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NIGMS supports basic biomedical research that contributes to the understanding of fundamental cellular and physiological principles. General areas of interest include cell biology, biophysics, genetics, developmental biology, pharmacology, physiology, biological chemistry, biomedical technology, bioinformatics and computational biology. The material below provides details on these areas.
Bioinformatics applications in the general area of complex biological systems to create or maintain databases; develop or use methods to manage, visualize, and analyze data in these databases; or use methods commonly associated with bioinformatics to deduce information about biological systems. Computational biology applications should develop new approaches, algorithms, and methods for an integrative understanding of biomedical systems and could span temporal and spatial domains. Of interest are development of computational algorithms and tools, modeling techniques and approaches for understanding the complexity of biological systems. The scope of the systems covered ranges from cellular to tissue, organ, systems studies, and up to populational dynamics. This includes gene, protein and metabolic networks, cellular architecture and intracellular dynamics, cell communication and motility, cell division and differentiation, tissue formation and organogenesis, tissue and organ functions, changes in population characteristics as a consequence of interaction of organisms with their physical environment, with individuals of their own species, and with organisms of other species.
Paul Brazhnik, Ph.D. (Bioinformatics and Computational Biology) Tel: 301-451-6446 Email:
Veerasamy Ravichandran (Bioinformatics and Modeling) Tel: 301-451-6446 Email:
Haluk Resat, Ph.D. (Modeling) Tel: 301-827-6671 Email:
Biostatics areas of interest include development of advanced statistical techniques and methodologies for design of biological experiments, collection and analysis of the data from those experiments and interpretation of, and inference from, the results. The scope of studies ranges from those focused-on sequencing, mass spectrometry, bioimaging and other high-through-put techniques in data to medicine, pharmacology, and populational studies.
Paul Brazhnik, Ph.D. Tel: 301-451-6446 Email:
Scott D. Somers, Ph.D. Tel: 301-594-3827 Email:
Development of new or improved instruments, methods, and related software for the qualitative and quantitative analyses of biomedically relevant molecules, including biopolymers, metabolites, and macromolecular complexes. Relevant technologies and methods include sample handling, separations, mass spectrometry, microarrays, nuclear magnetic resonance, surface plasmon resonance, radionuclides and stable isotopes, optical and vibrational spectroscopy, flow-based systems, and computational tools for data interpretation, curation, and mining. Bioanalytical technology development also includes hardware, software, and methods for the identification and analysis of proteins and their post-translational modifications, carbohydrates, lipids, nucleic acids, and other metabolites, proteomics, glycomics, metabolomics.
Ward Smith, Ph.D. Tel: 301-443-9375 Email:
These resources create critical, often unique technology and methods at the forefront of their respective fields and apply them to a broad range of basic, translational, and clinical research. This occurs through a synergistic interaction of technical and biomedical expertise, both within the centers and in intensive collaborations with other leading laboratories.
Mary Ann Wu, Ph.D. Tel: 301-451-6446 Email:
Areas of interest include new or improved tools and methods to directly manipulate or investigate cells and their environment. Includes methods for delivery of molecules and nanoparticles into cells, transport between cellular compartments, and in situ imaging from organelles to cells.
Paul Sammak, Ph.D. Tel: 301-451-6446 Email:
Development of new or improved instruments, methods, and related software for the elucidation of 3D structures of macromolecules and macromolecular complexes. Relevant technologies cover areas of sample handling; x-ray diffraction; other x-ray techniques; magnetic resonance such as NMR, EPR and ESR; microscopic techniques that resolve at the molecular level, such as single particle cryo-electron microscopy. Computational tools for data collection, processing, interpretation, curation, and mining.
Research on the mechanisms of assembly, structure, and function of cellular ultra structures larger than a few million Daltons and dependent on high levels of molecular organization. These include large cellular machines such as the ribosome, spliceosome, cytoskeletal structures, interactions between intracellular and extracellular matrix components, signaling networks that depend on large scale interactions, when studied primarily by multiple methods and/or by methods that are not routine, such as single particle cryo-electron microscopy, cryo-electron tomography, scanning probe microscopy and other force transduction methods.
Paula Flicker, Ph.D. Tel: 301-594-0943 Email:
Research involving the application of physical principles to the study of viral attachment, fusion/penetration, uncoating, assembly, and budding/release. Areas of research include: analysis of virus-host interactions; phage and viral packaging; the structure and mechanism of assemblies from viral and host components; and the determination of factors and energetics that regulate protein-nucleic acid interactions necessary for virion entry, packaging, maturation, and release.
Michael Sakalian, Ph.D. Tel: 301-451-6446 Email:
Interdisciplinary research involving structural biologists, synthetic organic chemists, theoreticians and virologists to elucidate the structures of HIV virus related molecules and host cell components that are essential to the viral life cycle HIV, and to apply this information to the development of anti-AIDS drugs using structure-based drug design.
General principles of membrane structure and function including behavior of lipids, bilayers, and other lipid phases; membrane protein structure and function, including folding, assembly, dynamics, and general mechanisms of action, conformational changes and energy coupling; membrane protein-lipid interactions, effects of lipid compositions and phase separated domains; physical studies of fusion, fission, and deformation processes; as studied through the application of primarily biophysical methods and approaches.
Peter C. Preusch, Ph.D. Tel: 301-451-6446 Email:
Research involving the application of physical principles to the study of nucleic acids and protein-nucleic acid complexes. Areas of research include: physical and chemical studies of nucleic acids and protein-nucleic acid complexes; analysis of protein-nucleic acid interactions and assembly mechanisms; ligand-nucleic acid interactions; development of physical, chemical, and theoretical/computational techniques for the analysis of nucleic acids and their complexes.
