You may be interested in these recent funding opportunity announcements (FOAs): IDeA Networks of Biomedical Research Excellence (INBRE) [P20] (PAR-14-233) Purpose: Augment and strengthen the biomedical research capacity of an IDeA-eligible state Letter of intent due date: 30 days prior to the application due date Application due dates: July 29, 2014; May 27, 2015; May 26, 2016 NIGMS contact: Krishan K. Arora, 301-594-3900 Pharmacogenomics Knowledge Base (R24) (RFA-GM-15-002) Purpose: Develop a high-impact pharmacogenomics knowledge base that serves as a research resource available to the entire scientific community Letter of intent due date: 30 days prior to the application due date Application due date: October 7, 2014 NIGMS contact: Rochelle Long, 301-594-3827

You may be interested in these recent funding opportunity announcements (FOAs): NIH Research Evaluation and Commercialization Hub (REACH) Awards (U01) (RFA-OD-14-005) Purpose: Facilitate and accelerate the translation of biomedical innovations into commercial products that improve patient care and enhance health Letter of intent due date: May 26, 2014 Application due date: June 26, 2014 NIH contact: Kurt W. Marek, 301-443-8778 Limited Competition: Centers of Biomedical Research Excellence (COBRE) Phase III - Transitional Centers (P30) (PAR-14-178) Purpose: Transition the core resources and biomedical research activities of Centers of Biomedical Research Excellence (COBRE) into independence and sustainability Application due dates: June 30, 2014; May 26, 2015; May 26, 2016 NIGMS contact: Rafael Gorospe, 301-435-0832 Enabling Resources for Pharmacogenomics (R24) (PAR-14-185) Purpose: Support critical enabling resources that will accelerate new research discoveries and/or the implementation of research discoveries in pharmacogenomics Letter of intent due date: 30 days prior to the application due date Application due dates: September 25, 2014; September 25, 2015; September 25, 2016 NIGMS contact: Rochelle Long, 301-594-3827 Administrative Supplements for Research on Dietary Supplements (Admin Supp) (PAR-14-201) Purpose: Provide supplemental funding to investigate the role of dietary supplements and/or their ingredients in health maintenance and disease prevention Application due dates: October 15, 2014; January 15, 2015; April 15, 2015 NIGMS contact: Scott Somers, 301-594-3827

You may be interested in the following announcements: Undiagnosed Diseases Gene Function Research (R21) (RFA-RM-14-005) Purpose: Investigate the underlying genetics, biochemistry and/or pathophysiology of newly diagnosed diseases in association with the respective gene variant(s) identified through the Undiagnosed Diseases Network Letter of intent due date: May 23, 2014 Application due date: June 23, 2014 NIGMS contact: Donna Krasnewich, 301-594-0943 NIH Blueprint Program for Enhancing Neuroscience Diversity through Undergraduate Research Education Experiences (R25) (RFA-NS-14-010) Purpose: Enhance biomedical research workforce diversity through the development of creative educational activities primarily focused on research experiences, skills development courses and mentoring activities Letter of intent due date: April 28, 2014 Application due date: May 28, 2014 NIH contact: Michelle D. Jones-London, 301-451-7966 Request for Information: Current Clinical Questions in Post-Resuscitation Hypothermia (NOT-GM-14-112) Purpose: Provide feedback on the clinical research questions that need to be answered surrounding post-resuscitation therapeutic hypothermia Response due date: May 30, 2014 Send responses to: Jeremy Brown, 301-594-2755

As part of our efforts to develop and sustain a highly skilled and diverse biomedical research workforce, we have introduced a new mechanism to complement or enhance research training activities. The Innovative Programs to Enhance Research Training (IPERT) will support creative and innovative research educational activities through courses for skills development, structured mentoring activities and outreach programs. We expect the scope, purpose and objectives of IPERT applications to be as varied as the potential applicants. Both institutions and organizations are eligible to apply. An IPERT program should address a documented need, problem or challenge in research training and include measurable goals and objectives. Applications should explain the balance of effort and resources dedicated to each activity and how the activities will integrate. Proposals should also align with the NIGMS Strategic Plan for Biomedical and Behavioral Research Training, which recognizes that:

• Research training is a responsibility shared by NIH, academic institutions, faculty and trainees.
• Research training must focus on student development, not simply the selection of talent.
• Breadth and flexibility enable research training to keep pace with the opportunities and demands of contemporary science and provide the foundation for a variety of scientific career paths.
• Diversity is an indispensable component of research training excellence and must be advanced across the entire research enterprise.

