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Color coding of the Drosophila brain - video
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This video results from a research project to visualize which regions of the adult fruit fly (Drosophila) brain derive from each neural stem cell. Yong Wan from Charles Hansen’s lab, University of Utah. Data preparation and visualization by Masayoshi Ito in the lab of Kei Ito, University of Tokyo. View Media
Annotated TEM cross-section of C. elegans (roundworm)
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The worm Caenorhabditis elegans is a popular laboratory animal because its small size and fairly simple body make it easy to study. Piali Sengupta, Brandeis University View Media
Fluorescence in situ hybridization (FISH) in mouse ES cells shows DNA interactions
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Researchers used fluorescence in situ hybridization (FISH) to confirm the presence of long range DNA-DNA interactions in mouse embryonic stem cells. Kathrin Plath, University of California, Los Angeles View Media
Nucleus and rough ER
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The nucleus contains the DNA of eukaryotic cells. Judith Stoffer View Media
Bacteriophage P22 capsid, detail
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Detail of a subunit of the capsid, or outer cover, of bacteriophage P22, a virus that infects the Salmonella bacteria. Dr. Wah Chiu, Baylor College of Medicine View Media
Transmission electron microscopy showing cross-section of the node of Ranvier
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Nodes of Ranvier are short gaps in the myelin sheath surrounding myelinated nerve cells (axons). Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
Human retinal organoid
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A replica of a human retina grown from stem cells. Kevin Eliceiri, University of Wisconsin-Madison. View Media
Mitosis and meiosis compared-labeled
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Meiosis is used to make sperm and egg cells. During meiosis, a cell's chromosomes are copied once, but the cell divides twice. Judith Stoffer View Media
A panorama view of cells
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This photograph shows a panoramic view of HeLa cells, a cell line many researchers use to study a large variety of important research questions. Tom Deerinck, National Center for Microscopy and Imaging Research View Media
Trajectories of labeled cell receptors
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Trajectories of single molecule labeled cell surface receptors. This is an example of NIH-supported research on single-cell analysis. Gaudenz Danuser, Harvard Medical School View Media
Cross section of a Drosophila melanogaster pupa lacking Draper
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In the absence of the engulfment receptor Draper, salivary gland cells (light blue) persist in the thorax of a developing Drosophila melanogaster pupa. Christina McPhee and Eric Baehrecke, University of Massachusetts Medical School View Media
Induced stem cells from adult skin 03
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The human skin cells pictured contain genetic modifications that make them pluripotent, essentially equivalent to embryonic stem cells. James Thomson, University of Wisconsin-Madison View Media
Circadian rhythm neurons in the fruit fly brain
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Some nerve cells (neurons) in the brain keep track of the daily cycle. This time-keeping mechanism, called the circadian clock, is found in all animals including us. Justin Blau, New York University View Media
Genetic mosaicism in fruit flies
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Fat tissue from the abdomen of a genetically mosaic adult fruit fly. Genetic mosaicism means that the fly has cells with different genotypes even though it formed from a single zygote. Akhila Rajan, Fred Hutchinson Cancer Center View Media
HIV-1 virus in the colon
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A tomographic reconstruction of the colon shows the location of large pools of HIV-1 virus particles (in blue) located in the spaces between adjacent cells. Mark Ladinsky, California Institute of Technology View Media
Bacillus anthracis being killed
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Bacillus anthracis (anthrax) cells being killed by a fluorescent trans-translation inhibitor, which disrupts bacterial protein synthesis. John Alumasa, Keiler Laboratory, Pennsylvania State University View Media
Scanning electron microscopy of the ECM on the surface of a calf muscle
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This image shows the extracellular matrix (ECM) on the surface of a soleus (lower calf) muscle in light brown and blood vessels in pink. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
Zebrafish embryo
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Just 22 hours after fertilization, this zebrafish embryo is already taking shape. By 36 hours, all of the major organs will have started to form. Philipp Keller, Bill Lemon, Yinan Wan, and Kristin Branson, Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Va. View Media
Three neurons and human ES cells
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The three neurons (red) visible in this image were derived from human embryonic stem cells. Undifferentiated stem cells are green here. Anirvan Ghosh lab, University of California, San Diego, via CIRM View Media
Yeast art depicting the New York City skyline
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This skyline of New York City was created by “printing” nanodroplets containing yeast (Saccharomyces cerevisiae) onto a large plate. Each dot is a separate yeast colony. Michael Shen, Ph.D., Jasmine Temple, Leslie Mitchell, Ph.D., and Jef Boeke, Ph.D., New York University School of Medicine; and Nick Phillips, James Chuang, Ph.D., and Jiarui Wang, Johns Hopkins University. View Media
HeLa cells
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Scanning electron micrograph of an apoptotic HeLa cell. Zeiss Merlin HR-SEM. National Center for Microscopy and Imaging Research View Media
Hydra 02
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Hydra magnipapillata is an invertebrate animal used as a model organism to study developmental questions, for example the formation of the body axis. Hiroshi Shimizu, National Institute of Genetics in Mishima, Japan View Media
Mouse heart fibroblasts
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This image shows mouse fetal heart fibroblast cells. The muscle protein actin is stained red, and the cell nuclei are stained blue. Kara McCloskey lab, University of California, Merced, via CIRM View Media
Podocytes from a chronically diseased kidney
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This scanning electron microscope (SEM) image shows podocytes--cells in the kidney that play a vital role in filtering waste from the bloodstream--from a patient with chronic kidney disease. Olga Troyanskaya, Princeton University and Matthias Kretzler, University of Michigan View Media
CRISPR surveillance complex