Biophysical studies of all aspects of protein structure and function in which the goal is to elucidate general principles, primarily by experimental methods, but may involve established computational methods and/or confirmatory in vivo studies. Included are studies that establish the physical and thermodynamic basis for native structure; protein-protein interactions, and protein-ligand recognition; protein de novo design and engineering. Experimental studies of protein folding; protein folding mechanisms and kinetics. Experimental studies of intrinsically disordered proteins; folding upon binding, protein aggregation, and phase separations. The role of structural dynamics in protein function, folding, and allosteric control.
Janna Wehrle, Ph.D. Tel: 301-451-6446 Email:
Includes theoretical, computational, and physics-based studies of the fundamental behaviors of atoms to molecules and their interactions. This would include predominantly theoretical and computational studies in the following areas: quantum mechanical and molecular dynamics simulations; thermodynamics and statistical mechanics; basic principles of molecular recognition, development and validation of force fields and scoring functions, and algorithms for prediction of molecular properties; macromolecule-ligand binding predictions by docking and other in silico screening methods applicable to drug design; predictions of protein and other macromolecular structures; and studies in macromolecular design, protein folding, RNA folding, molecular interactions, membrane and membrane protein simulations, phase separations, aggregation, and complex formation.
Peter Lyster, Ph.D. Tel: 301-451-6445 Email:
This portfolio comprises SBIR/STTR projects of general interest to the Division of Biophysics, Biomedical Technology, and Computational Biosciences. These projects are notable for their general pertinence to basic science issues and broad applicability of the proposed developments.
Dmitriy Krepkiy, Ph.D. Tel: 301-435-0752 Email:
Mitosis and meiosis, spindle functions, structure, assembly, mechanisms, and mechanics, regulation of kinetochore functions, spindle assembly check points, chromosome attachment and movement.
James F. Deatherage, Ph.D. Tel: 301-594-0943 Email:
Chemotaxis, gradient sensing in motility. Bacterial chemotaxis, flagellar motor. Junctions, focal adhesions, Extracellular matrix (ECM). Integrins, cadherins and cell cortex in adhesion signaling that controls migration.
Establishment of cellular polarity, e.g. epithelial topogenesis, yeast bud site selection, leading edge, filopodia, and other protrusions. Bacterial flagella, pili, organelles. Positioning of organelles and other components in cells. Mechanotransduction, cellular mechanics, force production, cell shape changes, epithelial-mesenchymal transition, other morphogenetic processes.
Membrane and protein recycling, endocytosis. Function and biogenesis of endosomes, lysosomes, and lysosome-related organelles. Membrane dynamics in related or interacting processes, including autophagy. Membrane dynamics of processes using endocytic/lysosomal related-machinery, membrane remodeling, scission, and related processes.
Stefan Maas, Ph.D. Tel: 301-594-0943 Email:
Nuclear envelope, mitochondria, chloroplasts, vacuoles, lipid droplets, other organelles and organelle interactions. Organelle biogenesis, inheritance. Nuclear import and export, nuclear envelope, nuclear-cytoplasmic transport, mRNA localization and targeting. Membrane biogenesis, protein targeting, and anchoring, plasma membrane, membranes in cell-wall biogenesis, sporulation.
Cytoskeletal filaments and their interactions with molecular motors. Dynamics and control of the assembly, disassembly and association of cytoskeletal filaments and systems. Structure and function of cytoskeletal proteins. Motor cargo interactions, intracellular transport. Cilia, flagella, primary cilia, centrosomes, centrioles.
Joe Gindhart, Ph.D. Tel: 301-594-0943 Email:
Protein folding and degradation in cellular physiology. Chaperones, proteosomes, protein degradation, cellular roles of ubiquitin. Unfolded protein response and other stress responses. Cellular responses and management of misfolded proteins, abnormal protein folding, pathological responses.
Protein processing and trafficking for export, secretion, Golgi and ER functions and biogenesis. Bacterial DNA and protein export. Membrane dynamics of processes using Golgi/ER-related-machinery, including membrane fusion.
Control of cell cycle progression: areas include genetic and molecular regulation and function of cell cycle checkpoints and components of the cell cycle, such as cyclins, cyclin-dependent kinases (CDKs), inhibitors, activators and tumor suppressors; synthesis, post-translational modification and degradation of the cell cycle machinery, including ubiquitination and sumoylation; temporal and spatial regulation of the cell cycle.
Amanda Melillo, Ph.D. Tel: 301-594-0943 Email:
Focuses on the regulation of cellular homeostasis, autophagy and cell death pathways. Emphasis is on principles determining intracellular signaling pathway dynamics and network organization. Areas include metabolic and protein homeostasis, induction and regulation of macroautophagy, programmed cell death, apoptosis and alternative cell death pathways.
Focuses on cellular decision processes, e.g., growth initiation, proliferation, cell senescence, terminal differentiation, sporulation and chemotaxis regulation. Emphasis is on principles determining intracellular signaling pathway dynamics and network organization. Approaches may include genomics, proteomics or computational modeling, where such models are focused on signaling networks.
The principal areas of focus are higher order chromosome architecture, telomeres, centromeres, specialized nuclear substructures, boundary elements, long distance regulators, and spatial organization of genes. Research topics include: structure/function of telomerase, maintenance of telomere length, noncoding RNA effects on telomerase, centromere structure and identity, centromere assembly, and large scale programmed genome rearrangements.
