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Rhodopsin bound to visual arrestin
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Rhodopsin is a pigment in the rod cells of the retina (back of the eye). It is extremely light-sensitive, supporting vision in low-light conditions. Protein Data Bank. View Media
Natcher Building 04
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NIGMS staff are located in the Natcher Building on the NIH campus. Alisa Machalek, National Institute of General Medical Sciences View Media
Fly cells
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If a picture is worth a thousand words, what's a movie worth? Denise Montell, Johns Hopkins University School of Medicine View Media
NCMIR Tongue 2
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Microscopy image of a tongue. One in a series of two, see image 5810 National Center for Microscopy and Imaging Research (NCMIR) View Media
Golden gene chips
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A team of chemists and physicists used nanotechnology and DNA's ability to self-assemble with matching RNA to create a new kind of chip for measuring gene activity. Hao Yan and Yonggang Ke, Arizona State University View Media
Beta2-adrenergic receptor protein
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Crystal structure of the beta2-adrenergic receptor protein. The Stevens Laboratory, The Scripps Research Institute View Media
RNA interference (with labels)
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RNA interference or RNAi is a gene-silencing process in which double-stranded RNAs trigger the destruction of specific RNAs. Crabtree + Company View Media
iPS cell facility at the Coriell Institute for Medical Research
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This lab space was designed for work on the induced pluripotent stem (iPS) cell collection, part of the NIGMS Human Genetic Cell Repository at the Coriell Institute for Medical Research. Courtney Sill, Coriell Institute for Medical Research View Media
HeLa cells
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Scanning electron micrograph of an apoptotic HeLa cell. Zeiss Merlin HR-SEM. National Center for Microscopy and Imaging Research View Media
Polarized cells- 02
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Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a complex process. Rong Li and Praveen Suraneni, Stowers Institute for Medical Research View Media
Mouse retina close-up
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Keunyoung ("Christine") Kim National Center for Microscopy and Imaging Research (NCMIR) View Media
Histone deacetylases
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The human genome contains much of the information needed for every cell in the body to function. However, different types of cells often need different types of information. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
Sphingolipid S1P1 receptor
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The receptor is shown bound to an antagonist, ML056. Raymond Stevens, The Scripps Research Institute View Media
Relapsing fever bacterium (gray) and red blood cells
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Relapsing fever is caused by a bacterium and transmitted by certain soft-bodied ticks or body lice. The disease is seldom fatal in humans, but it can be very serious and prolonged. NIAID View Media
Cell cycle wheel
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A typical animal cell cycle lasts roughly 24 hours, but depending on the type of cell, it can vary in length from less than 8 hours to more than a year. Most of the variability occurs in Gap1. Judith Stoffer View Media
Mouse sperm sections
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This transmission electron micrograph shows sections of mouse sperm tails, or flagella. Tina Weatherby Carvalho, University of Hawaii at Manoa View Media
Anti-tumor drug ecteinascidin 743 (ET-743), structure without hydrogens 04
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Ecteinascidin 743 (ET-743, brand name Yondelis), was discovered and isolated from a sea squirt, Ecteinascidia turbinata, by NIGMS grantee Kenneth Rinehart at the University of Illinois. Timothy Jamison, Massachusetts Institute of Technology View Media
A molecular interaction network in yeast 2
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The image visualizes a part of the yeast molecular interaction network. Keiichiro Ono, UCSD View Media
PanB from M. tuberculosis (1)
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Model of an enzyme, PanB, from Mycobacterium tuberculosis, the bacterium that causes most cases of tuberculosis. This enzyme is an attractive drug target. Mycobacterium Tuberculosis Center, PSI View Media
Cells use bubble-like structures called vesicles to transport cargo
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Cells use bubble-like structures called vesicles (yellow) to import, transport, and export cargo and in cellular communication. A single cell may be filled with thousands of moving vesicles.Tatyana Svitkina, University of Pennsylvania View Media
Dynamin Fission
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Time lapse series shows short dynamin assemblies (not visible) constricting a lipid tube to make a "beads on a string" appearance, then cutting off one of the beads i.e., catalyzing membrane fission). Ramachandran, Pucadyil et al. , The Scripps Research Institute View Media
Sea urchin embryo 04
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Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). George von Dassow, University of Washington View Media
Podocytes from a chronically diseased kidney
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This scanning electron microscope (SEM) image shows podocytes--cells in the kidney that play a vital role in filtering waste from the bloodstream--from a patient with chronic kidney disease. Olga Troyanskaya, Princeton University and Matthias Kretzler, University of Michigan View Media
Pigment cells in the fin of pearl danio
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Pigment cells are cells that give skin its color. David Parichy, University of Washington View Media
Carbon building blocks
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The arrangement of identical molecular components can make a dramatic difference. For example, carbon atoms can be arranged into dull graphite (left) or sparkly diamonds (right). Crabtree + Company View Media
Ribosome illustration from PDB
