Advanced Photon Source Sector Development Contract Information

Release Date:
4/18/2000
Contact:
Thomas L. Danver, NCI
(301) 846-5422
tdanver@mail.ncifcrf.gov

We would like to invite comments from potential offerors on the draft of a statement of work for a construction effort which appears below. It is intended to select a contractor to build a full sector at the Advanced Photon Source by a competitive negotiation process. At this stage, we envision that the contractor will be called upon to design and build the sector exclusive of the construction of radiation enclosures, experimental stations and their attendant equipment and controls, and security complements and guarantee its working condition. Note that the radiation enclosures should be fully incorporated into the sector designs submitted by offerors. Wherever Argonne National Laboratory services are required to implement items such as safety systems and utilities, the contractor will not be asked to produce these but must be able to interact their delivered components to these facilities. Inquiries about this contract opportunity may be directed to:

Mr. Thomas L. Danver
Senior Contracts Specialist
NCI-FCRF
P.O. Box B
Frederick, MD 21702-1201
Telephone: (301) 846-5422
Fax: (301) 846-5414
E-mail: tdanver@mail.ncifcrf.gov

Draft Statement of Work

Development of the GM/CA-CAT Sector at the APS

It is the intention of Science Applications International Corporation (SAIC), acting for the National Institute of General Medical Sciences (GM) and the National Cancer Institute (CA), to request proposals for the design and build of bending magnet and insertion device beamlines to occupy a sector of the Advanced Photon Source (APS). The aim is to establish a user facility (the GM/CA-CAT) for crystallographic structure determination of proteins and other macromolecules at the forefront of biological research by x-ray diffraction, and to satisfy the technical and operational objectives of GM/CA-CAT. Please send comments on the following Draft Statement of Work to Thomas L. Danver by FAX at (301) 846-5414.

The solicitation process, including award, is expected to be from June - September 2000.

The following three (3) approaches are being considered for the sector development. Alternate approaches may also be proposed.

Approach 1: Construction of the sector to include one (1) each rapidly tunable bending magnet (BM) beamline and rapidly tunable insertion device (ID) beamline. The final sector should be optimally configured for subsequent upgrade with an additional one (1) independently functioning rapidly tunable ID beamline, with an expected horizontal deflection angle, between the two ID beams, of about 1 mrad.

Approach 2: Construction of two (2) independently operating rapidly tunable ID beamlines, with an expected horizontal deflection angle, between the two (2) ID beams, of about 1 mrad.

Approach 3: Construction of one (1) rapidly tunable BM beamline and two (2) independently operating rapidly tunable ID beamlines, with an expected horizontal deflection angle, between the two (2) ID beams, of about 1 mrad.


Proposal Guidelines

A. Design, Management and Personnel, Cost Estimates, Construction Schedule, and Quality Assurance from Offerors

A.1. Design

The fully developed GM/CA-CAT sector (Approach 3) is intended to include two insertion device (ID) beamlines, each one viewing a separate undulator source installed in a straight section of the APS, and a bending magnet (BM) beamline. Although initial budgets may permit build-out of just two of the three beamlines (Approaches 1 or 2), the maximum practical infrastructure outside the shield wall for the support of all three desired beamlines must be in place at the end of the contracted development.

The angular separation between the two ID beams is an important consideration for the design of the two ID beamlines. The maximum potential angular separation of two ID beams radiated from the same accelerator straight section has not yet been determined and requires accelerator R&D which is not part of the contracted effort. Aspects of this question will be the topic of at least one workshop meeting to be scheduled before the submission deadline for this solicitation. Potential responders to the solicitation for the sector development contract will be notified of the location(s), date(s) and time(s) for this(ese) workshop(s). The results of the workshop will be distributed in a timely fashion to prospective offerors. The contractor for this sector development must respond to the progress on this question as well as undulator and front end design choices made during the anticipated collaboration among the APS developers, GM/CA-CAT, and other CATs at the APS interested in the pursuit of these goals. At the present time, a horizontal angular deflection between the two ID beams of about 1 mrad is considered feasible and shall serve as the initial design baseline requirement.

The design shall include the following:

A.1.1. Experimental stations (enclosures) with APS-approved personnel safety design requirements, radiation shielding and required utilities. The enclosure sizes shall be consistent with space requirements for instrumentation and infrastructure, to be specified by the GM/CA-CAT.