Alexandra Ainsztein, Ph.D. Tel: 301-594-0943 Email:
Identification and characterization of structural and functional components of gene activation and repression. Areas include structure and function of chromatin and large protein-DNA complexes, including interactions of DNA with nonhistone proteins; epigenetic factors influencing gene expression such as histone modifications, chromatin remodeling, DNA methylation, heterochromatin formation, position effects, imprinting, X-inactivation, gene silencing.
Anthony Carter, Ph.D. Tel: 301-594-0943 Email:
Regulation of early development in multicellular organisms, with an emphasis on non-mammalian systems. Areas include but are not limited to: genetic and molecular regulation of embryonic pattern formation, tissue induction, cell fate determination, and cell and tissue polarity; spatial and temporal localization of developmental determinants; regulation of cell movements in embryogenesis, including early morphogenesis (including biophysical/biomechanical forces); gene regulatory networks controlling developmental pathways; sex determination.
Tanya Hoodbhoy, Ph.D. Tel: 301-594-0943 Email:
Investigations whose major emphasis is on understanding signaling pathways underlying fundamental processes that drive early (pre-organogenesis) development, primarily using non-mammalian systems. Research should be predominantly focused on the signaling cascades involved in developmental patterning and morphogenetic events rather than on gene regulatory networks or biophysical/biomechanical and cell-level mechanisms. Topics include but are not limited to growth factor/morphogen signaling networks, planar cell polarity signaling, cytoneme/airineme-based signaling, and signaling during collective cell migration.
Investigations into the regulation and evolution of pathways that control expression of protective genes in response to growth-limiting environmental stressors (such as antibiotics, oxygen levels, temperature, pH, light, gravity, parasitism, toxins and metal ions). Analyses range from molecular, chemical and structural analysis to theoretical model development.
Michael Reddy, Ph.D. Tel: 301-594-0943 Email:
Ethical, legal and social issues in genetics, especially as they relate to the use of stored human tissues for research and to studies on ethnically identifiable populations.
Donna Krasnewich, M.D., Ph.D. Tel: 301-594-0943 Email:
Studies of the genetic, physiological and ecological mechanisms governing interchanges between dissimilar organisms, such as commensal, mutualistic, parasitic and symbiotic relationships. The manner by which the microbiota, including biofilms, respond - either at the community, population, organismal or molecular level - to maintain homeostasis or respond to dysbiosis of the host.
Alexandra Ainsztein, Ph.D. Tel: 301-534-0943 Email:
Genetic, molecular and/or genomic characterization of simple and complex behaviors in nonhuman model systems, where the focus is on neural function rather than neural development. Genetic, molecular and/or genomic characterization of circadian rhythms, sleep and related phenomena in nonhuman systems, with an emphasis on invertebrates, plants, fungi and bacteria.
Michael Sesma, Ph.D. Tel: 301-594-0943 Email:
Studies on the fundamental properties of adult, germline and embryonic stem cells and on the regulation of tissue and organ regeneration. Stem cell areas include: molecular, cellular, genetic and epigenetic properties of stem cells; nuclear reprogramming of somatic cells, including induced pluripotent stem cells (iPS); signaling pathways in stem cell differentiation; role of stem cell niches and microenvironments in stem cell differentiation; germ cell formation and development. Regeneration areas include genetic, molecular and/or genomic regulation of tissue and organ regeneration in nonhuman model systems, including plants.
Kenneth Gibbs, Ph.D. Tel: 301-594-3901 Email:
Desirée Salazar, Ph.D. Tel: 301-594-3900 Email:
Enzymes and mechanisms of DNA repair; mechanisms of action of mutagens and carcinogens; genetics and biochemistry of mutation; interactions of mutagens with nucleic acids.
Kristine Willis, Ph.D. Tel: 301-594-0943 Email:
Enzymes and mechanisms of DNA and RNA replication; chromatin regulation of DNA replication; genetics of meiosis; role of recombination in replication; and evolutionary analyses of replication pathways.
Investigations of genetic mechanisms in humans that determine phenotypes evaluated at the molecular, biochemical, cellular or clinical level; genetic studies employing eukaryotic model organisms relevant to a human genetic disorder or phenotype; genetic and environmental factors that influence common disorders with complex inheritance; computational and statistical approaches to the analysis of genetic variation influencing human phenotypes; development of genetic and genomic techniques specific to investigations of human material.
Structure, function and metabolism of cytoplasmic mRNA. Control of gene expression at the level of translation, including RNA editing, mRNA stability, and nonsense-mediated decay.
Michael Bender, Ph.D. Tel: 301-594-0943 Email:
Genetics of natural and laboratory populations; analysis of genetic variation in complex traits in humans and model organisms; evolutionary principles of living systems, including chromosome evolution, phenotypic evolution and speciation; evolution of development; co-adapting systems such as host-pathogen evolution; statistical methods and mathematical models for evolutionary and population genetic analysis.
Daniel Janes, Ph.D. Tel: 301-594-0943 Email:
Protein synthesis as a process, including initiation, elongation and termination; synthesis, structure and function of all biochemical components of the translation system, namely tRNA, rRNA, ribosomal proteins and initiation and termination factors.
Darren Sledjeski, Ph.D. Tel: 301-594-0943 Email:
Anissa J. Brown, Ph.D. Tel: 301-594-3900 Email:
Mechanisms of production and regulation of regulatory RNAs including siRNAs, microRNAs, piRNAs, CRISPR RNAs and related non-coding RNAs. Function of regulatory RNA including effects on mRNA stability or translation.
Splicing of all species of RNA following completion of transcription and prior to translational events in the cytoplasm; processing of RNA, including methylation, capping and polyadenylation; mechanism and regulation of alternative splicing and trans-splicing; formation, structure, function and regulation of spliceosomal precursors and components; mechanism and regulation of self-splicing; intranuclear transport of RNA.
