NIGMS - News Releases About NIGMS-Supported Research http://www.nigms.nih.gov/News/Results/ NIH CMS RSS feeder 2.0 NIH Awards $18.3 Million in Recovery Act Funds to Support S.T.E.M. Education http://www.nigms.nih.gov/News/Results/20090107B.htm Wed, 19 December 2012 12:00:42 EST {3B792CD4-E46D-4900-A24A-0D395582EAB5} NIH has awarded $18.3 million to bolster research on science, technology, engineering and math (S.T.E.M.) education. N/A Thu, 7 January 2010 00:00:00 Structure Shows Molecular Machinery That Helps Export Messenger RNA From Nucleus http://www.nigms.nih.gov/News/Results/032811.htm Tue, 11 December 2012 11:02:40 EST {DC3B127D-B9FB-4B2D-95DD-81BFF276C28A} ARRA Mon, 28 March 2011 00:00:00 Heterochromatin is Key to Reproductive Isolation http://www.nigms.nih.gov/News/Results/102609c.htm Mon, 3 December 2012 11:38:00 EST {DA571C35-704E-4CB7-8060-122CC65E0D45} An NIGMS-funded study suggests that the tightly packed, gene-poor portion of DNA prevents breeding among closely related species. N/A Mon, 26 October 2009 00:00:00 Short-Term School Closures May Worsen Flu Pandemics http://www.nigms.nih.gov/News/Results/20091230.htm Mon, 3 December 2012 11:31:21 EST {D6C8A983-BAA6-4528-AF8A-0B9E1DBB5393} Closing schools for less than two weeks during a flu pandemic may increase infection rates and prolong an epidemic, according to an NIGMS-supported study. ModelingInfectiousDiseases Wed, 30 December 2009 00:00:00 A Step Closer to Tiny Implantable Biocomputers http://www.nigms.nih.gov/News/Results/052107.htm Mon, 3 December 2012 11:27:46 EST {B5390874-19B1-40DD-96F1-A806ACEACBD1} NIGMS-funded researchers are working to create tiny implantable computers made of DNA, RNA and proteins that could serve as biosensors or specifically deliver medicine to diseased cells. ComplexBiologicalSystemsInitiatives Thu, 24 May 2007 00:00:00 Protein Complex Helps Erase Cell Identities http://www.nigms.nih.gov/News/Results/20100106.htm Mon, 3 December 2012 11:27:23 EST {1BC5C8C6-97FB-41EB-9DF9-5B8BD28AEAC3} A protein complex called elongator could prove valuable for changing cell fate, such as converting cancer cells to normal cells, according to a new NIGMS-supported study. N/A Wed, 6 January 2010 00:00:00 Scientists Reveal Function of DNA Replication Enzyme http://www.nigms.nih.gov/News/Results/20100107.htm Mon, 3 December 2012 11:24:38 EST {597DC067-1E59-493A-88F3-525AE03F81CC} NIGMS-supported scientists have discovered how a protein long known to be an essential activator of DNA replication actually triggers this process in cells. N/A Thu, 7 January 2010 00:00:00 Nutrient Status Affects Biological Clock http://www.nigms.nih.gov/News/Results/03142008.htm Mon, 3 December 2012 11:23:49 EST {85FDE828-D280-4374-AA79-30BE07C983C7} Using a systems biology approach, a team of NIGMS-supported researchers has revealed that the master gene that controls the biological clock in Arabidopsis is sensitive to nutrient status. ComplexBiologicalSystemsInitiatives Thu, 20 March 2008 00:00:00 Paradigm Changing Gene Regulatory Mechanism Revealed http://www.nigms.nih.gov/News/Results/20100113A.htm Mon, 3 December 2012 11:18:57 EST {CEAC2120-4B58-4FAF-9288-706C413BB5D9} A new NIGMS-supported study sheds light on Rho, a key regulatory protein in E. Coli and other bacteria, revealing a new paradigm for understanding the molecular basis of gene transcription. N/A Wed, 13 January 2010 00:00:00 Vaccine Could be a Weapon Against Both Malaria and Cholera http://www.nigms.nih.gov/News/Results/012610b.htm Mon, 3 December 2012 11:17:03 EST {56DEA2F4-6BC5-4DEF-BD63-F557A1446088} N/A Tue, 26 January 2010 00:00:00 Antiviral Drugs Curb Seasonal Flu http://www.nigms.nih.gov/News/Results/011607b.htm Thu, 29 November 2012 14:18:43 EST {AB47513E-2B81-4D1D-81E3-29030D48F9D2} Antiviral drugs are effective in reducing the spread of the influenza virus among family members, report researchers funded by an NIGMS MIDAS grant. ModelingInfectiousDiseases Tue, 16 January 2007 00:00:00 MIDAS Researchers Will Use TeraGrid to Predict Disease Spread http://www.nigms.nih.gov/News/Results/032807a.htm Thu, 29 November 2012 14:17:30 EST {50695608-2095-4FA0-80CB-82E9442B9EA7} NIGMS-funded researchers will use TeraGrid, the world's largest cyber infrastructure, to develop models projecting the spread of infectious disease. ModelingInfectiousDiseases Fri, 8 August 2008 00:00:00 Rapid Response Helped Contain 1918 Flu http://www.nigms.nih.gov/News/Results/040207.htm Thu, 29 November 2012 14:08:51 EST {67875699-F557-4607-9703-F84C8C6CD497} NIGMS-supported analyses of historic data show that cities that responded rapidly to the spread of flu in 1918 cut their mortality rates. The studies help plan for future pandemics. ModelingInfectiousDiseases Mon, 2 April 2007 00:00:00 MIDAS Study Confirms Limited Human-to-Human Spread of Avian Flu http://www.nigms.nih.gov/News/Results/082807a.htm Thu, 29 November 2012 14:07:01 EST {2B71B860-6D89-40E6-877F-3E4CD29F5BCB} Infectious-disease-modeling experts funded by NIGMS confirm that H5N1 avian influenza spread among a family in Indonesia in 2006. ModelingInfectiousDiseases Tue, 28 August 2007 00:00:00 Cholera Can Be Controlled With Oral Vaccines http://www.nigms.nih.gov/News/Results/112607.htm Thu, 29 November 2012 14:05:39 EST {5744B36F-DB44-4124-B58D-530CF06958F9} Researchers funded by the NIGMS Models of Infectious Disease Agent Study report that cholera could be controlled inexpensively by orally vaccinating affected populations. ModelingInfectiousDiseases Mon, 26 November 2007 00:00:00 Scientists Simulate Flu Outbreak in City Similar to Chicago http://www.nigms.nih.gov/News/Results/20080310A.htm Thu, 29 November 2012 14:01:39 EST {D5CBF1A5-4FCF-4C22-8F6B-85EE51586310} Antiviral medications and social-distancing measures may be sufficient to mitigate a flu pandemic outbreak until a vaccine becomes available, according to a new NIGMS-supported study. ModelingInfectiousDiseases Mon, 10 March 2008 00:00:00 Vaccinating 70 Percent Would Control Swine Flu http://www.nigms.nih.gov/News/Results/091009a.htm Thu, 29 November 2012 14:00:09 EST {1DCE641A-8AE3-422A-808E-9970F854F2AE} NIGMS-funded disease modelers calculate that a vaccination program that reaches 70 percent of the U.S. population would control pandemic influenza H1N1. ModelingInfectiousDiseases Thu, 10 September 2009 00:00:00 Inequitable Access to Flu Vaccinations Could Worsen Flu Epidemic http://www.nigms.nih.gov/News/Results/20110609B.htm Thu, 29 November 2012 13:57:07 EST {B2FE40A1-0E31-48B6-A981-C6C2B73ED4EC} ModelingInfectiousDiseases Thu, 9 June 2011 00:00:00 Special Sugar, Nanoparticles Combine to Detect Cholera Toxin http://www.nigms.nih.gov/News/Results/011811a.htm Thu, 29 November 2012 12:46:45 EST {F02D6092-FB4B-4C93-9670-7F56C572971F} N/A Tue, 18 January 2011 00:00:00 Weather Forecast Techniques Used to Predict Flu Outbreaks http://www.nigms.nih.gov/News/Results/20121126c.htm Wed, 28 November 2012 12:48:01 EST {C4451B2B-0DF6-4AFF-98B1-9C9461115AB4} ModelingInfectiousDiseases Mon, 26 November 2012 00:00:00 Component of the Immune Response Points to Potential New Cancer Therapies http://www.nigms.nih.gov/News/Results/20121127a.htm Wed, 28 November 2012 08:23:34 EST {4D087CA1-90C7-4963-88D3-B28CF816E967} N/A Tue, 27 November 2012 00:00:00 Study Uncovers What Keeps a Cell's Energy Source Going http://www.nigms.nih.gov/News/Results/20121126b.htm Wed, 28 November 2012 08:21:52 EST {488F5B21-66A8-454C-A605-6097BF86C2B9} N/A Mon, 26 November 2012 00:00:00 New Mechanism for Cancer Progression Discovered http://www.nigms.nih.gov/News/Results/20121127.htm Wed, 28 November 2012 08:19:51 EST {1D6FF399-6C37-4D89-A39C-F49A613A4AA6} N/A Tue, 27 November 2012 00:00:00 Inactivation of Specific DNA Sites Governs X Chromosome Inactivation http://www.nigms.nih.gov/News/Results/20121126a.htm Wed, 28 November 2012 08:17:34 EST {23F8A8D3-28F9-4531-BE0F-27C1B05B1E43} N/A Mon, 26 November 2012 00:00:00 Metabolic Protein Launches Sugar Feast That Nurtures Brain Tumors http://www.nigms.nih.gov/News/Results/20121126.htm Wed, 28 November 2012 08:14:55 EST {9F36D8DC-D5D2-44A3-8F5E-46D06224B840} N/A Mon, 26 November 2012 00:00:00 Computational Model Can Predict Plant Gene Functions, a Boost to Agricultural Research http://www.nigms.nih.gov/News/Results/020110a.htm Fri, 23 November 2012 11:18:33 EST {B9EBEF8D-D447-40D1-9B57-BE800101FFFC} N/A Mon, 1 February 2010 00:00:00 Using Surfactants With Anesthetic Stops Pain Without Affecting Muscle Function http://www.nigms.nih.gov/News/Results/020110d.htm Fri, 23 November 2012 11:16:29 EST {7E69563A-7156-4E20-9738-81A4AAFADF19} N/A