Image and Video Gallery

This is a searchable collection of scientific photos, illustrations, and videos. The images and videos in this gallery are licensed under Creative Commons Attribution Non-Commercial ShareAlike 3.0. This license lets you remix, tweak, and build upon this work non-commercially, as long as you credit and license your new creations under identical terms.

Beta-galactosidase montage showing cryo-EM improvement--gradient background

5883

Composite image of beta-galactosidase showing how cryo-EM’s resolution has improved dramatically in recent years. Older images to the left, more recent to the right. Veronica Falconieri, Sriram Subramaniam Lab, National Cancer Institute View Media

Tiny strands of tubulin, a protein in a cell's skeleton

3611

Just as our bodies rely on bones for structural support, our cells rely on a cellular skeleton. Pakorn Kanchanawong, National University of Singapore and National Heart, Lung, and Blood Institute, National Institutes of Health; and Clare Waterman, National Heart, Lung, and Blood Institute, National Institutes of Health View Media

DNA replication origin recognition complex (ORC)

3307

A study published in March 2012 used cryo-electron microscopy to determine the structure of the DNA replication origin recognition complex (ORC), a semi-circular, protein complex (yellow) that recogni Huilin Li, Brookhaven National Laboratory View Media

X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 5

3417

X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View Media

HIV Capsid

3477

This image is a computer-generated model of the approximately 4.2 million atoms of the HIV capsid, the shell that contains the virus' genetic material. Juan R. Perilla and the Theoretical and Computational Biophysics Group, University of Illinois at Urbana-Champaign View Media

VDAC-1 (1)

2488

The structure of the pore-forming protein VDAC-1 from humans. Gerhard Wagner, Harvard Medical School View Media

Serum albumin structure 2

3745

Serum albumin (SA) is the most abundant protein in the blood plasma of mammals. SA has a characteristic heart-shape structure and is a highly versatile protein. Wladek Minor, University of Virginia View Media

Jack bean concanavalin A

2407

Crystals of jack bean concanavalin A protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media

Bacteriophage P22 capsid

5874

Cryo-electron microscopy (cryo-EM) has the power to capture details of proteins and other small biological structures at the molecular level. This image shows proteins in the capsid, or outer co Dr. Wah Chiu, Baylor College of Medicine View Media

Crane fly spermatocyte undergoing meiosis

6898

A crane fly spermatocyte during metaphase of meiosis-I, a step in the production of sperm. Michael Shribak, Marine Biological Laboratory/University of Chicago. View Media

Drosophila (fruit fly) myosin 1D motility assay

6562

Actin gliding powered by myosin 1D. Note the counterclockwise motion of the gliding actin filaments. Serapion Pyrpassopoulos and E. Michael Ostap, University of Pennsylvania View Media

ARTS triggers apoptosis

2432

Cell showing overproduction of the ARTS protein (red). ARTS triggers apoptosis, as shown by the activation of caspase-3 (green) a key tool in the cell's destruction. The nucleus is shown in blue. Hermann Steller, Rockefeller University View Media

Ubiquitin-fold modifier 1 from C. elegans

2388

Solution NMR structure of protein target WR41 (left) from C. elegans. Northeast Structural Genomics Consortium View Media

3D image of actin in a cell

3749

Actin is an essential protein in a cell's skeleton (cytoskeleton). It forms a dense network of thin filaments in the cell. Xiaowei Zhuang, Howard Hughes Medical Institute, Harvard University View Media

Section of an electron density map

2354

Electron density maps such as this one are generated from the diffraction patterns of X-rays passing through protein crystals. The Southeast Collaboratory for Structural Genomics View Media

Protein from E. faecalis

2342

X-ray structure of a DNA repair enzyme superfamily representative from the human gastrointestinal bacterium Enterococcus faecalis. Midwest Center for Structural Genomics View Media

Structure of a key antigen protein involved with Hepatitis C Virus infection

5866

A three-dimensional representation of the structure of E2, a key antigen protein involved with hepatitis C virus infection. Mansun Law Associate Professor Department of Immunolgy and Microbial Science The Scripps Research Institute View Media

A2A adenosine receptor

3361

The receptor is shown bound to an inverse agonist, ZM241385. Raymond Stevens, The Scripps Research Institute View Media

Dimeric ferredoxin-like protein from an unidentified marine microbe

2340

This is the first structure of a protein derived from the metagenomic sequences collected during the Sorcerer II Global Ocean Sampling project. Joint Center for Structural Genomics View Media

CRISPR

6351

RNA incorporated into the CRISPR surveillance complex is positioned to scan across foreign DNA. Cryo-EM density from a 3Å reconstruction is shown as a yellow mesh. NRAMM National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View Media

TFIID complex binds DNA to start gene transcription

3766

Gene transcription is a process by which the genetic information encoded in DNA is transcribed into RNA. Eva Nogales, Berkeley Lab View Media

Epithelial cell migration

6899

High-resolution time lapse of epithelial (skin) cell migration and wound healing. It shows an image taken every 13 seconds over the course of almost 14 minutes. Michael Shribak, Marine Biological Laboratory/University of Chicago. View Media