A.1.2. Required optics capable of delivering high resolution monochromatic beams of x-rays rapidly tunable in the energy range from 3.5 keV to 35 keV (with exchange of crystals if necessary) at the experimental end station, without compromise of the attributes of the individual radiation sources, with the following minimum characteristics.

Energy resolution (delta-E/E): less than 0.02% at any energy without use of any flux-reducing apertures (i.e. using the full vertical beam opening angles) and filters

Focussed beam flux at 12 keV: >10 13 photons/s for IDs and >10 11 photons/s for BM

Harmonic contamination: <0.01 % at all desired energies.

Rate of energy change: 350 ev/s @ 6.5 keV and 3500 eV/s @ 20 keV (i.e. monochromator crystal rotation angle rate of 1 deg/s for Si(111))

A.1.3. Focussing optics designed to deliver the monochromatic beam to the sample crystal at a fixed position during energy adjustments.

Size of full beam focus at crystal:
ID: vertical/horizontal <50/200 microns
BM: vertical/horizontal <100/200 microns

Maximum beam divergence at crystal at 12 keV in full beam focus:
IDs: vertical/horizontal 0.05/0.25 mrad
BM: vertical/horizontal 0.25/2 mrad

Beam position stability: <5% of focal spot size.

The focusing optics should incorporate independent focusing elements with adjustable curvatures (for the horizontal and vertical directions) to permit focus at different positions within the experimental station (e.g. at the sample or at the detector), to collimate (focus at infinity), or to deliver fully unfocussed beams in one or both directions as desired.

A.1.4. Mechanical components, UHV rated where required, to confine, define, and stop the monochromatic beam, as well as adequately shield bremsstrahlung and synchrotron radiation.

A.1.5. Adequate space allocated to install an appropriate state-of-the-art 2-D detector system, goniometer, and cryogenic crystal cooling equipment in the experimental end station as defined by the GM/CA-CAT. For the upstream ID experimental station (in the case of two simultaneously functioning ID beamlines), there must exist a minimum clearance between the two ID beams of 0.3 meters. It is preferred that displacement be larger to permit unfettered installation and operation of the above cited experimental equipment on the first of the ID beams while simultaneously allowing propagation of the other ID beam to the downstream ID experimental station.

A.1.6. The required shielded vacuum beam transports between various stations and enclosures.

A.1.7. All utilities to support the work to be performed in all stations which include: compressed air, vacuum, water, electrical outlets, lighting, temperature control, electronic/computer communications conduits, and video and audio communications with the outside control areas.

A.1.8. Beamline controls and computers to manipulate the optics and sample using a user-friendly interface, and simultaneously control the ID gaps as needed.

A.1.9. Control stations/desks outside radiation enclosures to be used for computer terminals for data collection control and data processing. Control of the beamline optics and status, cryogenic monitoring and control, vacuum status, and goniometer and detector control and status should all be located at the control stations. Phone and Internet communications are required.

A.1.10. Cryogenic liquid storage and handling facility

Liquid nitrogen and possibly other hazardous cryogens may require storage and access. The size and extent of this facility depends on the final cryogenic systems chosen. Use of helium as a cryogen is probable, but it may not be liquid. Consideration should be given to the danger of asphyxiation from any gas used in quantity.

A.1.11. Gas cylinder and tool storage

The offeror must include in the design an area for the storage of gas cylinders, tools, spare parts, etc.

A.1.12. Additionally:

The offeror must provide appropriate diagrams and figures to aid in understanding the proposal.

The offeror must identify the sources for all designs used for GM/CA-CAT components. If de novo designs are called for, the offeror must explain why existing designs cannot be used.

If exceptions to any of these requirements are proposed, the offeror must explain and justify them.

The design shall not include the following:

Detectors, goniostats, and cryo-cooling systems, data analysis computers and software. We are planning to procure these components near completion of the beamlines to capture the most current and appropriate technology.

A2. Management and Personnel

The offeror must define a management and technical staffing plan for the construction period and state who the personnel are (including service dates), biographical sketches, their roles in the project, their fractional effort contributions, and their salary levels.

