Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) Grants Archive

September 2009

National Institute of General Medical Sciences

Mark Collin Alliegro, Marine Biological Laboratory
"Rediscovery of the Nucleolinus"

Rene Anand, Ohio State University
"Fish Electric Organ as a Factory for Membrane Proteins"

Michael A. Glotzer and Tobin R. Sosnick, University of Chicago
"Spatial and Temporal Control of Cell Behavior with a Genetically-Encoded Photoswitch"

Rodney Allan Hill, Patrick J. Hrdlicka and Madhusudhan Papasani, University of Idaho
"Invader LNAs as Novel Gene Specific Therapeutics"

Joseph Holoshitz, University of Michigan at Ann Arbor
"Class II MHC Allele-Specific Signaling: A New Paradigm in Disease Pathogenesis"

Qiu-Xing Jiang, University of Texas Southwestern Medical Center at Dallas
"Obtaining 3D Structures with Subnanogram Macromolecules"

Chuan He and Tao Pan, University of Chicago
"Discovering the Epigenetics of RNA Modifications"

Carl Hirschie Johnson, Vanderbilt University
"Experimental Evolution of Circadian Oscillators"

Douglas F. Lake, Arizona State University, Tempe
"Working Backwards from the Proteome"

Edward M. Marcotte, University of Texas at Austin
"Systematic Discovery of Nonobvious Human Disease Models by Orthologous Phenotypes"

Robert Lewis Margolis, Burnham Institute for Medical Research
"Induction and Maintenance of Mitosis by CDK1 Suppression of Protein Phosphatase 1"

Leo E. Otterbein, Beth Israel Deaconess Medical Center
"Endogenous Gas Molecules as Transcription Factors"

Lois Pollack, Cornell University
"New Targets for Antibiotics: Self Assembling Ribonucleoprotein Complexes"

Oliver J. Rando, University of Massachusetts Medical School
"Transgenerational Effects of Diet in Mammals"

Peter T.A. Reilly, Oak Ridge National Laboratory*
"Accurate Mass Analysis of Singly-Charged Intact Proteins"

Jane S. Richardson, Duke University
"Low-Resolution Interiors & Interfaces Can Achieve High-Resolution Accuracy"

Enrique Saez, Scripps Research Institute
A Genome-Wide RNAi Screening Platform for the Common Lab"

Karsten Sauer, Scripps Research Institute*
Integrated Functional Genomics Analysis of Druggable T Cell-Activating Genes"

Jonathan M. Slack, University of Minnesota, Twin Cities
"Reprogramming Cells to Enable Limb Regeneration"

Matthew B. Soellner, University of Michigan at Ann Arbor
"Methodology for Identification of Substrate-Competitive Kinase Inhibitors"

Jie Song, University of Massachusetts Medical School
"A Nanostructured Approach to Complex Tissue Scaffolds and Smart Implants"

National Cancer Institute

Nancy J. Boudreau, Lisa Marie Coussens and Heike Elizabeth Daldrup-Link, University of California, San Francisco
"Improved Drug Delivery to Tumors Using Novel Tissue Perfusion Approaches"

Xandra Owens Breakefield, Massachusetts General Hospital
"Tumor Exosomes as Agents of Genetic Change"

Hua Xu, Vanderbilt University Medical Center
"An In-Silico Method for Epidemiological Studies Using Electronic Medical Records"

National Institute on Aging

Dale E. Bredesen, Buck Institute for Age Research
"Novel Prionic Mechanism Underlying Alzheimer's Disease"

Pinchas Cohen, University of California, Los Angeles
"A Family of Novel Mitochondrially-Encoded Peptides and Their Role in Aging"

James J. Heckman, National Opinion Research Center
"Life-Span Evolution of the Capabilities of Rhesus Monkeys"

Amanda J. Myers, University of Miami School of Medicine
"The Human Brainome: Genome, Transcriptome and Proteome Interaction in Human Cortex"

Jan Vijg, Yeshiva University
"Single-Cell Functional Genomics"

National Institute on Drug Abuse

Iris Lindberg and Bryan L. Roth, University of Maryland, Baltimore County
"Deorphanizing the Peptidome"

Fan Wang, Duke University
"Genetically Encoded Anatomical Probes for Neuronal Activity and Plasticity"

National Institute of Mental Health

Gilad Barnea, Brown University
"A Molecular Method to Selectively Record Activation of Dopamine Receptor Subtypes"

