We're once again soliciting applications from research-intensive institutions for the NIGMS Institutional Research and Academic Career Development Award program. Now in its 12th year, the IRACDA program supports traditional postdocs at research-intensive universities who also teach at nearby institutions with substantial enrollments of minority students. The program offers an opportunity to conduct top-notch research while developing teaching and other academic skills, such as problem-solving, communication, time management and grant-writing. Eighteen institutions currently participate in the program. Because the IRACDA program combines a traditional mentored research experience with instruction, it prepares scientists for careers in both research and teaching. It also benefits the students at the institutions where the teaching takes place. So far, the data indicate that IRACDA postdocs do as well as or better than their peers in publishing and in getting jobs in academia and industry. In fostering a diverse scientific workforce, IRACDA is a model program. Underrepresented groups currently make up about 28.5% of the national population, yet just 9.1% of college-educated Americans in science and engineering occupations. Nationally, about 7.5% of postdocs are from underrepresented groups. The IRACDA program, although not targeted to minorities, has about 40% of its postdocs from underrepresented groups. The program also strengthens the overall teaching and research opportunities at institutions with substantial minority enrollments. In these ways, IRACDA further promotes the development of the next generation of a diverse pool of scientists who are available to address the Nation’s biomedical, behavioral and clinical research needs. IRACDA also addresses the growing recognition that future faculty should not only be able to conduct research, but also be effective teachers in the classrooms. Most faculty positions require some amount of teaching, and so it’s only natural that postdocs are trained in modern pedagogy before they start teaching as part of their faculty duties. To this end, major research universities are beginning to offer teaching certificate programs for their doctoral students. If you'd like to know more about IRACDA or find out how you can participate, please contact me.

For 25 years, NIGMS has supported AIDS-related structural biology research that has provided fundamental insights into the replication of HIV and contributed toward the development of essential therapeutics. As Joe Gindhart discussed in an earlier Feedback Loop post, NIGMS marked the anniversary of this program with a special meeting in March. Many participants expressed excitement and offered overwhelmingly positive feedback about the program, in particular the progress and achievements reported from the three P50 Centers for the Determination of Structures of HIV/Host Complexes: Center for the Structural Biology of Cellular Host Elements in Egress, Trafficking and Assembly of HIV, HIV Accessory and Regulatory Complexes and Center for HIV Protein Interactions. Following endorsement by our Advisory Council at its meeting last month, we plan to reissue the centers RFA this summer. The new RFA will encompass the goals of the previous one, but will be broadened to include RNA/protein and membrane/protein interactions and a push to move beyond static structures to characterize the dynamics of complexes as a way to improve future drug design. This reissued RFA will also include a new requirement for a collaborative development program intended to recruit skilled investigators, especially early stage investigators, into AIDS-related structural biology research. We expect to fund four or five centers for a 5-year period. I will post more information about this funding opportunity once it has been published in the NIH Guide.

Have an idea for a great collaboration that will advance your NIGMS-funded research project? If your current award has active funding through at least November 30, 2012, you may be eligible to jump-start your idea with an administrative supplement for collaborative science. The next submission deadline is May 15, 2011. To ensure that your project is appropriate for this program, please review the funding opportunity announcement. You should also discuss the project idea with your NIGMS program director before preparing an application. For general questions about the program, contact me or Marion Zatz.

At the recent NIGMS Council meeting, I gave an overview of a new section of the NIGMS Web site called Evaluation: Measuring What Works. In addition to offering tips on planning and conducting evaluations, the section provides links to “how-to” guides, tools and other resources.

I invite you to take a look at the material and send your comments and suggestions via the feedback form link (no longer available).

Why did we develop this new Web site section? Increasingly, the Office of Management and Budget and other entities are calling for the use of formal program evaluation to help determine if programs are operating efficiently and achieving their goals. Some NIGMS research and training grant programs already include an evaluation component. If you’re an applicant or grantee on one of these programs, you may find our new online program evaluation resource useful.

Do you have an idea for a great collaboration that will advance your NIGMS-funded research project? If your current award has active funding through at least July 31, 2012, you may be eligible to jump-start your idea with an administrative supplement for collaborative science. The next submission deadline is January 15, 2011. To be sure that your project is appropriate for this program, please review the funding opportunity announcement. You should also discuss the project idea with your NIGMS program director before preparing an application. For general questions about the program, contact me at hayness@nigms.nih.gov or Marion Zatz at zatzm@nigms.nih.gov.

