Biomedical Technology Research Resources (BTRRs)

These centers create critical, often unique technology and methods at the forefront of their respective fields and apply them to a broad range of basic, translational and clinical research. This occurs through a synergistic interaction of technical and biomedical expertise, both within the centers and in intensive collaborations with other leading laboratories.

The centers serve a unique purpose in the broad context of NIH-funded research. They represent a critical mass of technological and intellectual capacity with a strong focus on service and training for outside investigators, as well as providing access to and dissemination of technologies, methods and software. Their goal is to promote the widespread and routine application of the cutting-edge technologies they develop across the full spectrum from bench to bedside.

Biomedical Technology Research Resources (P41) - PAR-17-316

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Mary Ann Wu , Ph.D.
Health Scientist Administrator
Division of Biophysics, Biomedical Technology, and Computational Biosciences
National Institute of General Medical Sciences
National Institutes of Health
45 Center Drive MSC 6200
Bethesda, MD 20892-6200

Search Results for ALL BTRRs

BioCARS: A Synchrotron Structural Biology Resource
University of Chicago
Principal Investigator: J. Keith Moffat, Ph.D.
BioCARS is a state-of-the art, national user facility for synchrotron-based studies of the dynamic and static properties of macromolecules by X-ray scattering techniques such as crystallography (specializing in time-resolved), small- and wide-angle X-ray scattering and fiber diffraction. BioCARS operates two X-ray beamlines, embedded in a Biosafety Level 3 (BSL-3) facility unique in the U.S. that permits safe studies of biohazardous materials such as human pathogens.
Biophysics Collaborative Access Team (BioCAT)
Illinois Institute of Technology
Principal Investigator: Thomas C. Irving, Ph.D.
BioCAT operates facilities at Argonne National Laboratory’s Advanced Photon Source as a national research resource for the study of the structure of partially ordered biological molecules, complexes of biomolecules and cellular structures under conditions similar to those present in living cells and tissues.
Center for Biomolecular NMR Data Processing and Analysis
University of Connecticut School of Medicine and Dentistry
Principal Investigator: Jeffrey C. Hoch, Ph.D.
The Center for Bio-NMR Data Processing and Analysis develops robust methods to facilitate discovery, dissemination, management, training, and support for the biomolecular NMR software, to enable the application of NMR to biomolecular systems, and provide software persistence that is essential for reproducible research.
Center for Computational Mass Spectrometry
University of California, San Diego
Principal Investigator: Pavel A. Pevzner, Ph.D.
This center focuses on the computational bottlenecks that impair the interpretation of data, bringing modern algorithmic approaches to mass spectrometry and building a new generation of reliable, open-access software tools to support both new mass spectrometry instrumentation and emerging applications.
Center for Integrative Biomedical Computing
University of Utah
Principal Investigator: Christopher R. Johnson, Ph.D.
This resource produces open-source software tools for biomedical image-based modeling, biomedical simulation and estimation, and visualization of biomedical data.
Center on Macromolecular Dynamics by NMR Spectroscopy
New York Structural Biology Center
Principal Investigator: Arthur G. Palmer, Ph.D.
The Center on Macromolecular Dynamics by NMR Spectroscopy (CoMD/NMR) is developing the technology and application of NMR spin relaxation and associated methods for characterizing protein and nucleic acid conformational dynamics in biological processes including ligand recognition, allosterism, catalysis, and folding.
Center on Membrane Protein Production and Analysis (COMPPAA)
New York Structural Biology Center
Principal Investigator: Wayne A. Hendrickson, Ph.D.
The Center on Membrane Protein Production and Analysis (COMPPÅ) is engaged in developing technologies for functional assays of membrane proteins, and advancing technology for the efficient production of recombinant membrane proteins for structural analysis and structure determination.
Integrated Technology Resource for Biomedical Glycomics
Complex Carbohydrate Research Center, University of Georgia
Principal Investigator: J. Michael Pierce, Ph.D.
This resource develops and implements new technologies to investigate the glycome of cells, including glycoproteomics and glycoconjugate analysis, transcript analysis and bioinformatics.
Laboratory for Fluorescence Dynamics
University of California, Irvine
Principal Investigator: Enrico Gratton, Ph.D.
This resource develops novel fluorescence technologies, including instrumentation, methods and software. These are applicable to cellular imaging and the elucidation of dynamic processes in cells.
Life Science and Biomedical Technology Research Resource
Brookhaven National Laboratory
Principal Investigator: Sean McSweeney, Ph.D.
This resource will develop and provide access to two advanced beam lines for macromolecular crystallography and one for general x-ray scattering studies, and will offer smaller programs in macromolecular crystallography correlated with optical spectroscopy, and x-ray fluorescence imaging.  The crystallography and scattering beam lines will be available in 2016.
Macromolecular Diffraction Facility at the Cornell High Energy Synchrotron Source (MacCHESS)
Cornell University
Principal Investigator: Richard A. Cerione, Ph.D.
