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Three muscle fibers; the middle has a defect found in some neuromuscular diseases

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Christopher Pappas and Carol Gregorio, University of Arizona

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Three muscle fibers; the middle has a defect found in some neuromuscular diseases 

Of the three muscle fibers shown here, the one on the right and the one on the left are normal. The middle fiber is deficient a large protein called nebulin (blue). Nebulin plays a number of roles in the structure and function of muscles, and its absence is associated with certain neuromuscular disorders.

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This page last reviewed on July 29, 2016