Administrative Supplements to NIGMS Predoctoral Training Grants
NIH Web Portal on Rigor and Reproducibility
NIH Grants & Funding Web Site on Rigor and Reproducibility in Grant Applications
NIH Reproducibility WorkshopsCell BiologyStructural BiologyGenome TechnologyCell Culture StudiesVideocast [Day 1 | Day 2]
In January 2014, NIH launched a series of initiatives to enhance rigor and reproducibility in research. As a part of this initiative, NIGMS, along with nine other NIH institutes and centers, issued a funding opportunity announcement (FOA)
RFA-GM-15-006 to develop, pilot and disseminate
training modules to enhance data reproducibility. This FOA was reissued in 2018 (RFA-GM-18-002).
For the benefit of the scientific community, we will be posting the products of grants funded by these FOAs on this website as they become available. In addition, we are sharing here other relevant training modules developed, including courses developed from
administrative supplements to NIGMS predoctoral T32 grants.
These modules, developed by NIH, focus on integral aspects of rigor and reproducibility in the research endeavor, such as bias, blinding and exclusion criteria. The modules are not meant to be comprehensive, but rather are intended as a foundation to build on and a way to stimulate conversations, which may be facilitated by the accompanying discussion materials. Currently, the modules are being integrated into NIH training activities.
Introduction to the Modules [PDF, 110KB]
Module 1: Lack of TransparencyLack of Transparency Discussion Material [PDF, 97.2KB]
Module 2: Blinding and RandomizationBlinding and Randomization Discussion Material [PDF, 104KB]
Module 3: Biological and Technical ReplicatesBiological and Technical Replicates Discussion Material [PDF, 98.7KB]
Module 4: Sample Size, Outliers, and Exclusion CriteriaSample Size, Outliers, and Exclusion Criteria Discussion Material [PDF, 107KB]
This 7-part online course aims to help researchers design and analyze group-randomized trials (GRTs). It includes video presentations, slide sets, suggested reading materials, and guided activities. The course is presented by ODP's Director, Dr. David M. Murray.
Access the course and related materials.
This course is designed for anyone from a high school student working in a lab, all the way through academic faculty who really want to figure out what's the big deal about reproducibility. Why are people now asking for cell line authentication? Why does it matter? Topics covered in the course include validating with STR, cell line databases, problematic and authenticated cells, evaluating STR data, other cell authentication methods and more.
A series of 14 tutorials on improving the reproducibility of data analysis for those doing microbial ecology research. Although the materials focus on issues in microbiome research, the principles are broadly applicable to other areas of microbiology and science. This series of lessons will focus on the importance of command line practices (e.g. bash), scripting languages (e.g. mothur, R), version control (e.g. git), automation (e.g. make), and literate programming (e.g. Rmarkdown). These are the tools that are used by a growing number of microbiome researchers to help improve the reproducibility of their research. By completing the activities in the tutorials, you will be listed on the Reproducible Research Tutorial Honor Roll, which provides a certification of your training.
Access the Tutorials
In order to promote better training and ensure the reliability and reproducibility of research, we developed a series of webisodes (thematically related online videos) targeted at graduate students, postdoctoral fellows, and beginning investigators that will address critical features of experimental design and analysis/reporting.
Module 1: Experimental Design Learning Module
The Experimental Design Learning Module focuses on the intricacies of designing research that is robust, with an eye towards making it reproducible. It is comprised of four distinct learning units: 1) Replication, 2) Randomization, 3) Pitfalls with Experimental Design, and 4) Measurement. Each of these learning units has one or more sub-topics that is the subject of an individual webisode.
Module 2: Analysis/Reporting Learning Module The Analysis/Reporting Learning Module covers the various factors that are critical to writing about research with enough clarity to ensure its reproducibility. Very few researchers are given formal education on how to properly report findings to support reproducibility. It is comprised of three distinct learning units: 1) Power and P-values, 2) Scientific Writing, 3) The Review Process. Each of these units has one or more sub-topics that are the subject of an individual webisode.
The topics of scientific rigor and data reproducibility have been increasingly covered in the scientific and mainstream media, and they are being addressed by publishers, professional organizations and funding agencies. This webinar addresses topics of scientific rigor as they pertain to preclinical neuroscience research.
Investigations into the lack of reproducibility in preclinical research often identify unintended biases in experimental planning and execution. This webinar covers random sampling, blinding and balancing experiments to avoid sources of bias.
Proper data handling standards, including appropriate use of statistical tests, are integral to rigorous and reproducible neuroscience research. Training in quantitative neuroscience is a specific area of emphasis for the
BRAIN Initiative, and rigorous statistical analysis methods are included in the recent
Proposed Principals and Guidelines for Reporting Preclinical Research [PDF, 69KB]. This webinar covers best practices in post-experimental data analysis.
Efforts to enhance scientific rigor, reproducibility and robustness critically depend on archiving and retrieving experimental records, protocols, primary data and subsequent analyses. In this webinar, presenters discuss best practices and challenges for data management and reporting, particularly when dealing with information security and sensitive material; archiving and disclosure of pre- and post-hoc data analytics; and data management on multidisciplinary teams that include collaborators around the globe.
How can neuroscientists improve their "statistical thinking" and make full and effective use of their data? This webinar covers common applications of statistics in neuroscience, including the types of research questions statistics are best positioned to address, modeling paradigms and exploratory data analysis. The presenters also share examples and case studies from their research.
Common sources of bias in animal behavior and electrophysiology experiments can be minimized or avoided by following best practices of unbiased experimental design and data analysis and interpretation. In this webinar, presenters discuss experimental design and hypothesis testing for mouse behavioral assays, as well as sampling, interpretational bias and referencing in
in vitro and in vivo electrophysiology recording studies.
This webinar explores practical examples of the challenges and solutions in conducting rigorous science from neuroscientists at various career stages. It focuses on development of the interpersonal, scientific and technical skills needed to address various issues in scientific rigor, such as what to do when you can't replicate a published result, how to get support from a mentor and how to cope with various career pressures that might affect the quality of your science.
Learn skills and tools that support data science and reproducible research to ensure you can trust your research results, reproduce them yourself, and communicate them to others.
This free course covers fundamentals of reproducible science, case studies, data provenance, statistical methods for reproducible science, computational tools for reproducible science, and reproducible reporting science. These concepts are intended to translate to fields throughout the data sciences: physical and life sciences, applied mathematics and statistics, and computing.
Consider this course a survey of best practices that will help you create an environment in which you can easily carry out reproducible research and integrate with similar situations for your collaborators and colleagues.
Access the course
This page last reviewed on
8/14/2018 1:33 PM
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