NIGMS is actively involved in efforts to catalyze the modernization of graduate education. As part of our work on this issue, we will host a symposium at NIH on Monday, April 11, where we will convene stakeholders from the biomedical graduate education community to continue the momentum for positive change and showcase innovative approaches in Ph.D. training. You can register to attend in person or watch the meeting live or later.

The agenda for the morning session includes an overview of the current landscape from the perspective of various stakeholders (students, institutions and employers) followed by a discussion on implementing change and assessing the effectiveness of educational innovations. The afternoon session will highlight experiments in various areas of graduate education such as curriculum redesign, quantitative skills enhancement, rigor and reproducibility, diversity and inclusion, and career and professional development. We will hear about why and how these experiments were implemented, their outcomes to date and aspects that could be exported to other institutions.

We hope you can join us for what promises to be a broad and stimulating discussion.

UPDATE: The Webinar slides and answers to frequently asked questions are available.

If you’re preparing an institutional training grant application, you might have questions about the new research training tables required for receipt dates on or after the one coming up on May 25. We’ll field these questions during a webinar on Tuesday, March 8, from 1:00-2:30 p.m. EST. You can send questions to me or post them here before the webinar.

The revisions reduce the number of tables from 12 to 8, minimize the reporting of individual-level information and extend the tracking of trainee outcomes from 10 to 15 years. Table 8A must also be used to prepare annual progress reports. Table formats, instructions and samples are available on the NIH website.

To access the webinar, visit https://face2face.nih.gov/hope.mabry/7GZSC5SY (link no longer available) and click “OK.” If you’re away from your computer, you can access the site from a mobile device. You can also listen to a voice-only option by calling 1-888-390-0678 from anywhere in the United States or Canada and entering access code 50106.

We look forward to talking to you about the new training tables.

UPDATE: To join this meeting, visit Webinar on Administrative Supplements to T32 Grants, PA-16-060 and click “OK.” The site is compatible with mobile devices.  We'll field your questions about the recently announced Availability of Administrative Supplements to NIGMS Predoctoral Training Grants during a webinar on Monday, Feb. 8, from 3:15-4:15 p.m. EST. Details about how to access the webinar online will be available soon. You can send questions to me ahead of time. Since announcing this funding opportunity, we've received many inquiries. The following points address most of the common questions:

• The supplement is designed to provide support for the development and implementation of curricular activities aimed at providing graduate students with a strong foundation in research design and methods in areas related to conducting reproducible and rigorous research.

• To be eligible, your training grant must be active through at least June 30, 2018. Thus, training grants that might have received outstanding priority scores and are expected to be renewed effective July 1, 2016, are NOT eligible.

This blog is one way that we reach out to the scientific community with information about research and research training policies, funding opportunities, analyses, resources, meetings and other useful news. It’s also a key way in which we get your input on our activities and plans. When I looked back at some recent posts, I was struck by how many of them are relevant to the graduate students and postdocs in your labs. For example, the post describing our plans to modernize graduate education is a must-read for graduate students, whose ideas and perspective will further inform our efforts. The post on talking to NIH staff about your application and grant provides essential information for postdocs who will soon be independent investigators. Please encourage your students and postdocs to subscribe to the Feedback Loop as well as to send us their suggestions for topics to cover in future posts.

NIH has launched a major new initiative called the Environmental Influences on Child Health Outcomes (ECHO) program to investigate environmental exposures on child health and development. An important component of the program will be the IDeA States Pediatric Clinical Trials Network (ISPCTN), which the Eunice Kennedy Shriver National Institute of Child Health and Human Development is leading in collaboration with us. The ISPCTN will give medically underserved and rural populations access to state-of-the-art pediatric clinical trials. The network’s clinical trials sites, which will be located in states eligible for funding through our Institutional Development Award (IDeA) program, will receive support for the development of appropriate research infrastructure as well as supervised professional development in all aspects of clinical trials research and implementation. We expect the ISPCTN to help strengthen pediatric research opportunities and capacity in IDeA states, which historically have not received extensive NIH funding. If you’re in an IDeA-eligible state (including Puerto Rico), we encourage you to apply to either or both of the ISPCTN FOAs:

• Clinical Sites for the IDeA States Pediatric Clinical Trials Network (UG1)
• Data Coordinating and Operations Center for the IDeA States Pediatric Clinical Trials Network (U24)

Applications proposing studies on all pediatric diseases and conditions will be considered, but priority will be given to those on the focus areas and core elements of the ECHO program, which include upper and lower airway disease; obesity; pre-, peri-, and postnatal outcomes; and neurodevelopment. The application deadline for both announcements is April 15, 2016, with optional letters of intent due by March 15, 2016. For more information about the ECHO program and its various FOAs, you can participate in webinars scheduled for January 14, 2016, and February 1, 2016, or contact one of us (douthardr@mail.nih.gov, gorospejr@mail.nih.gov).

