Miriam BocarslyMiriam Bocarsly is a PRAT fellow in the lab of Veronica Alvarez, National Institute on Alcohol Abuse and Alcoholism. She obtained her Ph.D. in psychology and neuroscience from Princeton University, where she worked first with Bart Hoebel on the shared neurobiological underpinnings of food intake and drug addiction, and then with Elizabeth Gould exploring alterations in brain morphology associated with cognitive deficits in an obese animal model. In her postdoctoral studies, Bocarsly is broadly interested in identifying the neural circuitry driving aberrant consummatory and appetitive behaviors, such as psychostimulant-induced anorexia and polydipsia. In doing so, her research aims to identify potential neurological targets that may provide therapeutic benefit in disorders such as obesity. Bocarsly aspires to be an independent investigator with a research program focused on further resolving the neural circuitry modulating food and water consumption in healthy and diseased states.View Publications
Jonathan BusadaJonathan Busada is a PRAT fellow in the laboratory of John Cidlowski at the National Institute of Environmental Health Sciences. He obtained his Ph.D. at East Carolina University in anatomy and cell biology where he studied the cellular processes regulating spermatogonial stem cell differentiation and self-renewal in the laboratory of Chris Geyer. His postdoctoral research is on the role of glucocorticoids in suppressing gastric inflammation and metaplasia. He is interested in the cellular and physiological processes that maintain tissue homeostasis and suppress inflammation in the stomach, and how disruption of these processes leads to inflammatory disease, metaplasia, and eventually gastric cancer. Jon’s long-term goal is to continue his research in gastric biology as an independent investigator at an academic institution. View Publications
William (Drew) ComrieDrew Comrie is a PRAT fellow in the laboratories of Helen Su and Michael Lenardo, National Institute of Allergy and Infectious Diseases. He obtained his Ph.D. in immunology at the University of Pennsylvania, where he studied the role of the actin cytoskeleton in the mechano-activation of cell adhesion molecules within the immunological synapse in the lab of Janis K. Burkhardt. His PRAT research investigates rare human mutations that lead to the development of primary immunodeficiencies or autoimmunity. These studies help identify mechanisms by which the human immune system functions and provide critical information related to the clinical treatment of patients with primary immune disorders. He is interested in the study of the activation and control of adaptive immune responses and would ultimately like to run a research program that helps translate basic understanding of these mechanisms to new discoveries and clinical intervention.View Publications
Laura Corrales-Diaz PomattoLaura Corrales-Diaz Pomatto is a PRAT fellow in the laboratory of Rafael de Cabo, National Institute on Aging. She received her Ph.D. in biology of aging from the joint program between the University of Southern California (USC) and the Buck Institute on Aging, and is first in the nation to be awarded a doctorate in this new program. Under the mentorship of Kelvin J. A. Davies, Pomatto explored the age-related changes in the adaptive stress response in the model organism, D. melanogaster. She uncovered not only sex-dependent differences in the activation of the stress response, but the age-dependent loss in its activation. She characterized similar trends in other models including the nematode worm and a mouse model for smog exposure in young and middle-aged female mice. At the NIH, Pomatto plans to pursue her desire to uncover not only the mechanism behind the adaptive stress response, but interventions to restore its age-dependent loss. She is very excited to explore this area of research in conjunction with caloric restriction and other non-pharmacological interventions identified in extending the lifespan.
James D’Amour James D’Amour is a PRAT fellow in the laboratory of Chris McBain, National Institute of Child Health and Human Development. He obtained his Ph.D. in physiology and neuroscience at The New York University Medical School, where he studied inhibitory synaptic plasticity and neuromodulation in the lab of Robert Froemke. In his PRAT research, James is studying the development of cell-type specific neuronal circuitry in the hippocampus using a mouse model of the genetic disorder lissencephaly, in which cells improperly migrate and fail to form canonical layers. By examining preserved versus lost synaptic (cell-cell) connections as a result of cellular mispositioning, James hopes to gain insights on the developmental processes instructing circuit specification. His broader scientific interests are in disentangling the various factors governing neuronal circuit formation in healthy and diseased brains for the purposes of therapeutic intervention.
