Biomedical Technology Development and Dissemination (BTDD) Centers

These centers create critical, often unique technology and methods at the forefront of their respective fields and apply them to a broad range of basic, translational and clinical research. This occurs through a synergistic interaction of technical and biomedical expertise, both within the centers and in intensive collaborations with other leading laboratories.

The centers serve a unique purpose in the broad context of NIH-funded research. They represent a critical mass of technological and intellectual capacity with a strong focus on service and training for outside investigators, as well as providing access to and dissemination of technologies, methods and software. Their goal is to promote the widespread and routine application of the cutting-edge technologies they develop across the full spectrum from bench to bedside.

The BTDD (RM1) program replaces the Biomedical Technology Research Resources (P41) program.

Find out how to apply for funding for a BTDD: Biomedical Technology Development and Dissemination Centers (RM1) – PAR-20-104

Find a center with the capabilities you need on the BTR Portal Site Link to external website (Note you are leaving the official NIGMS website).

For additional information on NIGMS Biomedical Technology Development and Dissemination (BTDD) Centers, please contact:​

Dr. Haluk Resat
BTDD Program Director
National Institute of General Medical Sciences
National Institutes of Health
45 Center Drive MSC 6200
Bethesda, MD 20892-6200

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Please select a category from the drop-down menu below.​​
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Search Results for All BTDDs and BTRRs

BioCARS: A Synchrotron Structural Biology Resource Link to external website
University of Chicago

5 P41 GM118217-02
Principal Investigator: Rama Ranganathan, Ph.D., J. Keith Moffat, Ph.D., and Vukica Srajer, Ph.D.
BioCARS is a state-of-the art, national user facility at the Advanced Photon Source, Argonne National Laboratory for synchrotron-based studies of the dynamic & static properties of macromolecules. Using X-ray scattering techniques such as time-resolved crystallography, small- & wide-angle X-ray scattering & fiber diffraction. BioCARS operates 2 X-ray beamlines, embedded in a Biosafety Level 2 (BSL-2) facility unique in the U.S. that permits safe studies of biohazardous materials such as human pathogens.

Biophysics Collaborative Access Team (BioCAT) Link to external website
Illinois Institute of Technology

5 P41 GM118217-02
Principal Investigator: Thomas C. Irving, Ph.D.
BioCAT operates facilities at Argonne National Laboratory’s Advanced Photon Source as a national research resource for the study of the structure of partially ordered biological molecules, complexes of biomolecules and cellular structures under conditions similar to those present in living cells and tissues.

Center for Biomolecular NMR Data Processing and Analysis Link to external website
University of Connecticut School of Medicine and Dentistry

5P41 GM111135-05
Principal Investigator: Jeffrey C. Hoch, Ph.D.
The Center for Bio-NMR Data Processing and Analysis develops robust methods to facilitate discovery, dissemination, management, training, and support for the biomolecular NMR software, to enable the application of NMR to biomolecular systems, and provide software persistence that is essential for reproducible research.

Center for Computational Mass Spectrometry Link to external website
University of California, San Diego

5 P41 GM103484-10
Principal Investigator: Pavel A. Pevzner, Ph.D., Vineet Bafna, Ph.D., and Nuno F. Cabrita, Ph.D.
This center focuses on the computational bottlenecks that impair the interpretation of data, bringing modern algorithmic approaches to mass spectrometry and building a new generation of reliable, open-access software tools to support both new mass spectrometry instrumentation and emerging applications.

Center for Integrative Biomedical Computing Link to external website
University of Utah

5 P41 GM103484-10
Principal Investigator: Christopher R. Johnson, Ph.D., Rob S. MacLeod, Ph.D., and Ross T. Whitaker, Ph.D.
This resource produces open-source software tools for biomedical image-based modeling, biomedical simulation and estimation, and visualization of biomedical data.

Center for Open Bioimage Analysis Link to external website
Broad Institute

1 P41 GM135019-01
Principal Investigator: Anne E. Carpenter, Ph.D. and Kevin W. Eliceiri, Ph.D.
COBA will provide quantitative image analysis software tools that have broad applicability in biological optical microscopy. This effort will build on two widely used open source bioimage analysis programs, CellProfiler and ImageJ/FIJI, and add deep learning capability to enhance accuracy, ease-of-use, and reproducibility.

