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Telomeres on outer edge of nucleus during cell division
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New research shows telomeres moving to the outer edge of the nucleus after cell division, suggesting these caps that protect chromosomes also may play a role in organizing DNA. Laure Crabbe, Jamie Kasuboski and James Fitzpatrick, Salk Institute for Biological Studies View MediaBiofilm formed by a pathogen
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A biofilm is a highly organized community of microorganisms that develops naturally on certain surfaces. Scott Chimileski, Ph.D., and Roberto Kolter, Ph.D., Harvard Medical School. View MediaSea urchin embryo 01
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Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). George von Dassow, University of Washington View MediaBiofilm blocking fluid flow
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This time-lapse movie shows that bacterial communities called biofilms can create blockages that prevent fluid flow in devices such as stents and catheters over a period of about 56 hours. Bonnie Bassler, Princeton University View MediaChromatin in human tenocyte
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The nucleus of a degenerating human tendon cell, also known as a tenocyte. It has been color-coded based on the density of chromatin—a substance made up of DNA and proteins. Melike Lakadamyali, Perelman School of Medicine at the University of Pennsylvania. View MediaHungry, hungry macrophages
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Macrophages (green) are the professional eaters of our immune system. Meghan Morrissey, University of California, Santa Barbara. View MediaDeveloping nerve cells
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These developing mouse nerve cells have a nucleus (yellow) surrounded by a cell body, with long extensions called axons and thin branching structures called dendrites. Torsten Wittmann, University of California, San Francisco View MediaSkin cell (keratinocyte)
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This normal human skin cell was treated with a growth factor that triggered the formation of specialized protein structures that enable the cell to move. Torsten Wittmann, University of California, San Francisco View MediaHuman Adenovirus
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The cryo-EM structure of human adenovirus D26 (HAdV-D26) at near atomic resolution (3.7 Å), determined in collaboration with the NRAMM facility*. National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View MediaLarvae from the parasitic worm that causes schistosomiasis
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The parasitic worm that causes schistosomiasis hatches in water and grows up in a freshwater snail, as shown here. Bo Wang and Phillip A. Newmark, University of Illinois at Urbana-Champaign, 2013 FASEB BioArt winner View MediaEndoplasmic reticulum abnormalities
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Human cells with the gene that codes for the protein FIT2 deleted. Green indicates an endoplasmic reticulum (ER) resident protein. Michel Becuwe, Harvard University. View MediaMisfolded proteins in mitochondria, 3-D video
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Three-dimensional image of misfolded proteins (green) within mitochondria (red). Related to image 5878. Rong Li, Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University View MediaGrowing hair follicle stem cells
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Wound healing requires the action of stem cells. Hermann Steller, Rockefeller University View MediaOlfactory system
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Sensory organs have cells equipped for detecting signals from the environment, such as odors. Judith Stoffer View MediaPanorama view of golden mitochondria
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Mitochondria are the powerhouses of the cells, generating the energy the cells need to do their tasks and to stay alive. Torsten Wittmann, University of California, San Francisco View MediaWorms and human infertility
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This montage of tiny, transparent C. elegans--or roundworms--may offer insight into understanding human infertility. Abby Dernburg, Lawrence Berkeley National Laboratory View MediaFruit fly brain responds to adipokines
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Drosophila adult brain showing that an adipokine (fat hormone) generates a response from neurons (aqua) and regulates insulin-producing neurons (red).Akhila Rajan, Fred Hutchinson Cancer Center View Media
Neural circuits in worms similar to those in humans
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Green and yellow fluorescence mark the processes and cell bodies of some C. elegans neurons. Shawn Xu, University of Michigan View MediaH1N1 Influenza Virus
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Related to image 6355. Dr. Rommie Amaro, University of California, San Diego View MediaLife in balance
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Mitosis creates cells, and apoptosis kills them. The processes often work together to keep us healthy. Judith Stoffer View MediaTelomerase illustration
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Reactivating telomerase in our cells does not appear to be a good way to extend the human lifespan. Cancer cells reactivate telomerase. Judith Stoffer View MediaEpithelial cells
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This image mostly shows normal cultured epithelial cells expressing green fluorescent protein targeted to the Golgi apparatus (yellow-green) and stained for actin (magenta) and DNA (cyan). Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View MediaMicrosporidia in roundworm 3
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Many disease-causing microbes manipulate their host’s metabolism and cells for their own ends. Keir Balla and Emily Troemel, University of California San Diego View MediaNeural tube development
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Proteins in the neural tissues of this zebrafish embryo direct cells to line up and form the neural tube, which will become the spinal cord and brain. Alexander Schier, Harvard University View MediaShiga toxin being sorted inside a cell
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Shiga toxin (green) is sorted from the endosome into membrane tubules (red), which then pinch off and move to the Golgi apparatus. Somshuvra Mukhopadhyay, The University of Texas at Austin, and Adam D. Linstedt, Carnegie Mellon University View MediaTranscription factor Sox17 controls embryonic development of certain internal organs
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During embryonic development, transcription factors (proteins that regulate gene expression) govern the differentiation of cells into separate tissues and organs. James M. Wells, Cincinnati Children's Hospital Medical Center View MediaMicrotubule growth