A3. Cost Estimate

The offeror must estimate costs; in terms of future dollars assuming a construction start date in late 2000, of all components. Any component whose cost is greater than $100,000 needs further cost breakdown if applicable. A budget breakdown and payment schedule should also be included.

A4. Construction Schedule and Milestones (Timeline)

Time zero will be taken to be the award of the construction contract. All stages of design, review, construction and installation will be completed by fourteen (14) months from time zero. Within that period, reviews will be conducted. A commissioning period with x-rays of at least six (6) months will be carried out on each beamline. This commissioning exercise may proceed in parallel on all three beam lines. A fully operational sector will be available in no more than twenty four (24) months after time zero. A monetary bonus may be offered for early completion.The offeror must identify expected milestones or identifiable end points, which can be monitored. Included in this series of conspicuous events will be regular review meetings. The construction schedule, including these milestones and reviews, should be itemized to a sufficiently fine level that GM/CA-CAT could monitor progress. Fifteen to twenty such timepoints are expected for the two years of the project. In addition to constructing and delivering components, the offeror will be required to install them at the sector and guarantee their working condition, prior to as well as during the commissioning period.

A5. Quality Assurance

The offeror must provide an inclusive program of safety, environmental and quality assurance. The offeror must identify and explain plans to assure the quality of components and of their assembly, and how the offeror or independent scientists can prove that the individual components/facilities satisfy the design specifications. These should include documentation about fabrication facilities and testing procedures, including those for subcontractors. All subcontractors must be identified. Provision for visits to fabrication facilities and inspections by GM/CA-CAT representatives should be included in the plans.

A6. References

The offeror must supply the GM/CA-CAT names, addresses, phone numbers, and e-mail addresses of referees that can attest to the quality of their work. GM/CA-CAT will request letters of reference from this list and two additional letters from independent crystallographers (not affiliated with the offerors) who have used beamlines, which the offeror has built.

A7. Documentation

The offeror is required to work closely with GM/CA-CAT in the preparation of all documentation required by APS for the design, construction, review, and verification of the sector, including all formal design reports.

In addition, the offeror must supply GM/CA-CAT with documentation covering usage, maintenance, replacement, and warranty of beamline components, and diagrams and drawings of the facility and beamline components.

Training of GM/CA-CAT personnel in the safe and effective operation of the installed instrumentation and hardware will be the responsibility of the offeror.

It is anticipated that technical factors will be given paramount consideration in the selection of the offeror and that all evaluation factors, other than cost or price when combined, will be significantly more important than cost or price. Cost or price may become critical factor in selection of a contractor in the event that two (2) or more offerors are rated approximately equal during the evaluation of technical factors. Proposals will be evaluated solely on the factors and subfactors contained in the solicitation and award will be made to the offeror whose proposal represents the best value to the Government. It is anticipated that the procurement will result in a negotiated fixed price contract.

B. Additional Information

B1. The following general areas will likely figure prominently among the criteria for evaluation of offerors. These are presented in no particular order and relative importance remains to be determined.

Technical merit and feasibility.

Timeline.

Cost-benefit analysis.

Management plan.

Quality assurance plan.

Past performance: Evidence of successful completion (designing, constructing, and commissioning) of similar beamline projects on budget and schedule in the past. Record of successful interface with the relevant authorities at the APS.

Design aspects which might support the unique objectives of the sector. Examples of such features follow. We would welcome discussion of these and others with potential offerors.

Robust beamline designs suitable to perform macromolecular crystallography experiments by non-instrumentation specialists.

Features to assure efficient and reliable operation of all beamline components requiring minimal maintenance and upkeep.

Features which would support phased commissioning and early capability to perform scientific measurements.

Upgrades and/or addition of optical components to deliver higher brightness to the sample.

Innovations to increase the throughput of samples at the beamlines with enhancements in user data collection efficiency and optimal use of beamtime.

B2. Attachment

This additional text ( /News/Releases/pages/ConceptualDesign) is extracted from the proposal prepared by GM/CA-CAT and recently submitted to the Program Evaluation Board of the APS and contains the conceptual design section of that document (Sections. 4.1 - 4.2). This may be consulted for additional guidance as to our objectives and preliminary thinking on how they might be accomplished.