP sperm
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Fruit fly sperm cells glow bright green when they express the gene for green fluorescent protein (GFP). View Media
Adult and juvenile Hawaiian bobtail squids
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An adult Hawaiian bobtail squid, Euprymna scolopes, (~4 cm) surrounded by newly hatched juveniles (~2 mm) in a bowl of seawater.Margaret J. McFall-Ngai, Carnegie Institution for Science/California Institute of Technology, and Edward G. Ruby, California Institute of Technology. View Media
Fused, dicentric chromosomes
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This fused chromosome has two functional centromeres, shown as two sets of red and green dots. Beth A. Sullivan, Duke University View Media
Katanin protein regulates anaphase
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The microtubule severing protein, katanin, localizes to chromosomes and regulates anaphase A in mitosis. David Sharp, Albert Einstein College of Medicine View Media
V. Cholerae Biofilm
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Industrious V. cholerae bacteria (yellow) tend to thrive in denser biofilms (left) while moochers (red) thrive in weaker biofilms (right). View Media