Mon, 1 February 2010 00:00:00 Mechanism Whereby Estrogen Feeds Breast Cancer Suggests New Angle for Treatment http://www.nigms.nih.gov/News/Results/030110c.htm Fri, 23 November 2012 11:14:05 EST {19AFAF82-F321-452A-96A8-17186BC5032E} N/A Mon, 1 March 2010 00:00:00 New Techniques Identify Interactions Between Chromosomes That Drive Human Cell Division http://www.nigms.nih.gov/News/Results/030910c.htm Fri, 23 November 2012 11:10:30 EST {AF3284A9-F583-4A70-AEA5-3F3C59F8E0D6} N/A Tue, 9 March 2010 00:00:00 Immune Cells That Kill Cancerous and Infected Cells Slow Down Wound Healing http://www.nigms.nih.gov/News/Results/041610.htm Fri, 23 November 2012 11:06:38 EST {D89678DB-785D-4768-9E69-65595E8838A3} N/A Fri, 16 April 2010 00:00:00 Worm Embryos and Yeast Better Survive Cold When Deprived of Oxygen http://www.nigms.nih.gov/News/Results/20100610D.htm Fri, 23 November 2012 10:54:29 EST {E7644DDA-0C14-4697-B6F6-653E24F00FD2} ModelOrganisms Thu, 10 June 2010 00:00:00 New World Strain of H. Pylori Helps Scientists Identify Inflammation-Related Genes http://www.nigms.nih.gov/News/Results/20100615A.htm Fri, 23 November 2012 10:51:42 EST {841F0F1F-833A-40C3-BA20-E95FE3A92E6A} N/A Tue, 15 June 2010 00:00:00 Long-Neglected Cell Structure, the Nucleolinus, May Regulate Cell Cycle http://www.nigms.nih.gov/News/Results/072210a.htm Fri, 23 November 2012 10:45:32 EST {08603918-DB70-41E9-8822-06AC6AF532EF} N/A Thu, 22 July 2010 00:00:00 RNA Snippets Jam Protein Production by Disabling mRNAs http://www.nigms.nih.gov/News/Results/20100816A.htm Fri, 23 November 2012 10:42:44 EST {B2DB6F92-5ECB-43EE-8DF2-312CEE802330} N/A Mon, 16 August 2010 00:00:00 New Class of Objects Discovered in the Genome http://www.nigms.nih.gov/News/Results/100510.htm Fri, 23 November 2012 10:40:20 EST {AEF619F2-3DBD-4258-B914-E20B4CE3ACD1} N/A Tue, 5 October 2010 00:00:00 Structural Study Shows That Epigenetic Enzyme Complex Fits Like a Halo Over a Histone http://www.nigms.nih.gov/News/Results/012011b.htm Fri, 23 November 2012 10:21:20 EST {4178C689-84AF-4754-B0D4-C5F5F8B1CA79} N/A Thu, 20 January 2011 00:00:00 Two Proteins May Hold the Key to Creating Human Artificial Chromosomes http://www.nigms.nih.gov/News/Results/20110428B.htm Thu, 15 November 2012 11:40:09 EST {33720FEF-FE1E-44D1-B076-70427E0B6C00} N/A Thu, 28 April 2011 00:00:00 Ancient Pathway Heads Off Head Regeneration in Flatworm Tails http://www.nigms.nih.gov/News/Results/20110512A.htm Wed, 14 November 2012 11:21:34 EST {4BD2508B-4EB2-47C3-ADD9-77AA96004929} N/A Thu, 12 May 2011 00:00:00 Pluripotent Adult Stem Cells Power Planarian Regeneration http://www.nigms.nih.gov/News/Results/20110512.htm Wed, 14 November 2012 11:19:02 EST {16E75B9F-4B25-445A-A68D-3029D91F09E3} StemCellInitiatives Thu, 12 May 2011 00:00:00 Researchers Uncover New Target for Anticancer Drug Development http://www.nigms.nih.gov/News/Results/20121024a.htm Thu, 1 November 2012 15:54:19 EST {9AA040A8-1E30-4460-8A85-C5EC1FE731A8} TelomeresAndTelomerase Thu, 25 October 2012 00:00:00 NIGMS Grantee Honored with Nobel Prize in Chemistry http://www.nigms.nih.gov/News/Results/20121010.htm Thu, 1 November 2012 12:49:55 EST {00CECCA0-BF5A-497D-A7B8-B4BD2F7FF3BA} Nobel Prize Wed, 10 October 2012 00:00:00 Study Details Structure of Potential Target for HIV and Cancer Drugs http://www.nigms.nih.gov/News/Results/20101007.htm Wed, 31 October 2012 09:54:24 EST {67B57DDE-5869-4099-9FBC-93C814DA489F} ProteinStructureInitiative Thu, 7 October 2010 00:00:00 Could Genetics Improve Warfarin Dosing? http://www.nigms.nih.gov/News/Results/Warfarin02182009.htm Wed, 31 October 2012 09:28:57 EST {C9F10617-B9FC-442A-B747-24BFDF663917} A world wide team of researchers used computer modeling to address one of the trickiest drugs to prescribe—the blood-thinner warfarin. To test the gene-based strategy in patients, NIH is launching a large-scale clinical trial. PharmacogeneticsResearchNetwork Wed, 18 February 2009 00:00:00 Lactation Protein Suppresses Tumors and Metastasis in Breast Cancer http://www.nigms.nih.gov/News/Results/20121023.htm Fri, 26 October 2012 16:09:34 EST {F78ECE5C-155A-4C82-B49F-B9E930D1F67E} N/A Tue, 23 October 2012 00:00:00 Study Suggests Bacteria Sparked Evolution of Multicellular Life http://www.nigms.nih.gov/News/Results/20121024.htm Thu, 25 October 2012 07:54:50 EST {C60956C2-2808-45F4-8E8A-83B8120C5BFF} TrainingWorkforceDevelopmentandDiversity Wed, 24 October 2012 00:00:00 New National Centers for Systems Biology to Study Microbial Communities and RNA http://www.nigms.nih.gov/News/Results/20121011.htm Thu, 11 October 2012 09:33:21 EST {13F3D345-1151-4FC6-9148-CF0BFC597541} ComplexBiologicalSystemsInitiatives Thu, 11 October 2012 00:00:00 Top U.S. Science Prize Recognizes NIGMS-Funded Basic Research http://www.nigms.nih.gov/News/Results/20120911.htm Tue, 11 September 2012 11:15:09 EST {88D5B3EF-DD49-4A1A-8266-27BE75D3AE17} N/A Tue, 11 September 2012 00:00:00 NIGMS Grantee Honored with 2011 Nobel Prize in Physiology or Medicine http://www.nigms.nih.gov/News/Results/20111004.htm Tue, 4 October 2011 13:55:01 EST {1191AA09-F44A-4E61-A98A-6616BD0A8758} Nobel Prize Tue, 4 October 2011 00:00:00 NIH Study Links Gene Variants to Breast-Cancer Drug Side Effect http://www.nigms.nih.gov/News/Results/gap_100928.htm Fri, 29 April 2011 15:14:38 EST {F201EC24-C65C-4234-800B-A9DA134484B2} PharmacogeneticsResearchNetwork Tue, 28 September 2010 00:00:00 Cell Membrane Lipids Appear to be More Important Than Previously Thought in the Interactions of Proteins http://www.nigms.nih.gov/News/Results/20120322.htm Tue, 27 March 2012 13:22:36 EST {2EA35DB8-F5B7-4ECB-9C76-CB28D5C633E9} N/A Thu, 22 March 2012 00:00:00 Sugar Is Likely Involved in Regulating Neuron Protein That Is Tangled in Alzheimers http://www.nigms.nih.gov/News/Results/20120416a.htm Wed, 5 September 2012 13:55:16 EST {AE407611-E8CF-4A23-81B3-85D0E6503285} BiomedicalTechnology Mon, 16 April 2012 00:00:00 Human Testes May Multiply Mutations http://www.nigms.nih.gov/News/Results/082707b.htm Thu, 23 August 2012 08:04:16 EST {352E2370-E30E-4A68-9443-EB047209EE41} NIGMS-supported biologists suggest that natural selection may favor the development of germline cells that carry a mutation causing Apert syndrome. N/A Mon, 27 August 2007 00:00:00 Telomeres Send Out an SOS Signal When Cells Take Too Long to Divide, Explaining How a Class of Chemotherapy Drugs Works http://www.nigms.nih.gov/News/Results/20120311.htm Tue, 27 March 2012 13:27:38 EST {1669F77C-8266-4877-B1EA-EF00F6B651E4} N/A Sun, 11 March 2012 00:00:00 National Institute of General Medical Sciences Reorganizes http://www.nigms.nih.gov/News/Results/20120104.htm Mon, 6 August 2012 10:52:04 EST {72BD381A-965E-4F00-AC8C-061DB3E1258A} N/A Wed, 4 January 2012 00:00:00 Chemists Discover Stabler Version of Antibiotic Found Naturally in Milk and Widely Used in Food http://www.nigms.nih.gov/News/Results/20120319.htm Fri, 29 June 2012 14:41:25 EST {D4A8A3C6-9C25-4FBF-80FD-A2F898FB1FA8} N/A Mon, 19 March 2012 00:00:00 Four New Members Appointed to NAGMS Council http://www.nigms.nih.gov/News/Results/20120525a.htm Fri, 25 May 2012 13:15:06 EST {4711123C-1520-43C5-8909-C04BF9790A47} AdvisoryCouncil Fri, 25 May 2012 00:00:00 Exception to Splicing Rule Revealed http://www.nigms.nih.gov/News/Results/20120517a.htm Fri, 18 May 2012 12:24:07 EST {4506EE38-8A55-462F-9BBC-61F4A17C2867} N/A Thu, 17 May 2012 00:00:00 New Technique Reveals Unseen Information in DNA Code http://www.nigms.nih.gov/News/Results/20120517.htm Fri, 18 May 2012 12:21:55 EST {F56FB18A-CBCC-45C7-A425-F9C8F2A2D3AA} N/A Thu, 17 May 2012 00:00:00 Discovery May Lead to New Way to Target Lymphoma http://www.nigms.nih.gov/News/Results/20120516.htm Fri, 18 May 2012 12:18:35 EST {C54E12A3-AB38-4DCA-B53F-C540D7BDD8B3} N/A Wed, 16 May 2012 00:00:00 NIGMS Grantees Recognized with Nobel Prize in Chemistry http://www.nigms.nih.gov/News/Results/nobel_chemistry20081008.htm Thu, 17 May 2012 11:11:49 EST {65425CE0-CC33-4FD4-B824-DA58366979B9} Three NIGMS grantees are honored with a Nobel Prize in chemistry for their groundbreaking work on green fluorescent protein. Nobel Prize Wed, 8 October 2008 00:00:00 The Origin of Centrosomes http://www.nigms.nih.gov/News/Results/050508a.htm Thu, 17 May 2012 11:09:37 EST {9E44EBBA-B097-4117-8B1D-C63F7A7BE445} NIGMS-funded researchers discovered that centrosomes contain RNA that suggests these organelles were incorporated into cells by symbiosis. N/A Mon, 5 May 2008 00:00:00 Stem Cell Differentiation Requires DNA Compaction http://www.nigms.nih.gov/News/Results/20120510b.htm Fri, 11 May 2012 09:07:16 EST {5C964A55-A993-43EF-96E7-E85DB358AD79} N/A Thu, 10 May 2012 00:00:00 Study of DNA Damage-Detecting Enzyme Reveals Potential New Targets for Anti-Cancer Drugs http://www.nigms.nih.gov/News/Results/20120510a.htm Fri, 11 May 2012 09:03:46 EST {B0EE287A-861B-4B70-824E-A6AB7393FD01} N/A Thu, 10 May 2012 00:00:00 Stem Cells Quickly Self Destruct for the Good of the Embryo if They Suffer DNA Damage http://www.nigms.nih.gov/News/Results/20120503.htm Fri, 4 May 2012 14:15:33 EST {1A93DCE5-D861-4194-82C4-5C4B1BFA435D} StemCellResearch Thu, 3 May 2012 00:00:00 Study Examines Reasons for Gender and Racial, Ethnic Disparities in General Surgery Certification http://www.nigms.nih.gov/News/Results/20120430.htm Thu, 3 May 2012 14:59:43 EST {BCD7E4C0-4638-4783-95F2-15F96F813243} N/A Mon, 30 April 2012 00:00:00 Finding in Arginine Paradox Study Translates Into Treatment for Teen http://www.nigms.nih.gov/News/Results/20120426d.htm Tue, 1 May 2012 12:41:11 EST {2F070DAF-20F4-4F75-9730-FADC486D5D80} N/A Thu, 26 April 2012 00:00:00 Biochemical Crosstalk Between DNA Interacting Proteins and Their Modifications http://www.nigms.nih.gov/News/Results/20120501.htm Tue, 1 May 2012 12:28:46 EST {62ADB3AE-1FAF-469D-836D-821903F97C4C} N/A Tue, 1 May 2012 00:00:00 Cell Biologist Chris A. Kaiser to Lead NIH’s National Institute of General Medical Sciences http://www.nigms.nih.gov/News/Results/20111018.htm Tue, 24 April 2012 09:00:34 EST {C227C88F-6CCB-4714-9C1F-9E167B414435} N/A Tue, 18 October 2011 00:00:00 Loop Structures Formed During DNA Transcription Help Regulate What Portions of Chromosomes Are Active http://www.nigms.nih.gov/News/Results/20120301g.htm Fri, 20 April 2012 14:12:28 EST {22F7C04B-CBC1-45CA-A273-A3BF224F3BFB} N/A Thu, 1 March 2012 00:00:00 Research Suggests That Bacteria Communicate By Touch to Cooperate http://www.nigms.nih.gov/News/Results/20120301b.htm Fri, 20 April 2012 14:11:41 EST {2BD4499B-8A5C-4551-A9E2-E8C91A14C36E} N/A Thu, 1 March 2012 00:00:00 Circadian Clocks Influence the Production of Most Metabolic Products Present in the Liver http://www.nigms.nih.gov/News/Results/20120319a.htm Fri, 20 April 2012 14:10:21 EST {AD6E6FDE-119F-42C9-B3EA-D83C1DCCD7A0} N/A Mon, 19 March 2012 00:00:00 The Common Stimulant Ritalin May Speed Recovery From Several Anesthetic Drugs http://www.nigms.nih.gov/News/Results/20120405.htm Fri, 6 April 2012 13:37:28 EST {2B67571A-D3D9-41E5-A6E6-B3AACD9FDB44} N/A Thu, 5 April 2012 00:00:00 Method Detects Sequence Differences in Individual DNA Molecules by Taking Nanoscopic Pictures http://www.nigms.nih.gov/News/Results/20120327.htm Wed, 28 March 2012 14:53:53 EST {6EA48C6F-215E-4DCA-8340-A8B1667F2F87} SingleMoleculeDetectionAndManipulation Tue, 27 March 2012 00:00:00 Anesthetic Isoflurane Induces Alzheimer's-Like Changes in Mammalian Brains, Apparently By Damaging Mitochondria http://www.nigms.nih.gov/News/Results/20120301a.htm Tue, 27 March 2012 13:31:19 EST {F008CB16-CAEF-4099-8524-FC7AB869E0C9} N/A Thu, 1 March 2012 00:00:00 Biology Major at LIU Brooklyn Overcomes Adversity to Earn Prestigious Honor http://www.nigms.nih.gov/News/Results/20120301i.htm Tue, 27 March 2012 13:31:01 EST {38A03FC5-DBDD-4288-95D6-7D371B88DC7B} TrainingWorkforceDevelopmentandDiversity Thu, 1 March 2012 00:00:00 Freely Available Web-Based Program Predicts Whether Genetic Mutations Are Likely to Disrupt Splicing, Potentially Leading to Disease http://www.nigms.nih.gov/News/Results/20120301h.htm Tue, 27 March 2012 13:30:39 EST {FCDCDEDC-8D76-481F-A4B6-F273E968DF56} N/A Thu, 1 March 2012 00:00:00 How Flexibility and Chaperones Help Proteins Handle Stressful Situations http://www.nigms.nih.gov/News/Results/20120301e.htm Tue, 27 March 2012 13:30:21 EST {DB4E9431-B5DE-4272-83BC-8F109E2A6520} N/A Thu, 1 March 2012 00:00:00 Study Promises to Allow Researchers to Control Stem Cell Differentiation http://www.nigms.nih.gov/News/Results/20120301d.htm Tue, 27 March 2012 13:29:03 EST {6D4D2979-1C95-4940-B98A-A69292001A4C} ARRA Thu, 1 March 2012 00:00:00 Variations in the Parts of RNA Polymerases Appear to Affect the Regulation of Gene Expression http://www.nigms.nih.gov/News/Results/20120301c.htm Tue, 27 March 2012 13:28:41 EST {97A7E38E-B22E-4FEE-B0B9-F6C91A108BA1} N/A Thu, 1 March 2012 00:00:00 Structure Shows How Protein Machinery Binds and Wraps DNA to Start Replication http://www.nigms.nih.gov/News/Results/20120306.htm Tue, 27 March 2012 13:28:22 EST {FF9EE4C8-36BD-4C2C-A213-7A97717410B0} N/A Tue, 6 March 2012 00:00:00 Tool Called Pathwalking Rapidly Generates Draft Models for Protein Structures http://www.nigms.nih.gov/News/Results/20120306a.htm Tue, 27 March 2012 13:28:01 EST {DB37FB6A-13F1-4940-BF3C-3F25B9DE60A7} N/A Tue, 6 March 2012 00:00:00 New Computer Program Can Speed the Discovery of Genes Affected by Epigenetic Regulation Linked to Cancer http://www.nigms.nih.gov/News/Results/20120313.htm Tue, 27 March 2012 13:27:11 EST {6A53BEBE-0DED-4267-A0D2-B623256EA9CF} N/A Tue, 13 March 2012 00:00:00 Technique Uses RNA Interference to Target Cancer Cells' Ability to Resist Radiation Treatment http://www.nigms.nih.gov/News/Results/20120313a.htm Tue, 27 March 2012 13:26:50 EST {726ECA8E-864F-4918-953B-04BE7A0BAA02} RNAandRNAinterference Tue, 13 March 2012 00:00:00 Genome-Wide Study Reveals How Key Immune Sensors Arrive at the Front Lines of Infection http://www.nigms.nih.gov/News/Results/20120314.htm Tue, 27 March 2012 13:26:30 EST {9A7F1D95-F171-4831-BD08-4421050FB6BB} ComplexBiologicalSystemsInitiatives Wed, 14 March 2012 00:00:00 New Technique Enables Researchers to Mine Drug Reports to Discover Side Effects and Interactions http://www.nigms.nih.gov/News/Results/20120314a.htm Tue, 27 March 2012 13:26:11 EST {1A980A8D-5336-4D4C-B0B5-2D0444C91C37} PharmacogeneticsResearchNetwork Wed, 14 March 2012 00:00:00 Personalized "Omics" Profile Allows Scientist to Discover, Track His Diabetes Onset http://www.nigms.nih.gov/News/Results/20120315.htm Tue, 27 March 2012 13:25:46 EST {DE19BCDF-B744-4536-B82D-A3333C3DB3E8} PharmacogeneticsResearchNetwork Thu, 15 March 2012 00:00:00 Researchers Boost Potency, Reduce Side Effects of IL-2 Protein Used to Treat Cancer http://www.nigms.nih.gov/News/Results/20120318.htm Tue, 27 March 2012 13:25:18 EST {47BCB036-02E2-4FE9-A391-FBD7D29CA2CA} N/A Sun, 18 March 2012 00:00:00 Findings Suggest Anesthesia Causes Unconsciousness by Altering Lipids and Their Ability to Send Signals Along Nerve Cell Membranes http://www.nigms.nih.gov/News/Results/20120321.htm Tue, 27 March 2012 13:24:12 EST {06B4A61E-8B90-4E31-BB3E-F89C76E85684} N/A Tue, 20 March 2012 00:00:00 Atomic Structure of Molecule That Binds to Opioids in the Human Brain Opens the Door to Developing Better Drugs for Pain, Depression and Other Conditions http://www.nigms.nih.gov/News/Results/20120321a.htm Tue, 27 March 2012 13:23:49 EST {217A56AA-C857-46FB-B76B-1D639F9C4BBB} ProteinStructureInitiative Wed, 21 March 2012 00:00:00 Roundworms Provide Tool for Studying How Cancers Override Cellular Growth Controls Based on Wearing Down Telomeres http://www.nigms.nih.gov/News/Results/20120321b.htm Tue, 27 March 2012 13:23:25 EST {8A9D7D8F-0E3D-4F5B-BF9C-7F55579B484D} TelomeresAndTelomerase Wed, 21 March 2012 00:00:00 Embryonic Stem Cells Shift Metabolism in Cancer-Like Way Upon Implanting in Uterus http://www.nigms.nih.gov/News/Results/20120323.htm Tue, 27 March 2012 13:22:16 EST {9BE88304-E9E7-4736-823F-C98AE14C0AA2} StemCellInitiatives Fri, 23 March 2012 00:00:00 Statistical Method Estimates to What Extent Widespread Heritable Components Contribute to the Risk of Four Common Diseases http://www.nigms.nih.gov/News/Results/20120325.htm Tue, 27 March 2012 13:21:54 EST {CB451FB0-ED92-4FF5-8E63-31BD1597621C} PharmacogeneticsResearchNetwork Sun, 25 March 2012 00:00:00 New Method Produces Human Therapeutic Glycoproteins Simply and Quickly in E. coli http://www.nigms.nih.gov/News/Results/20120326.htm Tue, 27 March 2012 13:21:09 EST {F774EDC3-CC3B-490F-B184-2E47E88D2341} N/A Mon, 26 March 2012 00:00:00 Studying Sperm Proteins to Understand Infertility http://www.nigms.nih.gov/News/Results/101008a.htm Fri, 10 October 2008 16:02:35 EST {63DF4329-6C92-47C6-9903-413CC1A06BC3} NIGMS-funded researchers are showing how proteomics can be used to identify which proteins in sperm are dysfunctional in certain cases of infertility. TrainingWorkforceDevelopmentandDiversity Fri, 10 October 2008 00:00:00 HHMI’s Gilliam Fellowships Aim to Increase Diversity in Sciences http://www.nigms.nih.gov/News/Results/minority_100309.htm Wed, 31 March 2010 09:18:14 EST {5C4D93AE-72AB-4B0D-BCEB-BC198FDBDC39} Former IMSD scholar Lisandro