Center on Macromolecular Dynamics by NMR Spectroscopy Link to external website
New York Structural Biology Center

5 P41 GM118302-03
Principal Investigator: Arthur G. Palmer, Ph.D.
The Center on Macromolecular Dynamics by NMR Spectroscopy (CoMD/NMR) is developing the technology and application of NMR spin relaxation and associated methods for characterizing protein and nucleic acid conformational dynamics in biological processes including ligand recognition, allosterism, catalysis, and folding.

Center on Membrane Protein Production and Analysis (COMPPAA) Link to external website
New York Structural Biology Center

5 P41 GM116799-04
Principal Investigator: Wayne A. Hendrickson, Ph.D.
The Center on Membrane Protein Production and Analysis (COMPPÅ) is engaged in developing technologies for functional assays of membrane proteins, and advancing technology for the efficient production of recombinant membrane proteins for structural analysis and structure determination.

Drosophila Research & Screening Center-Biomedical Technology Research Resource (DRSC-BTRR) Link to external website
Harvard Medical School

1 P41 GM132087-01
Principal Investigator: Norbert Perrimon, Ph.D.
The DRSC-BTRR helps researchers realize the full potential of Drosophila melanogaster as a model for the study of human health and disease through development of technologies and community engagement, including (1) Development of technologies for Drosophila studies, (2) Application of technologies for study of mosquito vectors of human diseases, and (3) Development of in vivo proteomics technologies for Drosophila.

Integrated Technology Resource for Biomedical Glycomics Link to external website
University of Georgia

5 P41 GM103490-15
Principal Investigator: J. Michael Pierce, Ph.D.
This resource is located at the Complex Carbohydrate Research Center and develops and implements new technologies to investigate the glycome of cells, including glycoproteomics and glycoconjugate analysis, transcript.

Laboratory for Fluorescence Dynamics Link to external website
University of California, Irvine

5 P41 GM103540-34
Principal Investigator: Enrico Gratton, Ph.D.
This resource develops novel fluorescence technologies, including instrumentation, methods and software. These are applicable to cellular imaging and the elucidation of dynamic processes in cells.

Life Science and Biomedical Technology Research Resource Link to external website
Brookhaven National Laboratory

5 P41 GM111244-05
Principal Investigator: Sean McSweeney, Ph.D.
This resource provides access to two advanced beam lines for macromolecular crystallography and one for general x-ray scattering studies, as well as smaller programs in macromolecular crystallography correlated with optical spectroscopy, and x-ray fluorescence imaging.

Macromolecular Diffraction Facility at the Cornell High Energy Synchrotron Source (MacCHESS) Link to external website
Cornell University

5 P41 GM103485-35
Principal Investigator: Richard A. Cerione, Ph.D.
This resource operates two beamlines devoted to macromolecular crystallography and small-angle scattering at the Cornell High Energy Synchrotron Source (CHESS) and provides expertise in large unit-cell diffraction, MAD phasing, microdiffraction, high- pressure cryocooling, multiple beam diffraction and software development.

MIT/Harvard Center for Magnetic Resonance Link to external website
Massachusetts Institute of Technology

1 P41 GM132079-01
Principal Investigator: Robert G. Griffin, Ph.D.
The MIT-Harvard Center for Magnetic Resonance develops new instrumentation for dynamic nuclear polarization experiments at high field, solid-state MAS NMR experiments to elucidate the structure of proteins, and advancing solution NMR experiments.

National Biomedical Center for Advanced ESR Technology Link to external website
Cornell University

5 P41 GM103521-18
Principal Investigator: Jack H. Freed, Ph.D.
This resource develops electron spin resonance technologies that are applicable to elucidating the structure and complex dynamics of proteins and to other biomedical applications.

National Biomedical Computation Resource (NBCR) Link to external website
University of California, San Diego

5 P41 GM103426-25
Principal Investigator: Rommie Amaro, Ph.D.
NBCR's mission is to conduct, catalyze and enable biomedical research by harnessing cutting-edge computational and information technologies, with a strong focus on translational and multiscale research.

