Proteins Quiz Graduate Level

Questions

You can study the class notes before you take the quiz.

Question 1: Which of the following can cause disease?

A. A protein that contains an incorrect amino acid
B. A protein that is incorrectly folded
C. A protein that is missing from the body
D. All of the above

Question 2: What is structure-based drug design?

A. A rigorous, highly structured way to create new medicines
B. A strategy that relies on the structure of the drug delivery method (tablet, time-release capsule, syringe, nasal spray, etc.)
C. A method of designing medicines that relies on computational models of protein structures
D. All of the above

Question 3: Which of the following statements are true about graphic representations of proteins (computer models)?

A. Ribbon diagrams highlight organized regions of the proteins.
B. Space-filling molecular models attempt to show atoms as spheres whose size correlates with the amount of space the atoms occupy.
C. A surface rendering of the protein shows its overall shape and surface properties.
D. All of the above

Question 4: Why do X-ray crystallographers like to use synchrotrons?

A. Synchrotrons generate intense beams of X-rays that can be tuned to the appropriate wavelength.
B. Synchrotrons analyze and refine structural data, so scientists don't need computers to do this.
C. The X-rays from synchrotrons are much less harmful than traditional X-ray sources.
D. All of the above

Question 5: Why does NMR have an advantage over X-ray crystallography for certain research?

A. It can determine the structures of proteins that are too large for X-ray crystallography.
B. Proteins are closer to their natural state in NMR studies, which rely on a solution, than they are in the crystalline form used for X-ray crystallography.
C. It is much faster than X-ray crystallography.
D. It doesn't require the use of isotopes.
E. It shows hydrogen atoms, which do not appear in X-ray crystal structures. 

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