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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 1
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View MediaDrosophila (fruit fly) myosin 1D motility assay
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Actin gliding powered by myosin 1D. Note the counterclockwise motion of the gliding actin filaments. Serapion Pyrpassopoulos and E. Michael Ostap, University of Pennsylvania View MediaX-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 4
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View MediaProtein from Methanobacterium thermoautotrophicam
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A knotted protein from an archaebacterium called Methanobacterium thermoautotrophicam. This organism breaks down waste products and produces methane gas. Midwest Center For Structural Genomics, PSI View MediaMolecules blocking Huntington's protein production
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The molecules that glow blue in these cultured cells prevent the expression of the mutant proteins that cause Huntington's disease. Jiaxin Hu, David W. Dodd and Robert H. E. Hudson, UT Southwestern Medical Center View MediaHimastatin and bacteria
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A model of the molecule himastatin overlaid on an image of Bacillus subtilis bacteria. Mohammad Movassaghi, Massachusetts Institute of Technology. View MediaZebrafish embryo
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A zebrafish embryo showing its natural colors. Zebrafish have see-through eggs and embryos, making them ideal research organisms for studying the earliest stages of development. Michael Shribak, Marine Biological Laboratory/University of Chicago. View MediaHuman Adenovirus
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The cryo-EM structure of human adenovirus D26 (HAdV-D26) at near atomic resolution (3.7 Å), determined in collaboration with the NRAMM facility*. National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View MediaTiny strands of tubulin, a protein in a cell's skeleton
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Just as our bodies rely on bones for structural support, our cells rely on a cellular skeleton. Pakorn Kanchanawong, National University of Singapore and National Heart, Lung, and Blood Institute, National Institutes of Health; and Clare Waterman, National Heart, Lung, and Blood Institute, National Institutes of Health View MediaNetwork Map
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This network map shows the overlap (green) between the long QT syndrome (yellow) and epilepsy (blue) protein-interaction neighborhoods located within the human interactome. Seth Berger, Mount Sinai School of Medicine View MediaLife of an AIDS virus (with labels and stages)
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HIV is a retrovirus, a type of virus that carries its genetic material not as DNA but as RNA. Crabtree + Company View MediaKluyveromyces polysporus Argonaute bound to guide RNA
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A segment of siRNA, shown in red, guides a "slicer" protein called Argonaute (multi-colored twists and corkscrews) to the target RNA molecules. Kotaro Nakanishi and David Weinberg, Massachusetts Institute of Technology View MediaVDAC video 03
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This video shows the structure of the pore-forming protein VDAC-1 from humans. Gerhard Wagner, Harvard Medical School View MediaSeeing signaling protein activation in cells 04
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Cdc42, a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including motility, proliferation, apoptosis, and cell morphology. Klaus Hahn, University of North Carolina, Chapel Hill Medical School View MediaFull-length serotonin receptor (ion channel)
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A 3D reconstruction, created using cryo-electron microscopy, of an ion channel known as the full-length serotonin receptor in complex with the antinausea drug granisetron (orange). Sudha Chakrapani, Case Western Reserve University School of Medicine. View MediaAbnormal, spiky fibroblast
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This is a fibroblast, a connective tissue cell that plays an important role in wound healing. Normal fibroblasts have smooth edges. Praveen Suraneni, Stowers Institute for Medical Research, Kansas City, Mo. View MediaG switch (with labels)
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The G switch allows our bodies to respond rapidly to hormones. G proteins act like relay batons to pass messages from circulating hormones into cells. Crabtree + Company View MediaBacterial nanowire model
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A model of a Geobacter sulfurreducens nanowire created from cryo-electron microscopy images. Edward Egelman, University of Virginia. View MediaLife of an AIDS virus
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HIV is a retrovirus, a type of virus that carries its genetic material not as DNA but as RNA. Crabtree + Company View MediaProteasome
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This fruit fly spermatid recycles various molecules, including malformed or damaged proteins. Sigi Benjamin-Hong, Rockefeller University View MediaStetten Lecture 2017poster image
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This image is featured on the poster for Dr. Rommie Amaro's 2017 Stetten Lecture. Dr. Rommie Amaro, University of California, San Diego View MediaProtein crystals
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Structural biologists create crystals of proteins, shown here, as a first step in a process called X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View MediaZ rings in bacterial division
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Lab-made liposomes contract where Z rings have gathered together and the constriction forces are greatest (arrows). Masaki Osawa, Duke University View MediaX-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 7
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View MediaDimeric ferredoxin-like protein from an unidentified marine microbe
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This is the first structure of a protein derived from the metagenomic sequences collected during the Sorcerer II Global Ocean Sampling project. Joint Center for Structural Genomics View MediaAtomic Structure of Poppy Enzyme