National Center for Dynamic Interactome Research (NCDIR) Link to external website
Rockefeller University

2 P41 GM109824-06
Principal Investigator: Michael P. Rout, Ph.D.
NCDIR combines expertise in cell biology, genetics, mass spectrometry and computational structural biology to develop new integrated approaches for the detection, isolation and analysis of macromolecular complexes that that make up the dynamic cellular interactome.

National Center for Functional Glycomics (NCFG) Link to external website
Beth Israel Deaconess Medical Center

5 P41 GM103694-06
Principal Investigator: Richard D. Cummings, Ph.D.
NCFG develops technologies in the glycosciences, with an emphasis on glycan microarray and glycan presentation for exploration of the molecular mechanisms of glycan recognition by proteins important in human biology and disease.

National Center for Macromolecular Imaging (NCMI) Link to external website
Stanford University

5 P41 GM103832-34
Principal Investigator: Wah Chiu, Ph.D.
NCMI is focused on extending the resolution, speed and flexibility of cryo-electron microscopy for the 3-D structure determination of biological macromolecular assemblies. The center also develops cryo-electron tomography techniques to capture molecular structures in situ.

National Center for Microscopy and Imaging Research (NCMIR) Link to external website
University of California, San Diego

5 P41 GM103412-30
Principal Investigator: Mark H. Ellisman, Ph.D.
NCMIR develops computer-aided, advanced microscopy for the acquisition of structural and functional data in the dimensional range of 1 nm to 100 um, which encompasses macromolecules, subcellular structures and cells.

National Center for Multiscale Modeling of Biological Systems (MMBioS) Link to external website
University of Pittsburgh

5 P41 GM103712-08
Principal Investigator: Ivet Bahar, Ph.D.
MMBioS develops technology and tools to facilitate research and training at the interface between computing technology and the life sciences. The center also works to deepen understanding of the molecular and cellular organization and mechanisms that underlie synaptic signaling and regulation.

National Center for Quantitative Biology of Complex Systems Link to external website
University of Wisconsin-Madison

5 P41 GM108538-04
Principal Investigator: Joshua J. Coon, Ph.D.
The National Center for Quantitative Biology of Complex Systems (NCQBCS) is developing next-generation protein, metabolite, and lipid measurement technologies for a wide variety of biomedical applications and making whole omic analysis faster and broadly accessible.

National Center for X-ray Tomography (NCXT) Link to external website
Advanced Light Source, Lawrence Berkeley National Laboratory

5 P41 GM103445-15
Principal Investigator: Carolyn A. Larabell, Ph.D.
NCXT develops soft X-ray tomography for visualizing and quantifying the internal structure of whole, hydrated cells and high-numerical aperture fluorescence microscopy for locating the position of specific cellular molecules.

National Magnetic Resonance Facility at Madison Link to external website
University of Wisconsin-Madison

5 P41 GM103399-34
Principal Investigator: John L. Markley, Ph.D. and Samuel E. Butcher, Ph.D.
This resource develops NMR technologies for the high-throughput structure determination of small proteins and RNA, for elucidating the structure and dynamics of complex systems, and for metabolomics.

National Research Resource for Imaging Mass Spectrometry Link to external website
Vanderbilt University

5 P41 GM103310-19
Principal Investigator: Richard M. Caprioli, Ph.D.
The mission of this resource is to advance the technology of imaging mass spectrometry, to facilitate the application of this novel imaging modality to problems of biological and clinical significance, and to promote the adoption of these technologies by a larger community of scientists and clinicians.

National Resource For Advanced NMR Technology Link to external website
Florida State University

5 P41 GM122698-03
Principal Investigator: Timothy Cross, Ph.D., William W. Brey, Ph. D., and Joanna R. Long, Ph. D.
The National Resource for Advancing NMR Technology is developing technologies to increase the sensitivity and spectral resolution of NMR spectroscopy, with a focus on instrumentation development.

National Resource for Automated Molecular Microscopy (NRAMM) Link to external website
New York Structural Biology Center

5 P41 GM103310-19
Principal Investigator: Bridget O. Carragher, Ph.D. and Clinton S. Potter
NRAMM develops, tests and applies technology aimed toward completely automating the processes involved in solving macromolecular structures using cryo-electron microscopy. The goal is to establish a resource that will serve as a center for high-throughput molecular microscopy as well as for transferring this technique to the research community.

