NIGMS has just issued a call for Program Projects for Collaborative Research on the Basic Biology of Pluripotency and Reprogramming (P01), with an emphasis on human induced pluripotent stem (iPS) cells. We are particularly interested in studies that propose comprehensive analyses of the basic biology of pluripotency, the molecular events and mechanisms of reprogramming, and the epigenetics and epigenomics of the pluripotent and reprogrammed states. These applications have special requirements, so please read the announcement carefully. Letters of intent are due on November 1, and applications are due on December 1. If your research involves stem cells but isn’t appropriate for this announcement, you may submit an investigator-initiated R01 application that addresses the basic biology of stem cells and/or uses these cells as model systems to study fundamental life processes. You may contact me at hayness@nigms.nih.gov or Marion Zatz at zatzm@nigms.nih.gov with questions about this new opportunity or about NIGMS support for stem cell research.