Start Date: 4/4/2000 8:00 AM
End Date: 4/6/2000 6:30 PM
NOTE: Hyperlinks within the text may have been deactivated because they no longer link to active sites and/or e-mail addresses.
This document reports the principles agreed at the April 4-6, 2000 meeting of representatives of the structural genomics community. Its purpose is to generate further co-operation in the structural biology and general scientific communities. The document may serve as a basis for an appropriately timed announcement to the international public on the initiation of a worldwide effort in structural genomics.
Success of the genome sequencing projects and major advances in methods of protein structure determination have led the structural biology community to propose the large scale mapping of protein structure space. This structural genomics initiative aims at the discovery, analysis and dissemination of three-dimensional structures of protein, RNA and other biological macromolecules representing the entire range of structural diversity found in nature. Such a complete knowledge will facilitate fundamental understanding and applications in biology, agriculture and medicine. The three-dimensional structures will be crucial for rational drug design, for advancing catalysis in chemistry and biotechnology, and for diagnosis and treatment of disease, as well as for advancing basic principles of biology.
This opportunity is made possible by rapid recent progress in several related key technologies. These include the construction of synchrotrons and high-field NMR instruments, the MAD method of phase determination, high throughput cloning and recombinant expression, a flood of information from genome sequencing projects, and new bioinformatic methods for fold assignment, model building, and prediction of function.
The following document outlines issues related to achieving this expansion of knowledge. The goal is to encourage harmonious cooperation among a broad range of public and private sector institutions in the international effort to characterize macromolecular structures in living organisms on a pan-genomic scale.
A. Specific goals
B. Programs needed
A. Public funding agencies can cooperate:
B. Information and Material Release in the National Structural Genomics Programs
C. Relationship to industrial activities
Raw fundamental data on the shape of natural protein molecules, including 3D positional coordinates, should be made freely available to researchers everywhere. However, intellectual property protection for inventions based on these can play an important role in stimulating the development of important new health care projects. Policies should be established to permit an appropriate balance between these goals.
Annual meetings of representatives of the structural genomics community are anticipated for the continued discussion of these issues. The Second International Structural Genomics Meeting is being planned for April 4-6, 2001, in Virginia, USA.
These principles were supported by the participants in the First International Structural Genomics Meeting in Cambridge, UK, April 4-6, 2000.
Dr Sherin Abdel-Meguid Suntory Pharmaceutical Research Laboratories One Kendall Square Building 1400W Cambridge, MA 02139 USA Phone: 00 1 617 621 0222 Fax: 00 1 617 621 0555 sherin2@aol.com
