Division of Genetics and Molecular, Cellular, and Developmental Biology

The Division of Genetics and Molecular, Cellular, and Developmental Biology (GMCDB) supports research to understand the structure and function of cells and cellular components, and the cellular and molecular mechanisms that underlie inheritance, gene expression, and development. The results of this research form the foundation for advances in diagnosing, preventing, treating, and curing a wide variety of diseases. Most of the projects supported by the division make use of research organisms, which advance the general understanding of biological processes. In most cases, research whose overall goal is to gain knowledge about a specific organ or organ system or the pathophysiology, treatment, or cure of a specific disease or condition is not supported by the GMCDB Division.

The division has three components: the Cell Biology Branch, the Developmental and Cellular Processes Branch, and the Genetic Mechanisms Branch.

Research areas NIGMS supports within this division and contact names are listed on the Contacts by Research Area page. For a list of all GMCDB staff and links to their biographical sketches, see the Division Staff Contacts page.

Cell Biology Branch

This branch supports studies on the molecular basis of cellular function in a wide range of cell types and model systems. Research topics include plasma and intracellular membrane systems and functions; protein processing, membrane trafficking, and intracellular transport; cellular aspects of protein folding; organelle biogenesis, inheritance, and dynamics; cell division; cytoskeletal structure and function; cellular organization, motility, and mechanics; cell adhesion and signaling; and cell-cell junctions and interactions.

Developmental and Cellular Processes Branch

This branch supports studies on the genetic and biochemical pathways that cells utilize in development and in normal physiological processes, spanning the spectrum from the genetic basis of development and cell function to biochemical signaling pathways that underlie normal cell physiology. Research topics include cell cycle control; mechanisms of cell death; regulation of cell growth, differentiation, and homeostasis; adaptive responses to stress and nutrients; stem cell biology; organismal response to the environment and microbe-host interactions; developmental genetics; developmental signaling; neurogenetics and the genetics of behavior; and chromosome structure and epigenetic regulation of gene expression.

Genetic Mechanisms Branch

This branch supports studies on the mechanism and regulation of basic molecular processes. Research topics include DNA and RNA metabolism (i.e., replication, modification, and repair), transcription, coding and noncoding RNA mechanisms of action and function, and protein synthesis. Studies that investigate interactions among these processes are also supported. In addition, the branch supports studies of population genetics, evolution, and the genetic basis of human biology. The emphasis is on general principles governing these processes rather than on the expression of specific genes in relation to organismal phenotypes or disease.

Along with its research and research training activities, the division supports the NIGMS Human Genetic Cell Repository, which maintains and distributes to research scientists cell lines and DNA samples from people with and without genetic disorders.

For more information about the NIGMS Division of Genetics and Molecular, Cellular, and Developmental Biology, contact:

Dr. Dorit Zuk
Director, Division of Genetics and Molecular, Cellular, and Developmental Biology
National Institute of General Medical Sciences
National Institutes of Health
45 Center Drive MSC 6200
Bethesda, MD 20892-6200