Protein Structure Initiative Annual Meeting

Hyatt Regency Bethesda

Start Date: 12/8/2009 7:00 PM

End Date: 12/10/2009 12:00 PM


December 8, 2009, 7:00 p.m. – 10:00 p.m. at the Hyatt Regency Bethesda Hotel

Reception and Facilitated Discussion Session

Session I. Accomplishments of the PSI

Chairs: Peter Preusch and Jeremy Berg
Moderators: John Moult and Ed Lattman
Reporters: Emily Carlson, Alison Davis, Juliana Blome

Agenda: Goals for the annual meeting. Welcome, introductions, announcements. Planning for capture and dissemination of the overall contributions of PSI-1 and PSI-2. Final year management matters to be resolved to bring PSI-2 to a close. Plans for additional meetings, publications, final progress reports, and PSI-2 final assessment.

Key Areas to Address:

  1. Enabling technology
  2. Cost per structure
  3. Structural coverage
  4. What did we learn about protein structure?
  5. What did we learn about the evolution of genes and protein structures?
  6. What did we learn about modeling protein structure from gene sequences?
  7. Over what universe of gene sequence/protein structure can we declare victory?
  8. What else did we learn?
  9. What has been the impact to date?
  10. What is the projected impact over the next decade?

December 9, 2009, 8:00 a.m. – 4:30 p.m., NIH Campus, Bldg 45, Conf Room D

PSI Center Presentations (30 minutes including discussion)

Chairs: Peter Preusch, Jeremy Berg

Session II. Individual Center Presentations (order TBD)

Speaker 1 Stephen Burley – New York Structural GenomiX Research Consortium
Speaker 2 Andrzej Joachimiak – Midwest Center for Structural Genomics
Speaker 3 Guy Montelione – Northeast Structural Genomics Consortium
Speaker 4 Ian Wilson – Joint Center for Structural Genomics

Break 10:00 a.m. - 10:30 a.m.

Speaker 5 Helen Berman – PSI-Nature Structural Genomics Knowledgebase
Speaker 6 Roland Dunbrack – New Methods of Comparative Modeling
Speaker 7 Adam Godzik – Joint Center for Protein Modeling

Lunch Break 12:00 p.m. – 1:00 p.m.

Session III. Individual Center Presentations

Speaker 8 Joshua LaBaer – PSI Materials Repository
Speaker 9 William Harries – Center for Structures of Membrane Proteins
Speaker 10 Wayne Hendrickson – New York Consortium on Membrane Protein Structure

Break 2:30 p.m. – 3:00 p.m.

Speaker 11 Michael Malkowski – Center for High-Throughput Structural Biology
Speaker 12 John Markley – Center for Eukaryotic Structural Genomics
Speaker 13 Lance Stewart – Accelerated Technologies Center Gene to 3D Structure
Speaker 14 Tom Terwilliger – Integrated Center for Structure & Function Innovation

Summary Discussion: 5:00 p.m. – 6:00 p.m.

Objective: There are 14 currently funded center PIs, each should have an opportunity to discuss most recent progress, but more importantly each should focus on the over-riding take-home lessons from the entire PSI effort. These talks will provide the flesh to fill-out the bullet points established the previous evening. They should also elaborate plans for capture and dissemination of these take-home lessons. These talks may also usefully point to future directions in structural genomics.

Adjourn for Transportation to Hotel or Walk to Restaurant

Dinner at Bangkok Garden Restaurant (St. Elmo and Norfolk) at 7:00 p.m.

December 10, 2009, 8:30 a.m. – 10:00 a.m., NIH Campus, Bldg 45, Conf Room D

Session IV. Steering a Course for the Future

Short Reports and Discussion

Session Chair: Wayne Hendrickson (Steering Committee Chairperson)

Steering Committee Report
Subcommittee Reports
Discussion of Final Year Objectives of PSI-2
Discussion of PSI Organizational Structures

The objective of this session is to make necessary plans for completion of the PSI-2 program and transition to PSI:Biology as effectively as possible.

  1. What functions of the Steering Committee have worked well?
  2. Which could be improved upon for PSI:Biology?
  3. What else should we be thinking about during the transition?
  4. Commitments for future activities and deliverables?

Adjourn Annual Meeting and Break at 10:00 a.m.

December 10, 2009, 10:30 a.m. – 12:00 noon, NIH Campus, Bldg 45, Conf Room D

V. PSI Advisory Committee Meeting

Chair: Brian Matthews

Agenda: Summary of impressions of PSI-2 and recommendations. Draft comments for report to National Advisory Council. Discussion of PSI:Biology. Plans for future PSI Advisory Committee activities.

Meeting adjourned by 12:00 p.m. for transportation to airport.


PSI:Biology Kickoff Meeting
July 19-20, 2010

PSI: Biology 1st Annual Meeting
December 8-9, 2010