The National Advisory General Medical Sciences (NAGMS) Council was convened in closed session for its one hundred fifty-fifth meeting at 8:31 a.m. on Thursday, May 22, 2014.
Dr. Jon R. Lorsch, director of the National Institute of General Medical Sciences (NIGMS), presided as chair of the meeting. After a closed session from 8:31 a.m. to 5:50 p.m. on May 22, the meeting was open to the public on May 23 from 8:30 a.m. to 12:14 p.m.
Council Members Present:
Gail E. Besner, M.D.Henry T. Greely, J.D.Alan (Rick) F. Horwitz, Ph.D.Richard Lalonde, Pharm.D.Scott J. Miller, Ph.D.Marc A. Nivet, Ed.D.Margaret C. Werner-Washburne, Ph.D.Holly A. Wichman, Ph.D.
Council Members Absent:
Special Consultants Present:
Eric Alani, Ph.D. Professor and Chair of GeneticsDepartment of Molecular Biology and GeneticsCornell University 459 Biotechnology BuildingIthaca, NY 14853-2703
Douglas A. Bayliss, Ph.D. Professor and ChairDepartment of PharmacologyProfessor of AnesthesiologyUniversity of Virginia1340 Jefferson Park AvenueCharlottesville, VA 22908
Vasant G. Honavar, Ph.D. Professor and Edward Frymoyer Chair of Information Sciences and TechnologyProfessor of Bioinformatics and GenomicsProfessor of NeurosciencePennsylvania State University301A Information Sciences and Technology BuildingUniversity Park, PA 16802
Tarun M. Kapoor, Ph.D. Pels Family ProfessorHead, Laboratory of Chemistry and Cell BiologyThe Rockefeller University1230 York Avenue, Box 202New York, NY 10065
Alfonso Mondragón, Ph.D. Professor Department of Molecular BiosciencesNorthwestern University2205 Tech DriveEvanston, IL 60208-3500
Tom W. Muir, Ph.D. Van Zandt Williams Class of 65 Chair of ChemistryProfessor and Associated Faculty in Molecular BiologyDepartment of ChemistryPrinceton University327 Frick Chemistry LaboratoryPrinceton, NJ 08544
Mark Peifer, Ph.D. Hooker Distinguished ProfessorDepartment of BiologyUniversity of North CarolinaCB#3280, Coker HallChapel Hill, NC 27599
Stephen W. Ragsdale, Ph.D. ProfessorDepartment of Biological ChemistryUniversity of Michigan Medical School1150 W. Medical Center Drive5301 MSRB IIIAnn Arbor, MI 48109-0606
Shankar Subramaniam, Ph.D. Professor, Departments of Bioengineering, Chemistry and Biochemistry and Cellular and Molecular Medicine and Nano EngineeringUniversity of California, San Diego9500 Gilman Drive, MC 0657La Jolla, CA 92093
Council roster (available from NIGMS)
Members of the Public Present
Dr. Stefano Bertuzzi, American Society for Cell BiologySara Lee DavisDr. Adam Fagen, Genetics Society of AmericaDr. Howard Garrison, Federation of American Societies for Experimental BiologyDr. Yihan Shao, Q-Chem, Inc. Dr. Kate Weber, American Chemical Society
Federal Employees Present:
NIGMS and other NIH employees:
Please see the sign-in sheet (available from NIGMS)
OPEN PORTION OF THE MEETING
I. Call to Order and Opening Remarks
Dr. Lorsch thanked the regular members of the Council who were present and then introduced the special consultants: Eric Alani, Ph.D., professor and chair of genetics, Department of Molecular Biology and Genetics, Cornell University; Douglas A. Bayliss, Ph.D., professor and chair, Department of Pharmacology, professor of anesthesiology, University of Virginia; Vasant G. Honavar, Ph.D., professor and chair of information sciences and technology, professor of bioinformatics and genomics, professor of neuroscience, Pennsylvania State University; Tarun M. Kapoor, Ph.D., professor and head, Laboratory of Chemistry and Cell Biology, The Rockefeller University; Alfonso Mondragón, Ph.D., professor, Department of Molecular Biosciences, Northwestern University; Tom W. Muir, Ph.D., chair of chemistry, professor in molecular biology, Department of Chemistry, Princeton University; Mark Peifer, Ph.D., professor, Department of Biology, University of North Carolina; Stephen W. Ragsdale, Ph.D., professor, Department of Biological Chemistry, University of Michigan Medical School; and Shankar Subramaniam, Ph.D., professor, Departments of Bioengineering, Chemistry and Biochemistry and Cellular and Molecular Medicine and Nano Engineering, University of California, San Diego. Dr. Lorsch then introduced and welcomed the guests in attendance.
II. Consideration of Minutes
The minutes of the January 23-24, 2014, meeting were approved as submitted.