Genetic, biochemical, biophysical and structural characterization of the macromolecular interactions that mediate DNA-dependent RNA transcription; genomics- and expression-based strategies for identifying, on a global basis, molecules and sequences involved in regulating transcription; development of reagents and techniques for visualizing or manipulating transcription.
Energy transducing enzymes of the mitochondrial inner and outer membranes, chloroplasts, and microorganisms; electron transport, photosynthesis, including biogenesis of cofactors and substrate transport.
Vernon Anderson, Ph.D. Tel: 301-594-3827 Email:
Biochemical tools (e.g., engineered DNA, RNA, protein, peptides or biomimetics), and processes derived from living cells or their components. Includes engineering technologies to produce useful biological materials.
Miles A. Fabian, Ph.D. Tel: 301-594-3827 Email:
Discovery and design of molecular probes, polymers, molecular assemblies, and nanostructured materials as mimics of macromolecular function.
Design, synthesis, and testing of novel small molecule probes that target specific biological pathways, potentially as new therapeutics. Includes computational docking studies.
Individual enzyme mechanisms, regulation, modification, and inhibition to understand the catalytic specificity of synthesis, modification, or degradation of metabolites and macromolecules.
Oleg Barski, Ph.D. Tel: 301-594-3827 Email:
Mechanisms of enzyme complexes that interact with DNA and RNA; focused on catalysis and sequence recognition, topology, and transformation of nucleic acids. (Genome-specific processes of recombination, replication, transcription, are assigned to GMCDB.)
Carbohydrate-containing macromolecules where emphasis is on the carbohydrate and their binding partner(s). Includes sugar transporters and carrier lipids, glycan processing enzymes, protein:glycan mediated interactions, and peptidoglycans.
Pamela Marino, Ph.D. Tel: 301-594-3827 Email:
Functions of metalloenzymes (containing Cu, Ni, Zn, Fe, Se), and design and characterization of bioinorganic catalysts and biomimetic complexes.
Biosynthetic pathways for natural products, including isolation and structure of natural products. Study of microbial communities and interactions with the host, such as the microbiome.
Metabolic pathways and information flow; includes studies of transient intermediates and stable multi-enzyme complexes, and how catalytic processes and fluxes are affected by the intracellular milieu.
Pathways responsible for generation or decomposition of reactive species (O, N, S), and the modification of cellular constituents by oxidative stressors; chemistry and maintenance of cellular redox balance.
Small business (SBIR) and tech transfer (STTR) grants in Biochesmitry and Bio-related Chemistry.
Pamela Marino, Ph.D. Tel: 301-594-3827 Email:
Synthetic methodology development, including physical organic, mechanistic, and bioorthogonal chemistry.
Robert Lees, Ph.D. Tel: 301-594-3827 Email:
Total synthesis of complex organic molecules.
Regulation of metal ions (Cu, Ni, Zn, Fe, Se), their transport and intracellular concentrations, metal ion chaperones, and metal ion ionophores; restriction of metal ion availability as a therapeutic intervention.
Cellular and molecular mechanisms of immune cell (T cells, B cells) functions in the adaptive immune response.
Mechanisms and systemic effects of anesthesia including general, regional, and local anesthetics. Includes sedation in the intensive care setting, pain control and studies of consciousness related to anesthesia and the peri-operative period.
Alison E. Cole, Ph.D. Tel: 301-594-3827 Email:
Temporal and spatial signaling within cells, including calcium fluxes, diffusion, and pumps; regulation of signaling molecules by compartmentalization within organelles, and cellular sinks and releasing proteins.
Zhongzhen Nie, Ph.D. Tel: 301-594-3827 Email:
G protein-coupled receptors and cell surface receptors for drugs, endogenous ligands, and other stimuli; purpose is to understand basic biology and/or for validation as potential therapeutic targets.
Sailaja Koduri, Ph.D. Tel: 301-594-3900 Email:
Drug metabolizing enzymes and drug transporters, including drug-drug and nutrient interactions, toxicity and adverse effects. Includes pharmacokinetics, dynamics and genetics.
Richard T. Okita, Ph.D. Tel: 301-594-3827 Email:
Cellular and molecular mediators of onset, regulation, and termination of inflammation and the innate immune response. Includes bioactive lipid mediators in inflammatory disorders.
Molecular pathways for signal transduction and regulation within cells, including second messengers such as kinases, phosphatases, adapter proteins, lipid messengers, phospholipases and others (excluding calcium). Includes intracellular nuclear and cytosolic receptors.
Sarah E. Dunsmore, Ph.D. Tel: 301-594-3827 Email:
Pore-forming proteins specialized for ions (Na, K, Cl), ligand and voltage-gated, found at cell surface and organelle membranes. Includes ion channel blockers such as venoms and toxins.
Scaffolding and functional components of cellular membranes and vesicles: structural lipids (e.g., cholesterol), integral proteins, and their modifications. Gap junctions and communications between cells.
Systemic biological responses to challenges spanning multiple organ systems, including the physiological consequences of circadian rhythms, nutritional requirements, and stress.
Delivery systems for small and large molecules and biologics, including liposomes, dendrimers, viruses, chemical cages, and platforms/devices, with an emphasis on drug release and kinetics.
Small business (SBIR) and tech transfer (STTR) grants in Pharmacological and Physiological Sciences.
Severe sepsis and septic shock, with emphasis on the host's response rather than a presumptive causative microorganism or injury.
Responses to injury (traumatic, thermal, or surgical) and shock, in post-injury period to acute phase through long-term effects, until recovery or mortality. Includes inflammatory and immune responses, hypermetabolism, and prediction of body-wide recovery.
