Biomedical Technology Development and Dissemination (BTDD) Centers

These centers create critical, often unique technology and methods at the forefront of their respective fields and apply them to a broad range of basic, translational and clinical research. This occurs through a synergistic interaction of technical and biomedical expertise, both within the centers and in intensive collaborations with other leading laboratories.

The centers serve a unique purpose in the broad context of NIH-funded research. They represent a critical mass of technological and intellectual capacity with a strong focus on service and training for outside investigators, as well as providing access to and dissemination of technologies, methods and software. Their goal is to promote the widespread and routine application of the cutting-edge technologies they develop across the full spectrum from bench to bedside. The BTDD program does not include development of new technologies. These efforts can be supported through research project grants (R01 and R21 activity codes) targeted for technology development in areas of the NIGMS mission.

The BTDD (RM1) program replaces the Biomedical Technology Research Resources (P41) program.

Find out how to apply for funding:

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For additional information on NIGMS Biomedical Technology Development and Dissemination (BTDD) Centers, please contact:

Christina Liu, Ph.D.
Chief, Biomedical Technology Branch​
National Institute of General Medical Sciences
National Institutes of Health
45 Center Drive MSC 6200
Bethesda, MD 20892-6200

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Search Results for All BTDDs and BTRRs

BioCARS: A Synchrotron Structural Biology Resource
University of Chicago

BTRR Grant Number: P41GM118217
Principal Investigator: Rama Ranganathan, Ph.D., J. Keith Moffat, Ph.D., and Vukica Srajer, Ph.D.
BioCARS is a state-of-the art, national user facility at the Advanced Photon Source, Argonne National Laboratory for synchrotron-based studies of the dynamic & static properties of macromolecules. Using X-ray scattering techniques such as time-resolved crystallography, small- & wide-angle X-ray scattering & fiber diffraction. BioCARS operates 2 X-ray beamlines, embedded in a Biosafety Level 2 (BSL-2) facility unique in the U.S. that permits safe studies of biohazardous materials such as human pathogens.

Biophysics Collaborative Access Team (BioCAT)
Illinois Institute of Technology

BTRR Grant Number: P41GM103622
Principal Investigator: Thomas C. Irving, Ph.D.
BioCAT operates facilities at Argonne National Laboratory’s Advanced Photon Source as a national research resource for the study of the structure of partially ordered biological molecules, complexes of biomolecules and cellular structures under conditions similar to those present in living cells and tissues.

Center for Biomolecular NMR Data Processing and Analysis
University of Connecticut School of Medicine and Dentistry

BTRR Grant Number: P41GM111135
Principal Investigator: Jeffrey C. Hoch, Ph.D.
The Center for Bio-NMR Data Processing and Analysis develops robust methods to facilitate discovery, dissemination, management, training, and support for the biomolecular NMR software, to enable the application of NMR to biomolecular systems, and provide software persistence that is essential for reproducible research.

Center for Computational Mass Spectrometry
University of California, San Diego

BTRR Grant Number: P41GM103484
Principal Investigator: Pavel A. Pevzner, Ph.D., Vineet Bafna, Ph.D., and Nuno F. Cabrita, Ph.D.
This center focuses on the computational bottlenecks that impair the interpretation of data, bringing modern algorithmic approaches to mass spectrometry and building a new generation of reliable, open-access software tools to support both new mass spectrometry instrumentation and emerging applications.

Center for Integrative Biomedical Computing
University of Utah

BTRR Grant Number: P41GM103545
Principal Investigator: Christopher R. Johnson, Ph.D., Rob S. MacLeod, Ph.D., and Ross T. Whitaker, Ph.D.
This resource produces open-source software tools for biomedical image-based modeling, biomedical simulation and estimation, and visualization of biomedical data.

Center for Open Bioimage Analysis
Broad Institute

BTRR Grant Number: P41GM135019
Principal Investigator: Anne E. Carpenter, Ph.D. and Kevin W. Eliceiri, Ph.D.
COBA will provide quantitative image analysis software tools that have broad applicability in biological optical microscopy. This effort will build on two widely used open source bioimage analysis programs, CellProfiler and ImageJ/FIJI, and add deep learning capability to enhance accuracy, ease-of-use, and reproducibility.

Center on Macromolecular Dynamics by NMR Spectroscopy
New York Structural Biology Center

BTRR Grant Number: P41GM118302
Principal Investigator: Arthur G. Palmer, Ph.D.
The Center on Macromolecular Dynamics by NMR Spectroscopy (CoMD/NMR) is developing the technology and application of NMR spin relaxation and associated methods for characterizing protein and nucleic acid conformational dynamics in biological processes including ligand recognition, allosterism, catalysis, and folding.