III. Future Meeting Dates
The following dates for future Council meetings were confirmed:
September 18-19, 2014 Thursday-FridayJanuary 22-23, 2015 Thursday-FridayMay 21-22, 2015 Thursday-Friday
IV. NIGMS Director’s Report
Dr. Lorsch updated the Council on staff hires and departures at NIGMS and noted two ongoing searches for the NIGMS deputy director and the director, Division of Training, Workforce Development, and Diversity. He alerted the group to “Life: Magnified,” an exhibit of scientific images at Washington Dulles International Airport June through November 2014, and the NIGMS Medical Scientist Training Program 50th Anniversary Symposium to be held at NIH on July 17, 2014. Dr. Lorsch also discussed various ongoing efforts and strategies to refocus the Institute toward its core mission of supporting investigator-initiated research. He mentioned a current collaborative project with Dr. Eric Green, director, National Human Genome Research Institute, on issues common to the two institutes, particularly database support and management. Dr. Lorsch then discussed NIGMS’ activities related to the NIH Initiative to Enhance Reproducibility and Transparency of Research Findings . These include support for grants to develop training modules and efforts to enhance cell authentication awareness, tools and methods.
Contact: Dr. Jon R. Lorsch, firstname.lastname@example.org, 301-594-2172
V. Presentation: Strategies for Scientific Workforce Diversity
The Working Group on Diversity in the Biomedical Research Workforce of the Advisory Committee to the Director, NIH, called for a newly created position entirely dedicated to diversity and charged with developing a vision and comprehensive strategy to expand recruitment and retention as well as promoting inclusiveness and equity throughout the biomedical research enterprise. Dr. Hannah Valantine has been hired to fill this position, leading NIH’s diversity efforts as its first chief officer for scientific workforce diversity. Dr. Valantine summarized her past career as a cardiologist and her most recent position as senior associate dean for diversity and leadership at Stanford University School of Medicine. She shared her own definition of diversity and its importance for research excellence, and she described the nature and success of diversity enhancement efforts at Stanford. These included interventions to address the academic scientific culture and its direct impact on the pipeline, recruitment and retention. Dr. Valantine concluded her presentation by discussing her goals and plans for promoting scientific workforce diversity at NIH.
Contact: Dr. Hannah Valantine, email@example.com, 301-451-4296
VI. Presentation: Why New Investigational Drugs Fail So Often and What We Should Do About It
Contact: Richard Lalonde, Pharm.D., Richard.Lalonde@Pfizer.com, 860-441-8517
VII. Concept Clearance: Data Reproducibility Training Modules
Several studies have shown that a surprising number of biomedical research studies cannot be reproduced by other laboratories under conditions detailed in scientific publications. Probable causes for this problem include the complexity of life-science research, which makes it difficult to identify and/or control all the experimental variables that could affect results. Other contributing factors are the culture and pressures to report high-profile biomedical research findings, the effects of unintentional experimental bias, weaknesses in experimental design and interpretation, and insufficient documentation of experimental procedures and results. Dr. Michael Rogers requested, and received, Council approval to solicit research education project (R25) applications for a small grant program to develop exportable training modules focused on good laboratory and research practices to improve data reproducibility. These modules will be designed to be incorporated into research training programs for graduate students, postdoctoral fellows and junior faculty.
Contact: Dr. Michael Rogers, firstname.lastname@example.org, 301-594-3827
VIII. Presentation: NIGMS Human Genetic Cell Repository
Contact: Dr. Michael Bender, email@example.com, 301-594-0943
IX. Presentation: PRAT Strategic Plan
The NIGMS PRAT Program represents NIGMS’ only intramural component. Initially intended to train a highly selected group of postdoctoral fellows in pharmacology, the program has evolved in recent years to support fellows in a broader range of biomedical research areas. In view of changes in how research training is conducted in the 21st century and recognizing that the program has evolved over its half-century existence, NIGMS conducted a strategic planning process to continue to optimize the direction of the program for the next 5 years. Dr. Judith H. Greenberg described the plan’s strategic goals to Council and Dr. Jessica Faupel-Badger presented plans for implementing these strategies.
Contacts: Dr. Judith H. Greenberg, firstname.lastname@example.org, 301-594-0943; Dr. Jessica Faupel-Badger, email@example.com, 301-451-8786.
X. Public Comment Period
Dr. Adam Fagen, executive director of the Genetics Society of America , presented an overview of the organization and its support for investigator-initiated research. He noted a recently issued white paper that speaks to the issue and publicly concurred with many current NIGMS strategies to support individual scientists and their laboratories.
Dr. Stefano Bertuzzi, executive director of the American Society for Cell Biology (ASCB), echoed support for NIGMS’ continued focus on investigator-initiated research. He encouraged NIGMS program staff to play an active role in identifying outstanding basic scientists working in areas of importance to the NIGMS mission. Finally, he noted that ASCB has created a reproducibility task force aligned with NIH efforts in this area.
Dr. Howard Garrison, deputy executive director for policy and director of the Office of Public Affairs at the Federation of American Societies for Experimental Biology (FASEB), thanked NIGMS for its service to the biomedical basic research community. He also informed the group that FASEB has created and distributed state-specific fact sheets about the benefits of NIH-funded research on health and on local economies.
CLOSED PORTION OF THE MEETING
A summary of applications reviewed by the Council is available from NIGMS.
The meeting adjourned at 12:14 p.m. on May 23, 2014.
I hereby certify that to my knowledge the foregoing minutes are accurate and complete.
___________________Jon R. Lorsch, Ph.D.ChairNational Advisory General Medical Sciences Council
______________________Ann A. Hagan, Ph.D.Executive SecretaryNational Advisory General Medical Sciences Council
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1/12/2016 4:54 PM
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