In most cases, letters of intent are not required and are not binding. However, all applications requesting greater than $500,000 in direct costs in any year require prior agreement by NIH staff to accept assignment to that institute or center. More information is available at http://grants1.nih.gov/grants/guide/notice-files/NOT-OD-02-004.html and https://grants.nih.gov/grants/guide/notice-files/NOT-OD-17-005.html.
Program Project Grants and Other Large Applications (>$500,000)
All applications requesting greater than $500,000 in direct costs in any year require prior agreement by NIH staff to accept assignment to that institute or center. More information is available at http://grants1.nih.gov/grants/guide/notice-files/NOT-OD-02-004.html and https://grants.nih.gov/grants/guide/notice-files/NOT-OD-17-005.html.
Conference Grants
Applications for support of scientific meetings require an acceptance letter from an institute or center. Potential applicants must submit a letter of intent at least 30 days before the application deadline. For more information, see Support for Scientific Meetings (R13, U13).