Maya-Ramos and former MARC undergraduate Mariam El-Ashmawy were named 2010 Gilliam fellows by the Howard Hughes Medical Institute. The fellowship provides graduate school support annually for up to 5 years to help move recipients toward careers in science research and teaching. TrainingWorkforceDevelopmentandDiversity Tue, 9 March 2010 00:00:00 Keystone Symposia Awarded $1.37 Million, 5-Year NIH Grant to Fund Ongoing Diversity Efforts http://www.nigms.nih.gov/News/Results/minority_100312.htm Wed, 17 March 2010 12:16:28 EST {22301C56-F9FC-4038-94E1-C380C6DD8336} NIGMS Awards 5-Year MARC Ancillary Training Activities Grant to Keystone Symposia on Molecular and Cellular Biology. TrainingWorkforceDevelopmentandDiversity Fri, 12 March 2010 00:00:00 Study Identifies Factors That Put Students at Risk in Medical School http://www.nigms.nih.gov/News/Results/091410.htm Mon, 20 September 2010 15:34:19 EST {0F2238DF-5E41-488B-9323-F961F04DF502} TrainingWorkforceDevelopmentandDiversity Tue, 14 September 2010 00:00:00 NIGMS Grantees Win Presidential Mentoring Awards http://www.nigms.nih.gov/News/Results/PresidentialAwards02152011.htm Thu, 24 February 2011 08:43:50 EST {8D5ACA2C-4389-4E3D-A14A-3AD93109DA94} TrainingWorkforceDevelopmentandDiversity Tue, 15 February 2011 00:00:00 Wayne State University Award for IMSD Program http://www.nigms.nih.gov/News/Results/20110804.htm Thu, 4 August 2011 13:16:02 EST {138B612C-2375-402A-A766-44DA19CA4FDD} TrainingWorkforceDevelopmentandDiversity Thu, 4 August 2011 00:00:00 Graduate School Wins Grant to Recruit, Retain Minority Students http://www.nigms.nih.gov/News/Results/20110913.htm Wed, 14 September 2011 08:38:57 EST {69752371-6661-45D7-B38E-DA53F57EA160} TrainingWorkforceDevelopmentandDiversity Tue, 13 September 2011 00:00:00 Structure of Protein That Helps Guide Blood Cell Movement Revealed http://www.nigms.nih.gov/News/Results/20101004.htm Thu, 5 January 2012 10:46:55 EST {A66CD51A-831D-419F-B66E-C87F0DD877E1} ProteinStructureInitiative Mon, 4 October 2010 00:00:00 Molecular Structure of Dopamine Receptor Solved http://www.nigms.nih.gov/News/Results/111610a.htm Thu, 5 January 2012 10:41:26 EST {812DC504-BA98-4CE7-BCED-E5EBD8C24313} ProteinStructureInitiative Tue, 16 November 2010 00:00:00 Tissue-Specific Genes Are 'Marked' in Embryonic Cells http://www.nigms.nih.gov/News/Results/20091215A.htm Mon, 5 December 2011 10:31:46 EST {B97D5946-3E56-45A4-968E-96AB5505AD5E} Tissue-specific genes, thought to be dormant in embryonic stem cells, are indeed marked by transcription factors, according to a new NIGMS-supported study. StemCellResearch Tue, 15 December 2009 00:00:00 New Imaging Technique Reveals Complex Microbial Interactions http://www.nigms.nih.gov/News/Results/20110510.htm Thu, 6 October 2011 11:25:55 EST {D3320046-58E7-4B5B-B022-EE1FA52C3DF3} N/A Tue, 10 May 2011 00:00:00 Conserved Biological Mechanism Plays Dual Role in Brain Development and Function http://www.nigms.nih.gov/News/Results/20110520.htm Thu, 6 October 2011 11:24:51 EST {99850CF3-9C0B-4FA1-9A83-6C612992D57E} N/A Fri, 20 May 2011 00:00:00 The Loss of a Single Gene Confers Mice With the Ability to Regenerate Tissue http://www.nigms.nih.gov/News/Results/031510a.htm Thu, 6 October 2011 11:08:35 EST {2AF6D04D-000F-4A86-BBDB-D75DB3E2E103} StemCellResearch Mon, 15 March 2010 00:00:00 Study Links Faulty DNA Repair to Huntington’s Disease Onset http://www.nigms.nih.gov/News/Results/042307.htm Tue, 27 September 2011 13:38:27 EST {B4AD930F-4D2E-48E2-B5B0-94456588B68A} Huntington's disease is a fatal, inherited neurodegenerative disorder that affects roughly 30,000 Americans. A new NIGMS-supported discovery about how cells repair their DNA points to a possible way to stop or slow the onset of the disease. N/A Mon, 23 April 2007 00:00:00 Pitt's School of Medicine Gets $16M for HIV Structural Biology Center http://www.nigms.nih.gov/News/Results/pitt_08072007.htm Fri, 9 September 2011 10:44:27 EST {4DA69D67-3457-4B48-A7B8-840E6FD9B1CA} With NIH support, the University of Pittsburgh School of Medicine will establish the Pittsburgh Center for HIV Protein Interactions. HIVStructuralBiology Mon, 27 August 2007 00:00:00 Utah Researchers Win Grant to Study HIV Structure http://www.nigms.nih.gov/News/Results/083007a.htm Fri, 9 September 2011 10:40:06 EST {A3E7B1AA-3736-45DE-B5A4-0BF5C1A2F97E} A researcher at the University of Utah is being supported by NIGMS to establish one of three new HIV research centers around the country. HIVStructuralBiology Thu, 30 August 2007 00:00:00 Study Suggests Why Some Common HIV Antibodies Don't Work http://www.nigms.nih.gov/News/Results/111910a.htm Tue, 6 September 2011 13:16:26 EST {F4E320FF-AB3E-4C28-B242-8861AC1969F3} HIVStructuralBiology Fri, 19 November 2010 00:00:00 Molecular Structures Help Shape the Design of New AIDS Treatments http://www.nigms.nih.gov/News/Results/structures_11152010.htm Tue, 6 September 2011 11:55:41 EST {3E1CD319-E905-49BA-A76A-99EBFA935482} HIVStructuralBiology Mon, 15 November 2010 00:00:00 Promising New Anti-HIV Drug Candidate Shuts Virus Out of Cells http://www.nigms.nih.gov/News/Results/20100818A.htm Tue, 6 September 2011 11:50:22 EST {484489C4-7A54-42C6-8EB3-3E498C2B3B16} HIVStructuralBiology Wed, 18 August 2010 00:00:00 HIV Resists AZT by Removing It http://www.nigms.nih.gov/News/Results/091910a.htm Tue, 6 September 2011 11:49:38 EST {E37E8651-8EBF-42F1-B9B5-71F6527CEDE1} HIVStructuralBiology Sun, 19 September 2010 00:00:00 Insight Into Structure of HIV Protein Could Aid Drug Design http://www.nigms.nih.gov/News/Results/20100609A.htm Tue, 6 September 2011 11:48:54 EST {FA5B15F4-29CE-4E4B-8BFB-680A05635B1A} HIVStructuralBiology Wed, 9 June 2010 00:00:00 Discovery of Compounds That Bind to HIV Protease Could Lay Foundation for New Drugs http://www.nigms.nih.gov/News/Results/020310b.htm Tue, 6 September 2011 11:48:18 EST {A81251E4-87EE-4938-96D8-D289D2935FC2} HIVStructuralBiology Wed, 3 February 2010 00:00:00 New Method Traces Drug-Resistance Mutations in HIV http://www.nigms.nih.gov/News/Results/20100111A.htm Tue, 6 September 2011 11:47:47 EST {1BC870D7-B9B1-4435-AE8C-F639BD438ABF} A team of NIGMS-supported chemists and statisticians has developed a novel way to trace mutations in HIV that lead to drug resistance. HIVStructuralBiology Mon, 11 January 2010 00:00:00 An Atomic-Level Look at HIV Accomplice http://www.nigms.nih.gov/News/Results/111909b.htm Tue, 6 September 2011 11:46:33 EST {BB004B97-4CE7-42A4-AA9A-28EBB601DF6A} NIGMS-funded biochemists have determined the structure of a precursor to a semen protein that makes cells more vulnerable to HIV. HIVStructuralBiology Thu, 19 November 2009 00:00:00 Compound Could Lead to New Class of AIDS Drugs http://www.nigms.nih.gov/News/Results/05142008.htm Tue, 6 September 2011 11:45:32 EST {544126CF-6759-417E-9824-56EE1250DD6C} NIGMS-supported researchers have developed what they believe is the first new mechanism in nearly 20 years for inhibiting HIV protease, a key viral enzyme. HIVStructuralBiology Wed, 14 May 2008 00:00:00 Scientists Image a Single HIV Particle Being Born http://www.nigms.nih.gov/News/Results/05252008A.htm Tue, 6 September 2011 11:45:00 EST {0E84599C-CAC6-4803-AAC5-81754E4A5F99} By using a special microscope, a team of NIGMS-supported scientists has become the first to see molecules coming together in a living cell to form a single HIV particle. HIVStructuralBiology Sun, 25 May 2008 00:00:00 Gene Stowaway Suggests Way to Block HIV http://www.nigms.nih.gov/News/Results/20091206.htm Tue, 6 September 2011 11:43:05 EST {D551CE39-C3B7-4A5B-BAE2-8E297BA582FD} An ancient gene, perhaps from a cat, has been found in the HIV genome. The gene enhances the ability of the virus to reproduce in human cells. HIVStructuralBiology Sun, 6 December 2009 00:00:00 NIGMS Funds $25.2 Million in New EUREKA Grants http://www.nigms.nih.gov/News/Results/20100902.htm Wed, 24 August 2011 11:46:01 EST {29604151-5BBB-41F2-8FDE-CFE6C3601195} N/A Thu, 2 September 2010 00:00:00 New NIH Program to Fund Exceptionally Innovative Research http://www.nigms.nih.gov/News/Results/EUREKA070724.htm Wed, 24 August 2011 11:35:37 EST {2E80FC3C-181E-4FD9-B196-12C7E93F9C1C} NIH announces a new program to fund exceptionally innovative research. N/A Tue, 24 July 2007 00:00:00 A New Set of Building Blocks For Simple Synthesis of Complex Molecules http://www.nigms.nih.gov/News/Results/20110822a.htm Wed, 24 August 2011 08:38:35 EST {A9701026-FBCD-4925-A753-2BDE98D7DC24} N/A Mon, 22 August 2011 00:00:00 Computational Method Predicts New Uses for Existing Medicines http://www.nigms.nih.gov/News/Results/20110815b.htm