Dr Geoff Barton EMBL-EBI The Wellcome Trust Genome Campus Hinxton Cambridgeshire, UK CB10 1SD Phone: 01223 494414 Fax: 01223 494496 geoff@ebi.ac.uk
Professor Helen Berman Protein Data Bank Rutgers University Chemistry Department 610 Taylor Road Piscataway, NJ 08854 USA Phone: 00 1 732 445 4667 Fax: 00 1 732 445 4320 berman@rcsb.rutgers.edu
Professor Ivano Bertini Director, Magnetic Resonance Center University of Florence Via L. Sacconi 6 50019 Sesto Fiorentino Italy Phone: 00 39 055 4209 270 Fax: 00 39 055 4209 271 bertini@cerm.unifi.it
Professor Sir Tom Blundell Department of Biochemistry University of Cambridge Tennis Court Road Cambridge, UK CB2 1GA Phone: 01223 333628 Fax: 01223 766082 tom@cryst.bioc.cam.ac.uk
Professor Stephen K Burley The Rockefeller University 1230 York Avenue Box 55 New York, NY 10021-6399 USA Phone: 00 1 212 327 7240 Fax: 00 1 327 7240 burley@rockvax.rockefeller.edu
Dr Christian Cambillau AFMB-CNRS 31 Ch. J. Aiguier 13402 Marseille Cedex 20 France Phone: 00 33 491 16 45 02 Fax: 00 33 491 16 45 36 cambillau@afmb.cnrs-mrs.fr
Mr. David Carr Policy Unit The Wellcome Trust 210 Euston Road London, UK NW1 2BE Phone: 0171 611 8220 Fax: 0171 611 8742 d.carr@wellcome.ac.uk
Dr Marvin Cassman Director, NIGMS NIH 45 Center Drive MSC-6200 Bethesda, MD 20892-6200 USA Phone: 00 1 301 594 2172 Fax: 00 1 301 402 0156 cassmanm@nigms.nih.gov
Dr Cyrus Chothia MRC Laboratory of Molecular Biology University of Cambridge Hills Road Cambridge, UK CB2 2QH Phone: 01223 402221 Fax: 01223 213556 chc1@mrc-lmb.cam.ac.uk
Miss Nicky Clarkson Conference & Meetings Administrator Hinxton Hall Conference Centre The Wellcome Trust Genome Campus Hinxton Cambridgeshire, UK CB10 1RQ Phone: 01223 495002 Fax: 01223 495114 nicky.clarkson@hinxton.wellcome.ac.uk
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Ms Anna Curson Project Analyst The Wellcome Trust 183 Euston Road London, UK NW1 2BE Phone: 0171 611 8773 Fax: 0171 611 0708 a.curson@wellcome.ac.uk
Professor Christopher Dobson New Chemistry Laboratory University of Oxford South Parks Road Oxford, UK OX1 3QT Phone: 01865 275916 Fax: 01865 275921 chris.dobson@icl.ox.ac.uk
Professor Guy Dodson Department of Chemistry University of York York, UK YO10 5DD Phone: 01904 432519 Fax: 01904 410519 ggd@ysbl.york.ac.uk
Dr Richard Durbin Head of Informatics Division The Sanger Centre The Wellcome Trust Genome Campus Hinxton Cambridgeshire, UK CB10 1SA Phone: 01223 494978 Fax: 01223 494919 rd@sanger.ac.uk
Dr Charles Edmonds Program Director Division of Cell Biology & Biophysics NIGMS/NIH 45 Center Drive RM 2AN18B Bethesda, MD 20892-6200 USA Phone: 00 1 301 594 4428 Fax: 00 1 301 480 2004 edmondsc@nigms.nih.gov
Professor Aled Edwards Associate Professor Banting and Best Department Of Medical Research C.H Best Institute Room 402 University of Toronto 112 College Street Toronto, Ontario M5G 1L6 Canada Phone: 00 1 416 946 3436 Fax: 00 1 416 978 8528 aled.edwards@utoronto.ca
Professor Roger Fourme LURE Universite Paris-Sud Bât 209 D Université Paris.Sud 91898 Orsay Cedex France Phone: 00 33 1 64 46 81 26 Fax: 00 33 1 64 46 41 02 fourme@lure.u-psud.fr
Professor Paul Freemont Centre for Structural Biology Imperial College of Science, Technology and Medicine South Kensington London, UK Phone: 0171 269 3291/594 5324 Fax: 0171 269 3671 p.freemont@ic.ac.uk
