We have just issued new program announcements to develop technologies for protein modeling (PAR-10-075, PAR-10-076) and high-throughput structural biology research (PAR-10-074, PAR-10-073). These announcements are part of the PSI:Biology initiative that will apply high-throughput structure determination to a broad range of biological problems. Advances in comparative molecular modeling and high-throughput approaches will play an important role in the success of this initiative. Protein Modeling The protein modeling announcements aim to increase the quality of protein structure models. Because they promote collaborative research and exploratory approaches in developing novel comparative modeling technology, we encourage applications from new and established investigators in mathematics, physics, computer science, statistics or other quantitative disciplines. High-Throughput Structural Biology Research These announcements solicit proposals for improved experimental methods and techniques for all aspects of structural biology investigations. We particularly welcome projects related to proteins that aren't currently amenable to high-throughput structural determination by X-ray crystallography and/or NMR spectroscopy. Successful applicants for all four announcements will become part of the PSI:Biology network. I can answer specific questions about the modeling announcements, and Charles Edmonds can answer questions about the high-throughput ones.