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Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the we​bsite may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit Updates regarding government operating status and resumption of normal operations can be found at

Chemical Methodologies and Library Development

The Chemical Methodologies and Library Development (CMLD) initiative has established multi-investigator research centers whose mission is to develop efficient, general, state-of-the-art methodologies for the design, synthesis, analysis, and handling of chemical diversity libraries. The goals of the program are to discover and to implement fundamental new chemistry that will facilitate access to high-quality libraries of expanded diversity. Each center hosts a library synthesis core facility that serves two purposes: to validate newly developed methodologies for application to diversity-oriented synthesis, and to apply newly developed chemical methodologies and strategies to the generation of chemical diversity libraries for high-throughput biological screening.


Discover more about the CMLD-funded centers, their missions and principal investigators. 

Funding Opportunities

View CMLD-related listings from the NIH Guide for Grants and Contracts, the official publication for NIH research grant policies, guidelines, and funding opportunities.

Contact Us

Reach CMLD program staff.​

This page last reviewed on December 07, 2016