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July 21, 2010

Archived: Even More on Criterion Scores: Full Regression and Principal Component Analyses

After reading yesterday’s post, a Feedback Loop reader asked for a full regression analysis of the overall impact score based on all five criterion scores. With the caveat that one should be cautious in over-interpreting such analyses, here it is:
Pearson correlation coefficients of overall impact score and five criterion scores (significance, approach, innovation, investigator and environment) in a sample of 360 NIGMS R01 applications reviewed during the October 2009 Council round. The various parameters are substantially correlated.
Pearson correlation coefficients of overall impact score and five criterion scores in a sample of 360 NIGMS R01 applications reviewed during the October 2009 Council round.
As one might expect, the various parameters are substantially correlated. A principal component analysis reveals that a single principal component accounts for 71% of the variance in the overall impact scores. This principal component includes substantial contributions from all five criterion scores, with weights of 0.57 for approach, 0.48 for innovation, 0.44 for significance, 0.36 for investigator and 0.35 for environment. Here are more results of the full principal component analysis:
Principal component analysis of overall impact score based on the five criterion scores (significance, approach, innovation, investigator and environment) in a sample of 360 NIGMS R01 applications reviewed during the October 2009 Council round. A single principal component accounts for 71% of the variance in the overall impact scores. This principal component includes substantial contributions from all five criterion scores, with weights of 0.57 for approach, 0.48 for innovation, 0.44 for significance, 0.36 for investigator and 0.35 for environment.
Principal component analysis of overall impact score based on the five criterion scores in a sample of 360 NIGMS R01 applications reviewed during the October 2009 Council round.
The second component accounts for an additional 9% of the variance and has a substantial contribution from approach, with significant contributions of the opposite sign for investigator and environment. The third component accounts for an additional 8% of the variance and appears to be primarily related to innovation. The fourth component accounts for an additional 7% of the variance and is primarily related to significance. The final component accounts for the remaining 5% of the variance and has contributions from investigator and environment of the opposite sign.

About the Author

Jeremy Berg

As former NIGMS director, Jeremy oversaw the Institute’s programs to fund biomedical research and to train the next generation of scientists. He was a leader in many NIH-wide activities and also found time to study a variety of molecular recognition processes in his NIH lab.