Undergraduate Research Training Initiative for Student Enhancement (U-RISE) (T34)

Program Goal and Structure

The goal of the Undergraduate Research Training Initiative for Student Enhancement (U-RISE) program is to develop a diverse pool of undergraduates who complete their baccalaureate degree, and transition into and complete biomedical, research-focused higher degree programs (e.g., Ph.D. or M.D./Ph.D.). Training grants offset the cost of stipends, tuition and fees, and training related expenses, including health insurance, for the appointed trainees in accordance with the approved NIH support levels. Training grants are usually awarded for five years and are renewable. Full details are found in the Funding Opportunity Announcement (FOA) PAR-21-146.

Institutional Eligibility

U-RISE provides support to eligible, domestic institutions to develop and implement effective, evidence-informed approaches to biomedical research training and mentoring that will keep pace with the rapid evolution of the research enterprise. This program is limited to applications from training programs at baccalaureate degree-granting research-active institutions (i.e., those with an average of NIH Research Project Grant (RPG) funding less than $7.5 million total costs over the last 3 fiscal years). RPG data are available through NIH RePORTER (see additional guidance here [PDF]). Only one U-RISE application per institution is allowed.

Trainee Eligibility and Participation

The individual to be trained must be a citizen or a noncitizen national of the United States or have been lawfully admitted for permanent residence at the time of appointment. Additional details on citizenship, training period, and aggregate duration of support are available in the NIH Grants Policy Statement. Trainees should be research-oriented individuals enrolled in a major leading to a baccalaureate degree in a STEM discipline that will prepare the trainee for a biomedical, research-focused higher degree program (e.g., Ph.D. or M.D./Ph.D.).

All trainees are required to pursue their research training full time as specified by the sponsoring institution in accordance with its own policies. Trainees are typically provided full-time support for two to three years of undergraduate studies. Use of training grant support in the final three years of undergraduate research training is strongly encouraged to allow for the participation in research, training, mentoring, professional development, and cohort-building activities that will prepare the trainees to successfully transition into a biomedical, research-focused higher degree program.

Information for Applicant Institutions

Applicants are strongly encouraged to read the FOA (including Related Notices in the Overview Section), Answers to Frequently Asked Questions, and consult NIGMS staff to discuss eligibility and application requirements prior to submission. NIGMS does not require applications requesting $500,000 or more in direct costs for any year to contact staff to obtain agreement that the IC will accept the application.​​

Potential applicants for U-RISE should contact Dr. Edgardo Falcón-Morales or Dr. Kenneth Gibbs.


​The Undergraduate Research Training Initiative for Student Enhancement Program (T34) is part of the NIGMS undergraduate program umbrella cited in 42 CFR 66.102.