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The atomic structure of the morphine biosynthetic enzyme salutaridine reductase bound to the cofactor NADPH. The substrate salutaridine is shown entering the active site. Judy Coyle, Donald Danforth Plant Science Center View MediaVDAC-1 (4)
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The structure of the pore-forming protein VDAC-1 from humans. Gerhard Wagner, Harvard Medical School View MediaLife of an AIDS virus (with labels)
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HIV is a retrovirus, a type of virus that carries its genetic material not as DNA but as RNA. Crabtree + Company View MediaProtein map
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Network diagram showing a map of protein-protein interactions in a yeast (Saccharomyces cerevisiae) cell. This cluster includes 78 percent of the proteins in the yeast proteome. Hawoong Jeong, KAIST, Korea View MediaCryo-electron microscopy revealing the "wasabi receptor"
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The TRPA1 protein is responsible for the burn you feel when you taste a bite of sushi topped with wasabi. Jean-Paul Armache, UCSF View MediaDisrupted vascular development in frog embryos
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Disassembly of vasculature in kdr:GFP frogs following addition of 250 µM TBZ. Related to images 3404 and 3505. Hye Ji Cha, University of Texas at Austin View MediaBacteria working to eat
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Gram-negative bacteria perform molecular acrobatics just to eat. Because they're encased by two membranes, they must haul nutrients across both. Emad Tajkhorshid, University of Illinois at Urbana-Champaign View MediaMap of protein structures 02
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A global "map of the protein structure universe" indicating the positions of specific proteins. Berkeley Structural Genomics Center, PSI View MediaCytoskeleton
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The three fibers of the cytoskeleton--microtubules in blue, intermediate filaments in red, and actin in green--play countless roles in the cell. Judith Stoffer View MediaMost abundant protein in M. tuberculosis
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Model of a protein, antigen 85B, that is the most abundant protein exported by Mycobacterium tuberculosis, which causes most cases of tuberculosis. Mycobacterium Tuberculosis Center, PSI View MediaCCP enzyme
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The enzyme CCP is found in the mitochondria of baker’s yeast. Scientists study the chemical reactions that CCP triggers, which involve a water molecule, iron, and oxygen. Protein Data Bank. View MediaRespiratory droplet
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This painting shows a cross section of a small respiratory droplet, like the ones that are thought to transmit SARS-CoV-2, the virus that causes COVID-19. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View MediaEnzymes convert subtrates into products (with labels)
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Enzymes convert substrates into products very quickly. See image 2521 for an unlabeled version of this illustration. Featured in The Chemistry of Health. Crabtree + Company View MediaElectrostatic map of human spermine synthase
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From PDB entry 3c6k, Crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine. Emil Alexov, Clemson University View MediaCysteine dioxygenase from mouse
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Model of the mammalian iron enzyme cysteine dioxygenase from a mouse. Center for Eukaryotic Structural Genomics, PSI View MediaCluster analysis of mysterious protein
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Researchers use cluster analysis to study protein shape and function. Each green circle represents one potential shape of the protein mitoNEET. Patricia Jennings and Elizabeth Baxter, University of California, San Diego View MediaPig trypsin (1)
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A crystal of porcine trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View MediaSerum albumin structure 2
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Serum albumin (SA) is the most abundant protein in the blood plasma of mammals. SA has a characteristic heart-shape structure and is a highly versatile protein. Wladek Minor, University of Virginia View MediaProtein from E. faecalis
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X-ray structure of a DNA repair enzyme superfamily representative from the human gastrointestinal bacterium Enterococcus faecalis. Midwest Center for Structural Genomics View MediaCell curvature
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Rendering of the surface of an endothelial cell; membrane curvature is color coded. This is an example of NIH-supported research on single-cell analysis. Gaudenz Danuser, Harvard Medical School View MediaProtein formation
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Proteins are 3D structures made up of smaller units. DNA is transcribed to RNA, which in turn is translated into amino acids. NIGMS, with the folded protein illustration adapted from Jane Richardson, Duke University Medical Center View MediaEpithelial cell migration
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High-resolution time lapse of epithelial (skin) cell migration and wound healing. It shows an image taken every 13 seconds over the course of almost 14 minutes. Michael Shribak, Marine Biological Laboratory/University of Chicago. View MediaSleep and the fly brain
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In the top snapshots, the brain of a sleep-deprived fruit fly glows orange, marking high concentrations of a synaptic protein called Bruchpilot (BRP) involved in communication between neurons. Chiara Cirelli, University of Wisconsin-Madison View MediaTex protein
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Model of a member from the Tex protein family, which is implicated in transcriptional regulation and highly conserved in eukaryotes and prokaryotes. New York Structural GenomiX Research Consortium, PSI View MediaShiga toxin being sorted inside a cell
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Shiga toxin (green) is sorted from the endosome into membrane tubules (red), which then pinch off and move to the Golgi apparatus. Somshuvra Mukhopadhyay, The University of Texas at Austin, and Adam D. Linstedt, Carnegie Mellon University View Media