Center on Membrane Protein Production and Analysis (COMPPAA)
New York Structural Biology Center

BTRR Grant Number: P41GM116799
Principal Investigator: Wayne A. Hendrickson, Ph.D.
The Center on Membrane Protein Production and Analysis (COMPPÅ) is engaged in developing technologies for functional assays of membrane proteins, and advancing technology for the efficient production of recombinant membrane proteins for structural analysis and structure determination.

Drosophila Research & Screening Center-Biomedical Technology Research Resource (DRSC-BTRR)
Harvard Medical School

BTRR Grant Number: P41GM132087
Principal Investigator: Norbert Perrimon, Ph.D.
The DRSC-BTRR helps researchers realize the full potential of Drosophila melanogaster as a model for the study of human health and disease through development of technologies and community engagement, including (1) Development of technologies for Drosophila studies, (2) Application of technologies for study of mosquito vectors of human diseases, and (3) Development of in vivo proteomics technologies for Drosophila.

Integrated Technology Resource for Biomedical Glycomics
University of Georgia

BTRR Grant Number: P41GM103490
Principal Investigator: J. Michael Pierce, Ph.D.
This resource is located at the Complex Carbohydrate Research Center and develops and implements new technologies to investigate the glycome of cells, including glycoproteomics and glycoconjugate analysis, transcript analysis, and bioinformatics.

Laboratory for Fluorescence Dynamics
University of California, Irvine

BTRR Grant Number: P41GM103540
Principal Investigator: Enrico Gratton, Ph.D.
This resource develops novel fluorescence technologies, including instrumentation, methods and software. These are applicable to cellular imaging and the elucidation of dynamic processes in cells.

Macromolecular Diffraction Facility at the Cornell High Energy Synchrotron Source (MacCHESS)
Cornell University

BTRR Grant Number: P41GM103485
Principal Investigator: Richard A. Cerione, Ph.D.
This resource operates two beamlines devoted to macromolecular crystallography and small-angle scattering at the Cornell High Energy Synchrotron Source (CHESS) and provides expertise in large unit-cell diffraction, MAD phasing, microdiffraction, high- pressure cryocooling, multiple beam diffraction and software development.

MicroED Imaging Center at UCLA (MEDIC)
University of California, Los Angeles

BTRR Grant Number: P41GM136508
Principal Investigator: Tamir Gonen, Ph.D. and Pawel A. Penczek, Ph.D.
MEDIC develops technologies for the study of the structure of nanocrystalline organic molecules & macromolecules by microcrystal electron diffraction (MicroED), & provides access & training. Research areas include: effective nanocrystal growth, screening & vitrification; phasing methods for MicroED for structure determination; effectively studying natural products, small molecules & toxins; & the engineering & fabrication of new hardware for nanocrystallization & time-resolved dynamics.

MIT/Harvard Center for Magnetic Resonance
Massachusetts Institute of Technology

BTRR Grant Number: P41GM132079
Principal Investigator: Robert G. Griffin, Ph.D.
The MIT-Harvard Center for Magnetic Resonance develops new instrumentation for dynamic nuclear polarization experiments at high field, solid-state MAS NMR experiments to elucidate the structure of proteins, and advancing solution NMR experiments.

National Biomedical Center for Advanced ESR Technology
Cornell University

BTRR Grant Number: P41GM103521
Principal Investigator: Jack H. Freed, Ph.D.
This resource develops electron spin resonance technologies that are applicable to elucidating the structure and complex dynamics of proteins and to other biomedical applications.

National Center for Dynamic Interactome Research (NCDIR)
Rockefeller University

BTRR Grant Number: P41GM109824
Principal Investigator: Michael P. Rout, Ph.D.
NCDIR combines expertise in cell biology, genetics, mass spectrometry and computational structural biology to develop new integrated approaches for the detection, isolation and analysis of macromolecular complexes that that make up the dynamic cellular interactome.

National Center for Macromolecular Imaging (NCMI)
Stanford University

BTRR Grant Number: P41GM103832
Principal Investigator: Wah Chiu, Ph.D.
NCMI is focused on extending the resolution, speed and flexibility of cryo-electron microscopy for the 3-D structure determination of biological macromolecular assemblies. The center also develops cryo-electron tomography techniques to capture molecular structures in situ.

National Center for Multiscale Modeling of Biological Systems (MMBioS)
University of Pittsburgh

BTRR Grant Number: P41GM103712
Principal Investigator: Ivet Bahar, Ph.D.
MMBioS develops technology and tools to facilitate research and training at the interface between computing technology and the life sciences. The center also works to deepen understanding of the molecular and cellular organization and mechanisms that underlie synaptic signaling and regulation.

National Center for Quantitative Biology of Complex Systems
University of Wisconsin-Madison

BTRR Grant Number: P41GM108538
Principal Investigator: Joshua J. Coon, Ph.D.
The National Center for Quantitative Biology of Complex Systems (NCQBCS) is developing next-generation protein, metabolite, and lipid measurement technologies for a wide variety of biomedical applications and making whole omic analysis faster and broadly accessible.

