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Multinucleated cancer cell
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A cancer cell with three nuclei, shown in turquoise. The abnormal number of nuclei indicates that the cell failed to go through cell division, probably more than once. Dylan T. Burnette, Vanderbilt University School of Medicine. View MediaProteasome
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This fruit fly spermatid recycles various molecules, including malformed or damaged proteins. Sigi Benjamin-Hong, Rockefeller University View MediaFloral pattern in a mixture of two bacterial species, Acinetobacter baylyi and Escherichia coli, grown on a semi-solid agar for 48 hours (photo 1)
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Floral pattern emerging as two bacterial species, motile Acinetobacter baylyi (red) and non-motile Escherichia coli (green), are grown together for 48 hours on 1% agar surface from a sma L. Xiong et al, eLife 2020;9: e48885 View MediaCaulobacter
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A study using Caulobacter crescentus showed that some bacteria use just-in-time processing, much like that used in industrial delivery, to make the glue that allows them to attach to surfaces, Yves Brun, Indiana University View MediaHydra 04
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Hydra magnipapillata is an invertebrate animal used as a model organism to study developmental questions, for example the formation of the body axis. Hiroshi Shimizu, National Institute of Genetics in Mishima, Japan View MediaFloral pattern in a mixture of two bacterial species, Acinetobacter baylyi and Escherichia coli, grown on a semi-solid agar for 72 hour
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Floral pattern emerging as two bacterial species, motile Acinetobacter baylyi and non-motile Escherichia coli (green), are grown together for 72 hours on 0.5% agar surface from a small i L. Xiong et al, eLife 2020;9: e48885 View MediaInsulin production and fat sensing in fruit flies
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Fourteen neurons (magenta) in the adult Drosophila brain produce insulin, and fat tissue sends packets of lipids to the brain via the lipoprotein carriers (green). Akhila Rajan, Fred Hutchinson Cancer Center View MediaFruit fly starvation leads to adipokine accumulation
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Adult Drosophila abdominal fat tissue showing cell nuclei labelled in magenta. Akhila Rajan, Fred Hutchinson Cancer Center View MediaPathways: What is It? | Why Scientists Study Cells
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Learn how curiosity about the world and our cells is key to scientific discoveries. National Institute of General Medical Sciences View MediaEndoplasmic reticulum abnormalities
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Human cells with the gene that codes for the protein FIT2 deleted. Green indicates an endoplasmic reticulum (ER) resident protein. Michel Becuwe, Harvard University. View MediaDraper, shown in the fatbody of a Drosophila melanogaster larva
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The fly fatbody is a nutrient storage and mobilization organ akin to the mammalian liver. The engulfment receptor Draper (green) is located at the cell surface of fatbody cells. Christina McPhee and Eric Baehrecke, University of Massachusetts Medical School View MediaMicrosporidia in roundworm 1
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Many disease-causing microbes manipulate their host’s metabolism and cells for their own ends. Keir Balla and Emily Troemel, University of California San Diego View MediaTranslation
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Ribosomes manufacture proteins based on mRNA instructions. Each ribosome reads mRNA, recruits tRNA molecules to fetch amino acids, and assembles the amino acids in the proper order. Judith Stoffer View MediaSupernova bacteria
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Bacteria engineered to act as genetic clocks flash in synchrony. Here, a "supernova" burst in a colony of coupled genetic clocks just after reaching critical cell density. Jeff Hasty, UCSD View MediaNCMIR Kidney Glomeruli
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Stained glomeruli in the kidney. The kidney is an essential organ responsible for disposing wastes from the body and for maintaining healthy ion levels in the blood. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View MediaCrawling cell
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A crawling cell with DNA shown in blue and actin filaments, which are a major component of the cytoskeleton, visible in pink. Actin filaments help enable cells to crawl. Dylan T. Burnette, Vanderbilt University School of Medicine. View MediaMouse cerebellum in pink and blue
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The cerebellum is the brain's locomotion control center. Found at the base of your brain, the cerebellum is a single layer of tissue with deep folds like an accordion. National Center for Microscopy and Imaging Research (NCMIR) View MediaVimentin in a quail embryo
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Video of high-resolution confocal images depicting vimentin immunofluorescence (green) and nuclei (blue) at the edge of a quail embryo yolk. Andrés Garcia, Georgia Tech View MediaStress Response in Cells
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Two highly stressed osteosarcoma cells are shown with a set of green droplet-like structures followed by a second set of magenta droplets. Julia F. Riley and Carlos A. Castañeda, Syracuse University View MediamDia1 antibody staining- 02
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Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a complex process. Rong Li and Praveen Suraneni, Stowers Institute for Medical Research View MediaFocal adhesions
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Cells walk along body surfaces via tiny "feet," called focal adhesions, that connect with the extracellular matrix. Crabtree + Company View MediaCells lining the trachea
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In this image, viewed with a ZEISS ORION NanoFab microscope, the community of cells lining a mouse airway is magnified more than 10,000 times. Eva Mutunga and Kate Klein, University of the District of Columbia and National Institute of Standards and Technology View MediaNeural tube development
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Proteins in the neural tissues of this zebrafish embryo direct cells to line up and form the neural tube, which will become the spinal cord and brain. Alexander Schier, Harvard University View MediaIn vitro assembly of a cell-signaling pathway