Dr Michael Geisow 16 The Banks Bingham Nottinghamshire, UK NG13 8BL Phone: 01949 876 156 Fax: 01949 876156 mike@biodigm1.u-net.com
Professor Paul Gilna Program Director Biological Databases & Informatics National Science Foundation 4201 Wilson Blvd Arlington, VA 22230 USA Phone: 00 1 703 306 1469 Fax: 00 1 703 306 0356 pgilna@nsf.gov
Professor Udo Heinemann Kristallographie Max-Delbrück-Centrum für Molekulare Medicin Robert-Rössle-Strasse 10 D-13125 Berlin Germany Phone: 00 49 30 9406 3420 Fax: 00 49 30 9406 2548 heinemann@mdc-berlin.de
Professor Wayne Hendrickson Department of Biochemistry and Molecular Biology Columbia University 630 West 168th Street BB-2-202 New York, NY 10032 USA Phone: 00 1 212 305 3456 Fax: 00 1 212 305 7379 wayne@convex.hhmi.columbia.edu
Dr Nobuo Kamiya Senior Scientist Division of Bio-Crystallography Technology RIKEN Harima Institute/Spring 8 Kocuto Mikazuki Myogo 679-5148 Japan Phone: 00 81 791 58 2839 Fax: 00 81 791 58 2834 nkamiya@sp8sun.spring8.or.jp
Professor Robert Kaptein Bijvoet Centre for Biomolecular Research University of Utrecht Padualaan 8 NL-CH-3584 Utrecht The Netherlands Phone: 00 31 30 253 3787 Fax: 00 31 30 253 7623 kaptein@nmr.chem.uu.nl
Professor Sung-Hou Kim Calvin Laboratory University of California Berkeley, CA 94720 USA Phone: 00 1 510 486 4333 Fax: 00 1 510 486 5272 shkim@cchem.berkley.edu
Dr Richard Kramer Novartis Pharmaceuticals Corp 556 Morris Avenue Summit, NJ 07901 USA Phone: 00 1 908 277 4687 Fax: 00 1 908 277 5035 richard.kramer@pharma.novartis.com
Dr Victor Lamzin EMBL C/O Desy Notkerstr 74 22603 Hamburg Germany Phone: 00 49 40 89 902 121 Fax: 00 49 40 89902 149 victor@embl-hamburg.de
Professor Michael Levitt Department of Structural Biology Stanford Medical School Stanford, CA 94305 USA Phone: 00 1 650 723 6800 Fax: 00 1 650 723 8464 michael.levitt@stanford.edu
Professor Peter Lindley European Synchrotron Radiation Facility ESRF, BP 220 F-38043 Grenoble Cedex France Phone: 00 33 4 7688 2014 Fax: 00 33 4 7688 2160 lindley@esrf.fr
Dr Michal Linial Department of Biological Chemistry Life Science Institute The Hebrew University Givat Ram Jerusalem 91904 Israel Phone: 00 972 2 658 5425 Fax: 00 972 2 658 6448 michall@leonardo.ls.huji.ac.il
Dr Albrecht Messerschmidt Max-Planck-Institute for Biochemistry AM Klopferspitz 18A Germany Phone: 00 49 89 8578 2669 Fax: 00 49 89 8578 3516 messersc@biochem.mpg.de
Dr Stefan Michalowski Head, Megascience Unit OECD 2 rue André-Pascal 75016 Paris France Phone: 00 33 1 45 24 92 89 Fax: 00 33 1 45 24 96 44 michalowski@oecd.org
Dr Colin Miles BBSRC Polaris House North Star Avenue Swindon SN2 1UH Phone: 01793 413359 Fax: 01793 413234 colin.miles@bbsrc.ac.uk
Dr Gaetano Montelione CABM - Rutgers University 679 Hoes Lane Piscataway, NJ 08854 USA Phone: 00 1 732 235 5321 Fax: 00 1 732 235 4850 guy@cabm.rutgers.edu
Dr Michael Morgan Chief Executive of The Wellcome Trust Genome Campus The Wellcome Trust 183 Euston Road London, UK NW1 2BE Phone: 020 7611 8691 Fax: 020 7611 8688 m.morgan@wellcome.ac.uk
Professor John Moult CARB University of Maryland 9600 Gudelsky Drive Rockville, MD 20850 USA Phone: 00 1 301 738 6241 Fax: 00 1 202 738 6255 jmoult@tunc.org
