The current NIGMS National and Regional Resources (R24) Program NOFO is PAR-25-416, with one receipt date per year. This NOFO will expire on June 15, 2027.

The due dates are September 25, 2025; June 15, 2026; and June 14, 2027.

Yes. The link to the website with information with a list of NRR R24 Awardees is https://www.nigms.nih.gov/Research/mechanisms/Pages/NIGMS-National-and-Regional-Resources-(R24)

Following scientific review, pending applications are presented at the National Advisory General Medical Sciences Council. Funding decisions may be made by the NIGMS approximately three months after the Council meeting.

No, applications responding to this NOFO are not eligible for the Continuous Submission Policy.

An LOI is not required. Potential applicants are strongly advised to contact NIGMS staff early, at least 2 months before the application due date, through the contact email: R24Mailbox@nigms.nih.gov to discuss the NIGMS mission relevance and suitability of a proposed project for the NIGMS NRR R24 Program.

Applicants requesting $500,000 or more in direct costs in any year are not required to contact a Scientific/Research Contact prior to submitting the application.

The proposed resource could be suitable for the Program if the answers to all questions below are YES.

• Is the resource technology/capability mature, i.e., it does not require further development and optimization?
• Is the resource technology/capability unique, i.e., it is not widely available to individual laboratories?
• Does the resource technology/capability support NIGMS mission-related research?
• Does the resource have more than 100 users? If not, do you have a good plan to increase the userbase to more than 100 users? Alternatively, do you have a strong justification for why a smaller user base is warranted?
• Are the users from geographical areas within one or more US regions (e.g., West, Southwest, Midwest, Southeast, and Northeast) or across the nation?

Please contact NIGMS staff at R24Mailbox@nigms.nih.gov for further discussions.

Yes. NIGMS PDs/PIs holding a Maximizing Investigators' Research Award (MIRA) are eligible to apply. Since the NRR R24 supports resources for the research community, MIRA PDs/PIs are eligible for support through the NRR R24 funding. However, the requirement of at least 45% effort towards the MIRA still applies to R24 PIs.

Yes, a PD/PI can submit a MIRA and NRR R24 simultaneously.

Yes. A new investigator listed as a project leader and not designated as a PD/PI or MPI for the NRR R24 will retain their NI status. However, a new investigator listed as a PD/PI or MPI for the NRR R24 will lose their NI status.

An NRR R24 PD/PI must provide a minimum of 2.4 person-months effort to provide overall guidance, and at least one senior scientist must devote 6 or more person-months of their effort to managing the resource. Each MPI must also provide a minimum of 2.4 person-months effort to the NRR R24 project. An NRR R24 PD/PI or MPI who is a current MIRA holder must maintain at least 45% research effort toward their MIRA and 2.4 person months' effort toward the NRR R24.

Application budgets are not limited, but need to reflect the actual needs of the proposed project.

Yes. The NRR R24 is a resource, and effort under NRR is not considered a research activity.