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PGRN-RIKEN CGM Collaborative Studies Underway

First Set of Studies (RIKEN I)
Second Set of Studies (RIKEN II)
Third Set of Studies (RIKEN III)
Fourth Set of Studies (RIKEN IV)
Fifth Set of Studies (RIKEN V)
Sixth Set of Studies (RIKEN VI)
Seventh Set of Studies (RIKEN VII)
Eighth Set of Studies (RIKEN VIII)
Ninth Set of Studies (RIKEN IX)


First Set of Studies (RIKEN I)

Title: Gemcitabine and Bevacizumab for Pancreatic Cancer
Principal investigators: Drs. F. Innocenti, N. Cox, K. Owzar, H. Kindler, K. Giacomini, H. McLeod, M. Ratain, with Dr. Y. Nakamura
Approximate number of samples: 352
   
Title: Aromatase Inhibitors for Breast Cancer w/ MA-27
Principal investigators: Drs. J. Ingle, R. Weinshilboum, D. Flockhart, V. Stearns, with Dr. T. Mushiroda
Approximate number of samples: 1688
   
Title: Drug-induced Long QT Syndrome Genetic Prediction
Principal investigators: Drs. D. Roden, M. Province, M. Ritchie and A.L. George, with Dr. T. Tanaka
Approximate number of samples: 1000+
   
Title: Cyclophosphamide and Doxorubicin/Paclitaxel for Breast Cancer
Principal investigators: Drs. D. Kroetz, E. Jorgenson, K. Owzar, J. Witte, L. Shulman, H. McLeod, M. Ratain, with Dr. H. Zembutsu
Approximate number of samples: 1984
   
Title: International Warfarin PGx Consortium (IWPC)
Principal investigators: Drs. J. Johnson, D. Roden, M. Caldwell for the International Warfarin Pharmacogenetics Consortium, IWPC, with Dr. T. Mushiroda
Approximate number of samples: 1000

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Second Set of Studies (RIKEN II)

Title: Bevacizumab Addition to Prostate Cancer Therapy
Principal investigators: Drs. McLeod, Ratain, Kroetz, Kelly, Ozwar, Cox, Motsinger-Rief with Dr. Zembutsu
Approximate number of samples: 835
   
Title: Tamoxifen/Raloxiphen Adjuvant to Treat Breast Cancer w/ NSABP
Principal investigators: Drs. Ingle, Wickerham, Schaid, Costantino, Vogel, Paik, Goetz, Flockhart, Wolmark, Weinshilboum with Dr. Zembutsu
Approximate number of samples: 1848
   
Title: Inhaled beta-Agonists for Asthma
Principal investigators: Drs. Weiss, Litonjua, Tantisira, Ritchie with Dr. Tamari
Approximate number of samples: 1121

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Third Set of Studies (RIKEN III)

 

Title: ACE Inhibitors and Andiogedema
Principal investigators: Drs. N. Brown, D. Roden, S. Williams, C. Ingram, R. Krauss, C. McCarty, with Dr. M. Kubo
Approximate number of samples: 818
   
Title: Antiretrovirals for HIV Infection in Uganda
Principal investigators: Drs. D. Kroetz, D. Bangsberg, J. Martin, P. Hunt, E. Jorgenson, J. Witte, H. McLeod, M. Wagner, with Dr. T. Mushiroda
Approximate number of samples: 500+
   
Title: Celecoxib Effectiveness for Colorectal Cancer
Principal investigators: Drs. M. Bertagnolli, S. Weiss, J. Su, M. Ratain, K. Owzar, with Dr. K. Matsuda
Approximate number of samples: 1660
   
Title: Citalopram and Escitalopram for Depression
Principal investigators: Drs. D. Mrazek, C. Schaefer, D. Schaid, K. Giacomini, and R. Weinshilboum, with Dr. T. Mushiroda
Approximate number of samples: 500+
   
Title: AV Nodal Blocking Agents for Atrial Fibrillation
Principal investigators: Drs. D. Darbar, D. Roden, M. Province, M. Ritchie, H. Okafor, P. Ellinor, S. Kabb, H. Watanabe, with Dr. T. Tanaka
Approximate number of samples: 2000

 

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Fourth Set of Studies (RIKEN IV)

Title: Corticosteroid and Inhaled Short-Acting Beta Agonists and Asthma
Principal investigators: Drs. S. Weiss, K. Tantisira, A. Litonjua, J. Lasky-Su, with Dr. M. Tamari
Approximate number of samples: 1,041
   
Title: Busulfan-Based Chemotherapy and Acute Myelogenous Leukemia
Principal investigators: Drs. C. Andreadis, K. Giacomini, J. Witte, L. Johnston, S. Baker, M. Relling, M. Baer, D. Kroetz, with Dr. K. Matsuda
Approximate number of samples: 444
   
Title: Aromatase Inhibitors and Bone Fractures
Principal investigators: Drs. P. Goss, D. Schaid, J.-A. Chapman, S. Khosla, L. Shepherd, M. Ellis, V. Stearns, D. Flockhart, R. Weinshilboum, J. Ingle, with Dr. H. Zembutsu
Approximate number of samples: 1,250
   