Manuel F. Casanova, University of Louisville
"Building a Selective Inhibitory Control Tone in Autism: An rTMS Study"

Valentin Dragoi, University of Texas Health Science Center at Houston
"Real-Time Population Coding Underlying Behavioral Decisions"

James Eberwine and Junhyong Kim, University of Pennsylvania
"Single-Cell Comparative Genomics of the Neuron"

Fred H. Gage, Salk Institute for Biological Studies
"L1 Retrotransposon and Neural Diversity"

Richard H. Kramer, University of California, Berkeley
"A Universal Photoswitch System for Optical Control of Neuronal Receptors"

Paul H. Patterson, California Institute of Technology
"Evaluation of Mouse Hallucinations by fMRI"

Randall T. Peterson, Massachusetts General Hospital
"In Vivo Discovery of Psychotropic Drugs by High-Throughput Behavioral Phenotyping"

Miklos Toth, Weill Medical College of Cornell University
"Non-Genetic Transmission of Genetic Risk: Mechanism and Relevance to Psychiatric Disease"

Jon-Kar Zubieta, University of Michigan at Ann Arbor
"Predicting Placebo Responses Across Disease States"

National Institute of Neurological Disorders and Stroke

Katerina Akassoglou, J. David Gladstone Institutes
"Imaging Signal Transduction in the Living Mouse Brain Using Two-Photon Microscopy"

Michael J. Black and Krishna V. Shenoy, Stanford University
"Toward an Animal Model of Freely Moving Humans"

Nancy Bonini, University of Pennsylvania
"Novel Approaches to Neural Regeneration: Defining New Genes & Pathways"

Miguel S. Esteves, University of Massachusetts Medical School
"Development of CNS-Targeted AAV Vectors"

Marc Hammarlund, Yale University
"Horseman, Pass By: Finding Post-Developmental Functions of Essential Genes"

Philip J. Horner and Chet T. Moritz, University of Washington
"Combined Stem Cell Transplantation and Targeted Microstimulation to Direct the Formation of Functional Connections and Neural Repair"

Mehmet F. Yanik, Massachusetts Institute of Technology
"High-Throughput Single-Cell-Resolution Genetic and Pharmacological Screens Using Sub-Micron-Scale Combinatorial Protein Patterns"

National Library of Medicine

James Allen Evans, Ian Foster and Andrey Rzhetsky, University of Chicago*
"Large-Scale Discovery of Scientific Hypotheses; Computation Over Expert Opinions"

Metin Nafi Gurcan, Ohio State University*
"OAMiner: Integrative Knowledge Anchored Hypothesis Discovery"

H.V. Jagadish, University of Michigan at Ann Arbor*
"Literature and Data Driven Hypothesis Generation for High Throughput Experiments"

Isaac S. Kohane, Harvard University Medical School*
"Preventing the Incidentalome"

John Quackenbush, Dana-Farber Cancer Institute*
"Integrated Approaches to Deriving Predictive Networks from Public Data Sources"

Raul Rabadan, Columbia University Medical Center*
"Integrated Discovery and Hypothesis Testing of New Associations in Rare Diseases"

Peter J. Tonellato, Harvard Medical School*
"Method for Prediction of Efficacy of Genetic-Based Prediction Models of Personalized Medicine with Clinical Avatars"

Karin Maria Verspoor, University of Colorado, Denver*
"Automated Literature Mining for Validation of High-Throughput Function Prediction"

*Funded by the American Recovery and Reinvestment Act

September 2008

National Institute of General Medical Sciences

John Chaput, Arizona State University, Tempe
"Discovering a Hidden Proteome in the Human Genome"

Daniel T. Chiu, University of Washington
"Super-Resolution Imaging with Difference Deconvolution Microscopy"

Tanja Dominko, Worcester Polytechnic Institute
"De-Differentiating Adult Human Fibroblasts into Stem-Like Cells Using Defined Conditions"

Iswar K. Hariharan, University of California, Berkeley
"Identifying Novel Strategies to Promote Tissue Regeneration"

James M. Hogle, Harvard University Medical School
"Correlative Cyro-Miscroscopy: A New Approach for Characterizing the Structure and Function of Intracellular Macromolecular Machines in Situ"

Laurence H. Hurley, University of Arizona, Tucson
"Establishing a Molecular System for Drug Targeting of Transcriptional Control"

Masayori Inouye, University of Medicine & Dentistry of New Jersey/Robert Wood Johnson Medical School
"The Method for Determination of Membrane Protein Structures Without Purification"

Michelle Krogsgaard, New York University School of Medicine
"Visualizing Ligand-Induced Signal Propagation in the TCR-Signaling Complex"

Jeanne B. Lawrence, University of Massachusetts Medical School, Worcester
"Is Chromosome Therapy Possible for Down Syndrome and Other Karyotypic Imbalances?"