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This image shows how the CRISPR surveillance complex is disabled by two copies of anti-CRISPR protein AcrF1 (red) and one AcrF2 (light green). NRAMM National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View Media
Fused, dicentric chromosomes
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This fused chromosome has two functional centromeres, shown as two sets of red and green dots. Beth A. Sullivan, Duke University View Media
Zebrafish embryo showing vasculature
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A zebrafish embryo. The blue areas are cell bodies, the green lines are blood vessels, and the red glow is blood. Kevin Eliceiri, University of Wisconsin-Madison. View Media
Movements of myosin
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Inside the fertilized egg cell of a fruit fly, we see a type of myosin (related to the protein that helps muscles contract) made to glow by attaching a fluorescent protein. Victoria Foe, University of Washington View Media
Dense tubular matrices in the peripheral endoplasmic reticulum (ER) 2
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Three-dimensional reconstruction of a tubular matrix in a thin section of the peripheral endoplasmic reticulum between the plasma membranes of the cell. Jennifer Lippincott-Schwartz, Howard Hughes Medical Institute Janelia Research Campus, Virginia View Media
Cell division phases in Xenopus frog cells
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These images show three stages of cell division in Xenopus XL177 cells, which are derived from tadpole epithelial cells. They are (from top): metaphase, anaphase and telophase. Claire Walczak, who took them while working as a postdoc in the laboratory of Timothy Mitchison View Media
Zebrafish pigment cell
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Pigment cells are cells that give skin its color. David Parichy, University of Washington View Media
Math from the heart
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Watch a cell ripple toward a beam of light that turns on a movement-related protein. View Media
Seeing signaling protein activation in cells 04
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Cdc42, a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including motility, proliferation, apoptosis, and cell morphology. Klaus Hahn, University of North Carolina, Chapel Hill Medical School View Media
Fruit fly larvae brains showing tubulin
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Two fruit fly (Drosophila melanogaster) larvae brains with neurons expressing fluorescently tagged tubulin protein. Vladimir I. Gelfand, Feinberg School of Medicine, Northwestern University. View Media
Electrode probe on mouse Huntington's muscle cell
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Using an electrode, researchers apply an electrical pulse onto a piece of muscle tissue affected by Huntington's disease. Grigor Varuzhanyan and Andrew A. Voss, California State Polytechnic University View Media
Mitochondria from rat heart muscle cell_2
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These mitochondria (brown) are from the heart muscle cell of a rat. Mitochondria have an inner membrane that folds in many places (and that appears here as striations). National Center for Microscopy and Imaging Research View Media
Confocal microscopy of perineuronal nets in the brain 1
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The photo shows a confocal microscopy image of perineuronal nets (PNNs), which are specialized extracellular matrix (ECM) structures in the brain. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
Wound healing in process
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Wound healing requires the action of stem cells. Hermann Steller, Rockefeller University View Media
Mitochondrion from insect flight muscle
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This is a tomographic reconstruction of a mitochondrion from an insect flight muscle. National Center for Microscopy and Imaging Research View Media
Cellular metropolis
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Like a major city, a cell teems with specialized workers that carry out its daily operations--making energy, moving proteins, or helping with other tasks. Kathryn Howell, University of Colorado Health Sciences Center View Media
Staphylococcus aureus aggregating upon contact with synovial fluid
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Staphylococcus aureus bacteria (green) grouping together upon contact with synovial fluid—a viscous substance found in joints. Paul Stoodley, The Ohio State University. View Media
G switch
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The G switch allows our bodies to respond rapidly to hormones. See images 2537 and 2538 for labeled versions of this image. Crabtree + Company View Media
Mitotic cell awaits chromosome alignment
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During mitosis, spindle microtubules (red) attach to chromosome pairs (blue), directing them to the spindle equator. View Media
Wound healing in process
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Wound healing requires the action of stem cells. Hermann Steller, Rockefeller University View Media
NCMIR Kidney Glomeruli
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Stained glomeruli in the kidney. The kidney is an essential organ responsible for disposing wastes from the body and for maintaining healthy ion levels in the blood. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
Pathways: What is Basic Science?
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Learn about basic science, sometimes called “pure” or “fundamental” science, and how it contributes to the development of medical treatments. National Institute of General Medical Sciences View Media
Fruit fly ovary
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A fruit fly ovary, shown here, contains as many as 20 eggs. Fruit flies are not merely tiny insects that buzz around overripe fruit—they are a venerable scientific tool. Denise Montell, Johns Hopkins University and University of California, Santa Barbara View Media
Cross section of a Drosophila melanogaster pupa
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This photograph shows a magnified view of a Drosophila melanogaster pupa in cross section. Compare this normal pupa to one that lacks an important receptor, shown in image 2759. Christina McPhee and Eric Baehrecke, University of Massachusetts Medical School View Media
ARTS triggers apoptosis
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Cell showing overproduction of the ARTS protein (red). ARTS triggers apoptosis, as shown by the activation of caspase-3 (green) a key tool in the cell's destruction. The nucleus is shown in blue. Hermann Steller, Rockefeller University View Media
Nucleolus subcompartments spontaneously self-assemble 4
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What looks a little like distant planets with some mysterious surface features are actually assemblies of proteins normally found in the cell's nucleolus, a small but very important protein complex lo Nilesh Vaidya, Princeton University View Media
