Alisa Zapp Machalek

Alisa Zapp Machalek

Originally trained in biochemistry, Alisa wrote about the full range of NIGMS-supported research before transferring to the National Institute of Arthritis and Musculoskeletal and Skin Diseases in April 2020. She managed the NIGMS image and video gallery, and helped foster science education at NIH.

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Science Snippet: Learn About the Cytoskeleton

May 12, 2021

The cytoskeleton is a collection of fibers that gives shape and support to cells, like the skeleton does for our bodies. It also allows movement within the cell and, in some cases, by the entire cell. Three different types of fibers make up the cytoskeleton: actin filaments, intermediate filaments, and microtubules.

Powering Muscles

Actin filaments contract or lengthen to give cells the flexibility to move and change shape. Along with the protein myosin, they’re responsible for muscle contraction, including voluntary movement and involuntary muscle contractions, such as our heartbeats. Actin filaments are the thinnest and most brittle of the cytoskeletal fibers, but they’re also the most versatile in terms of shape.

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