Processes underlying wound healing, tissue repair, and regeneration.
The goal of COBRE is to strengthen institutional biomedical research capabilities in IDeA-eligible states. COBRE supports three phases of infrastructure and faculty development in thematic, multidisciplinary centers.
COBRE Phase I COBRE Phase I focus on the development of requisite research resources and infrastructure, and the provision of formal research mentoring and research project funding to junior investigators to facilitate their acquisition of preliminary data and successful competition for independent research grant support.
Yanping Liu, M.D., Ph.D. Tel: 301-594-3900 Email:
COBRE Phase II COBRE Phase II is intended to further strengthen existing COBRE centers through the support and enhancement of the growing research infrastructure and continuing the development and expansion of a critical mass of investigators with shared scientific interests.
COBRE Phase III COBRE Phase III primarily provides support for scientific and technical cores to become independent service research facilities in the institution, and to sustain the research environment developed in the first two phases.
J. Rafael Gorospé, M.D., Ph.D. Tel: 301-594-3900 Email:
Science Education Partnership Award (SEPA) program supports educational activities, including interactive digital media resources, that complement or enhance the training of a workforce to meet the nation’s biomedical, behavioral and clinical research needs.
Tony Beck, Ph.D. Tel: 301-435-0805 Email:
INBRE's goal is to enhance, extend and strengthen the research capabilities of biomedical and behavioral research faculty in IDeA states. The strategy is to build statewide, multidisciplinary research networks that expand the research opportunities and increase the number of competitive investigators in those states. INBRE supports institutional research and infrastructure development; research by faculty, postdoctoral scientists and students at participating institutions; and outreach to build science and technology knowledge in the states' workforces.
Krishan Arora, Ph.D. Tel: 301-594-3900 Email:
IDeA-CTR encourages consortium applications from IDeA states to develop network infrastructure and capacity to conduct clinical and translational research focused on health concerns that affect medically underserved populations and/or that are prevalent in IDeA states. IDeA-CTR awards support mentoring and career development activities in clinical and translational research and facilitate collaboration among clinical researchers in IDeA and non-IDeA states.
This initiative provides support for partnerships of American Indian or Alaska Native tribes or tribal-based organizations with institutions that conduct intensive, academic-level biomedical research. The intent is to develop opportunities for conducting research and research training responsive to the needs of Native American communities.
Sheila A. Caldwell, Ph.D. Tel: 301-594-3900 Email:
This award supports new investigators at institutions that have a historical mission focused on serving students from population groups underrepresented in the biomedical research workforce who wish to establish a line of research within the NIH mission but need preliminary data. Investigators who have received SCORE support previously may only apply for a SCORE pilot project award if they seek to change research fields and need preliminary data. The award is nonrenewable.
Hinda Zlotnik, Ph.D. Tel: 301-594-3900 Email:
This mechanism supports investigators at institutions that have a historical mission focused on serving students from population groups that have been shown to be underrepresented in the biomedical research workforce who seek to increase their research competitiveness in biomedical research fields, with the ultimate goal of making the transition to major non-SCORE support. This award may be renewed once.
This mechanism supports investigators at institutions that have a historical mission focused on serving students from population groups underrepresented in the biomedical research workforce who still aim to improve their research competitiveness within an environment and circumstances that may require them to work at a less-intense pace than with a SCORE Research Advancement Award mechanism. The proposed projects must be of limited scope in a given biomedical field within the NIH mission. This award is renewable.
This initiative provides institutional support to partnerships between community colleges and colleges or universities that offer the baccalaureate degree to develop well-integrated developmental activities that will increase students preparation and skills as they advance academically in the pursuit and successful completion of the baccalaureate degree in biomedical sciences.
Mercedes Rubio, Ph.D. Tel: 301-594-3900 Email:
Patrick Brown, Ph.D. Tel: 301-594-3900 Email:
This initiative provides institutional support to partnerships between institutions granting a terminal master’s degree and institutions that offer Ph.D. degrees to develop well-integrated developmental activities that will increase students’ preparation and skills as they advance academically in the pursuit and successful completion of the Ph.D. degree in biomedical sciences.
BUILD is a set of experimental training awards designed to implement and study innovative and effective approaches to engaging and retaining students from diverse backgrounds in biomedical research and preparing students to become future contributors to the NIH-funded research enterprise.
BUILD is a part of the NIH Common Fund consortium
Enhancing the Diversity of the NIH-Funded Workforce. Consortium contact:
Richard Okita, Ph.D. Tel: 301-594-3827 Email:
Awards are for institutional programs that seek to increase the number of students from underrepresented groups in biomedical research who enter into and successfully complete Ph.D. degree programs in these fields. These awards are for institutions with a fully developed research infrastructure and full-time matriculated students from population groups that have been shown to be underrepresented in the biomedical research workforce. Support is limited to student development and training.
Veerasamy Ravichandran, Ph.D. Tel: 301-451-9822 Email:
This initiative provides institutional support for the research training and education of recent baccalaureate graduates from population groups that have been shown to be underrepresented in the biomedical research workforce, who plan to pursue Ph.D. degrees. This research apprenticeship serves as an educational transition for recent baccalaureate graduates who will acquire essential academic credentials and research skills to make them more competitive for Ph.D. programs at highly selective institutions.
Luis Cubano, Ph.D. Tel: 301-594-3900 Email:
This initiative provides support to institutions with significant enrollment of students from populations groups that have been shown to be underrepresented in the biomedical sciences to implement a set of well-integrated developmental activities designed to strengthen students’ academic preparation, research training and professional skills critical for completion of the Ph.D. degree in the in biomedical sciences.
