The Protein Structure Initiative (PSI), which ended in July 2015, was a national effort to assemble a large collection of protein structures in a high-throughput operation. Knowledge gained could help researchers better understand the function of proteins, learn how altered structures can contribute to disease and identify new targets for drug development.
Goal: To develop new approaches and tools needed to streamline and automate the steps of protein structure determination, and to incorporate those methods into high-throughput pipelines that use DNA sequence information to generate three-dimensional protein structure models
Project period: September 2000 to June 2005
Funding: $270 million (funded largely by the National Institute of General Medical Sciences, with additional support from the National Institute of Allergy and Infectious Diseases)
Number of Centers: 9
Solved protein structures: More than 1,100
Unique structures solved (structures sharing less than 30 percent of their sequence with other known proteins): More than 700
Additional information about the pilot centers.
TB Structural Genomics Consortium based in New Mexico, analyzed protein structures from Mycobacterium tuberculosis.Principal investigator: Thomas Terwilliger, Los Alamos National Laboratory
NIGMS supports basic biomedical research that is the foundation for advances in the diagnosis, treatment and prevention of disease. NIGMS is part of the National Institutes of Health, U.S. Department of Health and Human Services. To learn more about NIGMS, visit
Content revised July 2015
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