Biomedical Technology Research and Resource (BTRR) Centers

No active Funding Opportunity Announcement. The final program announcement, PAR-19-316, expired 5/8/2020.

Biomedical Technology Research Resources (BTRRs) create critical technologies, including instrumentation, methods and software, at the forefront of their respective fields that are applicable to a wide variety of problems in the biomedical sciences. This is accomplished through a synergistic interaction of technical and biomedical expertise, both within the Resource and through intensive collaborations with other leading laboratories. Ideally, these Resources identify opportunities for transformative technological advances that open new lines of biomedical inquiry. These Resources are charged with making their technologies available to the greater research community by several avenues: by providing direct access to the research resource through collaboration or service projects, by providing training in the use of the technologies, and by broadly disseminating these technologies and the Resource's experimental results. As of, February 2020, new and renewal applications are no longer being accepted. Instead, NIGMS supports Centers under the Biomedical Technology Development and Dissemination (BTDD) Centers program, which is focused on supporting late-stage technology development and dissemination. New projects promoting later-stage technology development and currently-active BTRR Centers with project periods of less than 15 years may seek support under the BTDD program for a total project period of 15 years. BTRR Centers having project periods beyond 15 years are being sunset.

Mary Ann Wu, Ph.D.
Program Director
Division of Biophysics, Biomedical Technology, and Computational Biosciences
National Institute of General Medical Sciences
National Institutes of Health
45 Center Drive MSC 6200
Bethesda, MD 20892-6200

BioCARS: A Synchrotron Structural Biology Resource
University of Chicago

BTRR Grant Number: P41GM118217
Principal Investigator: Rama Ranganathan, Ph.D., J. Keith Moffat, Ph.D., and Vukica Srajer, Ph.D.
BioCARS is a state-of-the art, national user facility at the Advanced Photon Source, Argonne National Laboratory for synchrotron-based studies of the dynamic & static properties of macromolecules. Using X-ray scattering techniques such as time-resolved crystallography, small- & wide-angle X-ray scattering & fiber diffraction. BioCARS operates 2 X-ray beamlines, embedded in a Biosafety Level 2 (BSL-2) facility unique in the U.S. that permits safe studies of biohazardous materials such as human pathogens.

Biology Linac Coherent Light Source
Stanford University

BTRR Grant Number: P41GM139687
Principal Investigator: Sebastien Boutet, Ph.D.
The unique capabilities of the LCLS facility allow unprecedented opportunities to study biological systems at the smallest length scales (atomic resolution) and the fastest time scales (10s of femtoseconds) and avoids conventional radiation damage, which allows structures to be determined at room temperature. Room temperature data collecting affords many advantages for studying biological systems, including introducing stimuli to perturb the biomolecules (such as by mixing a substrate with an enzyme) that are not possible when making measurements at cryogenic temperatures.

Biophysics Collaborative Access Team (BioCAT)
Illinois Institute of Technology

BTRR Grant Number: P41GM103622
Principal Investigator: Thomas C. Irving, Ph.D.
BioCAT operates facilities at Argonne National Laboratory’s Advanced Photon Source as a national research resource for the study of the structure of partially ordered biological molecules, complexes of biomolecules and cellular structures under conditions similar to those present in living cells and tissues.

Center for Biomolecular NMR Data Processing and Analysis
University of Connecticut School of Medicine and Dentistry

BTRR Grant Number: P41GM111135
Principal Investigator: Jeffrey C. Hoch, Ph.D.
The Center for Bio-NMR Data Processing and Analysis develops robust methods to facilitate discovery, dissemination, management, training, and support for the biomolecular NMR software, to enable the application of NMR to biomolecular systems, and provide software persistence that is essential for reproducible research.

Center for Open Bioimage Analysis
Broad Institute

BTRR Grant Number: P41GM135019
Principal Investigator: Anne E. Carpenter, Ph.D. and Kevin W. Eliceiri, Ph.D.
COBA will provide quantitative image analysis software tools that have broad applicability in biological optical microscopy. This effort will build on two widely used open source bioimage analysis programs, CellProfiler and ImageJ/FIJI, and add deep learning capability to enhance accuracy, ease-of-use, and reproducibility.

Center on Macromolecular Dynamics by NMR Spectroscopy
New York Structural Biology Center

BTRR Grant Number: P41GM118302
Principal Investigator: Arthur G. Palmer, Ph.D.
The Center on Macromolecular Dynamics by NMR Spectroscopy (CoMD/NMR) is developing the technology and application of NMR spin relaxation and associated methods for characterizing protein and nucleic acid conformational dynamics in biological processes including ligand recognition, allosterism, catalysis, and folding.