All requests for general information about training grants should be directed to:
Shiva Singh, Ph.D. Tel: 301-594-3900 E-mail:email@example.comBiographical sketch
Behavioral-Biomedical Science Interface Programs should provide graduate research training for students at the behavioral sciences-biomedical sciences interface. The goal of the program is to develop basic behavioral scientists with rigorous broad-based training in the biomedical sciences who are available to assume leadership roles related to the Nation’s biomedical research needs. These programs must provide an interdisciplinary research training experience and curriculum for predoctoral trainees that integrates both behavioral and biomedical perspectives, approaches and methodologies. Programs must include coursework, laboratory rotations and programmatic activities that reinforce training at this interface. Significant participation by faculty and leadership from both behavioral and biomedical science departments is required, as is co-mentoring of trainees by faculty from both components.
Bioinformatics and Computational Biology Programs should train students in the background theory and biological application of information sciences (including computer science, statistics and mathematics) to problems relevant to biomedical research. Of particular interest are multiscale and large-scale problems in biology. Training should include the use of theory and computer application to the full spectrum of basic research in the biomedical sciences, including the analysis of molecular sequence and structure, molecular function, cellular function, physiology, genomics and genetics.
Hulak Resat, Ph.D. Tel: 301-827-6671 Email:
Biostatistics Provides support for predoctoral training that integrates biostatistical theory and evolving methodologies with basic biomedical research including, but not limited to, bioinformatics, genetics, molecular biology, cellular processes and physiology, as well as epidemiological and clinical studies. The goal is to ensure that a workforce of biostatisticians with a deep understanding of statistical theory and new methodologies is available to assume leadership roles related to the Nation’s biomedical research needs.
Biotechnology This training program supports the education of graduate students in the techniques and principles needed to pursue research in biotechnology. The education should be multidisciplinary, but provide a firm grounding in one or more of the fields that contribute to biotechnology, such as engineering, biophysics, biochemistry, genetics and cell biology. Faculty trainers and students participating in this program should be drawn from several departments but with a focus on engineering. The trainers should be conducting research relevant to the understanding and utilization of biological processes for biotechnological applications. These programs are expected to provide holistic training that should include, besides scientific theoretical and practical knowledge, communications skills, career development, and an understanding of regulatory, commercialization and IP issues in bringing a biotechnology product to the market. The program requires a mandatory 3 month internship in pharmaceutical or biotechnological industry. A close interaction between academic and industrial partners is strongly recommended.
Cellular, Biochemical and Molecular Sciences Programs should be of cross-disciplinary nature and involve in-depth study of biological problems at the level of the cellular and molecular sciences. The research training offered should encompass related disciplines, such as biochemistry, biophysics, chemistry, cell biology, developmental biology, genetics, immunology, microbiology, neurobiology and pathology.
Chemistry-Biology Interface Training programs in this area should provide significant biological training to students receiving in-depth training in a chemical discipline and provide significant training in chemistry to students being trained in depth in the biological sciences. CBI programs should have a focus on the use of synthetic and mechanistic chemistry as approaches to studying biological problems. Programs will consist primarily of faculty drawn from departments of chemistry, medicinal chemistry and/or pharmaceutical chemistry and faculty from the biological disciplines, such as biochemistry, molecular biology and cell biology. Students trained at the chemistry-biology interface should be well-grounded in a core discipline and sufficiently well-trained in complementary fields to allow them to work effectively in a multidisciplinary team.
Genetics Programs should emphasize broad training in the principles and mechanisms of genetics and related sciences. Training in a variety of areas such as classical genetics, molecular genetics, population genetics, and developmental genetics should be included. Programs should also include training and research opportunities in related disciplines such as biochemistry, cell biology and statistics.
Medical Scientist Training Program (MSTP) The Medical Scientist Training Program (MSTP) supports the training of students who are motivated to undertake a career in biomedical research and academic medicine in an integrated program of scientific and medical study leading to the combined M.D.-Ph.D. degree. The program's goal is to prepare its graduates to function independently in both basic research and clinical investigations.
Joe Gindhart, Ph.D. Tel: 301-594-3900 Email:
Molecular Biophysics Training in this area should be multidisciplinary and focus on the application of physics, mathematics and chemistry to the problems of biological structure, primarily at the molecular level. These programs should bring together faculty from departments such as chemistry, physics and engineering who have an interest in biologically related research with faculty in biological science departments whose orientation is the application of physical methods and concepts to biological systems.
Molecular Medicine Training in molecular medicine is intended to combine rigorous didactic training in the basic biomedical sciences with exposure to concepts and knowledge underlying the molecular basis of disease. In addition to training in the core concepts of molecular biology, cell biology and biochemistry, trainees in molecular medicine should have specialized required courses such as pathophysiology and molecular pathogenesis, and program activities, such as seminar series or journal clubs, that provide students with a better understanding of disease mechanisms. Examples of other features that would enhance training in molecular medicine could include dual mentors in basic and clinical science, and exposure to the concepts of medicine through participation in grand rounds. As with all NIGMS training programs, training faculty should be broadly drawn from multiple departments and disciplines and thesis research topics should similarly reflect a broad range of interdisciplinary opportunities in the basic biomedical sciences. The goal is to train a cadre of scientists prepared to work at the interface of basic biomedical science and clinical research, an area sometimes referred to as translational research. This training opportunity should be primarily designed for Ph.D. candidates; M.D. and M.D./Ph.D. doctoral candidates may be interested in such a program and could participate, but should not be the ones for whom a training program in molecular medicine is designed and should not be appointed as trainees to the training grant. A training program in Molecular Medicine should attract a new and distinct pool of students, and the training should clearly be differentiated from that offered by other training programs at the Institution.