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T cells are white blood cells that are important in defending the body against bacteria, viruses and other pathogens. Xiaolei Su, HHMI Whitman Center of the Marine Biological Laboratory View MediaNerve ending
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A scanning electron microscope picture of a nerve ending. It has been broken open to reveal vesicles (orange and blue) containing chemicals used to pass messages in the nervous system. Tina Weatherby Carvalho, University of Hawaii at Manoa View MediaShiga toxin being sorted inside a cell
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Shiga toxin (green) is sorted from the endosome into membrane tubules (red), which then pinch off and move to the Golgi apparatus. Somshuvra Mukhopadhyay, The University of Texas at Austin, and Adam D. Linstedt, Carnegie Mellon University View MediaCrab nerve cell
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Neuron from a crab showing the cell body (bottom), axon (rope-like extension), and growth cone (top right). Tina Weatherby Carvalho, University of Hawaii at Manoa View MediaTetrapolar mitosis
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This image shows an abnormal, tetrapolar mitosis. Chromosomes are highlighted pink. The cells shown are S3 tissue cultured cells from Xenopus laevis, African clawed frog. Gary Gorbsky, Oklahoma Medical Research Foundation View MediaCell-like compartments emerging from scrambled frog eggs 3
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Cell-like compartments spontaneously emerge from scrambled frog eggs. Endoplasmic reticulum (red) and microtubules (green) are visible. Video created using epifluorescence microscopy. Xianrui Cheng, Stanford University School of Medicine. View MediaDynamin structure
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When a molecule arrives at a cell's outer membrane, the membrane creates a pouch around the molecule that protrudes inward. Josh Chappie, National Institute of Diabetes and Digestive and Kidney Diseases, NIH View MediaSmooth ER
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The endoplasmic reticulum comes in two types: Rough ER is covered with ribosomes and prepares newly made proteins; smooth ER specializes in making lipids and breaking down toxic molecules. Judith Stoffer View MediaCross section of a Drosophila melanogaster pupa lacking Draper
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In the absence of the engulfment receptor Draper, salivary gland cells (light blue) persist in the thorax of a developing Drosophila melanogaster pupa. Christina McPhee and Eric Baehrecke, University of Massachusetts Medical School View MediaHow a microtubule builds and deconstructs
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A microtubule, part of the cell's skeleton, builds and deconstructs. View Media3D reconstruction of the Golgi apparatus in a pancreas cell
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Researchers used cryo-electron tomography (cryo-ET) to capture images of a rat pancreas cell that were then compiled and color-coded to produce a 3D reconstruction. Xianjun Zhang, University of Southern California. View MediaBacillus anthracis being killed
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Bacillus anthracis (anthrax) cells being killed by a fluorescent trans-translation inhibitor, which disrupts bacterial protein synthesis. Kenneth Keiler, Penn State University View MediaBiosensors illustration
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A rendering of an activity biosensor image overlaid with a cell-centered frame of reference used for image analysis of signal transduction. Gaudenz Danuser, Harvard Medical School View MediaHuman ES cells turn into insulin-producing cells
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Human embryonic stem cells were differentiated into cells like those found in the pancreas (blue), which give rise to insulin-producing cells (red). Eugene Brandon, ViaCyte, via CIRM View MediaSea urchin embryo 04
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Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). George von Dassow, University of Washington View MediaBacillus anthracis being killed
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Bacillus anthracis (anthrax) cells being killed by a fluorescent trans-translation inhibitor, which disrupts bacterial protein synthesis. John Alumasa, Keiler Laboratory, Pennsylvania State University View MediaLeptospira bacteria
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Leptospira, shown here in green, is a type (genus) of elongated, spiral-shaped bacteria. Infection can cause Weil's disease, a kind of jaundice, in humans. Tina Weatherby Carvalho, University of Hawaii at Manoa View MediaPlanarian stem cell colony
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Planarians are freshwater flatworms that have powerful abilities to regenerate their bodies, which would seem to make them natural model organisms in which to study stem cells. Peter Reddien, Whitehead Institute View MediaSea urchin embryo 02
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Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). George von Dassow, University of Washington View MediaHIV, the AIDS virus, infecting a human cell
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This human T cell (blue) is under attack by HIV (yellow), the virus that causes AIDS. Seth Pincus, Elizabeth Fischer, and Austin Athman, National Institute of Allergy and Infectious Diseases, National Institutes of Health View MediaSea urchin embryo 01
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Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). George von Dassow, University of Washington View MediaMitochondria from rat heart muscle cell
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These mitochondria (red) are from the heart muscle cell of a rat. Mitochondria have an inner membrane that folds in many places (and that appears here as striations). National Center for Microscopy and Imaging Research View MediaCultured cells
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This image of laboratory-grown cells was taken with the help of a scanning electron microscope, which yields detailed images of cell surfaces. Tina Weatherby Carvalho, University of Hawaii at Manoa View MediaSea urchin embryo 05
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Stereo triplet of a sea urchin embryo stained to reveal actin filaments (orange) and microtubules (blue). George von Dassow, University of Washington View MediaHIV-1 virus in the colon
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A tomographic reconstruction of the colon shows the location of large pools of HIV-1 virus particles (in blue) located in the spaces between adjacent cells. Mark Ladinsky, California Institute of Technology View Media