NIGMS Funds $25.2 Million in New EUREKA Grants

Highly Innovative Studies Could Have Big Rewards

September 2, 2010

Highly innovative research with the potential for huge scientific reward is the goal of 21 new grants from the National Institute of General Medical Sciences (NIGMS), a component of the National Institutes of Health (NIH). The grants are part of an NIH program called EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration), which enables scientists to test novel concepts, tools and approaches that could have a major impact on biomedical science.

Now in its third year, the EUREKA program reflects NIH’s continued commitment to funding transformative research, even if it carries a higher degree of scientific risk. The program provides scientists with direct costs of approximately $200,000 per year for up to 4 years.

Among the new NIGMS grants this year are projects that seek to:

  • Use components from bacteria to generate patient-specific induced pluripotent stem cells, facilitating gene therapy and basic research on human development and disease.
    Cammie Lesser, Massachusetts General Hospital

  • Develop an innovative imaging method for tagging RNA molecules, allowing researchers to track them individually during gene regulation and protein production.
    Andrej Luptak, University of California, Irvine

  • Design a strategy to enhance the survival of mutant rat and mouse embryos, aiding the development of new animal models for human disease study.
    Jaime Antonio Rivera-Perez, University of Massachusetts Medical School

  • Create drugs that can be activated by sound, making it possible to spare healthy cells in the human body from the toxic effects of chemotherapy.
    Ching-Hsuan Tung, Methodist Hospital Research Institute, Texas

In addition to NIGMS, the other NIH components funding EUREKA grants this year are the National Cancer Institute, the National Institute on Aging, the National Institute on Alcohol Abuse and Alcoholism, the National Institute of Dental and Craniofacial Research, the National Institute on Drug Abuse, the National Institute of Mental Health, the National Institute of Neurological Disorders and Stroke and the National Library of Medicine.

A list of the new NIGMS EUREKA grants and EUREKA grants made in 2008 and 2009 is available at /Research/Mechanisms/pages/EUREKAGrants.aspx.

For more information about NIGMS’ EUREKA program, see /Research/Mechanisms/pages/EUREKA.aspx (Editor’s note: this page has been removed because the program was discontinued in 2011) or contact Susan Athey in the NIGMS Office of Communications and Public Liaison at 301-496-7301 or