Center on Membrane Protein Production and Analysis (COMPPAA)
New York Structural Biology Center

BTRR Grant Number: P41GM116799
Principal Investigator: Wayne A. Hendrickson, Ph.D.
The Center on Membrane Protein Production and Analysis (COMPPAA) is engaged in developing technologies for functional assays of membrane proteins, and advancing technology for the efficient production of recombinant membrane proteins for structural analysis and structure determination.

Drosophila Research and Screening Center-Biomedical Technology Research Resource (DRSC-BTRR)
Harvard Medical School

BTRR Grant Number: P41GM132087
Principal Investigator: Norbert Perrimon, Ph.D.
The DRSC-BTRR helps researchers realize the full potential of Drosophila melanogaster as a model for the study of human health and disease through development of technologies and community engagement, including (1) Development of technologies for Drosophila studies, (2) Application of technologies for study of mosquito vectors of human diseases, and (3) Development of in vivo proteomics technologies for Drosophila.

Laboratory for Fluorescence Dynamics
University of California, Irvine

BTRR Grant Number: P41GM103540
Principal Investigator: Enrico Gratton, Ph.D.
This resource develops novel fluorescence technologies, including instrumentation, methods and software. These are applicable to cellular imaging and the elucidation of dynamic processes in cells.

MicroED Imaging Center at UCLA (MEDIC)
University of California, Los Angeles

BTRR Grant Number: P41GM136508
Principal Investigator: Tamir Gonen, Ph.D. and Pawel A. Penczek, Ph.D.
MEDIC develops technologies for the study of the structure of nanocrystalline organic molecules and macromolecules by microcrystal electron diffraction (MicroED), and provides access and training in these technologies. Areas of research include the development of effective procedures for nanocrystal growth, screening and vitrification; novel phasing methods for MicroED for structure determination; effective procedures for studying natural products, small molecules and toxins; and the engineering and fabrication of new hardware for nanocrystallization and time-resolved dynamics by MicroED.

MIT/Harvard Center for Magnetic Resonance
Massachusetts Institute of Technology

BTRR Grant Number: P41GM132079
Principal Investigator: Robert G. Griffin, Ph.D.
The MIT-Harvard Center for Magnetic Resonance develops new instrumentation for dynamic nuclear polarization experiments at high field, solid-state MAS NMR experiments to elucidate the structure of proteins, and advancing solution NMR experiments.

National Biomedical Center for Advanced ESR Technology
Cornell University

BTRR Grant Number: P41GM103521
Principal Investigator: Jack H. Freed, Ph.D.
This resource develops electron spin resonance technologies that are applicable to elucidating the structure and complex dynamics of proteins and to other biomedical applications.

National Center for Dynamic Interactome Research (NCDIR)
Rockefeller University

BTRR Grant Number: P41GM109824
Principal Investigator: Michael P. Rout, Ph.D.
NCDIR combines expertise in cell biology, genetics, mass spectrometry and computational structural biology to develop new integrated approaches for the detection, isolation and analysis of macromolecular complexes that that make up the dynamic cellular interactome.

National Center for Multiscale Modeling of Biological Systems (MMBioS)
University of Pittsburgh

BTRR Grant Number: P41GM103712
Principal Investigator: James Faeder, Ph.D.
MMBioS develops technology and tools to facilitate research and training at the interface between computing technology and the life sciences. The center also works to deepen understanding of the molecular and cellular organization and mechanisms that underlie synaptic signaling and regulation.

National Center for Quantitative Biology of Complex Systems
University of Wisconsin-Madison

BTRR Grant Number: P41GM108538
Principal Investigator: Joshua J. Coon, Ph.D.
The National Center for Quantitative Biology of Complex Systems (NCQBCS) is developing next-generation protein, metabolite, and lipid measurement technologies for a wide variety of biomedical applications and making whole omic analysis faster and broadly accessible.

National Magnetic Resonance Facility at Madison (NMRFAM)
University of Wisconsin, Madison

BTRR Grant Number: P41GM136463
Principal Investigator: Chad M. Rienstra, Ph.D.
The National Magnetic Resonance Facility at Madison (NMRFAM) is a state of the art NMR spectrometer facility located in the Department of Biochemistry at the University of Wisconsin-Madison. NMRFAM equipment and resources are available to any scientist worldwide. Our experienced staff is available to train users as well as provide consultation and collaboration on experimental design, data collection, and analysis.

National Research Resource for Imaging Mass Spectrometry
Vanderbilt University

BTRR Grant Number: P41GM103391
Principal Investigator: Richard M. Caprioli, Ph.D.
The mission of this resource is to advance the technology of imaging mass spectrometry, to facilitate the application of this novel imaging modality to problems of biological and clinical significance, and to promote the adoption of these technologies by a larger community of scientists and clinicians.