The IPERT program may be of particular interest to institutions and organizations with current or past support from the MARC Ancillary Training Activities program (T36), which has lapsed and will not be reissued. Conference and meeting programs previously supported by the T36 mechanism may be more appropriately supported through the NIH conference grant mechanism (R13/U13). While a letter of intent is not required, we strongly encourage anyone who is interested in submitting an IPERT application to consult with me or other staff of the NIGMS Division of Training, Workforce Development, and Diversity to determine if this is the best mechanism to support their ideas and plans.

NIGMS grantees have one final opportunity to introduce new collaborations into their ongoing research projects through the Supplements for Collaborative Science (SCS) program. The submission deadline in response to NOT-GM-11-105 is May15, 2014. Investigators can request supplements of up to $90,000 per year in direct costs for two collaborating labs or up to $135,000 per year for three collaborating labs.

The proposed research must be within the original scope of the project and should propose approaches not used previously by the principal investigator. All collaborators should be able to make significant intellectual contributions, and we especially encourage proposals that involve less commonly combined areas of expertise.

To be eligible, an NIGMS parent R01 or R37 award must be actively funded through November 30, 2015. Proposals may request support to cover a period up to the end of the parent project. The application now requires that collaborating investigators provide a letter of commitment and “other support” page countersigned by their institutional official. Send any additional questions to me at andersonve@nigms.nih.gov or to Sue Haynes at hayness@nigms.nih.gov.

The SCS program is very competitive, so if you are interested in submitting an application, we recommend that you first discuss your potential proposal—and its new and novel aspects—with the program director of your grant.

You may be interested in the following funding opportunity announcements: Big Data Science Purpose: Research and develop new technologies in biomedical computing, informatics and big data science that will support rapid progress in biomedical research

• Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science (R43/R44) (PA-14-154)

• Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science (R01) (PA-14-155)

• Extended Development, Hardening and Dissemination of Technologies in Biomedical Computing, Informatics, and Big Data Science (R01) (PA-14-156)

• Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science (R41/R42) (PA-14-157)

Application due dates: Standard dates apply NIGMS contact: Peter Lyster, 301-451-6446 Initiative for Maximizing Student Development (IMSD) (R25) (PAR-14-121) Purpose: Develop new or expand existing institutional developmental programs at research-intensive institutions that prepare undergraduate and graduate students from diverse backgrounds for attaining the Ph.D. degree in biomedical or behavioral sciences and subsequent competitive research careers and leadership positions Application due dates: May 1, 2014; January 26, 2015; January 25, 2016 NIGMS contact: Daniel Janes, 301-594-0943

We are now supporting two additional Ruth L. Kirschstein National Research Service Award individual predoctoral fellowships in basic biomedical sciences relevant to our mission: the F30 fellowship for M.D.-Ph.D. or other dual-doctoral degree students and the F31 fellowship for Ph.D.-degree students. We will continue our support of the F31 fellowship to promote diversity in health-related research. NIGMS predoctoral fellowships, which generally provide up to 3 years of support, promote fundamental, interdisciplinary and innovative research training and career development leading to independent scientists who are well prepared to address the nation’s biomedical research needs. An applicant for an NIGMS predoctoral fellowship should:

• Be an advanced Ph.D. or M.D.-Ph.D. student.
• Demonstrate high academic performance in the biomedical sciences and independence in his or her research.
• Have identified a research sponsor and a dissertation project that includes a novel approach to the problem and has strong training potential.
• Demonstrate a commitment to a career as an independent scientist.

We expect the funding for F30 and F31 fellowships to be highly competitive, and we anticipate funding only a very limited number of these applications in any year. We will give priority to outstanding applicants with sponsors who are currently supported by NIGMS research grants. In addition, we strongly encourage F30 applications from students in combined M.D.-Ph.D. (or other dual-doctoral degree, such as D.O.-Ph.D., D.D.S.-Ph.D. and D.V.M.-Ph.D.) programs at institutions that are not currently supported by our Medical Scientist Training Program. For more details on F30 and F31 awards, see the NIGMS NRSA Individual Predoctoral Fellowships Web page or contact Peggy Schnoor.

