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Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the we​bsite may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit Updates regarding government operating status and resumption of normal operations can be found at


The National Institute of General Medical Sciences (NIGMS) supports basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention. NIGMS-funded scientists investigate how living systems work at a range of levels from molecules and cells to tissues and organs, in research organisms, humans, and populations. Additionally, to ensure the vitality and continued productivity of the research enterprise, NIGMS provides leadership in training the next generation of scientists, in enhancing the diversity of the scientific workforce, and in developing research capacity throughout the country.

NIGMS is one of the National Institutes of Health (NIH), the principal medical research agency of the Federal Government. NIH is a component of the U.S. Department of Health and Human Services.

All NIH Institutes and Centers support basic research that is relevant to the diseases, organ systems, stages of life, or populations within their mission areas. In contrast, NIGMS supports fundamental research that does not focus on those specific areas. NIGMS’ research mission is aimed at understanding the principles, mechanisms, and processes that underlie living organisms, often using research models. NIGMS also supports the development of fundamental methods and new technologies to achieve its mission. NIGMS-supported research may utilize specific cells or organ systems if they serve as models for understanding general principles. Research whose overall goal is to gain knowledge about a specific organ or organ system or the pathophysiology, treatment, or cure of a specific disease or condition will, in most cases, be more appropriate for another Institute or Center. See the NIH listing of Institutes, Centers, and Offices to learn more about their specific missions.

NIGMS also supports research in specific clinical areas that affect multiple organ systems: anesthesiology and peri-operative pain; sepsis; clinical pharmacology that is common to multiple drugs and treatments; trauma, burn injury, and wound healing.

NIGMS is organized into the following divisions and a center that support researchresearch training, and capacity building in a range of scientific fields.

Division of Biomedical Technology, Bioinformatics, and Computational Biology

Division of Cell Biology and Biophysics

Division of Genetics and Developmental Biology

Division of Pharmacology, Physiology, and Biological Chemistry

Division of Training, Workforce Development, and Diversity

Center for Research Capacity Building

Selected Advances

Among the advances that scientists have made with NIGMS support are:

  • - Discovering a gene-silencing process called RNA interference, or RNAi, that is both a powerful research tool and a promising new approach for treating diseases.
  • - Revealing how a protein's shape affects its function, which plays a key role in health and disease and also informs the design of new drugs.
  • - Increasing survival from burn injury, in part by improving methods of wound care, nutrition and infection control.
  • - Shedding light on the critical functions of carbohydrates, sugar molecules found on all living cells that are vital to fertilization, inflammation, blood clotting and viral infection.
  • - Understanding and modeling infectious disease outbreaks through computer simulations to provide valuable information for researchers and public health stakeholders.
  • - Developing new methods to look inside cells and other living systems. These approaches have advanced what we know about basic life processes in a range of organisms.
This page last reviewed on January 19, 2018