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“I think it’s really an exciting time for science. Some people might think that everything out there to be discovered has already been discovered, but that’s far from the truth. There is still much, much more to discover,” says John Jimah, Ph.D., an assistant professor of molecular biology at Princeton University in Princeton, New Jersey. We talked with him about how he moved internationally to pursue his career, how his current research on cellmembranes could help treat malaria, and how science holds space for everyone.
Get to Know Dr. Jimah
Books or movies? Movies
Coffee or tea? Mocha
Beach or mountains? Beach
Cats or dogs? Dogs
Music, podcasts, or quiet? Podcasts
Early bird or night owl? Early bird
Childhood dream job? Judge
Favorite hobby? Bicycling
Favorite piece of lab safety equipment? Gloves
A scientist (past or present) you'd like to meet? Leonardo da Vinci
“I think there’s a very creative side to science, in figuring out how to approach a problem, which I find really engaging,” says Mia Huang, Ph.D., an associate professor of chemistry at the Scripps Research Institute in La Jolla, California. In an interview, Dr. Huang discussed her shift in interest from medicine to science, her graduate school work on nature-inspired antifreeze molecules, and her lab’s exploration of the roles of sugar-coated proteins in our bodies.
Get to Know Dr. Huang
Coffee or tea? Coffee
Favorite music genre? EDM
Cats or dogs? Dogs—I’m a proud mom to a 15-pound Bernedoodle
Rainy or sunny? Sunny
What was your childhood dream job? Scientist—I’m living the dream!
Favorite hobby? Playing video games
Favorite piece of lab safety equipment? Safety goggles
A scientist (past or present) you'd like to meet? Gilbert Ashwell and Anatol Morell (accidentally co-discovered the asialoglycoprotein receptor)
This post is part of a miniseries on genetics. Be sure to check out the
other posts in this series
that you may have missed.
Credit: NIGMS.
In our miniseries on
genetics, we've introduced the
genome and how
variants in
DNA affect us. We've also
discussed how people inherit genetic information and the way
genes are
expressed, as well as common
tools researchers use to study DNA. We hope you've paid close attention
because it's time to test your knowledge of genetics! Take our quiz below, and
let us know how many questions you answered correctly.
This post is part of a miniseries on genetics. Be sure to check out the other posts in this series that you may have missed.
DNA carries information needed for all cellular functions. Credit: NIGMS.
You may wonder how scientists study something as tiny as DNA. Over the past decades, researchers have developed a wide range of tools and techniques to help them unlock the secrets of human genomes and those of other organisms. Two key examples are DNA sequencing and gene editing.
DNA Sequencing
DNA sequencing, sometimes called gene or genome sequencing, enables researchers to "read" the order of the bases in a segment of DNA, which contains the information a cell needs to make important molecules like proteins, the functional building blocks of the cell. There are several methods for sequencing, but they all require many copies of the same DNA segment to get accurate results. Fortunately, scientists have developed a technique called polymerase chain reaction, often referred to as PCR, that can quickly and inexpensively create a large number of copies of a DNA segment.
Beta-galactosidase, also known as lactase, a metabolic enzyme that breaks down the sugar lactose. Credit: PDB 6DRV.
You've likely heard someone attribute their body size to a fast or slow metabolism. But did you know there's much more to metabolism than calories burned? Metabolism includes all the chemical changes that occur as our bodies use enzymes to break down food, medicines, and biological substances as well as produce energy and materials needed for growth.
The Two Sides of Metabolism
Our bodies have many metabolic pathways, but they all fall into two main categories: catabolic and anabolic. Catabolic pathways break down complex molecules into simpler ones, usually releasing energy in the process. For example, catabolic pathways turn large carbohydrate molecules from our food into simple sugars, such as glucose. Some of the most well-known catabolic pathways then convert the simple sugar glucose into adenosine triphosphate (ATP), a molecule that cells commonly use as an energy source.
This post is part of a miniseries on genetics. Be sure to check out the other posts in this series that you may have missed.
Have you ever been told that you have your mother’s eyes? Or maybe you’ve found that you and your father share a condition such as asthma? People who are biologically related often have similarities in appearance and health because they have some of the same geneticvariants. However, you’ve likely noticed that siblings with the same biological parents can differ significantly. Each person’s genome is a combination of DNA from both of their parents, but siblings’ DNA can differ because of the mixing and matching involved in creating reproductive cells.
Genetics is the study of genes and heredity—how traits are passed from parents to children through DNA. A gene is a segment of DNA that contains instructions for building one or more molecules that help the body work. Researchers estimate that humans have about 20,000 genes, which account for about 1 percent of our DNA. The remainder of the DNA plays a role in regulating genes, and scientists are researching other potential functions.
Did you know that molecules can be unionized? But it doesn’t mean they form a labor union. In chemistry, unionized (pronounced “un-ionized”) is the opposite of ionized, which means “electrically charged.”
The brain is a large and complex organ, but some very small structures guide its development. Xuecai Ge, Ph.D., an associate professor of molecular and cell biology at the University of California, Merced (UC Merced), has devoted her career to understanding one of these structures called the primary cilium. In an interview, Dr. Ge shared how her childhood experience inspired her to study science and what makes the primary cilium fascinating.
Q: How did you first become interested in science?
A: When I was a little kid, my mom was a primary care doctor, and I saw her treat patients in our community. I noticed that no matter who got a particular illness, she could use the same medicine to treat them. My little mind was amazed that the same medicine could work for so many different people! I think this early experience planted the original seed of my interest in life science.
Happy Valentine's Day! In place of red roses, we hope you'll accept a bouquet
of beautiful scientific images featuring rich, red hues. Be sure to click all
the way through to see the festive
protein flowing through your
blood!
For more scientific photos, illustrations, and videos in all the colors of the
rainbow, visit our image and video gallery.