National Resource for Biomedical Accelerator Mass Spectrometry (AMS) Link to external website
Lawrence Livermore National Laboratory

5 P41 GM103483-20
Principal Investigator: Kenneth W. Turteltaub, Ph.D.
This resource develops and refines accelerator mass spectrometry methods and instrumentation for the precise, quantitative measurement of radionuclides in biomedical research. AMS is most useful when sample size is limited, specific activity is very low, the level of isotope that can be used is very limited (human studies) or the events being studied occur with very low frequency or at very low concentration.

National Resource for Network Biology (NRNB) Link to external website
University of California, San Diego

5 P41 GM103504-10
Principal Investigator: Trey Ideker, Ph.D.
NRNB provides a freely available, open-source suite of software technology that broadly enables network-based visualization, analysis and biomedical discovery for NIH-funded researchers.

National Resource for Translational and Developmental Proteomics Link to external website
Northwestern University

5 P41 GM108569-05
Principal Investigator: Neil L. Kelleher, Ph.D.
The National Resource for Translational and Developmental Proteomics (NRTDP) is dedicated to accelerating a significant shift in how protein molecules are analyzed by mass spectrometrywith a focus on intact protein measurements.

Proteomics Research Resource for Integrative Biology Link to external website
Pacific Northwest National Laboratory

5 P41 GM103493-17
Principal Investigator: Richard D. Smith, Ph.D.
This resource develops and integrates new proteomic technologies for use in biomedical research, with an emphasis on high-resolution, quantitative approaches.

Resource for Integrated Glycotechnology Link to external website
University of Georgia

5 P41 GM103390-30
Principal Investigator: Kelley Moremen, Ph.D.
This resource develops technologies to increase understanding of the molecular basis of protein-carbohydrate interactions in disease. The resource combines complementary technologies: synthetic chemistry, nuclear magnetic resonance, mass spectrometry, computational biology, protein expression and cell-based assays.

Resource for Macromolecular Modeling and Bioinformatics Link to external website
University of Illinois at Urbana-Champaign

5 P41 GM104601-30
Principal Investigator: Emad Tajkhorshid, Ph.D.
This resource’s technology research and development activities focus on the structure and function of supramolecular systems in the living cell as well as on the development of new algorithms and efficient computing tools for physical biology. The development and maintenance of widely distributed software tools, nanoscale molecular dynamics and visual molecular dynamics are central to this work.

Resource for Native Mass Spectrometry Guided Structural Biology Link to external website
Ohio State University

5 P41 GM128577-02
Principal Investigator: Vicki H. Wysocki, Ph.D.
The Resource for Native MS-Guided Structural Biology is building an integrated MS-based workflow for intact, native complexes, i.e. “complex-down” characterization, with innovative scientific instrumentation and computational tools to reveal the complex chemical structures of biomedically relevant molecules.

Stanford Synchrotron Radiation Lightsource Link to external website
Stanford University

5 P41 GM103393-40
Principal Investigator: Keith O. Hodgson, Ph.D.
SSRL is an integrated resource with macromolecular crystallography, X-ray absorption spectroscopy and small-angle X-ray scattering/diffraction services.

Washington University Mass Spectrometry Resource Link to external website
Washington University in St. Louis

5 P41 GM103422-42
Principal Investigator: Michael L. Gross, Ph.D.
This resource develops mass spectrometry-based tools for the study of proteins, lipids and metaboilites. These include biomarker identification, stable isotope mass spectrometry and the analysis of intact proteins.

Yeast Resource Center Link to external website
University of Washington

5 P41 GM103533-23
Principal Investigator: Michael MacCoss, Ph.D.
The Yeast Resource Center (YRC) has a focus on understanding how genome sequence relates to protein function by studying how variation in proteins affects their levels, modification, function and structure. New technologies are being developed in three  areas: 1) Perturbing and sensing changes to complex pathways; 2) Protein detection and quantitation by mass spectrometry; and 3) Higher order protein structure.

For additional information on NIGMS biomedical technology research resources, please contact:

Dr. Mary Ann Wu​
Health Scientist Administrator
Division of Biophysics, Biomedical Technology, and Computational Biosciences
National Institute of General Medical Sciences
National Institutes of Health
45 Center Drive MSC 6200
Bethesda, MD 20892-6200

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