NIGMS has just issued a call for Program Projects for Collaborative Research on the Basic Biology of Pluripotency and Reprogramming (P01), with an emphasis on human induced pluripotent stem (iPS) cells. We are particularly interested in studies that propose comprehensive analyses of the basic biology of pluripotency, the molecular events and mechanisms of reprogramming, and the epigenetics and epigenomics of the pluripotent and reprogrammed states. These applications have special requirements, so please read the announcement carefully. Letters of intent are due on November 1, and applications are due on December 1. If your research involves stem cells but isn’t appropriate for this announcement, you may submit an investigator-initiated R01 application that addresses the basic biology of stem cells and/or uses these cells as model systems to study fundamental life processes. You may contact me at hayness@nigms.nih.gov or Marion Zatz at zatzm@nigms.nih.gov with questions about this new opportunity or about NIGMS support for stem cell research.

NIGMS has just re-announced the Dynamics of Host-Associated Microbial Communities (R01) funding opportunity. Microbes make up the vast majority of our bodies’ cells, and this program supports projects that aim to dissect these complex communities and their roles within a host. We are particularly interested in applications that propose:

• Genetic, physiological and ecological research on mixed microbial communities, their internal dynamics and how they relate to those of the host; and
• Studies on other experimental models that could make breakthrough contributions to understanding the formation and dynamics of host-microbe symbiotic systems.

We encourage interdisciplinary approaches, including bioinformatics/computational/modeling and/or experimental manipulations to investigate host-associated microbial community ecology. You may apply for up to $250,000 (direct costs) per year (plus up to $100,000 for exceptional equipment in the first year). Most awards will be for 4 years. Letters of intent are due on December 14, 2010, and applications are due on January 14, 2011. For more details about the program, see the funding opportunity announcement or contact me at 301-594-3900 or singhs@nigms.nih.gov.

In keeping with the Institute’s long-standing interest in training and its strong commitment to fostering a diverse scientific workforce, we have just re-announced our Modeling the Scientific Workforce (U01) program. This program provides support for developing computational models of the scientific workforce in the United States. It takes a systems-based approach to understanding the underlying dynamics that produce successful scientists, examining strategies for increasing the diversity of the scientific workforce, identifying research questions and guiding data collection and analysis. The models will help inform our program development, management and evaluation. We are particularly interested in models of the academic scientific workforce, but applicants should also consider industry and the government. We strongly encourage collaboration among scientists who are experts in simulation modeling, large-scale educational data sets, national policy and program development and other appropriate areas. Letters of intent are due on October 4, 2010, and applications are due on November 4, 2010. For additional information about the program, see the funding opportunity announcement or contact me at 301-594-3900 or singhs@nigms.nih.gov.

Our research programs often produce valuable scientific resources. But if one of these initiatives ends, then what becomes of the resource it generated? To address this issue, we formed a committee of NIGMS staff to explore options for maintaining scientific resources resulting from NIGMS-supported research. We defined a resource as a non-hypothesis-driven activity to provide data, materials, tools or services that are essential to making the most timely, high-quality and cost-efficient progress in a field. We proposed principles for continuing support of “legacy” resources that are of great benefit to researchers working within the Institute’s mission areas. Based on our discussions, we recommended that NIGMS pilot a limited program to fund the maintenance of existing, high-value resources. The NIGMS Council approved the concept in May, and the funding opportunity announcement just appeared in the NIH Guide. Applications are due once per year in October. If you are interested in applying, read the announcement for details, including the special eligibility requirements. And before you apply, be sure to contact the appropriate NIGMS division director to discuss your ideas. We hope that the results of this limited pilot program will help guide future decisions about maintaining important research-generated resources.

The program announcement for NIGMS program project grants was published yesterday in the NIH Guide. This grant mechanism enables outstanding scientists working on different aspects of a similar problem to collaborate. Applicants should propose innovative, complementary approaches to solving a significant biological question within the NIGMS mission. Over a 5-year period, program projects may receive total direct costs of up to $6.5 million (excluding any proposed equipment purchases and subcontract indirect costs). If you request more than $500,000 in direct costs in any year, you must receive approval from NIGMS staff before submitting your proposal. I strongly encourage you to speak to the relevant program staff member before submitting a P01 application. For more information, see the NIGMS Program Project Funding Policies Web site.