National Resource For Advanced NMR Technology
Florida State University

BTRR Grant Number: P41GM122698
Principal Investigator: William W. Brey, Ph.D., Timothy Cross, Ph.D. and Joanna R. Long, Ph.D.
The National Resource for Advancing NMR Technology is developing technologies to increase the sensitivity and spectral resolution of NMR spectroscopy, with a focus on instrumentation development.

National Resource for Automated Molecular Microscopy (NRAMM)
New York Structural Biology Center

BTRR Grant Number: P41GM103310
Principal Investigator: Bridget O. Carragher, Ph.D. and Clinton S. Potter
NRAMM develops, tests and applies technology aimed toward completely automating the processes involved in solving macromolecular structures using cryo-electron microscopy. The goal is to establish a resource that will serve as a center for high-throughput molecular microscopy as well as for transferring this technique to the research community.

National Resource for Network Biology (NRNB)
University of California, San Diego

BTRR Grant Number: P41GM103504
Principal Investigator: Trey Ideker, Ph.D.
NRNB provides a freely available, open-source suite of software technology that broadly enables network-based visualization, analysis and biomedical discovery for NIH-funded researchers.

National Resource for Translational and Developmental Proteomics
Northwestern University

BTRR Grant Number: P41GM108569
Principal Investigator: Neil L. Kelleher, Ph.D.
The National Resource for Translational and Developmental Proteomics (NRTDP) is dedicated to accelerating a significant shift in how protein molecules are analyzed by mass spectrometrywith a focus on intact protein measurements.

Proteomics Research Resource for Integrative Biology
Pacific Northwest National Laboratory

BTRR Grant Number: P41GM103493
Principal Investigator: Richard D. Smith, Ph.D.
This resource develops and integrates new proteomic technologies for use in biomedical research, with an emphasis on high-resolution, quantitative approaches.

Resource for Macromolecular Modeling and Bioinformatics
University of Illinois at Urbana-Champaign

BTRR Grant Number: P41GM104601
Principal Investigator: Emad Tajkhorshid, Ph.D.
This resource’s technology research and development activities focus on the structure and function of supramolecular systems in the living cell as well as on the development of new algorithms and efficient computing tools for physical biology. The development and maintenance of widely distributed software tools, nanoscale molecular dynamics and visual molecular dynamics are central to this work.

Resource for Native Mass Spectrometry Guided Structural Biology
Ohio State University

BTRR Grant Number: P41GM128577
Principal Investigator: Vicki H. Wysocki, Ph.D.
The Resource for Native MS-Guided Structural Biology is building an integrated MS-based workflow for intact, native complexes, i.e. “complex-down” characterization, with innovative scientific instrumentation and computational tools to reveal the complex chemical structures of biomedically relevant molecules.

Resource for Quantitative Elemental Mapping for the Life Sciences
Northwestern University

BTRR Grant Number: P41GM135018
Principal Investigator: Thomas V. O'Halloran, Ph.D. and Chris J. Jacobsen
The Resource for Elemental Imaging for Life Sciences (QE-MAP) is developing emerging technologies for quantitative evaluation of inorganic signatures in cells and tissues that are essential to understanding the regulation of physiological and pathogenic processes and developmental decisions. QE-MAP operates resources at Northwestern University, Michigan State University and the Advanced Photon Source, Argonne National Lab, offering three imaging and detection methods—laser ablation inductively coupled plasma TOF-MS, scanning x-ray fluorescence microscopy and photoacoustic microscopy—that allow investigators to quantitatively map the distribution of dozens of elements in a wide range of biological samples.

Washington University Biomedical Mass Spectrometry Resource
Washington University in St. Louis

BTRR Grant Number: P41GM103422
Principal Investigator: Michael L. Gross, Ph.D.
The Washington University NIGMS Biomedical Resource proposes to continue its 37 years of support for biomedical research through the development of technology based on mass spectrometry (MS). The Resource will pursue this in three areas: 1) The characterization of complex lipids and lipid biosynthesis with a focus on a) pathogenic microorganisms like trypanosomes and mycobacteria and the biosynthetic pathways that offer targets for therapy, b) the characterization of lipid antigens, and c) lipids and large peptides, especially those predicted from genomic data.

Yeast Resource Center
University of Washington

BTRR Grant Number: P41GM103533
Principal Investigator: Michael MacCoss, Ph.D.
The Yeast Resource Center (YRC) has a focus on understanding how genome sequence relates to protein function by studying how variation in proteins affects their levels, modification, function and structure. New technologies are being developed in three areas: 1) Perturbing and sensing changes to complex pathways; 2) Protein detection and quantitation by mass spectrometry; and 3) Higher order protein structure.