Dr John Norvell Program Director Division of Cell Biology & Biophysics NIGMS/NIH 45 Center Drive Room 2AS13B Bethesda, MD 20892-6200 USA Phone: 00 1 301 594 0533 Fax: 00 1 301 480 2004 norvellj@nigms.nih.gov
Dr Mark Palmer Medical Research Council 20 Park Crescent London, UK W1N 4AL Phone: 0171 7670 5360 Fax: 0171 7637 2856 palmer@headoffice.mrc.ac.uk
Dr Ari Patrinos Associate Director for Biological & Environmental Research US Department of Energy 19901 Germantown Road Germantown, MD 20874-1290 USA Phone: 00 1 301 903 3251 Fax: 00 1 903 5051 ari.patrinos@science.doe.gov
Professor Simon Phillips Astbury Centre for Structural Molecular Biology School of Biochemistry and Molecular Biology University of Leeds Leeds, UK LS2 9JT Phone: 0113 233 3027 Fax: 0113 233 1407 s.e.v.phillips@leeds.ac.uk
Dr Debbie Poole Programme Manager The Wellcome Trust Genome Campus Hinxton Cambridgeshire, UK CB10 1RQ Phone: 01223 495006 Fax: 01223 495114 d.poole@hinxton.wellcome.ac.uk
Professor Randy Read Wellcome Trust/MRC Building Hills Road Cambridge, UK CB2 2XY Phone: 01223 336500 Fax: 01223 336827 rjr27@cam.ac.uk
Professor David Rice Department of Molecular Biology and Biotechnology University of Sheffield Firth Court Western Bank Sheffield, UK S10 2TN Phone: 0114 222 2750 Fax: 0114 222 2850 d.rice@sheffield.ac.uk
Dr Ajay Royyuru Computational Biology Center IBM T J Watson Research Center PO Box 704 Yorktown Heights, NY 10598 USA Phone: 00 1 914 784 7813 Fax: 00 1 914 784 7455 ajayr@us.ibm.com
Professor Chris Sander CISO Millennium Predictive Medicine 700 One Kendall Square Cambridge, MA 02139 USA Phone: 00 1 617 577 3534/7245 Fax: 00 1 617 249 0169 sander@mpi.com
Mr. David Seemungal Policy Unit The Wellcome Trust 210 Euston Road London, UK NW1 2BE Phone: 0171 611 8290 Fax: 0171 611 8742 d.seemungal@wellcome.ac.uk
Dr Barbara Skene Scientific Programme Manager Wellcome Trust 183 Euston Road London, UK NW1 2BE Phone: 0171 611 8677 Fax: 0171 611 0708 b.skene@wellcome.ac.uk
Dr Sharon Spencer Catalyst Biomedica Ltd. 183 Euston Road London, UK NW1 2BE Phone: 0171 611 8310 Fax: 0171 611 8857 spencer@wellcome.ac.uk
Professor Joel Sussman Department of Structural Biology Weizmann Institute of Science Rehovot 76100 Israel Phone: 00 972 8 934 2638 Fax: 00 972 8 934 4159 joel.sussman@weizmann.ac.il
Dr William Taylor Division of Mathematical Biology National Institute for Medical Research The Ridgeway, Mill Hill London, UK NW7 1AA Phone: 0181 959 3666 Fax: 0181 913 8545 Wtaylor@nimr.mrc.ac.uk
Dr Tom Terwilliger Los Alamos National Laboratory Mail Stamp M888 Los Alamos, NM 87545 USA Phone: 00 1 505 667 0072 Fax: 00 1 505 665 3024 terwilliger@lanl.gov
Dr Jean-Claude Thierry CNRS IGBMC - 1 rue Laurent Fries 67400 Illkirch France Phone: 00 33 3 88 65 33 06 Fax: 00 33 3 88 65 32 76 jct@igbmc.u-strasbg.fr
Professor Janet Thornton Biomolecular & Molecular Biology University College London Gower Street London WC1E 6BT Phone: 0171 3807048 Fax: 0171 9618499 thornton@biochem.ucl.ac.uk
Dr Tony Wilkinson AstraZeneca Mereside, Room 8AF4 Alderley Park Macclesfield Cheshire SK10 4TG Phone: 01625 515167 Fax: 01625 517692 tony.wilkinson@astrazeneca.com
Dr Shigeyuki Yokoyama Genomic Sciences Centre RIKEN 2-1 Hirosawa Wako Saitama 351-0198 Japan Phone: 00 81 48 467 9427 Fax: 00 81 48 462 4675 yokoyama@biochem.s.u-tokyo.ac.jp
