The National Institute of General Medical Sciences (NIGMS)
announces that administrative supplements for microarray analysis
are available to principal investigators (PIs) of NIGMS-funded
research grants. The purpose of these supplements is to enable PIs
who will not be submitting competing renewal applications in the
near future to obtain resources for DNA microarray expression
analysis that is directly related to the aims of the parent grant.
NIGMS intends to commit up to $5 million to the microarray
supplement program in FY 2001.
To be eligible for a supplement, a PI must have an active NIGMS
research grant (R01, R15, R29, R37, P01, P50, or S06) as of October
1, 2000, with at least 11 months of funding remaining on the
requested start date of the supplemental award. The proposed
research must be directly related to the aims of the parent grant
without constituting an expansion of scope. Requests for
supplements are limited to one per NIGMS grant and PI. The
principal investigator/program director of a multicomponent award
(P01, P50, or S06) is eligible for a supplement, but leaders of the
subprojects are not.
Grantees may request funds for equipment, supplies, and
part-time personnel with expertise in data analysis (bioinformatics
or statistics). Requests that are solely for personnel will not be
considered. Applicants may request up to $50,000 in direct costs
for 1 year. Applicable facilities and administrative costs
("indirect costs") will also be awarded.
Groups of PIs who are interested in sharing microarray resources
may coordinate their requests. Each PI in the group must have an
NIGMS-funded grant that meets the criteria listed above.
This is a one-time solicitation with a single receipt date. An
original and three copies of the request for an administrative
supplement must be received at the NIGMS address below by October
Microarray Supplement Request
45 Center Drive MSC 6200
Bethesda, MD 20892-6200
A request for an administrative supplement should be in the form
of a letter from the PI that is countersigned by an authorized
institutional business official. On page 1, the applicant should
type "MICROARRAY SUPPLEMENT REQUEST," then provide the following
information, formatted as follows:
PI's name, mailing address, and signature
PI's phone number and e-mail address
Amount requested (direct costs and total costs)
Requested start date (on or after February 1, 2001; not later than
September 1, 2001)
Business official's name and signature
On subsequent pages, the PI should provide the information
requested below. Include the PI's name and grant number on each
page. The supplement request, including the cover page, should not
exceed five pages. Price quotes, letters from collaborators and
consultants, and the checklist (see Section
5 below) are excluded from the five-page limit.
Section 1: Describe the proposed experiments, explaining
and justifying methodologies, reagents, quality control,
statistical analyses, and data sharing. Include an explanation of
how the genes that will be represented on the chips were chosen.
Discuss the relationship of the proposed research to the aims of
the parent grant.
Section 2: Describe the resources that are available for
the microarray analysis. If groups of NIGMS-funded PIs are
coordinating their requests, list the equipment and other resources
for which multiple PIs are requesting supplemental funds and
provide the names and grant numbers of the other PIs. If the
planned microarray experiments will not be fully supported by
supplemental funds from NIGMS to an individual or a group, the
sources and amounts of additional funds should be specified.
Section 3: Describe the qualifications of the PI and
other personnel who will participate in the proposed research
involving microarray analysis, including the statistical analysis
of the data. If personnel in the PI's laboratory do not have the
required expertise, provide a letter from a collaborator or
consultant who does.
Section 4: List items for which funding is requested on
PHS 398 Form Page 4 ("Detailed Budget for Initial Budget Period").
Justify each item. Price quotes should be provided for single
pieces of equipment that cost more than $25,000. If groups of PIs
are requesting funds to purchase a piece of equipment that will be
shared, PIs should request funds for the equipment in proportion to
their anticipated use (e.g., if two PIs will each use the equipment
50 percent of the time, each PI should request 50 percent of the
price of the equipment).
Section 5: Complete
Section 3 ("Facilities and Administrative Costs") of the PHS 398
Review and Award Considerations
Upon receipt, requests will be reviewed for completeness by
NIGMS staff. Incomplete requests will be returned without review.
Requests that are responsive to the supplement announcement will be
reviewed by NIGMS staff, with consultation by appropriate outside
reviewers as necessary.
