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NIGMS Nobelists Fact Sheet

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The National Institute of General Medical Sciences (NIGMS) has a strong track record of funding scientists who receive a Nobel Prize.

An enzyme encircles the double helix to repair a broken strand of DNA.
Credit: Tom Ellenberger, Washington University School of Medicine in St. Louis, and Dave Gohara, Saint Louis University School of Medicine.

Since its creation in 1962, NIGMS has supported the work of 87 Nobel laureates—43 in physiology or medicine and 44 in chemistry. These investigators perform cutting-edge basic research that is the foundation for understanding normal life processes and disease. Among their discoveries are:

  • Translating the genetic code of DNA and explaining how it functions in the production of proteins in the cell.
    Robert W. Holley and H. Gobind Khorana (shared with Marshall W. Nirenberg)
  • Defining the internal organization of cells using electron microscopy and other techniques. This laid the foundation for understanding key cellular pathways and processes.
    George E. Palade and Christian de Duve (shared with Albert Claude)
  • Finding that RNA can act as a catalyst to control and direct cellular functions.
    Thomas Cech and Sidney Altman
  • Discovering restriction enzymes, which cut DNA at precise locations. This is a cornerstone of recombinant DNA technology—joining pieces of DNA from different sources.
    Hamilton O. Smith and Daniel Nathans (shared with Werner Arber)
  • Identifying proteins that trigger a cell’s response to outside signals. These are involved in normal activities as well as diseases such as cancer, cholera, and diabetes.
    Alfred G. Gilman (shared with Martin Rodbell)

These and other important breakthroughs in chemistry and biology often lead to more focused research that, years later, leads to important medical advances or products such as medicines or biotechnology tools.

Recent Nobel Laureates Supported by NIGMS

NAME NOBEL PRIZE OFFICIAL CITATION
Joachim Frank Chemistry 2017 For developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution
Jeffrey C. Hall, Michael Rosbash, & Michael W. Young Physiology or Medicine 2017 For their discoveries of molecular mechanisms controlling the circadian rhythm
Paul Modrich &
Aziz Sancar
Chemistry 2015 For mechanistic studies of DNA repair
William E. Moerner Chemistry 2014 For the development of super-resolved fluorescence microscopy
Martin Karplus, Michael Levitt & Arieh Warshel Chemistry 2013 For the development of multiscale models for complex chemical systems
James E. Rothman & Randy W. Schekman Physiology or Medicine 2013 For their discoveries of machinery regulating vesicle traffic, a major transport system in our cells
Brian K. Kobilka Chemistry 2012 For studies of G-protein-coupled receptors
Ei-ichi Negishi Chemistry 2010 For palladium-catalyzed cross couplings in organic synthesis

See a full list of NIGMS-supported Nobel Prize winners and links to news releases about their work.

Crossword Puzzle: Test Your Nobel Knowledge | Accessible Version

NOBEL QUICK FACTS

Nobel Prize Medal. Copyright The Nobel Foundation
© The Nobel Foundation

The Nobel Prize was created by Swedish inventor Alfred Nobel. The international award has been given yearly since 1901 for achievements in physics, chemistry, physiology or medicine, literature, and peace. Another category, economics, was added by the Nobel Foundation in 1968. Winners receive their awards on December 10, the anniversary of Nobel's death. For more facts about the Nobel Prize, visit https://www.nobelprize.org/nobel_prizes/facts. Link to external Web site

MORE INFORMATION

Want to know more about NIGMS and the award-winning researchers it funds? Visit https://www.nigms.nih.gov.

NIGMS is a part of the National Institutes of Health that supports basic research to increase our understanding of biological processes and lay the foundation for advances in disease diagnosis, treatment, and prevention. For more information on the Institute's research and training programs, visit https://www.nigms.nih.gov.

Content revised October 2017

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This page last reviewed on October 04, 2017