Communication and transparency are core values of NIGMS, and the Feedback Loop is one way we put those values into practice. On the occasion of our 300th blog post, we take a moment to look back, look ahead, and look for your continued input. Our former director, Jeremy Berg, started the Feedback Loop in 2005 as an e-newsletter distributed three times a year. In 2009, we switched it to a blog format to share information in a timelier way and provide a better platform for discussion. Since then, more than 50 NIGMS staff members have contributed posts announcing funding opportunities, meetings and job openings; offering application guidance and tips; sharing funding trend data and other analyses; and more. Whether posted on the blog or addressed to me or other staff, your comments and questions have helped us provide or clarify information about the funding process and other topics important to you. Since we created this blog, a number of other NIH components have started blogs of their own. Sally Rockey of the NIH Office of Extramural Research has been blogging for nearly 2 years on Rock Talk about grant policies, funding trends and other issues of interest to the extramural research community. And earlier this month, Francis Collins launched the NIH Director’s Blog to highlight recent discoveries in biology and medicine. We look forward to new opportunities for synergy with these and other blogs. Above all, we hope you find the Feedback Loop a useful resource. As always, we welcome your comments, input and feedback on topics for future posts or other ways the blog can best meet your needs.

As I told you in July, NIGMS houses the new NIH Office of Emergency Care Research (OECR), which was created to advance, coordinate and provide information about basic, clinical and translational biomedical research and research training within the emergency care setting.

The search is now open for an outstanding physician and leader in emergency medicine research to oversee this office as its first director. This position offers an important and unique opportunity to shape trans-NIH approaches to improving the health outcomes of persons with emergency medical conditions.

Candidates must possess an M.D. and professional knowledge of and skill in applying concepts, principles and methodology in clinical emergency medicine. For additional qualification requirements, evaluation criteria and application instructions, please view the vacancy announcements for:

Supervisory Medical Officer, GS15 Clinical, Extramural (NCI, NHLBI, NIAID, NIGMS, and NICHD)
or
Supervisory Medical Officer, GS15 Research, Extramural (NCI, NHLBI, NIGMS and NIAID)

You can apply to either one. A key difference between the two is that the first one requires a current, valid medical license. The listings close on November 4, 2012.

I encourage you to share this information with others who may be interested in applying.

UPDATE: This vacancy listing has been extended to November 6, 2012, due to weather issues during the week of October 29.

We’re looking forward to a very special event this week—a symposium on the NIH campus marking our 50th anniversary. If you can’t join us in person, you can watch the talks online. The event is on Wednesday, October 17, from 1:00 to 4:00 p.m. Eastern time. NIH Director Francis Collins will lead things off by sharing his perspective on the Institute and the research it funds. Next will be talks by three NIGMS grantees—Carlos Bustamante, Kathy Giacomini and Tim Mitchison—who reflect the range of our support as well as the theme of our anniversary: “investigate, innovate, inspire.” You can watch the event live or later.

2012 Nobel Prize in chemistry with Robert J. Lefkowitz of Duke University Medical School, a long-time grantee of the National Heart, Lung, and Blood Institute. They are being recognized “for studies of G-protein-coupled receptors.”

Their seminal work, primarily involving the β-adrenergic receptor, has widened understanding of how these biologically and medically important proteins operate. It has also contributed to an expanding library of related structures, which have been notoriously difficult to obtain. And it complements the ongoing efforts of many other researchers, including those funded through a variety of special NIH activities, among them the NIH Common Fund Structural Biology Program, which NIGMS helps administer.

Dr. Kobilka’s “molecular masterpiece,” the high-resolution structure of the β2-adrenergic receptor attached to its G protein partner, was published just last year. We’re proud that our funding contributed to this achievement.

We also congratulate the 2012 Nobel laureates in physiology or medicine, Sir John B. Gurdon of the Gurdon Institute and Shinya Yamanaka of Kyoto University and the Gladstone Institutes. They’re honored "for the discovery that mature cells can be reprogrammed to become pluripotent.” Their advances have propelled this area of stem cell research forward and have opened up many new avenues of investigation that are being pursued by NIGMS grantees.

We are delighted that these prizes, which were awarded during our 50th anniversary year, offer a further testament to the importance and value of basic research. We look forward to continuing to support basic studies that form the foundation for new and better ways to treat and prevent disease and improve health.

At the 150th meeting of our Advisory Council last week, I presented several budget slides that I’d like to share with you. They summarize funding allocations for this fiscal year, which ends on September 30.

Figure 1 shows the $2.429 billion Fiscal Year 2012 NIGMS budget by major component. The biggest portion is for research project grants (RPGs), most of which are R01s. Due to the transfer of programs—predominantly center grants—from the former National Center for Research Resources (NCRR) partway through the fiscal year, the RPG budget as a percentage of the total is less than the estimate I provided earlier, while the centers percentage is greater. About 74%, or just over $1 billion, of the RPG budget goes to fund noncompeting grant commitments and about 25%, or $349 million, is used to fund competing grants.

Below is a closer look at the competing RPGs. It shows that 94%, or about $330 million, is used to pay investigator-initiated research and that the remaining 6%, or about $19 million, funds mainly R01 grants submitted in response to requests for applications (RFAs). At last week’s meeting, the Advisory Council approved one new RFA and the reissue of several other RFAs for funding consideration in Fiscal Year 2014.

Another snapshot (Figure 3) shows a historical view of the RPG budget and number of RPGs compared to the total NIGMS budget. The increase in the total budget in Fiscal Year 2012 is due to the addition of NCRR programs. The decline in the number of RPGs is due to increasing grant costs.