Fly by night

2417

This fruit fly expresses green fluorescent protein (GFP) in the same pattern as the period gene, a gene that regulates circadian rhythm and is expressed in all sensory neurons on the surface of the fl Jay Hirsh, University of Virginia View Media

Cytonemes in developing fruit fly cells

3574

Scientists have long known that multicellular organisms use biological molecules produced by one cell and sensed by another to transmit messages that, for instance, guide proper development of organs Sougata Roy, University of California, San Francisco View Media

Shiga toxin

6997

E. coli bacteria normally live harmlessly in our intestines, but some cause disease by making toxins. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media

Morphine Structure

3438

The chemical structure of the morphine molecule Judy Coyle, Donald Danforth Plant Science Center View Media

Cells keep their shape with actin filaments and microtubules

3617

This image shows a normal fibroblast, a type of cell that is common in connective tissue and frequently studied in research labs. James J. Faust and David G. Capco, Arizona State University View Media

Pig alpha amylase

2412

Crystals of porcine alpha amylase protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media

X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 1

3413

X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View Media

RAC1 activation in motile fibroblast

2457

Novel biosensor system maps the timing and location of Rac protein activation in a living mouse embryo fibroblast. Klaus Hahn, University of North Carolina, Chapel Hill Medical School View Media

Catalase diversity

7003

Catalases are some of the most efficient enzymes found in cells. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media

Atomic-level structure of the HIV capsid

6601

This animation shows atoms of the HIV capsid, the shell that encloses the virus's genetic material. Juan R. Perilla and the Theoretical and Computational Biophysics Group, University of Illinois at Urbana-Champaign View Media

Blood clots show their flex

2450

Blood clots stop bleeding, but they also can cause heart attacks and strokes. Eric Lee, University of Illinois at Urbana-Champaign View Media

Serum albumin structure 1

3744

Kluyveromyces polysporus Argonaute bound to guide RNA

3408

A segment of siRNA, shown in red, guides a "slicer" protein called Argonaute (multi-colored twists and corkscrews) to the target RNA molecules. Kotaro Nakanishi and David Weinberg, Massachusetts Institute of Technology View Media

Mouse embryo showing Smad4 protein

2607

This eerily glowing blob isn't an alien or a creature from the deep sea--it's a mouse embryo just eight and a half days old. The green shell and core show a protein called Smad4. Kenneth Zaret, Fox Chase Cancer Center View Media

Dense tubular matrices in the peripheral endoplasmic reticulum (ER) 1

5855

Superresolution microscopy work on endoplasmic reticulum (ER) in the peripheral areas of the cell showing details of the structure and arrangement in a complex web of tubes. Jennifer Lippincott-Schwartz, Howard Hughes Medical Institute Janelia Research Campus, Virginia View Media

Myotonic dystrophy type 2 genetic defect

3573

Scientists revealed a detailed image of the genetic defect that causes myotonic dystrophy type 2 and used that information to design drug candidates to counteract the disease. Matthew Disney, Scripps Research Institute and Ilyas Yildirim, Northwestern University View Media

800 MHz NMR magnet

3526

Scientists use nuclear magnetic spectroscopy (NMR) to determine the detailed, 3D structures of molecules. Asokan Anbanandam, University of Kansas View Media

Nuclear Lamina

6572

The 3D single-molecule super-resolution reconstruction of the entire nuclear lamina in a HeLa cell was acquired using the TILT3D platform. Anna-Karin Gustavsson, Ph.D. View Media

Actin filaments bundled around the dynamin helical polymer

6571

Multiple actin filaments (magenta) are organized around a dynamin helical polymer (rainbow colored) in this model derived from cryo-electron tomography. Elizabeth Chen, University of Texas Southwestern Medical Center. View Media

Zika virus

6998

Zika virus is shown in cross section at center left. On the outside, it includes envelope protein (red) and membrane protein (magenta) embedded in a lipid membrane (light purple). Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media

Measles virus proteins

6996

A cross section of the measles virus in which six proteins (enlarged on the outside of the virus) work together to infect cells. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media

Rabbit GPDA

2405

A crystal of rabbit GPDA protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media

Bacteriophage P22 capsid, detail

5875

Detail of a subunit of the capsid, or outer cover, of bacteriophage P22, a virus that infects the Salmonella bacteria. Dr. Wah Chiu, Baylor College of Medicine View Media

Seeing signaling protein activation in cells 03

2453

Cdc42, a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including motility, proliferation, apoptosis, and cell morphology. Klaus Hahn, University of North Carolina, Chapel Hill Medical School View Media

Calcium uptake during ATP production in mitochondria

3449

Living primary mouse embryonic fibroblasts. Mitochondria (green) stained with the mitochondrial membrane potential indicator, rhodamine 123. Nuclei (blue) are stained with DAPI. Lili Guo, Perelman School of Medicine, University of Pennsylvania View Media

More Images...

View All Images