Because research funds are limited and many outstanding biomedical scientists are deserving of
support, NIGMS believes that, to sustain the research enterprise and maximize opportunities
for significant scientific advances, it is essential to have a diverse research
portfolio with a wide array of investigators and topics. Awarding R01s and
other research grants to investigators with substantial levels of long-term, unrestricted
research funding requires careful consideration, because these
researchers already have resources from other agencies or organizations that
support overall research programs
rather than individual projects. Although moderate levels of additional
research funding to such well-supported investigators can in some instances
produce significant returns on NIGMS’ investment, these investments need to be
carefully managed to ensure that the Institute’s research portfolio is
optimally diversified and that it can support as many talented and productive
research groups as possible.
In advising potential
applicants and making funding decisions, NIGMS staff carefully considers each
investigator’s overall research support, including institutional support.
with substantial, long-term, unrestricted research support may generally hold no
more than one NIGMS research grant. For
the purposes of these guidelines, investigators with substantial, long-term,
unrestricted support (“unrestricted investigators”) would have at least $400,000
in unrestricted support (direct costs per year excluding the principal investigator’s
salary and direct support of widely shared institutional resources, such as NMR
facilities) that extends at least 2 years beyond the onset of funding the NIGMS
grant. As in all cases, if NIGMS funding of a grant to an investigator with substantial,
long-term, unrestricted support would result in total direct costs from all
sources exceeding $750,000, National Advisory General Medical Sciences Council
approval would be required through the standard process.
Effective for applications submitted on or after
January 2, 2016:
In keeping with federal
grants administration statutes, regulations and policies, unrestricted investigators
under consideration to receive new or continuing support from NIGMS must provide
a detailed, accurate accounting of all their research support, including unrestricted
support. When reporting other support, investigators should describe their other research projects in sufficient detail that NIGMS staff and Council members can determine the differences between the proposed NIGMS project and research supported by other sources. Investigators are encouraged to explain any appearance of overlapping research goals and should report the time commitment to each existing project.
Unrestricted research support is monetary support from any agency, organization or institution that is not project-based and may be used to conduct research on a broad topic at the discretion of the principal investigator. Investigators with unrestricted research support include but are not limited to Howard Hughes Medical Institute investigators, holders of endowed chairs that fund an undefined research project or projects, recipients of unrestricted gifts designed to support research, and staff at scientific institutes that provide long-term research funding (not including start-up funds). Such support is defined as unrestricted if it extends for at least 2 years from the time of funding the NIGMS grant.
An unrestricted investigator is an investigator with unrestricted research support.
Substantial research support is $400,000 or more per year in direct costs excluding the principal investigator’s salary and direct support of widely shared institutional resources.
Long-term refers to research support that extends at least 2 years from the time an NIGMS grant would be awarded.
This page last reviewed on
5/29/2019 8:10 AM
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