National Research Resource for Imaging Mass Spectrometry
Vanderbilt University

BTRR Grant Number: P41GM103391
Principal Investigator: Richard M. Caprioli, Ph.D.
The mission of this resource is to advance the technology of imaging mass spectrometry, to facilitate the application of this novel imaging modality to problems of biological and clinical significance, and to promote the adoption of these technologies by a larger community of scientists and clinicians.

National Resource For Advanced NMR Technology
Florida State University

BTRR Grant Number: P41GM122698
Principal Investigator: William W. Brey, Ph. D. and Joanna R. Long, Ph. D.
The National Resource for Advancing NMR Technology is developing technologies to increase the sensitivity and spectral resolution of NMR spectroscopy, with a focus on instrumentation development.

National Resource for Automated Molecular Microscopy (NRAMM)
New York Structural Biology Center

BTRR Grant Number: P41GM103310
Principal Investigator: Bridget O. Carragher, Ph.D. and Clinton S. Potter
NRAMM develops, tests and applies technology aimed toward completely automating the processes involved in solving macromolecular structures using cryo-electron microscopy. The goal is to establish a resource that will serve as a center for high-throughput molecular microscopy as well as for transferring this technique to the research community.

National Resource for Network Biology (NRNB)
University of California, San Diego

BTRR Grant Number: P41GM103504
Principal Investigator: Trey Ideker, Ph.D.
NRNB provides a freely available, open-source suite of software technology that broadly enables network-based visualization, analysis and biomedical discovery for NIH-funded researchers.

National Resource for Translational and Developmental Proteomics
Northwestern University

BTRR Grant Number: P41GM108569
Principal Investigator: Neil L. Kelleher, Ph.D.
The National Resource for Translational and Developmental Proteomics (NRTDP) is dedicated to accelerating a significant shift in how protein molecules are analyzed by mass spectrometrywith a focus on intact protein measurements.

Proteomics Research Resource for Integrative Biology
Pacific Northwest National Laboratory

BTRR Grant Number: P41GM103493
Principal Investigator: Richard D. Smith, Ph.D.
This resource develops and integrates new proteomic technologies for use in biomedical research, with an emphasis on high-resolution, quantitative approaches.

Resource for Integrated Glycotechnology
University of Georgia

BTRR Grant Number: P41GM103390
Principal Investigator: Kelley Moremen, Ph.D.
This resource develops technologies to increase understanding of the molecular basis of protein-carbohydrate interactions in disease. The resource combines complementary technologies: synthetic chemistry, nuclear magnetic resonance, mass spectrometry, computational biology, protein expression and cell-based assays.

Resource for Macromolecular Modeling and Bioinformatics
University of Illinois at Urbana-Champaign

BTRR Grant Number: P41GM104601
Principal Investigator: Emad Tajkhorshid, Ph.D.
This resource’s technology research and development activities focus on the structure and function of supramolecular systems in the living cell as well as on the development of new algorithms and efficient computing tools for physical biology. The development and maintenance of widely distributed software tools, nanoscale molecular dynamics and visual molecular dynamics are central to this work.

Resource for Native Mass Spectrometry Guided Structural Biology
Ohio State University

BTRR Grant Number: P41GM128577
Principal Investigator: Vicki H. Wysocki, Ph.D.
The Resource for Native MS-Guided Structural Biology is building an integrated MS-based workflow for intact, native complexes, i.e. “complex-down” characterization, with innovative scientific instrumentation and computational tools to reveal the complex chemical structures of biomedically relevant molecules.

Stanford Synchrotron Radiation Lightsource
Stanford University

BTRR Grant Number: P41GM103393
Principal Investigator: Keith O. Hodgson, Ph.D.
SSRL is an integrated resource with macromolecular crystallography, X-ray absorption spectroscopy and small-angle X-ray scattering/diffraction services.

Yeast Resource Center
University of Washington

BTRR Grant Number: P41GM103533
Principal Investigator: Michael MacCoss, Ph.D.
The Yeast Resource Center (YRC) has a focus on understanding how genome sequence relates to protein function by studying how variation in proteins affects their levels, modification, function and structure. New technologies are being developed in three  areas: 1) Perturbing and sensing changes to complex pathways; 2) Protein detection and quantitation by mass spectrometry; and 3) Higher order protein structure.

For additional information on NIGMS biomedical technology research resources, please contact:

Dr. Mary Ann Wu
Health Scientist Administrator
Division of Biophysics, Biomedical Technology, and Computational Biosciences
National Institute of General Medical Sciences
National Institutes of Health
45 Center Drive MSC 6200
Bethesda, MD 20892-6200