As we estimated earlier in the year, the Fiscal Year 2012 success rate is around 24%.

We will provide information on the Fiscal Year 2013 budget when it’s available.

Especially because it’s our anniversary year, I’m very pleased that basic biomedical research supported by NIGMS is receiving important recognition. The 2012 Lasker Awards honor five scientists whose research we have supported for decades:

• The Albert Lasker Basic Medical Research Award is shared by Michael Sheetz of Columbia University, James Spudich of Stanford University School of Medicine and Ronald Vale of the University of California, San Francisco, for their advances in the detailed study of cytoskeletal motor proteins.
• The Lasker-Koshland Award for Special Achievement in Medical Science is shared by Donald D. Brown of the Carnegie Institution for Science and Tom Maniatis of Columbia University for advancing the study of genes as well as for their support of the scientific enterprise. I should also note that Dr. Brown was among the first speakers in our annual DeWitt Stetten, Jr., lecture series, which we established in 1982 to mark our 20th anniversary.

Since the first Lasker Award was presented in 1946, 81 recipients have gone on to receive Nobel Prizes for their scientific accomplishments.

Our Strategic Plan for Biomedical and Behavioral Research Training stresses the importance of creating an individual development plan (IDP) for every graduate student and postdoctoral scholar, not just those supported on formal training grants. The plan’s implementation blueprint addresses this action item, and we’ve since posted more information and links to sample IDPs. The latest addition to this IDP page is a new tool developed by the Federation of American Societies for Experimental Biology and the American Association for the Advancement of Science called myIDP. The tool makes it easy for grad students and postdocs to examine their scientific skills, interests and values; identify scientific career paths that best match their skills and interests; and set goals for the coming year. The site also links to articles for early career scientists to use as they plan their future. I encourage mentors and mentees alike to check out this great new resource.

Many NIH components, including NIGMS, support research and training relevant to care in the emergency medical setting. To facilitate and coordinate its activities in this area, NIH has created an Office of Emergency Care Research (OECR) that is housed in NIGMS. Although OECR will not fund grants, it will serve as a focal point for basic, clinical and translational emergency care research and training across NIH. The office’s activities will include:

• Coordinating funding opportunities that involve multiple NIH institutes and centers.
• Working closely with the NIH Emergency Care Research Working Group, which includes representatives from many NIH institutes and centers.
• Organizing scientific meetings to identify new research and training opportunities in emergency settings.
• Catalyzing the development of new funding opportunities.
• Informing investigators about funding opportunities in their areas of interest.
• Fostering career development for trainees in emergency care research.
• Representing NIH in government-wide efforts to improve the nation's emergency care system.

OECR’s creation is a culmination of more than 5 years of discussions between NIH and the emergency medicine community. The initial impetus for these conversations was three Institute of Medicine reports on emergency care in 2006. While a search is being conducted for a permanent director, OECR is being led on an acting basis by Walter J. Koroshetz, M.D., deputy director of the National Institute of Neurological Disorders and Stroke. Assisting him is Alice M. Mascette, M.D., senior clinical science advisor in the Division of Cardiovascular Sciences of the National Heart, Lung, and Blood Institute. You can learn more about OECR at http://www.nigms.nih.gov/About/Overview/OECR/.

Last week, the Advisory Committee to the Director (ACD) of NIH released two reports that are very relevant to the NIGMS missions of supporting research training and promoting a diverse biomedical workforce. The reports, produced by working groups with impressive membership rosters, have many elements in common with our training strategic plan. For example, the report from the Biomedical Research Workforce Working Group suggests that institutions provide graduate students with experiences to better prepare them for various career options, recommends testing ways to shorten the Ph.D. training period, and calls for individual development plans for postdocs regardless of the NIH grant mechanism that supports them. The report from the Working Group on Diversity in the Biomedical Research Workforce affirms the importance of a diverse biomedical workforce and NIH’s role in helping to achieve it. NIH’s Sally Rockey, who co-chaired one of the working groups, has a blog post on these ACD reports, plus an additional report on large biomedical research datasets. We look forward to working with other parts of NIH to advance our shared commitment to training and diversity.

Last September, I posted our funding allocation for research project grants (RPGs) in Fiscal Year 2012. I noted our strong commitment to RPGs—the vast majority of which are investigator-initiated R01 grants—and showed that we expected to spend 67% of our budget on them.

I want to update you on our Fiscal Year 2012 budget, which now includes programs transferred from the former National Center for Research Resources (NCRR), and offer some historical perspective on our RPG funding.

Figure 1 shows the amount NIGMS spent on RPGs compared to the total budget from 1998 to the present. From 2003 through 2011, the total RPG budget increased nearly every year, but not at a pace sufficient to maintain the same number of grants. Nevertheless, we expect to fund 184 more RPGs in Fiscal Year 2012 than we did in Fiscal Year 1998.

The increase in the total budget for Fiscal Year 2012 reflects the transferred NCRR programs, many of which are centers. During the 1998-2003 budget doubling period, the proportion of centers rose from 0.6% to 8.6% and remained at about 8% through Fiscal Year 2011. These centers enabled NIGMS to address important scientific opportunities and enhance the basic science infrastructure.

Following the transfer of the NCRR programs, 58% of our budget will support RPGs and 20% will support centers, as shown in Figure 2. Despite the percentage shift, the amount of money spent on RPGs is comparable to that in recent fiscal years, and maintaining RPGs and investigator-initiated R01s will remain our focus.