NIGMS-Supported Biomedical Data Repositories and Knowledgebases

NIGMS participates in a trans-NIH effort to support a modern data resource ecosystem through PAR-20-089 and PAR-20-097 and their reissues (PAR-23-079PAR-23-078, and PAR-23-237​). For details, see NIH Biomedical Data Repositories and Knowledgebases. Potential applicants are strongly advised to contact NIGMS staff at least ten weeks before the application due date to discuss the suitability of a proposed project for the program.

Jean Yuan, Ph.D.
Program Director
Division of Biophysics, Biomedical Technology, and Computational Biosciences
National Institute of General Medical Sciences
National Institutes of Health
45 Center Drive MSC 6200
Bethesda, MD 20892-6200

NIGMS supports the following Data Repositories and Knowledgebases.


Grant Number: GM144232-01
Principal Investigator: Michael K. Gilson, Ph.D.
The Binding Database projects aims to make experimental data on the noncovalent association of molecules in solution searchable via the WWW. The initial focus is on biomolecular systems, but data on host-guest and supramolecular systems are also important and being included over time. It is expected that the enhanced access to data provided by this resource will facilitate drug-discovery, the design of self-assembling systems, and the development of predictive computer models of binding.

Biological Magnetic Resonance Data Bank (BMRB)

Grant Number: GM150703-01
Principal Investigator: Jeffrey Hoch, Ph.D.
BMRB collects, annotates, archives, and disseminates spectral and quantitative data from NMR spectroscopic investigations of biologically relevant molecules for structural and dynamic analyses of biomolecular NMR spectroscopy.

BioPortal Knowledgebase

Grant Number: GM143402-01
Principal Investigator: Mark A. Musen, Ph.D.
BioPortal provides a knowledgebase that integrates more than 800 biomedical ontologies, making it easy for scientists and clinicians to use the resulting knowledge to describe their data, to access information more reliably, to build other knowledge resources in standardized ways, and to bring biomedical knowledge both to the laboratory and to the point of care.

Gene Ontology Consortium and Knowledgebase

Grant Number: HG012212-01
Principal Investigator: Paul D. Thomas, Ph.D.
Gene Ontology is a computational resource that collects biological knowledge into a large network structure that connects genes with the roles they play.

Global Proteomics Mass Spectrometry Data Sharing Infrastructure

Grant Number: GM148372-01
Principal Investigator: Nuno Bandeira Ph.D.
This data-sharing infrastructure develops standards, workflows, and data indexes to advance FAIR (Findable, Accessible, Interoperable, and Reusable) access to proteomics mass spectrometry (MS) datasets within the MassIVE repository of MS data and the ProteomeCentral data portal for the global ProteomeXchange consortium of proteomics MS data repositories.


Grant Number: GM146616-01
Principal Investigator: Michael Tiemeyer, Ph.D.
The GlyGen knowledgebase is an essential resource for glycobiology and related domains through integration, harmonization, and annotation of data describing glycan and glycoconjugate dynamics in health and disease.

Knowledgebase of Escherichia coli Genome and Metabolism

Grant Number: GM150703-01
Principal Investigator: Peter Karp, Ph.D.
EcoCyc is a scientific database for Escherichia coli K-12 MG1655 bacterium and part of BioCyc Genome Database collection. This database performs literature-based curation of its genome and transcriptional regulation, transporters, and metabolic pathways.


Grant Number: GM142435-01
Principal Investigator: Marc s. Halfon, Ph.D.
GREDfly is a curated collection of known insect transcriptional cis-regulatory modules, cis-regulatory module segments, predicted cis-regulatory modules, and transcription factor binding sites. REDfly seeks to include all experimentally verified fly regulatory elements along with their DNA sequence, their associated genes, and the expression patterns they direct.

RRID Portal/ Resource Watch

Grant Number: GM144308-01
Principal Investigator: Anita Elzbieta Bandrowski, Ph.D.
The Resource Identification Portal was created in support of the Resource Identification Initiative, which aims to promote research resource identification, discovery, and reuse. The portal offers a central location for obtaining and exploring Research Resource Identifiers (RRIDs) - persistent and unique identifiers for referencing a research resource. This portal relies on the good work of many community repositories such as MGI, Addgene, MMRRC and Cellosaurus.


Grant Number: HG007822-08
Principal Investigator: Alex Bateman, Ph.D.
UniProt provides a reference resource that efficiently standardizes and organizes knowledge of proteins and their functions in forms that both humans and machines can understand and interpret. The UniProt knowledge framework enables biomedical researchers to rapidly understand what is already known, enabling them to design insightful experiments to understand human disease at a molecular level.