Joseph A. Loo, University of California, Los Angeles
"Impact of Non-Canonical Decoding on the Proteome"

Lee Makowski, University of Chicago
"MADMAX: Precise Measurement of Conformational Changes in Proteins"

Scott R. Manalis, Massachusetts Institute of Technology
"High-Throughput Monitoring of Mass, Density, and Fluorescence of Single Cells"

William E. Moerner, Stanford University
"Three-Dimensional Super-Resolution Imaging in Living Cells Using Single-Molecule Active Control"

John W. Sedat, University of California, San Francisco
"Enabling High-Resolution Imaging Deep in Live Tissue with Adaptive Optics"

David F. Smith, Emory University
"Shotgun Glycomics: Linking Glycan Structure and Function"

Charles E. Stebbins, Rockefeller University
"Exploiting a Bacterial Nano-Syringe for Protein Therapeutics"

Michael H. Stowell, University of Colorado at Boulder
"Self Assembled Lipid Icosohedra for High-Throughput Membrane Protein Structure Determination"

Brian D. Strahl, University of North Carolina, Chapel Hill
"A High-Throughput Approach Towards Deciphering the Histone Code"

Russell N. Van Gelder, University of Washington Medical Center, Seattle
"Mechanisms of Light-Mediated Protein Degradation"

Alexander J. Varshavsky, California Institute of Technology
"Split Proteins as Boolean Circuits and Drugs of a New Kind"

National Institute of Neurological Diseases and Stroke

Karen Ashe, University of Minnesota, Twin Cities
"In Search of the Molecular Basis of Memory Loss in Tauopathy"

Akira Chiba, University of Miami, Coral Gables
"Mechanical Force and Neural Regeneration"

Janis J. Daly, Case Western Reserve University
"Non-Invasive Brain-Signal Training to Induce Motor Control Recovery After Stroke"

Beverly Davidson, University of Iowa
"RNA Aptamers for Brain Delivery"

David Sretavan, University of California, San Francisco
"Microscale Axon Repair as a Novel Paradigm for Nerve Injuries"

National Institute of Mental Health

Paul Brehm, Oregon Health & Science University
"A Genetic Indicator Provides Long Term Mapping of Neuronal and Calcium Activity"

David Kleinfeld, University of California, San Diego
"Neuronal Signaling, Network Topology, and Blood Flow Dynamics in Cortex"

Todd Lencz, Feinstein Institute for Medical Research
"Identifying Molecular Subtypes of Schizophrenia: A Novel Genomic Approach"

Rick C.S. Lin, University of Mississippi Medical Center
"Serotonin, Corpus Callosum, and Autism"

Joshua Ahab Maurer, Washington University in St. Louis
"Unraveling Development: New Materials for Understanding Neuronal Wiring"

Andras Jagy and Hongkui Zeng, Allen Institute for Brain Science
"Generation and Characterization of Novel and Highly Specific Neuronal Subtype TRA"

Bernardo L. Sabatini, Harvard University Medical School
"Regulation of Neuron and Synapse Function by Neuropeptides"

Yi Eve Sun, University of California, Los Angeles
"A Novel Approach to Identify Neuronal mRNA Targets for Individual microRNAs"

Michael J. Tarr, Brown University
"Using Functional Physiology to Uncover the Fundamental Principles of Visual Cortex"

National Institute on Drug Abuse

Jeff W. Bulte, Johns Hopkins University
"Developing MPI for Non-Invasive and Quantitative Imaging of Stem Cells"

Benjamin F. Cravatt, Scripps Research Institute
"Toward a Potent and Selective Inhibitor for Every Mammalian Serine Hydrolase"

Rodolfo E. Diaz, Arizona State University, Tempe
"Feasibility Demonstration of an Artificial Electrocyte for Neuronal Observation & Stimulation"

Emad N. Eskandar, Massachusetts General Hospital
"Striatal Deep Brain Stimulation for Learning Enhancement"