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Map of microtubule growth rates. Rates are color coded. This is an example of NIH-supported research on single-cell analysis. Gaudenz Danuser, Harvard Medical School View MediaMicrosporidia in roundworm 2
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Many disease-causing microbes manipulate their host’s metabolism and cells for their own ends. Keir Balla and Emily Troemel, University of California San Diego View MediaHost infection stimulates antibiotic resistance
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This illustration shows pathogenic bacteria behave like a Trojan horse: switching from antibiotic susceptibility to resistance during infection. View MediaActin flow
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Speckle microscopy analysis of actin cytoskeleton force. This is an example of NIH-supported research on single-cell analysis. Gaudenz Danuser, Harvard Medical School View MediaEndothelial cell
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This image shows two components of the cytoskeleton, microtubules (green) and actin filaments (red), in an endothelial cell derived from a cow lung. Tina Weatherby Carvalho, University of Hawaii at Manoa View MediaRed blood cells
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This image of human red blood cells was obtained with the help of a scanning electron microscope, an instrument that uses a finely focused electron beam to yield detailed images of the surface of a sa Tina Weatherby Carvalho, University of Hawaii at Manoa View MediaSnowflake yeast 3
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Multicellular yeast called snowflake yeast that researchers created through many generations of directed evolution from unicellular yeast. William Ratcliff, Georgia Institute of Technology. View MediaDeveloping fruit fly nerve cord
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The glial cells (black dots) and nerve cells (brown bands) in this developing fruit fly nerve cord formed normally despite the absence of the SPITZ protein, which blocks their impending suicide. Hermann Steller, Rockefeller University View MediaSea urchin embryo 05
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Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). George von Dassow, University of Washington View MediaPathways – Bacteria vs. Viruses: What's the Difference?
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Learn about how bacteria and viruses differ, how they each can make you sick, and how they can or cannot be treated. National Institute of General Medical Sciences View MediaHuman embryonic stem cells on feeder cells
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This fluorescent microscope image shows human embryonic stem cells whose nuclei are stained green. Blue staining shows the surrounding supportive feeder cells. Michael Longaker lab, Stanford University School of Medicine, via CIRM View MediaTracking cells in a gastrulating zebrafish embryo
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During development, a zebrafish embryo is transformed from a ball of cells into a recognizable body plan by sweeping convergence and extension cell movements. This process is called gastrulation. Liliana Solnica-Krezel, Washington University School of Medicine in St. Louis. View MediaSpreading Cells 01
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Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a complex process. Rong Li and Praveen Suraneni, Stowers Institute for Medical Research View MediaMultivesicular bodies containing intralumenal vesicles assemble at the vacuole 1
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Collecting and transporting cellular waste and sorting it into recylable and nonrecylable pieces is a complex business in the cell. Matthew West and Greg Odorizzi, University of Colorado View MediaMouse cerebellum
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The cerebellum is the brain's locomotion control center. Found at the base of your brain, the cerebellum is a single layer of tissue with deep folds like an accordion. National Center for Microscopy and Imaging Research (NCMIR) View MediaElectrode probe on mouse Huntington's muscle cell
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Using an electrode, researchers apply an electrical pulse onto a piece of muscle tissue affected by Huntington's disease. Grigor Varuzhanyan and Andrew A. Voss, California State Polytechnic University View MediaA bundle of myelinated peripheral nerve cells (axons)
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The extracellular matrix (ECM) is most prevalent in connective tissues but also is present between the stems (axons) of nerve cells. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View MediaCaulobacter
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A study using Caulobacter crescentus showed that some bacteria use just-in-time processing, much like that used in industrial delivery, to make the glue that allows them to attach to surfaces, Yves Brun, Indiana University View MediaNerve cell
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Nerve cells have long, invisibly thin fibers that carry electrical impulses throughout the body. Some of these fibers extend about 3 feet from the spinal cord to the toes. Judith Stoffer View MediaZebrafish larva
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You are face to face with a 6-day-old zebrafish larva. What look like eyes will become nostrils, and the bulges on either side will become eyes. Oscar Ruiz and George Eisenhoffer, University of Texas MD Anderson Cancer Center, Houston View MediaFruit fly ovaries
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Fruit fly (Drosophila melanogaster) ovaries with DNA shown in magenta and actin filaments shown in light blue. This image was captured using a confocal laser scanning microscope.Vladimir I. Gelfand, Feinberg School of Medicine, Northwestern University. View Media
Vimentin in a quail embryo
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Confocal image showing high levels of the protein vimentin (white) at the edge zone of a quail embryo. Cell nuclei are labeled green. Andrés Garcia, Georgia Tech View MediaCircadian rhythm neurons in the fruit fly brain
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Some nerve cells (neurons) in the brain keep track of the daily cycle. This time-keeping mechanism, called the circadian clock, is found in all animals including us. Justin Blau, New York University View MediaFruit fly larvae brains showing tubulin
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Two fruit fly (Drosophila melanogaster) larvae brains with neurons expressing fluorescently tagged tubulin protein. Vladimir I. Gelfand, Feinberg School of Medicine, Northwestern University. View Media