This resource operates three beamlines devoted to macromolecular crystallography and small-angle scattering at the Cornell High Energy Synchrotron Source (CHESS) and provides expertise in large unit-cell diffraction, MAD phasing, microdiffraction, high-pressure cryocooling, multiple beam diffraction and software development.
Mass Spectrometry Resource for Biology and Medicine
Boston University School of Medicine
Principal Investigator: Catherine E. Costello, Ph.D.
This resource develops and applies sophisticated mass spectrometry technologies and methods in an environment of close interaction with life scientists and physicians. The primary emphasis is on studies of oligosaccharides and glycoconjugates.
National Biomedical Center for Advanced ESR Technology
Cornell University
Principal Investigator: Jack H. Freed, Ph.D.
This resource develops electron spin resonance technologies that are applicable to elucidating the structure and complex dynamics of proteins and to other biomedical applications.
National Biomedical Computation Resource (NBCR)
University of California, San Diego
Principal Investigator: Rommie Amaro, Ph.D.
NBCR's mission is to conduct, catalyze and enable biomedical research by harnessing cutting-edge computational and information technologies, with a strong focus on translational and multiscale research.
National Center for Dynamic Interactome Research (NCDIR)
Rockefeller University
Principal Investigator: Michael P. Rout, Ph.D.
NCDIR combines expertise in cell biology, genetics, mass spectrometry and computational structural biology to develop new integrated approaches for the detection, isolation and analysis of macromolecular complexes that that make up the dynamic cellular interactome.
National Center for Functional Glycomics (NCFG)
Beth Israel Deaconess Medical Center
Principal Investigator: Richard D. Cummings, Ph.D.
NCFG develops technologies in the glycosciences, with an emphasis on glycan microarray and glycan presentation for exploration of the molecular mechanisms of glycan recognition by proteins important in human biology and disease.
National Center for Macromolecular Imaging (NCMI)
Stanford University
Principal Investigator: Wah Chiu, Ph.D.
NCMI is focused on extending the resolution, speed and flexibility of cryo-electron microscopy for the 3-D structure determination of biological macromolecular assemblies. The center also develops cryo-electron tomography techniques to capture molecular structures in situ.
National Center for Microscopy and Imaging Research (NCMIR)
University of California, San Diego
Principal Investigator: Mark H. Ellisman, Ph.D.
NCMIR develops computer-aided, advanced microscopy for the acquisition of structural and functional data in the dimensional range of 1 nm to 100 um, which encompasses macromolecules, subcellular structures and cells.
National Center for Multiscale Modeling of Biological Systems (MMBioS)
University of Pittsburgh
Principal Investigator: Ivet Bahar, Ph.D.
MMBioS develops technology and tools to facilitate research and training at the interface between computing technology and the life sciences. The center also works to deepen understanding of the molecular and cellular organization and mechanisms that underlie synaptic signaling and regulation.
National Center for Quantitative Biology of Complex Systems
University of Wisconsin-Madison
Principal Investigator: Joshua J. Coon, Ph.D.
The National Center for Quantitative Biology of Complex Systems (NCQBCS) is developing next-generation protein, metabolite, and lipid measurement technologies for a wide variety of biomedical applications and making whole omic analysis faster and broadly accessible.
National Center for X-ray Tomography (NCXT)
Advanced Light Source, Lawrence Berkeley National Laboratory
Principal Investigator: Carolyn A. Larabell, Ph.D.
NCXT develops soft X-ray tomography for visualizing and quantifying the internal structure of whole, hydrated cells and high-numerical aperture fluorescence microscopy for locating the position of specific cellular molecules.
National Magnetic Resonance Facility at Madison
University of Wisconsin-Madison
Principal Investigator: John L. Markley, Ph.D.
This resource develops NMR technologies for the high-throughput structure determination of small proteins and RNA, for elucidating the structure and dynamics of complex systems, and for metabolomics.
National Research Resource for Imaging Mass Spectrometry
Vanderbilt University
Principal Investigator: Richard M. Caprioli, Ph.D.
The mission of this resource is to advance the technology of imaging mass spectrometry, to facilitate the application of this novel imaging modality to problems of biological and clinical significance, and to promote the adoption of these technologies by a larger community of scientists and clinicians.
National Resource For Advanced NMR Technology
Florida State University
Principal Investigator: Timothy Cross, Ph.D.
The National Resource for Advancing NMR Technology is developing technologies to increase the sensitivity and spectral resolution of NMR spectroscopy, with a focus on instrumentation development.
National Resource for Automated Molecular Microscopy (NRAMM)
New York Structural Biology Center
Principal Investigator: Bridget O. Carragher, Ph.D. and Clinton S. Potter
NRAMM develops, tests and applies technology aimed toward completely automating the processes involved in solving macromolecular structures using cryo-electron microscopy. The goal is to establish a resource that will serve as a center for high-throughput molecular microscopy as well as for transferring this technique to the research community.
National Resource for Biomedical Accelerator Mass Spectrometry (AMS)