Pharmacological Sciences Training programs in this area should be multidisciplinary and emphasize the acquisition of competence in the broad field of pharmacological sciences. Individuals should receive training that will enable them to conduct research on the biological phenomena and related chemical and molecular processes involved in the actions of therapeutic drugs and their metabolites. Thesis research opportunities should be available with faculty members in a variety of disciplines, such as biochemistry, chemistry, genetics, toxicology, medicinal chemistry, physiology and neurosciences, as well as pharmacology.
Systems and Integrative Biology Training in this area should be directed toward building the broad research competence required to investigate integrative, regulatory and developmental processes of higher organisms and their functional components. The training program should bring together varied resources, approaches and thesis research opportunities with faculty mentors of such disciplines/departments as physiology, biomedical engineering, the neurosciences, biochemistry and cell and developmental biology. Graduates of the program should be well-versed in quantitative, integrative and systems approaches to biology.
Zhongzhen Nie, Ph.D. Tel: 301-594-0828 Email:
Transdisciplinary Basic Biomedical Sciences This area is designed to increase efficiencies, and broaden the scope and geographic distribution of NIGMS training dollars. It is open only to: a) institutions that currently do not have a NIGMS-funded institutional predoctoral T32 training program in any of the basic biomedical sciences disciplines listed above (with the exception of Behavioral-Biomedical Sciences Interface or Biostatistics), or b) institutions with current NIGMS-funded predoctoral T32 training programs that propose to merge two or more of their existing NIGMS-funded predoctoral training programs in to a single program. Training supported under this area may be covered by the other NIGMS-supported areas of basic biomedical sciences disciplines, or may include other emerging area(s) within the NIGMS mission.
Shiva Singh, Ph.D. Tel: 301-594-3900 Email:
Awards are for individuals who seek advanced predoctoral research training in basic biomedical sciences relevant to the NIGMS mission. These fellowships promote fundamental, interdisciplinary and innovative research training and career development leading to independent scientists who are well prepared to address the nation's biomedical research needs.
NIGMS staff members who manage specific training programs are listed below.
Predoctoral M.D./Ph.D. or Other Dual-Doctoral Degree Fellowships (F30) These awards are designed to enhance the integrated research and clinical training of promising predoctoral students, who are matriculated in a combined M.D.-Ph.D. or other dual-doctoral degree training program (e.g. D.O.-Ph.D., D.D.S.-Ph.D., Au.D.-Ph.D., D.V.M.-Ph.D), and who intend careers as physician-scientists or other clinician-scientists. The fellowship experience is expected to clearly enhance the individuals’ potential to develop into productive, independent physician-scientists or other clinician-scientists.
Predoctoral Fellowships to Promote Diversity in Health-Related Research (F31) This NIH-wide program funds predoctoral fellowships for students (enrolled in Ph.D. or combined degree program) from population groups that have been shown to be underrepresented in the biomedical research workforce, preparing them to enter research careers in biomedical sciences.
These awards support the development of outstanding academic physician-scientists in the areas of anesthesiology, clinical pharmacology, innate immunity, inflammation, sepsis, and trauma and burn injury. They provide support for a period of 3 to 5 years of supervised research and study to clinically trained professionals who have the commitment and potential to develop into productive, independent investigators.
Anesthesiology Alison E. Cole, Ph.D. Tel: 301-594-3827 Email:
Clinical Pharmacology Rochelle M. Long, Ph.D. Tel: 301-594-3827 Email:
Innate Immunity and Inflammation Sarah E. Dunsmore, Ph.D. Tel: 301-594-3827 Email:
Sepsis Sarah E. Dunsmore, Ph.D. Tel: 301-594-3827 Email:
Trauma and Burn Injury Research Scott D. Somers, Ph.D. Tel: 301-594-3827 Email:
These awards support the career development of quantitatively trained investigators from the postdoctoral level to the senior faculty level who make a commitment to basic or clinical biomedicine, bioengineering or bioimaging research that is relevant to the NIH mission.
This program provides support for both mentored and independent research from the same award. The award provides up to 5 years of support consisting of two phases: the initial phase (K99) provides 1-2 years of mentored support to highly promising, postdoctoral research scientists, followed by up to 3 years of independent support (R00) contingent on the scientist securing an independent research position. Applications are accepted for research and training aligned with the NIGMS research priorities. NIGMS encourages postdoctoral trainees to apply by their third year of postdoctoral training.
Paula Flicker, Ph.D., Division of Cell Biology and Biophysics Tel: 301-594-0828 Email:
Dorit Zuk, Ph.D., Division of Genetics and Developmental Biology Tel: 301-594-0943 Email:
Oleg Barski, Ph.D., Division of Pharmacology, Physiology, and Biological Chemistry Tel: 301-594-3827 Email:
Michael Sesma, Ph.D., Division of Training, Workforce Development, and Diversity Tel: 301-594-3900 Email:
NRMN is developing a national network of motivated and skilled mentors from various disciplines linked to mentees across the country–both from
BUILD institutions and elsewhere–for individuals at the undergraduate to early career faculty levels and spanning biomedical disciplines relevant to the NIH mission. It is also developing best practices and training opportunities for mentors, as well as networking and professional development opportunities for mentees.
NRMN is a part of the NIH Common Fund consortium
Enhancing the Diversity of the NIH-Funded Workforce. Consortium contact:
Mercedes Rubio, Ph.D. Tel: 301-594-3900 Email:
CEC coordinates activities and will evaluate the efficacy of the training and mentoring approaches developed by
NRMN awardees. These findings will have implications for recruiting, training and mentoring of diverse groups nationwide, and the
CEC will disseminate effective approaches to the broader research and mentoring communities.
