Biomedical Technology Development and Dissemination (BTDD) Centers (RM1)

The NIGMS Biomedical Technology Development (BTDD) program has two goals:

  • Optimization of state-of-the-art, late-stage technologies in NIGMS' areas of interest
  • Broad dissemination of these technologies for use in biomedical research.

Technology optimization is achieved through collabo​rations between Technology Development Projects (TDPs) and Driving Biomedical Projects (DBPs). Working iteratively with test bed DBPs, the TDPs develop and improve technologies by addressing challenges in a range of biomedical research problems. Technology dissemination is accomplished through Community Engagement (CE) activities that communicate the proposed technologies to the broad research community through training and publicity. Collaboration and Service Projects (CSPs), optional components of Community Engagement, provide access to the technology’s more mature capabilities.


NIGMS encourages investigators to propose BTDD Centers that focus on any of the biomedical technology research areas within the NIGMS mission. Technologies of interest include, but are not limited to, one or combinations of the following: spectroscopy, microscopy, imaging, structural biology, molecular biology, cell manipulation, synthetic chemical biology, high throughput and analytical biochemistry, computational methods, molecular modeling, modeling of biological processes and data science.

The current BTDD program Funding Opportunity Announcement is PAR-20-104: Biomedical Technology Development and Dissemination Center (RM1 - Clinical Trial Not Allowed). Potential applicants are strongly advised to contact NIGMS staff at least 10 weeks prior to the application due date to discuss the suitability of a proposed project for the NIGMS BTDD Program. Projects that require significant technology development fall outside of the scope of this program but may be appropriate for NIGMS Technology Development Program (R21 or R01). Prospective applicants with mature technologies that are ready for a user resource may consider applying for the NIGMS National and Regional Resources (R24) or the NIGMS ​Mature Synchrotron Resources (P30).​

Christina Liu, Ph.D. PE
Program Director
Division of Biophysics, Biomedical Technology, and Computational Biosciences
National Institute of General Medical Sciences
National Institutes of Health
45 Center Drive MSC 6200
Bethesda, MD 20892-6200

Center on Macromolecular Dynamics by NMR Spectroscopy (COMD/NMR)
New York Structural Biology Center

BTDD ​Grant Number: RM1-GM145397
Principal Investigator: Arthur G. Palmer, Ph.D.
The COMD/NMR Center develops advanced methods in NMR spectroscopy for studying conformation and dynamics of protein and nucleic acid during biological processes and makes these sophisticated methods accessible to a wider research community to facilitate applications to biomedical questions. This Center was previously supported by the BTRR Program (P41GM118302).

The GCE4All Center: Unleashing the Potential of Genetic Code Expansion for Biomedical Research
Oregon State University

BTDD ​Grant Number: RM1-GM144227
Principal Investigator: Ryan A. Mehl, Ph.D.
Genetic Code Expansion (GCE) technology – the engineering of cellular translation to express proteins containing non-canonical amino acids – provides unprecedented ways to probe and manipulate macromolecular structure and function, analyze protein malfunctions in disease, engineer bioanalytical tools, and create precision biotherapeutics. The GCE4All Center's mission is to optimize and extend existing GCE technologies to enable facile use by non-specialists and broadly disseminate them via widespread education, effective training, and sustainable access so that powerful GCE approaches become standard widely-used biomedical research tools.

UTSW-UNC Center for Cell Signaling Analysis
UT Southwestern Medical Center and the University of North Carolina Chapel Hill

BTDD ​Grant Number: RM1-GM145399
Principal Investigators: Gaudenz Danuser, Ph.D.; Kevin M Dean, Ph.D.; Claus M Hahn, Ph.D.
The Center for Cell Signaling Analysis optimizes and disseminates advanced technologies for visualization and quantitative analysis of molecular events in living cells and tissues. User-friendly and integrated technologies of the Center combine biosensors, optogenetics and chemogenetics; modular, high-speed, and high resolution light-sheet microscopes; and image analysis and computational modeling to derive signaling circuits, including the inference of causality and kinetics of connections. Technologies are disseminated through existing infrastructure including imaging facilities throughout the U.S., the FIJI software ecosystem, and commercial and non-profit companies.​