Lawrence Livermore National Laboratory
Principal Investigator: Kenneth W. Turteltaub, Ph.D.
This resource develops and refines accelerator mass spectrometry methods and instrumentation for the precise, quantitative measurement of radionuclides in biomedical research. AMS is most useful when sample size is limited, specific activity is very low, the level of isotope that can be used is very limited (human studies) or the events being studied occur with very low frequency or at very low concentration.
National Resource for Cell Analysis and Modeling (NRCAM)
University of Connecticut Health Center
Principal Investigator: Leslie M. Loew, Ph.D.
NRCAM develops new technologies for the analysis, modeling and simulation of cell biological processes. The technologies are integrated and disseminated through Virtual Cell, a Web-based application.
National Resource for Network Biology (NRNB)
University of California, San Diego
Principal Investigator: Trey Ideker, Ph.D.
NRNB provides a freely available, open-source suite of software technology that broadly enables network-based visualization, analysis and biomedical discovery for NIH-funded researchers.
National Resource for the Mass Spectrometric Analysis of Biological Macromolecules
The Rockefeller University
Principal Investigator: Brian T. Chait, Ph.D.
This resource develops new instruments, methods and software, including proteomic tools for dissecting cellular function, with a special emphasis on the mass spectrometry of peptides and proteins.
National Resource for Translational and Developmental Proteomics
Northwestern University
Principal Investigator: Neil L. Kelleher, Ph.D.
The National Resource for Translational and Developmental Proteomics (NRTDP) is dedicated to accelerating a significant shift in how protein molecules are analyzed by mass spectrometrywith a focus on intact protein measurements.
NE-CAT Center for Macromolecular Crystallography
Cornell University
Principal Investigator: Steven E. Ealick, Ph.D.
NE-CAT is a facility for macromolecular crystallography at the Advanced Photon Source at Argonne National Laboratory devoted to X-ray diffraction studies of macromolecules, which often involve large unit cells, small crystals and weakly diffracting crystals with weak anomalous scattering.
Proteomics Research Resource for Integrative Biology
Pacific Northwest National Laboratory
Principal Investigator: Richard D. Smith, Ph.D.
This resource develops and integrates new proteomic technologies for use in biomedical research, with an emphasis on high-resolution, quantitative approaches.
Resource for Biocomputing, Visualization, and Informatics
University of California, San Francisco
Principal Investigator: Thomas E. Ferrin, Ph.D.
This resource develops software and Web-based resources for the analysis of molecular structures and related biomolecular data at scales ranging from the atomic to the supramolecular.
Resource for Integrated Glycotechnology
University of Georgia
Principal Investigator: Kelley Moremen, Ph.D.
This resource develops technologies to increase understanding of the molecular basis of protein-carbohydrate interactions in disease. The resource combines complementary technologies: synthetic chemistry, nuclear magnetic resonance, mass spectrometry, computational biology, protein expression and cell-based assays.
Resource for Macromolecular Modeling and Bioinformatics
University of Illinois at Urbana-Champaign
Principal Investigator: Emad Tajkhorshid, Ph.D.
This resource’s technology research and development activities focus on the structure and function of supramolecular systems in the living cell as well as on the development of new algorithms and efficient computing tools for physical biology. The development and maintenance of widely distributed software tools, nanoscale molecular dynamics and visual molecular dynamics are central to this work.
Stanford Synchrotron Radiation Lightsource
Stanford University
Principal Investigator: Keith O. Hodgson, Ph.D.
This is an integrated resource with macromolecular crystallography, X-ray absorption spectroscopy and small-angle X-ray scattering/diffraction services. The resource also provides enhanced computing and data management tools that enable "user-friendly, real-time and online" instrumentation control with remote access.
Ultrafast Optical Processes Laboratory
University of Pennsylvania
Principal Investigator: Feng Gai, Ph.D.
This resource develops ultrafast, time-resolved laser technologies and instrumentation, with a focus on 2-D IR spectroscopy, to enable atomic-level measurements of biomolecular structure and dynamics.
Washington University Mass Spectrometry Resource
Washington University in St. Louis
Principal Investigator: Michael L. Gross, Ph.D.
This resource develops mass spectrometry-based tools for the study of proteins, lipids and metaboilites. These include biomarker identification, stable isotope mass spectrometry and the analysis of intact proteins.
Yeast Resource Center
University of Washington
Principal Investigator: Michael MacCoss, Ph.D.
This center exploits the budding yeast S. cerevisiae to develop novel technologies for investigating and characterizing protein structure and function. The center offers access to technologies in the areas of mass spectrometry, protein structure prediction, fluorescence microscopy and computational biology.

For additional information on NIGMS biomedical technology research resources, please contact:

Mary Ann Wu , Ph.D.
Health Scientist Administrator
Division of Biophysics, Biomedical Technology, and Computational Biosciences
National Institute of General Medical Sciences
National Institutes of Health
45 Center Drive MSC 6200
Bethesda, MD 20892-6200