Thu, 18 August 2011 11:14:10 EST {C8CD9BC5-CE1F-4D61-AC8D-53F98CF06747} Scientists used computers and publicly available genomic information to predict new uses for existing medicines. Among the study's surprise findings: an anti-ulcer medicine that shrinks lung cancer, and an anticonvulsant that might alleviate inflammatory bowel disease. N/A Wed, 17 August 2011 00:00:00 Find New Uses For Existing Drugs By Mining Gene-Activity Data Banks http://www.nigms.nih.gov/News/Results/20110817.htm Thu, 18 August 2011 09:19:16 EST {C42A1508-6ACE-49DE-8E6A-AB2E97B77815} PharmacogeneticsResearchNetwork Wed, 17 August 2011 00:00:00 New NIGMS Grants to Advance Research on Modeling Infectious Disease Spread http://www.nigms.nih.gov/News/Results/20110815.htm Mon, 15 August 2011 14:53:26 EST {75724B2D-B037-4B40-866F-FAB46627033B} ModelingInfectiousDiseases Mon, 15 August 2011 00:00:00 New Genetic Study Suggests Zebrafish Sex is a Complicated Affair http://www.nigms.nih.gov/News/Results/20110811b.htm Mon, 15 August 2011 11:46:23 EST {30C62F36-5365-4368-9A12-E3D69A9943D9} N/A Thu, 11 August 2011 00:00:00 One Tiny Electron Could Be Key to Future Drugs That Repair Sunburn http://www.nigms.nih.gov/News/Results/osu-20110725.htm Mon, 1 August 2011 12:20:08 EST {C11D999C-F4C3-4749-A19F-F2BBFF7BA90E} N/A Mon, 25 July 2011 00:00:00 Scientists Map Attack Tactics of Plant Pathogen http://www.nigms.nih.gov/News/Results/unc-20110728.htm Mon, 1 August 2011 12:17:01 EST {EE15F31C-1328-448E-B4DB-401D911240AA} N/A Thu, 28 July 2011 00:00:00 Newly Developed Fluorescent Protein Makes Internal Organs Visible http://www.nigms.nih.gov/News/Results/20110717.htm Tue, 26 July 2011 14:59:54 EST {0B2E5E17-2EF4-4291-8CAA-F1A80979DE78} CellularImaging Sun, 17 July 2011 00:00:00 Biologists Discover an 'Evening' Protein Complex That Regulates Plant Growth http://www.nigms.nih.gov/News/Results/20110713.htm Tue, 26 July 2011 10:44:23 EST {91AA54A6-724A-49C5-8524-8D84ABEC0F98} N/A Wed, 13 July 2011 00:00:00 The Unfolding 'SAGA' of Transcriptional Co-Activators http://www.nigms.nih.gov/News/Results/20110714.htm Tue, 26 July 2011 10:43:28 EST {01477E57-B77C-4CAD-89B9-CA09B0026DBB} N/A Thu, 14 July 2011 00:00:00 Study Suggests New Approach for Anti-Flu Drug Development http://www.nigms.nih.gov/News/Results/20110712.htm Wed, 20 July 2011 11:21:45 EST {7EC6B302-5A63-48D5-AEDC-E1BD86360459} ModelingInfectiousDiseases Tue, 12 July 2011 00:00:00 Scientists Discover Mechanism That May Lead to Cancer http://www.nigms.nih.gov/News/Results/20110711A.htm Wed, 20 July 2011 11:15:49 EST {B3BFFAEC-5BFE-405C-A973-4BE7FB9DF8EB} N/A Mon, 11 July 2011 00:00:00 Induced Pluripotent Stem Cell Lines Now Available from the NIGMS Cell Repository http://www.nigms.nih.gov/News/Results/20110627.htm Fri, 15 July 2011 17:16:47 EST {A4E6E66E-2AF2-4D25-8DB7-C5281A606281} HumanGeneticCellRepository Mon, 27 June 2011 00:00:00 Three NIGMS Grantees Receive Nobel Prize in Chemistry for Ribosome Research http://www.nigms.nih.gov/News/Results/nobel_20091007a.htm Fri, 15 July 2011 14:16:19 EST {878D177C-C8EF-4BDF-BCEB-5FF4469AC434} Three NIGMS grantees will share the 2009 Nobel Prize for their “studies of the structure and function of the ribosome.” Nobel Prize Wed, 7 October 2009 00:00:00 New Salmonella-based 'Clean Vaccines' to Aid Fight Against Infectious Disease http://www.nigms.nih.gov/News/Results/salmonella_20110629.htm Wed, 13 July 2011 17:04:00 EST {4DFF3CC1-82A5-46DA-9FA9-21EED5C0E895} N/A Wed, 29 June 2011 00:00:00 Chaotic Methylation Patterns Characterize Cancer Cell DNA http://www.nigms.nih.gov/News/Results/20110626.htm Wed, 13 July 2011 15:19:39 EST {84068B5A-72F2-4188-9799-363C31A65236} N/A Sun, 26 June 2011 00:00:00 New Systems Biology Centers to Study Cellular Response Mechanisms http://www.nigms.nih.gov/News/Results/sysbio_100921.htm Mon, 11 July 2011 09:30:29 EST {6D2EC8EC-B758-424C-8595-ED8BC23675A9} ComplexBiologicalSystemsInitiatives Tue, 21 September 2010 00:00:00 Enzyme’s Inherent Inefficiency Benefits Immune System http://www.nigms.nih.gov/News/Results/20110624.htm Mon, 11 July 2011 08:10:57 EST {2BB07657-F62A-42D8-B89E-B4D98ACDFBD5} N/A Fri, 24 June 2011 00:00:00 New Findings Alter Conventional View of Vision Process http://www.nigms.nih.gov/News/Results/20110623.htm Mon, 11 July 2011 08:10:36 EST {8F4A4A4D-6DB0-484B-9C1C-ED9B7B96EE82} N/A Thu, 23 June 2011 00:00:00 Greenberg Named Acting Director of the National Institute of General Medical Sciences http://www.nigms.nih.gov/News/Results/20110613.htm Fri, 8 July 2011 14:40:47 EST {44F22889-39A4-4C09-8CD5-0C12DC119B94} N/A Mon, 13 June 2011 00:00:00 New Insights Into Origin of Deadly Cancer http://www.nigms.nih.gov/News/Results/20110623C.htm Wed, 6 July 2011 09:06:52 EST {F3F76AE6-6EB8-499A-ACBC-CED15A646127} N/A Thu, 23 June 2011 00:00:00 More Intense Activities While Awake Drives an Increased Need for Sleep in Flies http://www.nigms.nih.gov/News/Results/20110623B.htm Mon, 27 June 2011 17:34:41 EST {B0C6C00B-3C7E-4F0F-BEC1-F39E9A025728} N/A Thu, 23 June 2011 00:00:00 Histamine Receptor Structure Sheds Light on What Causes Allergies http://www.nigms.nih.gov/News/Results/20110623D.htm Mon, 27 June 2011 17:33:59 EST {CF416E35-085C-40B8-97C7-75DD89A1CBE2} ProteinStructureInitiative Thu, 23 June 2011 00:00:00 Social Amoeba Rely on Genetic 'Lock and Key' to Identify Kin http://www.nigms.nih.gov/News/Results/20110623A.htm Mon, 27 June 2011 15:48:17 EST {0480E5CC-3CBF-4C58-829C-24657A4E4E69} N/A Thu, 23 June 2011 00:00:00 Aggressive Use of Medications Could Promote Emergence of Drug-Resistant Pathogens http://www.nigms.nih.gov/News/Results/20110622.htm Fri, 24 June 2011 09:16:27 EST {001F1EC8-25CD-4715-900A-30CF5847858B} N/A Wed, 22 June 2011 00:00:00 Human Retina Protein Can Function as a Magnetic Sensor http://www.nigms.nih.gov/News/Results/20110621A.htm Fri, 24 June 2011 09:15:20 EST {64DF4C71-430C-48DC-B706-EDA990BC9A8B} N/A Tue, 21 June 2011 00:00:00 Antisense RNA linked to Inherited Neurological Disorder http://www.nigms.nih.gov/News/Results/20110621D.htm Fri, 24 June 2011 09:14:21 EST {477A860E-F2C3-44AB-8BFB-B3FBE5F5D6F3} ARRA Tue, 21 June 2011 00:00:00 New Visualization Tool Captures Cell Suicide in Action http://www.nigms.nih.gov/News/Results/20110621C.htm Thu, 23 June 2011 19:05:44 EST {978F1892-F77F-42EA-AC06-BA6C1DEC2841} N/A Tue, 21 June 2011 00:00:00 New Method Enables Researchers to Measure a Cell’s Density http://www.nigms.nih.gov/News/Results/20110621.htm Thu, 23 June 2011 19:05:06 EST {6CAAF8AD-7B43-4A1E-BCB3-A42361AFD706} N/A Tue, 21 June 2011 00:00:00 Changing Genetic ‘Red Light’ to Green Holds Promise for Treating Disease http://www.nigms.nih.gov/News/Results/20110615.htm Wed, 22 June 2011 16:52:52 EST {557B020C-7F3D-4396-A28D-599C8F40F380} N/A Wed, 15 June 2011 00:00:00 Research Uncovers Key Step in How RNA Is Marked for Destruction http://www.nigms.nih.gov/News/Results/20110609.htm Wed, 22 June 2011 16:18:06 EST {A36FF1A8-AAEA-41D9-96E7-4FE775A4D1B9} RNAandRNAinterference Thu, 9 June 2011 00:00:00 Chemists Devise Better Way to Produce Workhorse Molecules http://www.nigms.nih.gov/News/Results/20110609A.htm Wed, 22 June 2011 16:16:28 EST {A361C42F-442C-4EC3-9589-64D0BCB331BB} ChemHealth Thu, 9 June 2011 00:00:00 Computer Analysis Links Splicing Errors to Hundreds of Hereditary Diseases http://www.nigms.nih.gov/News/Results/20110613B.htm Wed, 22 June 2011 15:26:30 EST {37CEF81E-E1AB-4E79-ABD1-BEB8761211E3} N/A Mon, 13 June 2011 00:00:00 Genome Sequences Provide Complete Catalog of Diversity Among Group of Yeasts http://www.nigms.nih.gov/News/Results/20110621B.htm Wed, 22 June 2011 15:23:45 EST {8A489829-A71A-4107-B11E-8FDFC74C1801} N/A Tue, 21 June 2011 00:00:00 Mutation Rate Variation in Mammals Depends Heavily on Generation Time http://www.nigms.nih.gov/News/Results/20110613A.htm Wed, 22 June 2011 15:14:44 EST {F86D753A-AD03-4BD2-8425-BAF4ADA1B932} N/A Mon, 13 June 2011 00:00:00 Discovery Ends 50-Year Search for Calcium Channel http://www.nigms.nih.gov/News/Results/20110619.htm Wed, 22 June 2011 15:11:45 EST {3EAF1396-D999-40A4-8696-735D540E8335} N/A Sun, 19 June 2011 00:00:00 How Cells' Sensory Hairs Are Assembled http://www.nigms.nih.gov/News/Results/20110608.htm Thu, 16 June 2011 14:36:24 EST {71E6D3AC-0103-4DCE-B034-0CB3E10E912A} N/A Wed, 8 June 2011 00:00:00 Study Reveals How Major Biological Sensor in the Body Works http://www.nigms.nih.gov/News/Results/20110606.htm Thu, 16 June 2011 14:35:25 EST {AC3149B5-55FD-4CD5-99EA-BC911A0DB4F4} N/A Mon, 6 June 2011 00:00:00 In Evolution, Genetic Mutations Add Up to Less Than the Sum of the Parts