Title: SSRIs and Depression
Principal investigators: Drs. D. Mrazek, J. Kirchheiner, T. Klein, D. Schaid, R. Altman, K. Giacomini, R. Weinshilboum, with Dr. T. Mushiroda
Approximate number of samples: 2,000

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Fifth Set of Studies (RIKEN V)

Title: Colorectal Cancer Pharmacogenetics
Principal investigators: Drs. H. McLeod, K. Owzar, M. Ratain, A. Venook, P. Friedman, M. Bertagnolli, with Dr. H. Zembutsu
Approximate number of samples: 1,000

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Sixth Set of Studies (RIKEN VI)

Title: Pharmacogenomics of Methotrexate Response in Patients with Rheumatoid Arthritis
Principal investigators: Drs. T. Bongartz, E. Matteson, R. Weinshilboum, B. Fridley, with Dr. Y. Kochi
Approximate number of samples: 1600
   
Title: Genetic Determinants of Glycemic Response to Metformin in Type 2 Diabetes
Principal investigators: Drs. K. Giacomini, D. Roden, C. McCarty, R. Davis, J. Witte, A. Shuldiner, M. Hedderson, N. Iwasaki, with Dr. S. Maeda
Approximate number of samples: >500
   
Title: Pharmacogenetics of Prostacyclin Dosing in Pulmonary Arterial Hypertension
Principal investigators: Drs. M. Gomberg-Maitland, R. Benza, M. Maitland, N. Cox, with Dr. M. Tamari
Approximate number of samples: 1198
   
Title: Genome-Wide Association Study of 5-Lipoxygenase Inhibition in Asthma
Principal investigators: Drs. K. Tantisira, S. Weiss, A. Litonjua, J. Lasky-Su, W. Qiu, Q. L. Duan, B. Himes, M. McGeachie, A. Wu, S. M. Tse, J. Drazen, J. Lima, with Dr. M. Tamari
Approximate number of samples: 1334

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Seventh Set of Studies (RIKEN VII)

Title: A Genome-Wide Association Study in Patients Experiencing Breast Events While Receiving Aromatase Inhibitors for Early Breast Cancer on NCIC CTG Trial MA.27
Principal investigators: Drs. M. Ellis, J. Ingle, P. Goss, D. Schaid, J. Chapman, L. Shepherd, R. Weinshilboum with Dr. M. Kubo
Approximate number of samples: 270
   
Title: Pharmacogenetic Analysis of the Newly Established First-line Treatment Strategy in Patients with Advanced Ovarian Cancer: Adding Bevacizumab to Standard Carboplatin-Paclitaxel Chemotherapy.
Principal investigators: Drs. G. Liu, H. MacKay, W. Xu, A. Oza with Dr. K. Matsuda
Approximate number of samples: 492
   
Title: Genome-Wide Association Analyses of Pharmacogenomic Loci Associated with Adverse Cardiovascular Outcomes and New-onset Diabetes after Antihypertensive Therapy
Principal investigators: Drs. R. Cooper-DeHoff, Y. Gong, C. Pepine, S. Padmanabhan, A. Dominiczak, M. Caulfield, with Dr. T. Tanaka
Approximate number of samples: 1690

Eighth Set of Studies (RIKEN VIII)

Title: International Clopidogrel Pharmacogenomics Consortium (ICPC) Genome-wide Association Study
Principal investigators: Drs. A. Shuldiner, T. Klein, M. Ritchie, ICPC Investigators, with Dr. T. Mushiroda
Approximate number of samples: 3000
   
Title: A Genome-Wide Association Study in Patients Receiving Neoadjuvant Ghemotherapy with or without Bevacizumab on NSABP B40
Principal investigators: Drs. J. Ingle, D. Wickerham, D. Schaid, P. Rastogi, J. Costantino, S. Paik, M. Goetz, L. Wang, N. Wolmark, R. Weinshilboum, with Dr. A. Furukawa.
Approximate number of samples: 1114

Ninth Set of Studies (RIKEN IX)

Title: Genomewide Association Study of Metformin Glycemic Response and Gastro-Intestinal Side Effects in African Americans
Principal investigators: Drs. K. Giacomini, M. Hedderson, R. Davis, K. Silver, D. Roden, J. Witte, A. Shuldiner, W. Lowe, R. Chisholm, J. Denny, with Dr. S. Maeda
Approximate number of samples: 1000
   
Title: Pharmacogenetic Analysis of Cetuximab (CO.20 Trial)
Principal investigators: Drs. G. Liu, K. Owzar, D. Tu, C. O`Callaghan, D. Jonker, L. Siu, E. Morgen, with Drs. T. Mushiroda and Y. Furukawa
Approximate number of samples: 664
   
Title: Development of a Pharmacogenetic Test that Predicts Response to Inhaled Corticosteroids in Asthmatics in Large Real-life Populations
Principal investigators: Drs. A. Wu, S. Weiss, B. Himes, J. Su, K. Tantisira, D. Roden, J. Denny, H. Xu, M. Brilliant, with Dr. M. Tamari
Approximate number of samples: 1655
This page last reviewed on December 08, 2016