A major overhaul of how we educate graduate students in biomedical research is long overdue.

Science has changed dramatically over the past three decades. The amount of information available about biological systems has grown exponentially. New methods allow us to examine the inner workings of cells with unprecedented resolution and to generate expansive datasets describing the expression of every mRNA or metabolite in a system. Biomedical research is becoming increasingly interdisciplinary and collaborative, and the questions we seek to answer are more and more complex. Finally, as the scientific enterprise has expanded, Ph.D.s have pursued increasingly diverse careers in the research and development, education and related sectors.

Despite these major changes, we educate Ph.D. students in biomedical research in essentially the same way as we did 25 or more years ago. As Alan Leshner put it in a recent editorial in Science magazine, “It is time for the scientific and education communities to take a more fundamental look at how graduate education in science is structured and consider, given the current environment, whether a major reconfiguration of the entire system is needed.”

Problems related to the reproducibility and rigor of scientific studies are likely driven in part by the inadequacies of an outdated system for educating our trainees. When nearly any student can sequence hundreds of millions of bases of DNA in a few days, does it make sense that all of our students are not given a significant amount of training in quantitative and computational analyses? And as we delve into more complex biological systems, shouldn’t students be receiving in-depth training in rigorous experimental design and data interpretation before they embark on their thesis work?

We recently analyzed the educational and career outcomes of scholars who participated in the NIGMS Postbaccalaureate Research Education Program (PREP). The goal of this program, which we started in 2000, is to prepare recent baccalaureate graduates from groups that are underrepresented in the biomedical sciences for entry into—and completion of—rigorous Ph.D. training programs. PREP is part of a larger effort at NIGMS to support the development of a highly skilled, creative and diverse biomedical research workforce.

PREP grants are awarded to research-intensive institutions. Each grant supports five to 10 scholars who spend 75 percent of their time as apprentice scientists pursuing a mentored discovery research project and the remainder engaged in academic and professional development activities. These include a program of study to enhance their academic record and workshops to improve their writing and presentation skills.

Our assessment of PREP outcomes is based on various educational and career metrics for PREP scholars supported from 2001 to 2014 through 41 institutional programs. For more details about the analysis, read the report.

Last week, I wrote to NIGMS-funded T32 program directors to encourage them to inform students about trainee career outcomes. Because this topic is also relevant to the broader community, I'd like to share the message here.

Dear NIGMS T32 Training Grant Program Director:

At the June 2015 meeting of NIGMS training, workforce development, and diversity program directors, Peter Preusch, Dick Okita and I discussed the importance of making post-training career outcomes available to current and prospective students. The goal of collecting and sharing data on Ph.D. career outcomes is consistent with recommendations of the Biomedical Research Workforce Working Group of the Advisory Committee to the Director, NIH. This topic has also been addressed by the Association of American Medical Colleges, the Council of Graduate Schools and a recent Molecular Biology of the Cell article.

We recently analyzed outcomes of the NIGMS Research Supplements to Promote Diversity in Health-Related Research (referred to here as the Diversity Supplement Program or DSP), which provides investigators holding active NIGMS research grants with supplemental funds to support scholars from groups underrepresented in biomedical science. Using a public search approach, we could track a large proportion of participants—but not all—through doctoral training and into various careers. We assessed the educational and career outcomes for undergraduate, graduate student and postdoctoral participants supported by supplements between 1989 and 2006, and we encourage you to explore the report.

In the years since the first cohort of postdoctoral fellows entered the NIGMS Pharmacology Research Associate (PRAT) program in 1965, the program's alumni have become leaders in pharmacology, neuroscience, cell biology and related fields across multiple career sectors, including academia, government and industry. On November 6, we'll mark the accomplishments of the more than 400 PRAT alumni in a full-day scientific symposium on the NIH campus in Bethesda, MD.

The symposium will feature presentations by 10 alumni spanning the duration of the program and is free and open to the public, although we encourage you to register to attend. If you can't be there in person, you can watch the event live or later. If you have comments, anecdotes, historical data or photos from the PRAT program, please let us know by writing a note in the comments box on the meeting registration site or by sending me an e-mail message.