Using Model Organisms to Study Health and Disease Fact Sheet
NIH Policy on Sharing of Model Organisms for Biomedical Research
Generic Model Organism Database Construction Set
Mammalian Gene Collection
NIGMS "Visions of the Future" Meeting Report
Many NIGMS-funded investigators and other scientists use model organisms in their research, and to facilitate their work, the Institute has supported the development of a number of major model organism resources. These resources and more are listed below, and we welcome your suggestions for revisions to this page, including resources for additional organisms or new resources for organisms that are already listed.
Arabidopsis thaliana NIGMS Contact: Michael Reddy, Ph.D., email@example.com, 301-594-0943
The Arabidopsis Information Resource (TAIR) TAIR provides a comprehensive resource for the Arabidopsis thaliana scientific community. TAIR hosts a searchable, relational database. The Arabidopsis Gene Expression Database (AREX) AREX curates published Arabidopsis gene expression information and combines it with new data gained from traditional and microarray studies, so that all expression data can be found in a single, searchable database.
Trans-NIH C. elegans InitiativeThis site lists several links to funding opportunities, C. elegans repositories, microarray resources, and C. elegans Web sites.
Chlamydomonas Resource Center This site contains link to tools, resources, and other information for the Chlamydomonas scientific community. Chlamydomonas Genome Project This site contains sequence and annotation information produced by the Chlamydomonas reinhardtii genome project.
Ciona intestinalis Genome Project This site provides information and links to genomic resources for the Ciona scientific community.
Ciona savignyi Reference Genome and Genetic Map This site has downloadable data files from studies to integrate the C. savignyi reference sequence with a comprehensive genetic map. Genome comparisons between C. savignyi and C. intestinalis are also available.
Ascidian Stock Center The Ascidian Stock Center provides wild type C. intestinalis and C. savignyi strains to the research community. Some stable transgenic strains are also available.Ensembl AnnotationsEnsembl is a software for producing and maintaining automatic annotation on selected eukaryotic genomes.Ensembl-Annotated Ciona intestinalis genome Ensembl-Annotated Ciona savignyi genome
The Daphnia Genomics Consortium The Daphnia Genomics Consortium (DGC) is an international network of investigators committed to advancing the use of the freshwater crustacean, Daphnia, as a model system for studies in ecology, evolution and environmental sciences.The U.S. Department of Energy Joint Genome Institute Daphnia portal This site provides access to sequence data as well as to a set of tools available for use with Daphnia.
DictyBase This site provides a single portal for access to Dictyostelium discoideum and related Dictyostelid genome information, curated Dictyostelium literature and access to experimental resources such as the Dicty Stock Center.
The Dicty Stock Center The Dicty Stock Center is a central repository of strains of Dictyostelium discoideum and related organisms. Strains and reagents are distributed free of charge to bona fide teaching and non-profit research institutions.
Trans-NIH Fly Initiative This site lists several links to funding opportunities, resources, and Web sites for the Drosophila scientific community. Bloomington Drosophila Stock Center at Indiana University The Bloomington Stock Center collects, maintains, and distributes Drosophila melanogaster strains for research. Drosophila Genomics Resource Center (DGRC) The DGRC serves the Drosophila research community by manufacturing and distributing microarrays; collecting and distributing DNA vectors, cDNAs, and ESTs; collecting and distributing cell lines; assisting scientists in the use of these materials; and sponsoring and testing emerging genomics technologies on behalf of the Drosophila research community. Drosophila RNAi Screening Center (DRSC) The DRSC has generated a library of double-stranded RNAs (dsRNAs) directed against all predicted open reading frames, and provides a facility for conducting high-throughput cell-based RNA interference (RNAi) screens to identify genes involved in specific functions.
EcoCyc EcoCyc is a scientific database for the bacterium Escherichia coli K-12 MG1655. The EcoCyc project performs literature-based curation of the entire genome, and of transcriptional regulation, transporters, and metabolic pathways.
EcoGene The EcoGene database contains updated information about the E. coli K-12 genome. A major EcoGene focus has been the re-evaluation of translation start sites.
RegulonDB RegulonDB is a computational model of mechanisms of transcriptional regulation in E. coli K-12.
Coli Genetics Stock Center The Coli Genetics Stock Center at Yale provides samples primarily of strain K-12. The CGSC Database of E. coli genetic information includes genotypes and reference information for the strains in the CGSC collection, the names, synonyms, properties, and map position for genes, gene product information, and information on specific mutations and references to primary literature.
Trans-NIH Mouse InitiativeThis site lists several links to funding opportunities, genetic and genomic resources, and other information for the mouse scientific community.Mouse Genome Informatics This site, hosted by the Jackson Laboratory, provides integrated access to data on the genetics, genomics, and biology of the mouse.
The Peromyscus Genetic Stock Center This site provides a reliable source of Peromyscus (deer mice) and related materials to the national scientific and educational communities.
Mouse Phylogeny Viewer This online tool provides access to complete genomic data on 162 laboratory mouse strains.
Collaborative Cross This site provides information and resources on the Collaborative Cross, a large, genetically diverse panel of inbred mouse strains that are being developed through a community effort.
Trans-NIH Neurospora InitiativeThis NIH-hosted site contains useful information for the Neurospora scientific community including links to genomic resources, annotation and gene descriptions, and culture collections.
PlasmoDB This site contains the database for the malaria parasite genome project and provides access to finished sequence for the Plasmodium falciparum strain 3D7.
NIH Rat Genomics and Genetics Web site This Web site serves as a central point for information on NIH-sponsored and related rat genetic and genomic activities and resources.
Tetrahymena Genome Database This web site provides an up-to-date source of information for researchers in the Tetrahymena community and investigators interested in other ciliates.
Trans-NIH Xenopus Initiative This site tracks NIHhs progress and plans regarding support of the genomic and genetic needs for Xenopus research. It also provides links to community resources and to information about courses, meetings, and publications. Xenopus Gene Collection (XGC) The XGC is an NIH initiative that supports the production of cDNA libraries, clones and 5h/3h sequences to provide a set of full-length (open reading frame) sequences and cDNA clones of expressed genes for Xenopus laevis and Xenopus tropicalis. All resources generated by the XGC are publicly accessible to the biomedical research community.
Saccharomyces Genome Database The Saccharomyces Genome Database (SGD) is a comprehensive, publicly accessible resource about the yeast Saccharomyces cerevisiae (commonly known as baker's or budding yeast). SGD collects and organizes information about the molecular biology and genetics of S. cerevisiae, including review of the published literature, incorporation of DNA sequence updates, and management of S. cerevisiae gene nomenclature. Yeast Intron Database (a link is no longer available)This site contains information about the spliceosomal introns of S. cerevisiae, including documentation of actual splice site usage under different experimental conditions. The Schizosaccharomyces pombe Genome Project This site contains links to information, links, and resources for the S. pombe scientific community.
Trans-NIH Zebrafish Initiative (no longer available)This site is a central information resource for obtaining information about zebrafish genetic and genomic resources, funding opportunities, courses and scientific meetings, and selected reports and publications. Zebrafish Gene Collection (ZGC) The ZGC is an NIH initiative that supports the production of cDNA libraries, clones, and sequences to provide a complete set of full-length (open reading frame) sequences and cDNA clones of expressed genes for zebrafish. All resources generated by the ZGC are publicly accessible to the biomedical research community.
Zinc Finger Nuclease Target Site Algorithm This resource is used to recover sequences to use for zinc finger nucleases.
This page last reviewed on
9/5/2017 7:54 AM
Connect With Us: