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Dimeric association of receptor-type tyrosine-protein phosphatase
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Model of the catalytic portion of an enzyme, receptor-type tyrosine-protein phosphatase from humans. The enzyme consists of two identical protein subunits, shown in blue and green. New York Structural GenomiX Research Consortium, PSI View MediaDrosophila (fruit fly) myosin 1D motility assay
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Actin gliding powered by myosin 1D. Note the counterclockwise motion of the gliding actin filaments. Serapion Pyrpassopoulos and E. Michael Ostap, University of Pennsylvania View MediaHsp33 Heat Shock Protein Inactive to Active
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When the heat shock protein hsp33 is folded, it is inactive and contains a zinc ion, stabilizing the redox sensitive domain (orange). Dana Reichmann, University of Michigan View Media3-D Architecture of a Synapse
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This image shows the structure of a synapse, or junction between two nerve cells in three dimensions. From the brain of a mouse. Anton Maximov, The Scripps Research Institute, La Jolla, CA View MediaX-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 6
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View MediaPanC from M. tuberculosis
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Model of an enzyme, PanC, that is involved in the last step of vitamin B5 biosynthesis in Mycobacterium tuberculosis. PanC is essential for the growth of M. Mycobacterium Tuberculosis Center, PSI View MediaThymidylate synthase complementing protein from Thermotoga maritime
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A model of thymidylate synthase complementing protein from Thermotoga maritime. Joint Center for Structural Genomics, PSI View MediaAbnormal, spiky fibroblast
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This is a fibroblast, a connective tissue cell that plays an important role in wound healing. Normal fibroblasts have smooth edges. Praveen Suraneni, Stowers Institute for Medical Research, Kansas City, Mo. View MediaCalcium uptake during ATP production in mitochondria
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Living primary mouse embryonic fibroblasts. Mitochondria (green) stained with the mitochondrial membrane potential indicator, rhodamine 123. Nuclei (blue) are stained with DAPI. Lili Guo, Perelman School of Medicine, University of Pennsylvania View MediaEnzymes convert subtrates into products (with labels)
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Enzymes convert substrates into products very quickly. See image 2521 for an unlabeled version of this illustration. Featured in The Chemistry of Health. Crabtree + Company View MediaArtificial cilia exhibit spontaneous beating
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Researchers have created artificial cilia that wave like the real thing. Zvonimir Dogic View Media3D image of actin in a cell
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Actin is an essential protein in a cell's skeleton (cytoskeleton). It forms a dense network of thin filaments in the cell. Xiaowei Zhuang, Howard Hughes Medical Institute, Harvard University View MediaSleep and the fly brain
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In the top snapshots, the brain of a sleep-deprived fruit fly glows orange, marking high concentrations of a synaptic protein called Bruchpilot (BRP) involved in communication between neurons. Chiara Cirelli, University of Wisconsin-Madison View MediaARTS triggers apoptosis
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Cell showing overproduction of the ARTS protein (red). ARTS triggers apoptosis, as shown by the activation of caspase-3 (green) a key tool in the cell's destruction. The nucleus is shown in blue. Hermann Steller, Rockefeller University View MediaBacterial ribosome assembly
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3D reconstructions of two stages in the assembly of the bacterial ribosome created from time-resolved cryo-electron microscopy images. Ribosomes translate genetic instructions into proteins. Joachim Frank, Columbia University. View MediaGroup of fluorescent C. elegans showing muscle and ribosomal protein
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Three C. elegans, tiny roundworms, with a ribosomal protein glowing red and muscle fibers glowing green. Researchers used these worms to study a molecular pathway that affects aging. Jarod Rollins, Mount Desert Island Biological Laboratory. View MediaBacterial nanowire model
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A model of a Geobacter sulfurreducens nanowire created from cryo-electron microscopy images. Edward Egelman, University of Virginia. View MediaRespiratory droplet
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This painting shows a cross section of a small respiratory droplet, like the ones that are thought to transmit SARS-CoV-2, the virus that causes COVID-19. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media