Seth Dickey Seth Dickey is a PRAT fellow in the lab of Michael Otto, National Institute of Allergy and Infectious Diseases. He obtained his Ph.D. in molecular biology and genetics from the Johns Hopkins School of Medicine with Sinisa Urban, where he developed techniques to assay the activity of intramembrane rhomboid proteases in their natural membrane environment. As a PRAT fellow, he is combining bacterial genetics and biochemical assays to characterize and identify inhibitors of a Staphylococcus aureus ABC transporter that secretes virulent peptides. His long-term goal is to continue his work on membrane proteins in antibiotic-resistant bacteria as an independent investigator. View Publications
Amicia ElliottAmicia Elliott is a PRAT fellow in the laboratories of Benjamin White, National Institute of Mental Health, and Hari Shroff, National Institute of Biomedical Imaging and Bioengineering. Elliott completed her Ph.D. in molecular physiology and biophysics at Vanderbilt University with David Piston, where her primary focus was studying the role of paracrine factors in the glucose-dependent inhibition of glucagon secretion from pancreatic alpha cells. She also developed methodologies for studying, simultaneously, calcium and cAMP signaling in live cells using real-time hyperspectral imaging. Elliott’s current work also combines technique development and research. She is designing a light-sheet microscope which she will use to study behaviorally-associated neural activity in the fruit fly. Her project exploits the advanced genetics of the Drosophila model system with novel microscopy and computational biology methods to analyze brain-wide activity at cellular resolution. Her broad interests lie in systems neuroscience and technology development for the life sciences. View Publications
Jill FritzJill Fritz is a PRAT fellow in the lab of Michael Lenardo, National Institute of Allergy and Infectious Diseases. She received her Ph.D. in immunobiology at the University of Cincinnati and Cincinnati Children’s Hospital under the mentorship of Timothy Weaver, where her research helped to identify the physiological role of molecular chaperones regulated by the unfolded protein response. At NIH, Fritz’s PRAT-funded research aims to discover novel pathogenic variants in humans with primary immunodeficiency. Upon completing her postdoctoral training, Fritz would like to be an independent investigator with research focused on developing immunotherapies for the treatment of disease. View Publications
Sam A. GoldenSam A. Golden is a PRAT fellow in the laboratories of Yavin Shaham, Antonello Bonci and Da-Ting Lin, National Institute on Drug Abuse. Golden obtained his Ph.D. in neuroscience from the Icahn School of Medicine at Mount Sinai in New York City. Under the supervision of Scott Russo, he worked on elucidating the epigenetic and circuit-based mechanisms governing stress-induced structural plasticity within the mesolimbic reward system. At NIH, he is investigating the neuronal mechanisms that regulate the motivational component of aggressive behavior, through the use of circuit-specific in vivo awake-behaving genetically encoded calcium sensor microendoscopy. Golden plans to transition to a role as an independent principle investigator within the academic environment.View Publications
Joo Yun JunJoo Yun Jun is a PRAT fellow in the lab of Jack A. Yanovski, Eunice Kennedy Shriver National Institute of Child Health and Human Development. She obtained her Ph.D. in physiology from the University of Florida while working in the lab of Mohan K. Raizada, where she studied neurogenic hypertension using spontaneous hypertensive rat models. Jun joined Dr. Yanovski’s lab in 2014 and her current research involves identifying cellular and molecular mechanisms of melanocortin 3 receptor in childhood obesity using humanized knock-in mouse models. Jun is a recipient of the Fellows Award for Research Excellence Program at NIH. Her long-term goal is to become an established scientist in the field of metabolic disorder and to provide beneficial therapeutic strategies to help improve human health.View Publications
Samuel KotlerSamuel Kotler is a PRAT fellow in the lab of Marius Clore, National Institute of Diabetes and Digestive and Kidney Diseases. He obtained is Ph.D. in biophysics from the University of Michigan-Ann Arbor while working in the lab of Ayyalusamy Ramamoorthy. As a Ph.D. student, he worked on characterizing the structural and dynamic self-assembly processes of the Alzheimer’s amyloid-beta peptide. His PRAT-funded research focuses on disease-associated protein domains containing expanded polyglutamine (polyQ) tracts. More specifically, Kotler studies the ability of these expanded polyQ domains to aggregate and form fibrous structures known as amyloid. His long-term goal is to someday head his own lab in an academic setting.