http://www.nigms.nih.gov/News/Results/20110602.htm Thu, 9 June 2011 15:56:15 EST {9B4CD79F-37C8-4DA9-9AA3-3769764D2CC9} N/A Thu, 2 June 2011 00:00:00 New Map of Laboratory Mouse Genome Provides Insight on Key Model Organism http://www.nigms.nih.gov/News/Results/20110529.htm Thu, 9 June 2011 15:55:33 EST {FFE7FF0B-6300-46F0-8F20-324F363DADBB} BioinformaticsAndComputationalBiology Sun, 29 May 2011 00:00:00 Bacterial Protein Caught in the Act of Secreting Sticky Appendages http://www.nigms.nih.gov/News/Results/20110601.htm Thu, 9 June 2011 15:51:38 EST {971DF9BC-39E2-4DFA-8F44-D08B5CE442C1} N/A Wed, 1 June 2011 00:00:00 Team Solves Decades-Old Molecular Mystery Linked to Blood Clotting http://www.nigms.nih.gov/News/Results/20110531.htm Thu, 9 June 2011 15:50:23 EST {E8B76E00-45B9-45CA-B68A-42ED21FD5D7C} N/A Tue, 31 May 2011 00:00:00 Scientists Computationally Design Molecular Scaffolds for Building Nanoscale Devices http://www.nigms.nih.gov/News/Results/20110527.htm Tue, 7 June 2011 10:12:22 EST {5B17B82D-BD45-486D-A798-B21D095C2D7D} BioinformaticsAndComputationalBiology Fri, 27 May 2011 00:00:00 'Policing' Stops Cheaters From Dominating Groups of Cooperative Bacteria http://www.nigms.nih.gov/News/Results/20110526.htm Tue, 7 June 2011 10:11:18 EST {ABB003CA-92D3-411B-AA65-4570F058B89F} N/A Thu, 26 May 2011 00:00:00 Study Identifies Two Gene Classes Involved in Stepwise Formation of Prions http://www.nigms.nih.gov/News/Results/20110526A.htm Thu, 2 June 2011 17:47:37 EST {BFA30778-7593-4F10-824C-42B9D1266C87} N/A Thu, 26 May 2011 00:00:00 Model Predicts How Likely a Drug is to Cause Birth Defects http://www.nigms.nih.gov/News/Results/010411b.htm Thu, 2 June 2011 09:36:18 EST {F3213A5E-AFD4-493A-9D0D-6DBB9F281468} N/A Tue, 4 January 2011 00:00:00 Laboratory Mouse Genome Maps Provide New Tool for Interpreting Data and Designing Experiments http://www.nigms.nih.gov/News/Results/20110529A.htm Wed, 1 June 2011 10:55:13 EST {3FC96D1B-AD84-4A96-B815-CAEF831BBAE0} BioinformaticsAndComputationalBiology Sun, 29 May 2011 00:00:00 Protein Hitches Neurotransmitter Cargo to Nerve Cell Motors http://www.nigms.nih.gov/News/Results/20110525.htm Tue, 31 May 2011 18:07:50 EST {53763236-7AAE-4485-9DD5-66A7A8A60659} N/A Wed, 25 May 2011 00:00:00 Interaction Between Two Common Drugs Can Raise Blood Glucose Levels http://www.nigms.nih.gov/News/Results/20110525A.htm Tue, 31 May 2011 17:37:49 EST {1F1A38EA-167D-43AF-BDED-4C80B2E397C5} PharmacogeneticsResearchNetwork Wed, 25 May 2011 00:00:00 New Imaging Technique Sheds Light on How Nerve Cell Sheaths Break Down in Multiple Sclerosis http://www.nigms.nih.gov/News/Results/20110523A.htm Tue, 31 May 2011 16:55:11 EST {C926A9CF-6CBF-4C2D-8A64-41B54D36AC50} N/A Mon, 23 May 2011 00:00:00 Chromatin ‘Prepatterns’ Contribute to the Liver-Pancreas Cell Fate Decision http://www.nigms.nih.gov/News/Results/05192011.htm Thu, 26 May 2011 14:45:33 EST {9F42001E-5476-441E-A5E3-BAB2B4CBA044} StemCellResearch Thu, 19 May 2011 00:00:00 Study Reveals How Cell’s Protein-Making Machine Bends Without Breaking http://www.nigms.nih.gov/News/Results/20110519.htm Thu, 26 May 2011 13:15:07 EST {D08F1F92-6F44-49E8-AAA8-FE7AD6F7C8D6} ARRA Thu, 19 May 2011 00:00:00 Study Sheds Light on Neural Circuits Roundworms Use to Distinguish Between Gentle and Harsh Touch http://www.nigms.nih.gov/News/Results/05182011.htm Wed, 25 May 2011 16:42:57 EST {4D203370-7B44-4AF5-8192-55708D2A8551} N/A Wed, 18 May 2011 00:00:00 New Technique Sheds Light on the Mysterious Process of Cell Division http://www.nigms.nih.gov/News/Results/20110518.htm Tue, 24 May 2011 17:26:31 EST {64714930-FE09-4A74-AE0E-1879C9C9C777} N/A Wed, 18 May 2011 00:00:00 Body’s Built-In Defense Mechanism Tricks Invading Bacteria Into Self-Destructing http://www.nigms.nih.gov/News/Results/20110523.htm Mon, 23 May 2011 15:07:48 EST {10DE94DE-579F-45CC-8482-19BEC922F280} N/A Mon, 23 May 2011 00:00:00 Sodium Channels Predated Evolution of Animal Nervous Systems http://www.nigms.nih.gov/News/Results/05172011.htm Fri, 20 May 2011 17:28:35 EST {FC6876E4-A9A9-466D-ABAE-624AF6383A5A} N/A Tue, 17 May 2011 00:00:00 Powerful Technique Helps Reveal How Key Molecular Switch is Activated http://www.nigms.nih.gov/News/Results/05172011A.htm Fri, 20 May 2011 17:26:16 EST {0174D90A-AB08-4B22-981B-BF1F3E553347} N/A Tue, 17 May 2011 00:00:00 Zebrafish Regrow Fins Using Distinct Classes of Stem Cells http://www.nigms.nih.gov/News/Results/05162011.htm Fri, 20 May 2011 17:25:26 EST {8F03914A-1A66-4CEF-868B-3BAE54EAC56E} StemCellResearch Mon, 16 May 2011 00:00:00 Study Uncovers Link between Mechanical Stress on Cells and Cancer Gene Activation http://www.nigms.nih.gov/News/Results/05162011A.htm Fri, 20 May 2011 13:59:24 EST {E8D93BB3-14FA-4CCE-A0C2-7652B86D2795} ARRA Mon, 16 May 2011 00:00:00 Computer Models and Fuzzy Logic Used to Understand Cellular Aging http://www.nigms.nih.gov/News/Results/20100617.htm Thu, 19 May 2011 09:55:24 EST {A8BA82F5-35AC-4EA7-A393-05AA5122F24F} BioinformaticsAndComputationalBiology Thu, 17 June 2010 00:00:00 DNA’s Large Repository of Active Regulatory Elements Enables Dramatic Reprogramming of Gene Expression http://www.nigms.nih.gov/News/Results/20110515.htm Wed, 18 May 2011 15:06:46 EST {0DA96FFC-3266-4EFD-9F3D-3372323CF6BC} N/A Sun, 15 May 2011 00:00:00 New Tool for Turning Genes on and Off Could Help Uncover Protein Functions http://www.nigms.nih.gov/News/Results/20110508.htm Wed, 18 May 2011 11:31:54 EST {696898ED-3DA4-419B-A9D1-45FCD4A71069} N/A Sun, 8 May 2011 00:00:00 Researchers Use New Method to Solve Baffling Puzzles in Protein Structure http://www.nigms.nih.gov/News/Results/20110501.htm Mon, 16 May 2011 12:24:19 EST {66D003AA-1244-4320-9DA7-78AD986EDA6A} ProteinStructureInitiative Sun, 1 May 2011 00:00:00 Protein Found to Play a Key Role in the ‘Controlled Demolition’ That Helps Create Sperm http://www.nigms.nih.gov/News/Results/20110429.htm Mon, 16 May 2011 12:21:28 EST {FAE71C29-652A-4F7D-96BF-3130301FBC58} N/A Fri, 29 April 2011 00:00:00 NIGMS Issues Its First Strategic Plan for Research Training http://www.nigms.nih.gov/News/Results/20110428.htm Wed, 11 May 2011 14:23:31 EST {B0C64A79-E61D-457D-A1E0-360F7B62F718} N/A Thu, 28 April 2011 00:00:00 Bacteria Found to Resist Antibiotics Using a Unique Chemical Mechanism http://www.nigms.nih.gov/News/Results/20110428C.htm Fri, 6 May 2011 14:20:40 EST {76A5FC31-E4E8-4D1A-B720-2A2184C675C6} N/A Thu, 28 April 2011 00:00:00 Virginia Tech Researchers Awarded Grant to Develop Systems Biology Approaches to Study Cells http://www.nigms.nih.gov/News/Results/20110504.htm Thu, 5 May 2011 11:59:00 EST {1E8A2B64-44C3-4D88-98CB-26E1A37A27CC} N/A Wed, 4 May 2011 00:00:00 Selfish Genes Harnessed in Fight Against Malaria-Transmitting Mosquitoes http://www.nigms.nih.gov/News/Results/20110421G.htm Wed, 4 May 2011 17:46:59 EST {E80A4EE9-C558-4614-8562-AEF96A453770} N/A Thu, 21 April 2011 00:00:00 Scientists Use a New Technique to Build a Worm Gene Network http://www.nigms.nih.gov/News/Results/20110428A.htm Tue, 3 May 2011 17:10:32 EST {EA197214-24D7-4B71-8137-C9EA0FC4C6D0} N/A Thu, 28 April 2011 00:00:00 Scorpion Venom Discovery Offers New Way to Protect Plants from Bugs http://www.nigms.nih.gov/News/Results/20110427.htm Fri, 29 April 2011 17:09:34 EST {2B64AEB8-80C3-49AE-B552-C630297E0EFD} N/A Wed, 27 April 2011 00:00:00 Global Alliance for Pharmacogenomics Grows to 18 Projects http://www.nigms.nih.gov/News/Results/gap_100515.htm Fri, 29 April 2011 15:27:47 EST {BE7ABA07-82AB-48F3-BC8B-A94791B6C00E} PharmacogeneticsResearchNetwork Fri, 21 May 2010 00:00:00 DNA Reshuffling in Worms Offers Insight on How Tumors Develop http://www.nigms.nih.gov/News/Results/20110421D.htm Thu, 28 April 2011 17:17:35 EST {4B2B62F1-E67D-4DB8-A795-C10886A309B9} TelomeresAndTelomerase Thu, 21 April 2011 00:00:00 ‘Going Off the Grid’ Helps Some Bacteria Hide from Antibiotics http://www.nigms.nih.gov/News/Results/20110425.htm Thu, 28 April 2011 17:16:31 EST {D91DDD9D-D88B-479B-8B59-0E1BDF89D91C} N/A Mon, 25 April 2011 00:00:00 Scientists Reveal a New Ending to an Old 'Tail' http://www.nigms.nih.gov/News/Results/20110421A.htm Thu, 28 April 2011 17:14:49 EST {E1733183-9314-4053-A7AB-A1770BEB8B54} TelomeresAndTelomerase Thu, 21 April 2011 00:00:00 Nature’s Elegant Solution to Repairing DNA Offers New Way to Target Cancer http://www.nigms.nih.gov/News/Results/20110420.htm Thu, 28 April 2011 13:55:58 EST {D15F4F75-0B9C-465A-95C3-58872E0A9D0F} ARRA Wed, 20 April 2011 00:00:00 Researchers Observe Activity of a Single Gene in Living Cells http://www.nigms.nih.gov/News/Results/20110421C.htm Thu, 28 April 