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Artificial cilia exhibit spontaneous beating
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Researchers have created artificial cilia that wave like the real thing. Zvonimir Dogic View MediaATP Synthase
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Atomic model of the membrane region of the mitochondrial ATP synthase built into a cryo-EM map at 3.6 Å resolution. ATP synthase is the primary producer of ATP in aerobic cells. Bridget Carragher, <a href="http://nramm.nysbc.org/">NRAMM National Resource for Automated Molecular Microscopy</a> View MediaCCP enzyme
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The enzyme CCP is found in the mitochondria of baker’s yeast. Scientists study the chemical reactions that CCP triggers, which involve a water molecule, iron, and oxygen. Protein Data Bank. View MediaHuman endoplasmic reticulum membrane protein complex
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A 3D model of the human endoplasmic reticulum membrane protein complex (EMC) that identifies its nine essential subunits. Rebecca Voorhees, California Institute of Technology. View MediaRabbit GPDA
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A crystal of rabbit GPDA protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View MediaA2A adenosine receptor
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The receptor is shown bound to an inverse agonist, ZM241385. Raymond Stevens, The Scripps Research Institute View MediaX-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 4
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View MediaStructure of heme, top view
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Molecular model of the struture of heme. Heme is a small, flat molecule with an iron ion (dark red) at its center. Rachel Kramer Green, RCSB Protein Data Bank View Media3D image of actin in a cell
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Actin is an essential protein in a cell's skeleton (cytoskeleton). It forms a dense network of thin filaments in the cell. Xiaowei Zhuang, Howard Hughes Medical Institute, Harvard University View MediaWeblike sheath covering developing egg chambers in a giant grasshopper
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The lubber grasshopper, found throughout the southern United States, is frequently used in biology classes to teach students about the respiratory system of insects. Kevin Edwards, Johny Shajahan, and Doug Whitman, Illinois State University. View MediaTrp_RS - tryptophanyl tRNA-synthetase family of enzymes
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This image represents the structure of TrpRS, a novel member of the tryptophanyl tRNA-synthetase family of enzymes. View MediaAbnormal, spiky fibroblast
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This is a fibroblast, a connective tissue cell that plays an important role in wound healing. Normal fibroblasts have smooth edges. Praveen Suraneni, Stowers Institute for Medical Research, Kansas City, Mo. View MediaProtein rv2844 from M. tuberculosis
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This crystal structure shows a conserved hypothetical protein from Mycobacterium tuberculosis. Only 12 other proteins share its sequence homology, and none has a known function. Integrated Center for Structure and Function Innovation View MediaEnzymes convert subtrates into products
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Enzymes convert substrates into products very quickly. See image 2522 for a labeled version of this illustration. Featured in The Chemistry of Health. Crabtree + Company View MediaEnzyme reaction
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Enzymes speed up chemical reactions by reducing the amount of energy needed for the reactions. NIGMS View MediaHimastatin, 360-degree view
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A 360-degree view of the molecule himastatin, which was first isolated from the bacterium Streptomyces himastatinicus. Himastatin shows antibiotic activity. Mohammad Movassaghi, Massachusetts Institute of Technology. View MediaPig trypsin crystal
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A crystal of pig trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View MediaPhenylalanine tRNA molecule
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Phenylalanine tRNA showing the anticodon (yellow) and the amino acid, phenylalanine (blue and red spheres). Patrick O'Donoghue and Dieter Soll, Yale University View MediaEarly life of a protein
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This illustration represents the early life of a protein—specifically, apomyoglobin—as it is synthesized by a ribosome and emerges from the ribosomal tunnel, which contains the newly formed protein's Silvia Cavagnero, University of Wisconsin, Madison View MediaRNA folding in action
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An RNA molecule dynamically refolds itself as it is being synthesized. When the RNA is short, it ties itself into a “knot” (dark purple). Julius Lucks, Northwestern University View MediaCytonemes in developing fruit fly cells
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Scientists have long known that multicellular organisms use biological molecules produced by one cell and sensed by another to transmit messages that, for instance, guide proper development of organs Sougata Roy, University of California, San Francisco View MediaShiga toxin being sorted inside a cell
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Shiga toxin (green) is sorted from the endosome into membrane tubules (red), which then pinch off and move to the Golgi apparatus. Somshuvra Mukhopadhyay, The University of Texas at Austin, and Adam D. Linstedt, Carnegie Mellon University View MediaIntracellular forces
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Force vectors computed from actin cytoskeleton flow. This is an example of NIH-supported research on single-cell analysis. Gaudenz Danuser, Harvard Medical School View MediaSnowflake DNA origami
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An atomic force microscopy image shows DNA folded into an intricate, computer-designed structure. The image is featured on Biomedical Beat blog post Cool Images: A Holiday-Themed Collection. Hao Yan, Arizona State University View MediaPartial Model of a Cilium’s Doublet Microtubule
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Cilia (cilium in singular) are complex molecular machines found on many of our cells. Brown Lab, Harvard Medical School and Veronica Falconieri Hays. View MediaDense tubular matrices in the peripheral endoplasmic reticulum (ER) 2