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Ribosomes are complex machines made up of more than 50 proteins and three or four strands of genetic material called ribosomal RNA (rRNA). From PDB’s Molecule of the Month collection (direct link: http://pdb101.rcsb.org/motm/121) Molecule of the Month illustrations are available under a CC-BY-4.0 license. Attribution should be given to David S. Goodsell and the RCSB PDB. View Media
Confocal microscopy image of two Drosophila ovarioles
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Ovarioles in female insects are tubes in which egg cells (called oocytes) form at one end and complete their development as they reach the other end of the tube. 2004 Olympus BioScapes Competition View Media
Antitoxin GhoS (Illustration 1)
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Structure of the bacterial antitoxin protein GhoS. GhoS inhibits the production of a bacterial toxin, GhoT, which can contribute to antibiotic resistance. Rebecca Page and Wolfgang Peti, Brown University and Thomas K. Wood, Pennsylvania State University View Media
Circadian rhythm
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The human body keeps time with a master clock called the suprachiasmatic nucleus or SCN. Crabtree + Company View Media
Drosophila (fruit fly) myosin 1D motility assay
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Actin gliding powered by myosin 1D. Note the counterclockwise motion of the gliding actin filaments. Serapion Pyrpassopoulos and E. Michael Ostap, University of Pennsylvania View Media
Mandelate racemase from B. subtilis
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Model of the mandelate racemase enzyme from Bacillus subtilis, a bacterium commonly found in soil. New York Structural GenomiX Research Consortium, PSI View Media
Petri dish containing C. elegans
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This Petri dish contains microscopic roundworms called Caenorhabditis elegans. Researchers used these particular worms to study how C. H. Robert Horvitz and Dipon Ghosh, Massachusetts Institute of Technology. View Media
Bioluminescent imaging in adult zebrafish - overhead view
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Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. Kenneth Poss, Duke University View Media
Synapses in culture
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Cultured hippocampal neurons grown on a substrate of glial cells (astrocytes). The glial cells form the pink/brown underlayment in this image. The tan threads are the neurons. National Center for Microscopy and Imaging Research View Media
Blinking bacteria
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Like a pulsing blue shower, E. coli cells flash in synchrony. Genes inserted into each cell turn a fluorescent protein on and off at regular intervals. Jeff Hasty, University of California, San Diego View Media
X-ray crystallography
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X-ray crystallography allows researchers to see structures too small to be seen by even the most powerful microscopes. Crabtree + Company View Media
Adult and juvenile Hawaiian bobtail squids
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An adult Hawaiian bobtail squid, Euprymna scolopes, (~4 cm) surrounded by newly hatched juveniles (~2 mm) in a bowl of seawater.Margaret J. McFall-Ngai, Carnegie Institution for Science/California Institute of Technology, and Edward G. Ruby, California Institute of Technology. View Media
EM of yeast cell division
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Cell division is an incredibly coordinated process. Matthew West and Greg Odorizzi, University of Colorado View Media
Dividing cells showing chromosomes and cell skeleton
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This pig cell is in the process of dividing. The chromosomes (purple) have already replicated and the duplicates are being pulled apart by fibers of the cell skeleton known as microtubules (green). Nasser Rusan, National Heart, Lung, and Blood Institute, National Institutes of Health View Media
Induced stem cells from adult skin 03
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The human skin cells pictured contain genetic modifications that make them pluripotent, essentially equivalent to embryonic stem cells. James Thomson, University of Wisconsin-Madison View Media
Nucleolinus
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The nucleolinus is a cellular compartment that has been a lonely bystander in scientific endeavors. Mary Anne Alliegro, Marine Biological Laboratory View Media
Wound healing in process
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Wound healing requires the action of stem cells. Hermann Steller, Rockefeller University View Media
Transcription factor Sox17 controls embryonic development of certain internal organs
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During embryonic development, transcription factors (proteins that regulate gene expression) govern the differentiation of cells into separate tissues and organs. James M. Wells, Cincinnati Children's Hospital Medical Center View Media
Nerve ending
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A scanning electron microscope picture of a nerve ending. It has been broken open to reveal vesicles (orange and blue) containing chemicals used to pass messages in the nervous system. Tina Weatherby Carvalho, University of Hawaii at Manoa View Media
Human Adenovirus
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The cryo-EM structure of human adenovirus D26 (HAdV-D26) at near atomic resolution (3.7 Å), determined in collaboration with the NRAMM facility*. National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View Media
Drugs enter skin (with labels)
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Drugs enter different layers of skin via intramuscular, subcutaneous, or transdermal delivery methods. See image 2531 for an unlabeled version of this illustration. Crabtree + Company View Media
Section of an electron density map
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Electron density maps such as this one are generated from the diffraction patterns of X-rays passing through protein crystals. The Southeast Collaboratory for Structural Genomics View Media
Cas4 nuclease protein structure
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This wreath represents the molecular structure of a protein, Cas4, which is part of a system, known as CRISPR, that bacteria use to protect themselves against viral invaders. Fred Dyda, NIDDK View Media
Streptococcus bacteria
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Image of Streptococcus, a type (genus) of spherical bacteria that can colonize the throat and back of the mouth. Stroptococci often occur in pairs or in chains, as shown here. Tina Weatherby Carvalho, University of Hawaii at Manoa View Media