Review criteria include the scientific merit of the proposed
microarray analysis, the relevance of the proposed experiments to
the project that is funded by the parent grant, the likelihood that
the proposed microarray analysis will enhance the progress of the
parent grant, the adequacy of plans for quality control and data
analysis, the availability of the full range of resources necessary
for microarray analysis, and the appropriateness of the proposed
Each request will be judged on its own merits. PIs who are
coordinating their requests should have contingency plans for the
acquisition of necessary resources in the event that requests
submitted by other members of the group are not approved for
All awards are contingent on the availability of funds.
PIs are strongly encouraged to look at the questions and answers section below and to contact their
NIGMS Program Director before submitting supplement requests. For
additional programmatic information, applicants may contact:
Laurie Tompkins, Ph.D.
Program Director, NIGMS
Telephone: (301) 594-0943
Inquiries regarding NIH grant policy or fiscal matters should be
Ms. Marcia Cohn
Grants Management Officer, NIGMS
Telephone: (301) 594-3918
Questions and Answers
Q: I have two NIGMS-funded grants. One is a MERIT award
and the other is a regular research grant (R01). May I apply for
two microarray supplements?
A: No, you may only apply for one microarray supplement,
regardless of the type(s) of grants that you have.
Q: I am the head of an MBRS SCORE grant subproject. May I
apply for a microarray supplement?
A: No, only the PI of a multicomponent grant may apply
for a supplement. The PI of your SCORE grant may apply for a
microarray supplement to pay for resources that you will use,
assuming that doing the microarray analysis will not expand the
scope of your subproject.
Q: I am the PI on a P01 grant that has five subprojects.
How many microarray supplements may I apply for?
A: One. An NIGMS-funded PI may apply for only one
Q: My grant expires in 3 months, but my renewal
application did well and I expect it to be funded. Am I eligible
for a microarray supplement?
A: No. If you want to do microarray analysis next year,
your competing renewal application should have included a request
for funds for the resources that you'll need.
Q: I've read a lot about microarrays, but I've never done
a microarray experiment. May I apply for a supplement, even though
I have no experience with the technique?
A: Yes, but you will need to show that somebody in your
lab, a collaborator, or a consultant has the technical expertise to
assist you with the microarray analysis. If the person with
expertise is a collaborator or a consultant, that person should
provide a letter describing his/her qualifications and his/her role
on the project.
Q: May I apply for a supplement if one of the specific
aims of my grant involved a pilot project to determine whether
doing a complete microarray analysis was appropriate and feasible?
I've already done the pilot project.
A: Yes, as long as doing the complete microarray analysis
does not change the scope of the grant.
Q: I did not propose to do microarray analysis when I
wrote my grant. May I apply for a microarray supplement as a new
aim of my research?
A: No, but you may apply for a supplement if doing the
microarray analysis would enable you to make progress on one of the
Q: I am funded by NIGMS to study transcription in E.
coli. May I apply for a microarray supplement to look at gene
expression in another organism?
A: You may apply for a supplement only if looking at gene
expression in the other organism is one of the aims of your E.
Q: I want to apply for a supplement to buy a piece of
equipment that costs more than $50,000. If I get the supplement, my
department will provide the remainder of the funding. May I apply
for a supplement under these circumstances?
A: Yes, cost sharing is encouraged.
Q: May I apply for a supplement if the arrayer that I
plan to use is in another department, or if it belongs to a
colleague at another university?
A: Yes, as long as you can demonstrate that you will have
sufficient access to the arrayer to do the proposed
Q: A person with bioinformatics expertise wants to come
to my lab. May I apply for a microarray supplement to pay his/her
A: If this person will work full-time on the project, you
may not apply for funds to pay his/her salary. If he/she will work
part-time on the project, you may apply for a supplement to pay the
person's salary if you are also requesting funds for equipment
Q: I am requesting a supplement to buy chips. The
complete set of chips costs more than $25,000. Do I need to get a
A: No. You don't need a price quote unless you are
requesting funds to purchase a single piece of equipment that costs
more than $25,000. Chips are supplies, not equipment, and each chip
costs less than $25,000.
Q: If my supplement request is funded, do I have to
submit a separate progress report at the end of the year?
A: No, but you should include a section on the microarray
analysis in the next progress report that you submit for
noncompeting renewal of the parent grant, in the preliminary
results/progress report section of your next competing renewal
application, or in your final progress report.