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NIH Emergency Care Research and Training Activities

NIH supports a number of activities in emergency care research and training. These include:

More information about these activities is below.

Research Networks

Neurological Emergencies Treatment Trials Network (NETT)
National Institute of Neurological Disorders and Stroke (NINDS)

The NETT conducts large, simple trials to reduce the impact of very acute injuries and illnesses affecting the brain, spinal cord and peripheral nervous system.

Studies under way include:

  • ALIAS: Evaluating the effectiveness of high-dose, intravenous human serum albumin in acute stroke.
  • POINT Link to external Web site: Comparing aspirin and clopidogrel in patients with a minor stroke or transient ischemic attack.
  • ProTECT Link to external Web site: Examining whether progesterone can limit the amount of brain damage from a traumatic brain injury.
  • SHINE: Examining the efficacy of insulin infusion therapy for glucose control in hyperglycemic acute ischemic stroke patients.

Completed studies include:

  • RAMPART: Compared two anti-seizure medications used by paramedics. This clinical trial showed Link to external Web site that intramuscular midazolam was at least as effective as intravenous lorazepam.

Principal investigators and research sites include:

Resuscitation Outcomes Consortium (ROC)  Link to external Web site
National Heart, Lung, and Blood Institute (NHLBI)

The ROC focuses on two areas of research—traumatic injury and prehospital cardiac arrest.

Studies under way Link to external Web site include:

  • ALPS: Comparing amiodarone, lidocaine and placebo in patients with shock-resistant ventricular fibrillation.
  • CCC: Comparing, for patients with out-of-hospital cardiac arrest, continuous chest compressions with compressions that pause for rescue breathing.
  • PROPPR: Comparing different ratios of blood products given to patients with severe trauma.

Completed studies Link to external Web site include:

  • Hypertonic saline in traumatic brain injury: This study was stopped when it became clear during the enrollment period that hypertonic saline solutions offered no advantage over the standard treatment with normal saline.
  • CPR Feedback: Compared automated, real-time audio-feedback CPR with standard CPR in out-of-hospital cardiac arrest. It showed no difference in survival.

Collaborative Pediatric Critical Care Research Network (CPCCRN)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

This network studies pediatric injury and critical illness. It focuses on infection, sepsis, ICU protocols, functional outcomes of children who required intensive care and parental bereavement.

Studies under way include:

  • THAPCA Link to external Web site: Evaluating therapeutic hypothermia after cardiac arrest in children.
  • Critical Pertussis Link to external Web site [PDF, 0.3MB]: Optimizing the management of children with pertussis who require critical care hospitalization.
  • Bereavement Intervention Pilot Study: Examining how best to conduct physician-parent meetings after a child's death in the intensive care unit.

Completed studies include:

  • CAMMPS: Analyzed the medical treatment and outcomes of children with fatal and near-fatal asthma admitted to pediatric intensive care units. Its conclusions may shape further studies into the management of critical asthma.
  • MOTIF: Reported Link to external Web site [PDF, 0.7MB] on the use of opioids and sedation in the pediatric intensive care unit.

Research Projects

Many components of NIH support emergency care research. Of dozens of currently funded projects, a few examples are listed below.

National Institute on Aging (NIA)

Andrew Chang, Albert Einstein College of Medicine. Optimizing Emergency Department Treatment of Older Adults with Acute Pain.
Manish Shah, University of Rochester. Deriving a Prehospital Triage Decision Scheme for Injured Older Adults.
Timothy Platts-Mills, University of North Carolina, Chapel Hill. Pain and Physical Decline Among Elderly Involved in Minor Traffic Accidents.

National Institute of Allergy and Infectious Diseases (NIAID)

Yu-Hsiang Hsieh, Johns Hopkins University. Cost-Effectiveness of Emergency Department HIV Testing Programs: An Agent-Based Modeling Approach.
Michael Lyons, University of Cincinnati. Simulating the Operational Consequences of HIV Screening in the Emergency Department.

National Institute on Drug Abuse (NIDA)

Gail D'Onofrio, Yale University. Models of Screening, Brief Intervention and Referral to Treatment for Opioid-Dependent Patients in the Emergency Department.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Andrew Meltzer, George Washington University. Multi-Center Study of Tamsulosin for Ureteral Stones in the Emergency Department.

National Institute of General Medical Sciences (NIGMS)

John Younger, University of Michigan. Complement C5a in Human Sepsis.

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

E. Brooke Lerner, Medical College of Wisconsin. Use of Mechanism of Injury for the Identification of Severely Injured Children.
Michelle Macy, University of Michigan. A Brief Intervention to Increase Size-Appropriate Child Passenger Restraint Use.
Nathan Kuppermann, University of California, Davis. Fluid Therapy and Cerebral Injury in Pediatric Diabetic Ketoacidosis.
Mahajan Prashant, Wayne State University.  RNA Biosignatures in the Emergency Evaluation of Febrile Infants.

National Heart, Lung, and Blood Institute (NHLBI)

Lance Becker, University of Pennsylvania. Optimizing Heart and Brain Cooling During Cardiac Arrest.
James Menegazzi, University of Pittsburgh. Incidence, Outcomes and ECG Predictors of Re-Arrest in Prehospital Cardiac Arrest.
Lynne Richardson, Mount Sinai School of Medicine. Community Voices on Informed Consent in an Emergency Situation.
Benjamin Sun, Oregon Health & Science University. Improving Syncope Risk Stratification in Older Adults.
Chadwick Miller, Wake Forest University. Cardiac Magnetic Resonance (CMR) Imaging in the Emergency Department.
Jeffrey Kline, Indiana University-Purdue University Indianapolis.  Randomized Trial of Inhaled Nitric Oxide to Treat Acute Pulmonary Embolism.
Jeffrey Glassberg, Mount Sinai School of Medicine. Inhaled Mometasone to Promote Reduction in Vaso-Occlusive Events.

National Institute of Nursing Research (NINR)

Polly Bijur, Albert Einstein School of Medicine. Effectiveness and Feasibility of Patient-Controlled Analgesia in the Emergency Department. 

National Institute of Neurological Disorders and Stroke (NINDS)

Daniel Spaite, University of Arizona.  Impact of Implementing the Emergency Medical Services Systems Traumatic Brain Injury Treatment Guidelines.
Michael Frankel, Emory University.  Biomarkers of Injury and Outcome in Pro-TECT III.

Office of the Director, NIH

Ziad Obermeyer, Brigham and Women's Hospital. Unexpected Death after Medical Encounters: Measurement, Reporting, and Analysis.


NIH is committed to training the next generation of emergency care researchers. The programs below include an emphasis on training those who provide emergency care.

Research Career Development Programs in Emergency Medicine (K12)
National Heart, Lung, and Blood Institute (NHLBI)

This program runs at six sites across the U.S. and is funded through June 2015. It emphasizes the development of researchers who focus on diagnosis and clinical management of emergency department patients with acute, life-threatening manifestations of cardiovascular, pulmonary or hematologic diseases, or severe trauma.

The investigators and sites are:

Yale-Drug Abuse, Addiction, and HIV Research Scholars (Yale-DAHRS) Link to external Web site
National Institute on Drug Abuse (NIDA)

This 3-year interdisciplinary, mentored career development program aims to improve medical outcomes in general medical settings, including the emergency department, for drug abuse, addiction or HIV treatment.

Global Health Program for Fellows and Scholars
Fogarty International Center (FIC)

This program focuses on enhancing the global health research expertise and careers of early stage investigators from the U.S. and developing countries.

This page last reviewed on January 09, 2017