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Three-dimensional reconstruction of a tubular matrix in a thin section of the peripheral endoplasmic reticulum between the plasma membranes of the cell. Jennifer Lippincott-Schwartz, Howard Hughes Medical Institute Janelia Research Campus, Virginia View MediaH1N1 Influenza Virus
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Related to image 6355. Dr. Rommie Amaro, University of California, San Diego View MediaRNA Polymerase II
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NIGMS-funded researchers led by Roger Kornberg solved the structure of RNA polymerase II. David Bushnell, Ken Westover and Roger Kornberg, Stanford University View MediaZ rings in bacterial division
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Lab-made liposomes contract where Z rings have gathered together and the constriction forces are greatest (arrows). Masaki Osawa, Duke University View MediaRNA polymerase
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RNA polymerase (purple) is a complex enzyme at the heart of transcription. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View MediaComputer sketch of bird-and-flower DNA origami
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A computer-generated sketch of a DNA origami folded into a flower-and-bird structure. See also related image 3690. Hao Yan, Arizona State University View MediaDimeric association of receptor-type tyrosine-protein phosphatase
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Model of the catalytic portion of an enzyme, receptor-type tyrosine-protein phosphatase from humans. The enzyme consists of two identical protein subunits, shown in blue and green. New York Structural GenomiX Research Consortium, PSI View MediaProtein map
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Network diagram showing a map of protein-protein interactions in a yeast (Saccharomyces cerevisiae) cell. This cluster includes 78 percent of the proteins in the yeast proteome. Hawoong Jeong, KAIST, Korea View MediaAssembly of the HIV capsid
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The HIV capsid is a pear-shaped structure that is made of proteins the virus needs to mature and become infective. John Grime and Gregory Voth, The University of Chicago View MediaTex protein
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Model of a member from the Tex protein family, which is implicated in transcriptional regulation and highly conserved in eukaryotes and prokaryotes. New York Structural GenomiX Research Consortium, PSI View MediaHistone deacetylases
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The human genome contains much of the information needed for every cell in the body to function. However, different types of cells often need different types of information. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View MediaMost abundant protein in M. tuberculosis
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Model of a protein, antigen 85B, that is the most abundant protein exported by Mycobacterium tuberculosis, which causes most cases of tuberculosis. Mycobacterium Tuberculosis Center, PSI View MediaOligoendopeptidase F from B. stearothermophilus
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Crystal structure of oligoendopeptidase F, a protein slicing enzyme from Bacillus stearothermophilus, a bacterium that can cause food products to spoil. Accelerated Technologies Center for Gene to 3D Structure/Midwest Center for Structural Genomics View MediaIntasome
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Salk researchers captured the structure of a protein complex called an intasome (center) that lets viruses similar to HIV establish permanent infection in their hosts. National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View Media3-D Architecture of a Synapse
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This image shows the structure of a synapse, or junction between two nerve cells in three dimensions. From the brain of a mouse. Anton Maximov, The Scripps Research Institute, La Jolla, CA View MediaCRISPR surveillance complex
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This image shows how the CRISPR surveillance complex is disabled by two copies of anti-CRISPR protein AcrF1 (red) and one AcrF2 (light green). NRAMM National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View MediaMouse brain slice showing nerve cells
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A 20-µm thick section of mouse midbrain. The nerve cells are transparent and weren’t stained. Michael Shribak, Marine Biological Laboratory/University of Chicago. View MediaHimastatin
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A model of the molecule himastatin, which was first isolated from the bacterium Streptomyces himastatinicus. Himastatin shows antibiotic activity. Mohammad Movassaghi, Massachusetts Institute of Technology. View MediaSerum albumin structure 2
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Serum albumin (SA) is the most abundant protein in the blood plasma of mammals. SA has a characteristic heart-shape structure and is a highly versatile protein. Wladek Minor, University of Virginia View MediaNetwork Map
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This network map shows the overlap (green) between the long QT syndrome (yellow) and epilepsy (blue) protein-interaction neighborhoods located within the human interactome. Seth Berger, Mount Sinai School of Medicine View MediaVDAC-1 (3)
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The structure of the pore-forming protein VDAC-1 from humans. Gerhard Wagner, Harvard Medical School View MediaDrosophila (fruit fly) myosin 1D motility assay
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Actin gliding powered by myosin 1D. Note the counterclockwise motion of the gliding actin filaments. Serapion Pyrpassopoulos and E. Michael Ostap, University of Pennsylvania View MediaLife of an AIDS virus
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HIV is a retrovirus, a type of virus that carries its genetic material not as DNA but as RNA. Crabtree + Company View MediaCRISPR
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RNA incorporated into the CRISPR surveillance complex is positioned to scan across foreign DNA. Cryo-EM density from a 3Å reconstruction is shown as a yellow mesh. NRAMM National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View MediaMouse embryo showing Smad4 protein
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This eerily glowing blob isn't an alien or a creature from the deep sea--it's a mouse embryo just eight and a half days old. The green shell and core show a protein called Smad4. Kenneth Zaret, Fox Chase Cancer Center View Media