Lee LangerLee Langer is a PRAT fellow in the lab of Trevor Archer at the National Institute of Environmental Health Sciences. He received his Ph.D. in neurobiology from the University of North Carolina, Chapel Hill, where he studied the role of SOX2 in the development of the eye and hypothalamus. In his position as a PRAT fellow, he studies how epigenetic regulators control human embryonic stem cell pluripotency and differentiation. Specifically, Langer uses next-generation sequencing techniques to analyze how chromatin-remodeling complexes maintain or modify chromatin architecture in the steady state or in response to differentiating signals. His long-term goal is to lead a group that explores the roles of chromatin modifiers in the contexts of both health and disease.View Publications
Julia LiuJulia Liu is a PRAT fellow in the lab of Toren Finkel, National Heart, Lung, and Blood Institute. She obtained her Ph.D. in biophysics from Harvard University while working in the lab of Galit Lahav, where she studied apoptosis in response to DNA damage in human embryonic stem cells. Her current research focuses on genetic perturbations affecting the uptake of calcium into mitochondria, and their effects on mitochondrial and cellular function as well as tissue and organismal physiology. Her long term interests include the intersection between mitochondrial homeostasis and the regulation of cell death and aging.View Publications
Jonathan G. MurphyJonathan Murphy is a PRAT fellow in the lab of Dax A. Hoffman, Eunice Kennedy Shriver National Institute of Child Health and Human Development. Murphy obtained his Ph.D. in neuroscience from the University of Colorado, Anschutz Medical Campus. Under the supervision of Mark L. Dell’Acqua, he worked to understand how dynamic phosphorylation of neuronal L-type calcium channels regulates excitation-driven transcriptional activity in hippocampal neurons. As a PRAT fellow, Murphy studies ion channel translation in a mouse model of Fragile X Syndrome. Using microscopy and electrophysiology, Murphy aims to visualize ion channel translation in hippocampal pyramidal neurons to understand how this process is regulated during synaptic plasticity and may contribute to neuronal dysfunction during disease. View Publications
Dylan MurrayDylan Murray is a PRAT fellow in the lab of Robert Tycko, National Institute of Diabetes and Digestive and Kidney Diseases. He obtained his Ph.D. in molecular biophysics from Florida State University. Under the supervision of Timothy Cross, he worked at the National High Magnetic Field Laboratory to develop solid state nuclear magnetic resonance (ssNMR) methods for the study of membrane protein structure in native-like lipid environments. At NIH, he has worked to elucidate the structure and intermolecular interactions of low sequence complexity proteins using ssNMR. Aggregation of these proteins is linked to neurodegenerative disease and cancer. The aggregation also has a functional role in mRNA synthesis, transport and expression, which is not fully understood. Murray plans to lead a team of researchers working on the structure and function of insoluble protein complexes that cannot be studied by traditional structural biology techniques. View Publications
Jacob NordmanJacob Nordman is a PRAT fellow in the lab of Zheng Li at the National Institute of Mental Health. He obtained his Ph.D. in molecular neuroscience from the Krasnow Institute at George Mason University. Under the mentorship of Nadine Kabbani, Nordman characterized a novel signaling pathway involving ionotropic nicotinic acetylcholine receptors and a variety of secondary messenger proteins known as G proteins, which typically interact primarily with metabotropic receptors. These interactions were shown to regulate neurodevelopment pathways. He also developed methodologies for protein interaction network detection and simultaneous measurement of calcium and cytoskeletal dynamics in developing neural cells. Nordman’s current work at NIH involves an investigation into the role of synaptic plasticity in chronic violent aggression, through the use of optogenetics and in vivo electrophysiology. His broad neuroscience interests are aimed at understanding the neural mechanisms of psychiatric illness as a principle investigator at an academic institution.View Publications
