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“I remember thinking in my first cellular biology class how impossibly beautiful it is that there are tiny machines in our bodies doing work,” says Morgan DeSantis, Ph.D., an assistant professor of molecular, cellular, and developmental biology at the University of Michigan in Ann Arbor. We talked with Dr. DeSantis about how her career in science almost didn’t happen, how happy she is that it did, and what she’s learning through her research on molecular machines.
Q: How did you become interested in science?
A: I wasn’t remotely interested in science in high school—I was a self-identified artist. I went to the College of Wooster in Ohio with the sole purpose of studying art and doing pottery. But one day during my freshman year, a box with all the pieces I made throughout the year fell, and everything inside broke. It’s hard to describe the emotions I felt that day, but something changed in me, and I realized pottery wasn’t for me. I couldn’t start the projects over, and I didn’t want to drop out and move back home. So, I decided to become a medical doctor.
Happy Valentine's Day! In place of red roses, we hope you'll accept a bouquet
of beautiful scientific images featuring rich, red hues. Be sure to click all
the way through to see the festive
protein flowing through your
blood!
For more scientific photos, illustrations, and videos in all the colors of the
rainbow, visit our image and video gallery.
“It’s so fun to try to make meaning from a confusing experimental result and talk to other scientists who are excited by the same questions you are,” says Elizabeth Wayne, Ph.D., an assistant professor of biomedical engineering and chemical engineering at Carnegie Mellon University (CMU) in Pittsburgh, Pennsylvania. We talked to Dr. Wayne about her career trajectory, research on immune cells, and belief that scientists can change the world.
Q: How did you first become interested in science?
To make naturally colorless biological structures easier to study, scientists
often use fluorescent tags and other tools to color them. Here, we feature
images with purple hues and pair them with questions to test your knowledge of
basic science concepts.
Visit our image and video gallery
for more scientific photos, illustrations, and videos in all the colors of the
rainbow.
When she started college, Anne Carpenter, Ph.D., never guessed she’d one day create software for analyzing images of cells that would help identify potential medicines and that thousands of researchers would use. She wasn’t planning to become a computational biologist, or even to focus on science at all, but she’s now an institute scientist and the senior director of the Imaging Platform at the Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard in Cambridge.
Starting Out in Science
Before beginning her undergraduate studies at Purdue University in West Lafayette, Indiana, Dr. Carpenter’s strongest interests were reading and writing. Then, her subjects expanded. “In college, I liked science as much as anything else, and I realized that was unusual, as a lot of other people really struggled with it. I decided to pursue science because I enjoyed it and the field had good job prospects,” she says. Dr. Carpenter majored in biology because she felt it had the “juiciest questions” as well as a direct impact on human health.
Every year on March 14, many people eat pie in honor of Pi Day. Mathematically
speaking, pi (π) is the ratio of a circle’s circumference (the distance around
the outside) to its diameter (the length from one side of the circle to the
other, straight through the center). That means if you divide the
circumference of any circle by its diameter, the solution will always be pi,
which is roughly 3.14—hence March 14, or 3/14. But pi is an
irrational number, which means that the numbers after the decimal
point never end. With the help of computers, mathematicians have determined
trillions of digits of pi.
To celebrate Pi Day, check out this slideshow of circular microbes,
research organisms, and
laboratory tools (while you enjoy your pie, of course!). To explore more
scientific photos, videos, and illustrations, visit our
image and video gallery.
Throughout 2022, we shared the stories of dozens of NIGMS-supported researchers, trainees, and programs. We also highlighted new STEM education resources, tested your knowledge with quizzes, showcased extraordinary scientific images, and more. To celebrate the upcoming new year, we’re highlighting five of our most popular posts from 2022.
The intricate process of
mitosis—a
cell splitting into two
identical daughter cells—plays a pivotal role in sustaining life. Many
scientists study this process to understand what’s needed for it to progress
normally and why it sometimes goes awry, such as in cancer. During their
research, the scientists often create eye-catching images and videos, and we
showcase some of those visuals here.
Dr. Melike Lakadamyali with a microscope. Credit: Courtesy of Dr. Lakadamyali.
“It would be a dream come true if I could look at a cell within a tissue and have a Google Maps view to zoom in until I saw individual molecules,” says Melike Lakadamyali, Ph.D., an associate professor of physiology at the University of Pennsylvania’s Perelman School of Medicine in Philadelphia. Her lab is helping make part of that dream a reality by developing super-resolution microscopy tools that visualize cells at a near-molecular level.
Blending Physics and Biology
Science and math fascinated Dr. Lakadamyali since childhood, and she felt especially drawn to physics because she enjoyed using logic to solve problems. After graduating high school in her native country of Cyprus, she chose to study physics at the University of Texas, Austin. She never gave much thought to applying physics methods to biological questions—a field known as biophysics—until her third year as an undergraduate, when she gained her first research experience in the lab of Josef Käs, Ph.D.