Natural products are a prolific source of therapeutic drugs because they have been selected through evolution to be biologically active. New opportunities for natural products development made possible by genomic discoveries are poised to rapidly expand the utility of this critically important resource.

To further stimulate studies in this area, we have just issued the final funding opportunity announcement for Genomes to Natural Products (U01) research. Applications are due by June 10, 2014.

We’re looking for multidisciplinary teams of experts in natural products, synthetic biology, bioinformatics, genomics and analytical chemistry to develop high-throughput natural products discovery platforms based on a synthetic biology approach that leverages genomics and metagenomics data. The goal is to deliver broadly applicable, context-independent (i.e., independent of organism and/or natural products class) and game-changing tools, methods and resources in natural products discovery. The funded research also should lead to a deeper understanding of the regulation of natural products biosynthesis.

In addition to talking with potential collaborators, I encourage you to discuss your application with me.

You may be interested in these recent funding opportunity announcements: Postbaccalaureate Research Education Program (PREP) (R25) (PAR-14-076) Purpose: PREP provides support for well-designed courses for skills development and extensive research experiences aimed at preparing individuals from diverse backgrounds to complete doctoral degrees. Application receipt dates: March 31, 2014; January 25, 2015; and January 25, 2016. NIGMS contact: Michael Bender, 301-594-0943. Empirical Research on Ethical Issues Related to Central IRBs and Consent for Research Using Clinical Records and Data (R01) (RFA-OD-14-002) Purpose: This program furthers NIH’s commitment to enhanced protections for human subjects by encouraging research on the use of central Institutional Review Boards and on the use of clinical records and data. Application due date: April 18, 2014. NIGMS contact: Jeremy Brown, 301-594-2755. Innovative Technologies and Assays in Support of HIV Cure Research (ITAS-Cure) (PA-14-101) (R43/R44) (PA-14-102) (R41/R42) Purpose: ITAS-Cure encourages Small Business Innovation Research and Small Business Technology Transfer grant applications focusing on the development of sensitive and quantitative assays, methods or imaging techniques with commercial potential that can be applied to the measurement of residual HIV reservoirs in HIV-positive individuals on effective antiretroviral therapy. Application due date: Standard AIDS application due dates apply NIGMS contact: Mike Sakalian, 301-594-0829.

In January, NIH and several other agencies issued new omnibus solicitations for the Small Business Innovation Research (PA-14-071) and Small Business Technology Transfer (PA-14-072) programs. A program descriptions and research topics document gives details about each funding component’s areas of interest. The NIGMS section begins on page 91. Potential SBIR/STTR applicants often assume that, like some other federal agencies, NIGMS will be an end user of the tools, devices, products or services being created under the grant or will play an active role in their ongoing development toward eventual commercialization. As a result, we get questions like:

• How can I ensure that my project offers what NIGMS needs?
• Can NIGMS provide technical and/or regulatory assistance to help my project obtain FDA approval?
• What clinical trial/technology development expertise does NIGMS have that I may access?

These assumptions are not correct. Like the vast majority of NIGMS-funded research, our SBIR/STTR program is investigator-initiated. Applicants propose what to do, how to do it and the best path toward commercialization. Although we may occasionally issue or participate in SBIR/STTR funding opportunity announcements targeted to stimulate activity in a specific area, these are still independent projects because we do not prescribe what the activity should be or how it should be pursued. Our goal is to support innovative SBIR/STTR projects that could benefit the broader research and development communities and/or directly impact human health. If you’re interested in applying for an SBIR/STTR grant in an NIGMS area of interest, you can get general advice and answers to many procedural and technical questions about the application and review process from NIGMS program and grants management staff. If you don’t know whom to contact, you can start by asking me your program questions or asking Patrice Molnar your grants management questions. If we don’t know the answers ourselves, we can refer you to others as appropriate. You can also find useful information on the NIH SBIR/STTR Web site and in a recent blog post from NIH’s Sally Rockey titled What’s New with NIH’s Small Business Research Programs?