Abhignya Subedi is a PRAT fellow in the laboratory of Dr. Harold A. Burgess at the Eunice Kennedy Shriver National Institute of Child Health and Human Development. She obtained her Ph.D. in biology from The Johns Hopkins University under the supervision of Dr. Marnie Halpern at the Carnegie Institute of Science. As a graduate student in Dr. Halpern’s laboratory, she defined distinct subregions of the interpeduncular nucleus, a brain structure that is highly conserved in vertebrates, and established the connectivity of these regions in the zebrafish brain. As a PRAT fellow, she is characterizing the raphe nucleus in zebrafish brain using molecular, imaging and behavioral techniques. Her long term goal is to become a principle investigator and study the molecular basis of developmental disorders using zebrafish as the research organism.View Publications
Ashley SwansonAshley Swanson is a PRAT fellow in the lab of Roger Woodgate, Eunice Kennedy Shriver National Institute of Child Health and Human Development. She obtained her Ph.D. in environmental toxicology at the University of California, Riverside, examining how environmentally induced DNA lesions affect the fidelity and efficiency of DNA replication in the lab of Yinsheng Wang. As a PRAT fellow, Swanson is studying the molecular mechanisms of DNA damage-induced tumor progression, and specifically how translesion synthesis DNA polymerases may afford protection against tumorigenesis using in vitro, cellular and mouse models. Her long-term professional goal is to continue exploring mechanisms of carcinogenesis as an independent investigator in an academic or government institution.View Publications
Tommy VoTommy Vo is a PRAT fellow in the laboratory of Shiv Grewal, National Cancer Institute. He obtained his Ph.D. in molecular biology from Cornell University under the supervision of Haiyuan Yu, where he studied the structure and evolution of protein interactome networks in yeasts. As a PRAT fellow, he studies the role of transcription machinery in shaping the epigenetic landscape within cells. His long-term goal is to lead a research program focused on understanding mechanisms underlying epigenetic plasticity and inheritance.
Erin WallErin Wall is a PRAT fellow in the lab of Susan Gottesman, National Cancer Institute. She obtained her Ph.D. in microbiology and molecular biology and genetics from Virginia Commonwealth University under the mentorship of Gail Christie. There she explored mechanisms of phage capsid morphogenesis as well as unique ribosomal biology in Staphylococcus aureus that led to a novel target for antibiotics. As a PRAT fellow, she is utilizing bacterial genetics to explore the structure and mechanism of the signaling cascade that regulates virulent capsule formation in the Enterobacteriaceae, many of which are now multidrug-resistant hospital pathogens. She has collaborations with Susan Buchanan’s lab at NIDDK for structural biology of membrane proteins and Matt Hall’s group at NCATS for high throughput screening of small molecules against a bacterial reporter assay. Her main interest is to continue to develop novel genetic systems and pursue antimicrobial targets in recalcitrant bacteria. View Publications
Sara Young-Baird Sara Young-Baird is a PRAT fellow in the laboratory of Thomas E. Dever, Eunice Kennedy Shriver National Institute of Child Health and Human Development. She obtained her Ph.D. in biochemistry and molecular biology from Indiana University School of Medicine while working in the laboratory of Ronald C. Wek. During her graduate work, Sara studied the regulation of protein synthesis for key factors that are central to cellular stress remediation and cell viability. Specifically, her work centered on translational mechanisms involving short open reading frames (uORFs) in the 5’-leader of mRNA transcripts. For her post-doctoral work, Sara’s PRAT-funded research focuses on how misregulation of protein synthesis contributes to the symptoms of MEHMO syndrome, an X-linked intellectual disability disease caused by mutations in EIF2S3. Sara is utilizing induced pluripotent stem cells (iPSCs) from MEHMO patients and genome-wide informatics approaches to identify global and gene-specific disruptions in protein synthesis that may contribute to MEHMO syndrome. The results of Sara’s work will hopefully benefit both our understanding of this debilitating neurological disorder, and the molecular mechanisms underlying the fidelity of protein synthesis.View Publications
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5/17/2018 9:31 AM
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