CEC is a part of the NIH Common Fund consortium
Enhancing the Diversity of the NIH-Funded Workforce. Consortium contact:
Michael Sesma, Ph.D. Tel: 301-594-2772 Email:
The F32 fellowship is for individuals who seek postdoctoral research training in areas related to the scientific programs of the institute. The senior fellowships (F33) are for established independent investigators.
Requests for general information about individual postdoctoral fellowships should be directed to:
Michael Sesma, Ph.D. Tel: 301-594-2772 E-mail:
For postdoctoral fellowship information specific to the program areas listed below, contact the indicated staff member:
Bioinformatics and Computational Biology Veerasamy Ravichandran, Ph.D. Tel: 301-451-9822 Email:
Biotechnology Assigned to all postdoctoral areas/disciplines
Genetics and Developmental Biology Applicant's last name beginning A-F contact Dr. Melillo; Applicant's last name beginning G-N contact Dr. Maas; Applicant’s last name beginning O-Z contact Dr. Willis.
Molecular Biophysics Paula Flicker, Ph.D. Tel: 301-594-0943 Email:
Pharmacological Sciences, Anesthesiology and Clinical Pharmacology Oleg Barski, Ph.D. Tel: 301-594-3827 Email:
Physiology Oleg Barski, Ph.D. Tel: 301-594-3827 Email:
Robert Lees, Ph.D. Tel: 301-594-3827 Email:
Quantitative Biology Assigned to all postdoctoral areas/disciplines
These awards provide institutional support to partnerships between a research-intensive university and one or more partner institutions that have a historical mission and a demonstrated commitment to providing training, encouragement and assistance to students from population groups underrepresented in the biomedical research workforce. The grant supports postdoctoral trainees who are engaged in cutting-edge research at the research-intensive university and who also participate in teaching at a partner institution, thus helping improve the research environment and also providing diversity in courses available to students at these institutions.
The IPERT supports creative and innovative research educational activities designed to complement and/or enhance the training of a workforce to meet the nation’s biomedical research needs. Each IPERT program must address the NIGMS goals of creating a highly skilled and diverse biomedical workforce. The programs can be designed to support stages of research career development from the undergraduate to the faculty level and must be ancillary or complementary to those research training and research education programs in which they currently participate, regardless of the source of support. While the balance of activities in a single application may vary, an IPERT application must effectively integrate three core elements: short-courses/workshops for skills development; mentoring; and outreach. This opportunity may be appropriate for research conferences, program-related workshops and activities, and educational projects previously supported by the expired MARC Ancillary Training Activities (T36) FOA.
Requests for general information about institutional postdoctoral fellowships should be directed to:
Alison E. Cole, Ph.D. Tel: 301-594-3827 E-mail:
Anesthesiology Programs should provide multidisciplinary research training to help develop individuals with the skills and expertise to explore problems relevant to anesthesiology, including the fundamental mechanisms of anesthetic action. The goal is to provide rigorous postdoctoral research training with an emphasis on hypothesis-driven laboratory or clinical research. Trainees, most of whom would hold the M.D. degree, will be expected to spend at least 2 years in the training program and should have the opportunity to acquire fundamental knowledge and research techniques in such disciplines as biochemistry, biophysics, cell biology, molecular biology, neurobiology, pharmacology or physiology. For trainees with the Ph.D. degree, the research and training should be specifically designed to promote a research career addressing problems in anesthesiology.
Clinical Pharmacology Individuals in these training programs should receive experience in the methodology and in the conduct of clinical and basic research to qualify them to investigate the effects and mechanisms of drug actions in humans. Trainees, who would usually have the M.D. degree, should have the opportunity to acquire fundamental scientific knowledge and learn research techniques in areas such as basic pharmacology, biochemistry, physiology, biostatistics and other biomedical subdisciplines.
Medical Genetics Training programs should provide advances and specialized research training in the principles of genetics with the goal of understanding human genetic disorders. Trainees should be drawn from diverse backgrounds and should be offered opportunities for conducting research with faculty who represent a variety of approaches to genetics ranging from molecular genetics to human population genetics. For holders of the M.D. or other professional degrees, the program should provide training and research opportunities in areas of basic genetics. This training should build on, and complement, the trainee's clinical background. For holders of the Ph.D. degree, the research and training should emphasize the application of the trainee's basic genetics background to problems in human and medical genetics.
Trauma, Burn, and Peri-Operative Injury Support for multidisciplinary research training is offered to individuals holding the M.D. or Ph.D. degree who seek to improve the understanding of the body's systemic responses to major injury and to foster the more rapid application of this knowledge to the treatment of trauma and burn-injured victims and/or critically ill patients. The supervisory staff of the training program should include trauma surgeons, burn specialists and critical care specialists as well as basic scientists. Trainees, most of whom would hold the M.D. degree, will be expected to spend at least 2 years in the training program and to apply such basic disciplines as physiology, biochemistry, immunology, microbiology, cell biology, molecular biology, biomedical engineering or behavioral sciences to the study of injury and/or critical illness.
This NIH-wide program provides supplemental funds to principal investigators holding NIGMS research grants, to improve the diversity of the research workforce by supporting and recruiting students and postdoctoral fellows from underrepresented racial and ethnic groups, individuals with disabilities and individuals from economically or educationally disadvantaged backgrounds that have inhibited their ability to pursue a career in health-related research.
This page last reviewed on
6/29/2018 2:45 PM
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