2011 13:54:20 EST {01A0B01B-7171-4F57-81BA-EB8DCB98637C} N/A Thu, 21 April 2011 00:00:00 NIGMS Director Berg Receives Chemical Society’s Public Service Award http://www.nigms.nih.gov/News/Results/20110413.htm Wed, 27 April 2011 17:25:24 EST {F7A9A6D8-0094-456A-AD6C-EE5F58C2CA8E} N/A Wed, 13 April 2011 00:00:00 Study of Sugars on Cell Surface Identifies Key Factor in Flu Infection http://www.nigms.nih.gov/News/Results/NIGMS01072008.htm Wed, 27 April 2011 10:11:50 EST {03FFECA0-A7FC-4B1D-BEEF-B30037289A5F} NIGMS-supported scientists have identified a key factor that determines the ability of influenza viruses to infect cells of the human upper respiratory tract. GlueGrants Mon, 7 January 2008 00:00:00 RNA Nanoparticles Deliver Long-Lasting Therapy to Cells http://www.nigms.nih.gov/News/Results/20110421F.htm Mon, 25 April 2011 16:42:08 EST {1C122DC1-A2DA-4FE3-8B0C-68973E7344E6} N/A Thu, 21 April 2011 00:00:00 Disrupting Bacterial Communication Could Block Virulence http://www.nigms.nih.gov/News/Results/20110421E.htm Mon, 25 April 2011 16:38:56 EST {6D6EAACD-81F8-42A7-B91B-697F98DEBC92} N/A Thu, 21 April 2011 00:00:00 New Findings Suggest a Way to Prevent Heart Failure During Sepsis http://www.nigms.nih.gov/News/Results/20110411B.htm Mon, 25 April 2011 16:20:49 EST {133149F5-52E4-4787-A6AC-C8FF7536035F} N/A Mon, 11 April 2011 00:00:00 Stockpiling Cholera Vaccine Could Have Blunted Haiti Epidemic http://www.nigms.nih.gov/News/Results/20110411.htm Mon, 25 April 2011 16:19:51 EST {9BFE6DF3-2BEC-416C-A838-6786672246B1} ModelingInfectiousDiseases Mon, 11 April 2011 00:00:00 Single-Celled Fungus Reveals Clue to How Immune System Works http://www.nigms.nih.gov/News/Results/20110421B.htm Mon, 25 April 2011 16:10:54 EST {5429DDF4-41C1-4CE1-83D6-23DCF5C72CEB} N/A Thu, 21 April 2011 00:00:00 Compound Holds Promise for Treating Multiple Sclerosis http://www.nigms.nih.gov/News/Results/20110417.htm Mon, 25 April 2011 15:53:17 EST {5E0A73AC-524D-4D26-98AB-D829EC97AB06} N/A Sun, 17 April 2011 00:00:00 NIH Grants Will Advance Studies of the Form and Function of Proteins http://www.nigms.nih.gov/News/Results/20100930.htm Sun, 24 April 2011 10:09:08 EST {DF39D18C-70F2-4029-A8D3-E8126A780FB6} ProteinStructureInitiative Thu, 30 September 2010 00:00:00 New Grants Expand U.S. Infectious Disease Modeling Effort http://www.nigms.nih.gov/News/Results/MIDAS200909.htm Sat, 23 April 2011 11:58:52 EST {93CD5546-4AB7-4264-899F-6738274DD349} MIDAS adds new research expertise to simulate disease spread, evaluate different intervention strategies and help inform public health officials and policymakers. ModelingInfectiousDiseases Thu, 3 September 2009 00:00:00 NIH Study Models H1N1 Flu Spread http://www.nigms.nih.gov/News/Results/h1n1_092110.htm Sat, 23 April 2011 11:45:31 EST {3221B613-E73E-4109-B79A-68ECE5AA8014} ModelingInfectiousDiseases Tue, 21 September 2010 00:00:00 NIGMS Pledges Over $48 Million to Create Chemical Techniques and Libraries http://www.nigms.nih.gov/News/Results/20081001_announce.htm Sat, 23 April 2011 06:00:29 EST {007211F6-0FC7-444B-B462-9D474CD8A9DE} NIGMS pledges over $48 million over 5 years to support five Centers of Excellence in Chemical Methodologies and Library Development (CMLD). ChemicalMethodologiesAndLibraryDevelopment Wed, 1 October 2008 00:00:00 Drug Kills Cells through Novel Mechanism http://www.nigms.nih.gov/News/Results/20091210B.htm Fri, 11 December 2009 16:09:07 EST {001A8C49-C4DB-42A9-B0E5-C6A4699F04CD} NIGMS-supported researchers have discovered that the drug hydroxyurea kills bacteria by inducing them to produce molecules toxic to themselves, a finding that raises the possibility of finding new antibiotics that use similar mechanisms. N/A Thu, 10 December 2009 00:00:00 How Cell-Cycle Proteins Are Targeted for Destruction http://www.nigms.nih.gov/News/Results/20091202.htm Wed, 9 December 2009 19:35:30 EST {003F4554-798C-4E8C-8A1F-042942E8AF8D} NIGMS-supported researchers have viewed for the first time the previously mysterious process by which long chains of a protein called ubiquitin are added to proteins that control the cell cycle. N/A Wed, 2 December 2009 00:00:00 In Bacterial World, Sex is Linked to Virulence http://www.nigms.nih.gov/News/Results/090810c.htm Wed, 8 September 2010 17:07:15 EST {00450513-5D58-42D7-9AF6-D269CA173443} N/A Wed, 8 September 2010 00:00:00 Bacterial Clustering Triggers Blood Clotting http://www.nigms.nih.gov/News/Results/11022008.htm Mon, 17 November 2008 12:22:49 EST {00973219-8631-4A03-A47C-27DADCD27580} Blood clots, which sometimes form during severe bacterial infections, arise in response to bacterial clustering, according to an NIGMS-supported study. N/A Sun, 2 November 2008 00:00:00 Synthetic Protein Mimics Natural Counterpart http://www.nigms.nih.gov/News/Results/20091210.htm Fri, 18 December 2009 19:58:19 EST {00F6EC68-65B4-4617-B9C0-5F3D18A738CF} NIGMS-supported scientists have designed a synthetic protein that is both a structural and functional model of a native protein, nitric-oxide reductase. MetalsInMedicine Thu, 10 December 2009 00:00:00 Protein Mimic Made of Different Building Blocks http://www.nigms.nih.gov/News/Results/020507d.htm Mon, 16 March 2009 08:46:16 EST {0131A5FA-9C37-4A3D-820D-E1DEAFD7237D} NIGMS-funded chemists have built and analyzed a molecule that folds into a protein-like structure yet is made of different building blocks. N/A Mon, 5 February 2007 00:00:00 Model Simulates the Complex Signaling Patterns Involved in Stem Cell and Embryonic Development http://www.nigms.nih.gov/News/Results/030910b.htm Fri, 19 March 2010 14:45:49 EST {0192DC6F-DA7E-46C5-8140-5407DEED68EB} N/A Tue, 9 March 2010 00:00:00 Single Molecule Approach Reveals How Helicase Enzyme Helps Repair Damaged DNA http://www.nigms.nih.gov/News/Results/20100820.htm Wed, 25 August 2010 16:34:45 EST {02403E15-886B-4A18-8595-F017461597B4} SingleMoleculeDetectionAndManipulation Fri, 20 August 2010 00:00:00 Computational Technique Allows Easy Comparison of Genomes http://www.nigms.nih.gov/News/Results/012809d.htm Fri, 6 February 2009 17:51:22 EST {026C708A-40F0-456F-9AF2-1ADA03DEEED1} NIGMS-funded researchers have created a method for comparing entire genomes that are vastly different from each other. BioinformaticsAndComputationalBiology Wed, 28 January 2009 00:00:00 NIH Funds Multicenter "Glue Grant" to Study Enzyme Function http://www.nigms.nih.gov/News/Results/gluegrant_052110.htm Mon, 24 May 2010 10:12:10 EST {02F872FB-C149-4F79-962E-38279FAE3BB7} GlueGrants Fri, 21 May 2010 00:00:00 A Fingerprint of Evolution in the Human Genome http://www.nigms.nih.gov/News/Results/040808.htm Mon, 25 October 2010 13:32:45 EST {03449499-8B8C-4101-8EDB-1216C07B8C54} At least a third of the genome is affected by "fingerprints" that are conserved even though they don't code for protein, reports an NIGMS-funded study. N/A Tue, 8 April 2008 00:00:00 How Butterflies Sense the Earth's Magnetic Field http://www.nigms.nih.gov/News/Results/012510b.htm Thu, 4 February 2010 11:48:40 EST {035296A2-E0B1-4220-B534-4E539C96B32C} NIGMS-funded neurobiologists linked two related photoreceptor proteins found in butterflies to navigation using the Earth's magnetic field. N/A Mon, 25 January 2010 00:00:00 Supercomputer Helps Track Oxygen in Myoglobin http://www.nigms.nih.gov/News/Results/070108.htm Thu, 10 July 2008 12:33:17 EST {03A2ED2D-3B76-42E7-942F-3D2F1BB7B1A6} A half century after the structure of myoglobin was solved, NIGMS-funded researchers discovered exactly how oxygen moves in the protein. BioinformaticsAndComputationalBiology Tue, 1 July 2008 00:00:00 Dryness of Weather May be Why Flu Peaks in Winter and Could Predict Outbreak Severity http://www.nigms.nih.gov/News/Results/022210a.htm Mon, 1 March 2010 15:36:24 EST {03B2E1BC-EEE4-4C5C-9E23-960634F4888D} ModelingInfectiousDiseases Mon, 22 February 2010 00:00:00 Hybrid Molecule Causes Cancer Cells to Self-Destruct http://www.nigms.nih.gov/News/Results/20070103.htm Mon, 16 March 2009 09:22:02 EST {0400F38F-7597-4C26-80D3-FB47C90A204E} By joining a sugar to a short-chain fatty acid compound, NIGMS-supported researchers have developed a two-pronged molecular weapon that kills cancer cells in lab tests. N/A Wed, 3 January 2007 00:00:00 Unmoving Cilium Works Like an Antenna To Respond to Outside Signals http://www.nigms.nih.gov/News/Results/062410a.htm Wed, 30 June 2010 21:32:28 EST {042B291A-9472-42BE-8530-B32DA626D6E3} N/A Thu, 24 June 2010 00:00:00 How Flies Fight Wasp Infection Has Parallels With Development of Cancer http://www.nigms.nih.gov/News/Results/010311.htm Fri, 14 January 2011 13:08:43 EST {045EB61E-6004-445A-9E47-DB86675DE1C0} N/A Mon, 3 January 2011 00:00:00 How to Steer a Moving Cell http://www.nigms.nih.gov/News/Results/050707b.htm Fri, 18 May 2007 13:19:40 EST {047FEAF4-035C-4378-8525-D805DC7F6065} NIGMS-funded researchers have developed a comprehensive profile of the proteins involved in cell migration, a process integral to the spread of cancer and other diseases. GlueGrants Mon, 7 May 2007 00:00:00 Trawling Through Fish DNA Yields Insight for Mammals http://www.nigms.nih.gov/News/Results/091908a.htm Fri, 3 October 2008 10:42:29 EST {049E6306-4A5A-4D42-A145-31B61BF72993} A study supported in part by NIGMS has discovered master controllers of a gene critical to mammalian development. N/A Fri, 19 September 2008 00:00:00 Genome of Chlamydomonas Alga http://www.nigms.nih.gov/News/Results/101107b.htm Fri, 19 October 2007 15:41:24 EST {051007CC-E8E8-4CF7-A4AB-8B5EC9DBDA3A} Researchers from around the world, funded in part by NIGMS, have sequenced the genome of a green alga, revealing genes relating to photosynthesis and cilia, whose dysfunction causes human diseases. N/A Thu, 11 October 2007 00:00:00 Researchers Dissect How Fruit Flies Decide to Fight http://www.nigms.nih.gov/News/Results/112310.htm Thu, 2 December 2010 15:29:56 EST {05132A39-A6CB-4DA7-903B-48E0DCE518EF} N/A Tue, 23 November 2010 00:00:00 Stimulus Grants to Emory Fund 'Omics Research http://www.nigms.nih.gov/News/Results/102009a.htm Mon, 26 July 2010 10:38:04 EST {051AAA33-3966-4E17-948B-ABAD928E530E} NIH stiumulus grants to Emory include an NIGMS-funded study of the genome of voles, which are a good model for studying social attachment. ARRA Tue, 20 October 2009 00:00:00 How Plants Defend Themselves From Bacteria http://www.nigms.nih.gov/News/Results/110509a.htm Tue, 17 November 2009 17:19:46 EST {05222009-DF44-4FD2-9929-15C069846E20} An NIGMS-funded plant pathologist has shown how a receptor molecule in plants pairs with a specific molecule on invading bacteria, triggering an immune reaction. N/A Thu, 5 November 2009 00:00:00 Technique Will Produce Better Chromosome Map http://www.nigms.nih.gov/News/Results/050707.htm Mon, 14 May 2007 14:57:05 EST {058ABDE7-7A28-4866-B3DE-4CC2061DCAD1} Innovations in preparing fruit fly chromosomes for viewing will produce clearer images containing more information, report NIGMS-funded biologists. N/A Mon, 7 May 2007 00:00:00 Splicing Defect Underlies a Rare Form of Dwarfism http://www.nigms.nih.gov/News/Results/20110407A.htm Wed, 13 April 2011 10:08:02 EST {05ACBBF2-2BFE-4FC9-AA87-83B0FDE9F78E} RNAandRNAinterference Thu, 7 April 2011 00:00:00 NIH Grant to Establish Membrane Protein Structural Biology Consortium http://www.nigms.nih.gov/News/Results/psi_101124.htm Mon, 7 March 2011 09:27:18 EST {05DAC7A1-696A-4B7D-86B0-6C76BE8DE9AD} ProteinStructureInitiative Wed, 24 November 2010 00:00:00 Reprogramming Human Cells Without Inserting Genes http://www.nigms.nih.gov/News/Results/20090729B.htm Mon, 25 October 2010 13:40:43 EST {0723812E-A28E-4A56-B39E-A67F98F0C18C} An NIGMS-supported research team has discovered a novel way to turn on stem cell genes in human skin cells without the risks associated with inserting extra genes or using viruses. StemCellResearch Wed, 29 July 2009 00:00:00 Asking ‘What If?’ About H1N1 http://www.nigms.nih.gov/News/Results/midas_12012010.htm Thu, 2 December 2010 08:25:38 EST {0778A66E-77D3-469E-A74F-DD6FE6879DCD} ModelingInfectiousDiseases Wed, 1 December 2010 00:00:00 Artificial Nose Built on DNA Backbone Changes Color When it Detects Certain Scents http://www.nigms.nih.gov/News/Results/20100819.htm Wed, 25 August 2010 16:33:45 EST {07A6BD54-41EF-460A-A95C-66DDD81D5A8B} ChemHealth Thu, 19 August 2010 00:00:00 Whole Genome Sequencing of Family of Four Reveals New Genetic Power http://www.nigms.nih.gov/News/Results/031110b.htm Tue, 23 March 2010 13:45:38 EST {08058F9F-BF56-4DC0-9063-5CB72DA96C7A} N/A Thu, 11 March 2010 00:00:00 Oliver Smithies Wins 2007 Nobel Prize http://www.nigms.nih.gov/News/Results/10082007e.htm Fri, 14 November 2008 15:16:49 EST {082DADD1-2158-4ED0-B404-9B78EB5DA105} NIGMS grantee Oliver Smithies shares the 2007 Nobel Prize in physiology or medicine for pioneering work on gene targeting. Nobel Prize Mon, 8 October 2007 00:00:00 New Four-Step Approach to Genome Annotation http://www.nigms.nih.gov/News/Results/20091109.htm Wed, 18 November 2009 14:01:25 EST {0837A652-3759-4C84-AA3C-917FD085BF6B} A team of NIGMS-supported bioengineers has taken some of the guesswork out of genome annotation with a new four-step method. BioinformaticsAndComputationalBiology Mon, 9 November 2009 00:00:00 Extremophiles Evolved a Strange Molecular Trick http://www.nigms.nih.gov/News/Results/043009d.htm Fri, 15 May 2009 14:51:00 EST {08A25D42-DD26-4D68-BA22-AD380E4FBE88} NIGMS-funded researchers have found a mutation that may help an organism that grows in thermal vents survive. N/A Thu, 30 April 2009 00:00:00 Tool Uses Light to Move Individual Molecules in Living Cells http://www.nigms.nih.gov/News/Results/031611a.htm Wed, 23 March 2011 15:11:31 EST {09A802D0-4349-40A9-AEC1-1A7395D232DC} N/A Wed, 16 March 2011 00:00:00 Scientists Propose New Model for Ion Channel Regulation http://www.nigms.nih.gov/News/Results/20080130A.htm Thu, 7 February 2008 11:05:58 EST {0A2B1D8C-6C0B-4441-98EE-A322332249B2} A study supported by NIGMS proposes that bubbles may control the opening and closing of ion channels, conduits that controls a wide range of biological functions. N/A Wed, 30 January 2008 00:00:00 Genetic Pathways Involved in Form of Cell Suicide http://www.nigms.nih.gov/News/Results/121407a.htm Sat, 22 December 2007 13:06:19 EST {0A477958-7153-47FB-AE10-76DDF9EFB0CD} Using fly salivary glands, NIGMS-funded researchers are studying autophagy, a form of programmed cell death required for healthy development. N/A Fri, 14 December 2007 00:00:00 NIGMS Awards Contract to Expand Human Genetic Cell Repository http://www.nigms.nih.gov/News/Results/hgcr_011025.htm Tue, 2 February 2010 14:42:39 EST {0A54E19A-1A06-4996-8A10-FBC6C075BF0F} NIGMS has awarded a $27 million, five-year contract to the Coriell Institute for Medical Research to continue and expand operation of the NIGMS Human Genetic Cell Repository. HumanGeneticCellRepository Mon, 25 January 2010 00:00:00 Largest-Ever Study on African Genetics http://www.nigms.nih.gov/News/Results/043009b.htm Tue, 19 May 2009 14:26:57 EST {0A82A4AA-B50E-4C82-9614-0C262086D4D3} A 10-year study funded in part by NIGMS has produced an unprecedented amount of genetic data about Africans, demonstrating the great diversity on the continent. N/A Thu, 30 April 2009 00:00:00 Engineers Build Mini Drug-Producing Factories in Yeast http://www.nigms.nih.gov/News/Results/20080815.htm Fri, 22 August 2008 15:24:14 EST {0A88ECD0-1874-42E2-B81C-6999D6B8A997} NIGMS-supported researchers have developed a novel way to churn out large quantities of drugs, including antibiotics and morphine, in yeast. N/A Fri, 15 August 2008 00:00:00 Structure of Pumps That Make Bacteria Antibiotic Resistant http://www.nigms.nih.gov/News/Results/092310a.htm Tue, 28 September 2010 13:57:54 EST {0ADC0390-CF79-466B-B6FE-CA18931F9ADA} N/A Thu, 23 September 2010 00:00:00 An Automated Way to Determine Possible Drug Structures http://www.nigms.nih.gov/News/Results/033108a.htm Mon, 7 April 2008 14:30:19 EST {0AF50514-300B-4FB2-9269-71BA277DFB3D} An NIGMS-funded study reports a way to quickly determine the structure of natural peptides, which have shown promise as all kinds of drugs. N/A Mon, 31 March 2008 00:00:00 "Junk DNA" in Human Genes Can Alter Pace of Protein Production http://www.nigms.nih.gov/News/Results/022811.htm Wed, 9 March 2011 17:05:24 EST {0B31D269-028C-45A5-8E88-414B57934DAD} N/A Mon, 28 February 2011 00:00:00 How microRNAs Control Gene Expression http://www.nigms.nih.gov/News/Results/070907.htm Thu, 19 July 2007 12:52:50 EST {0B3D3A5E-8C3C-4ED1-94D4-EEF867079B90} NIGMS-funded researchers have determined how microRNAs team up with a regulatory protein to halt protein production. N/A Mon, 9 July 2007 00:00:00 UGA Researchers Win $9.2 Million Stem Cell Grant from the National Institutes of Health http://www.nigms.nih.gov/News/Results/20080804B.htm Tue, 5 August 2008 10:24:21 EST {0B6A0CD5-B740-49A5-BB1F-AF38D54DC85D} University of Georgia researcher Stephen Dalton will lead a new research program focused on understanding the unique properties of embryonic stem cells. StemCellInitiatives Mon, 4 August 2008 00:00:00 Dividing Cells Feel Their Way To Symmetry http://www.nigms.nih.gov/News/Results/091009c.htm Mon, 21 September 2009 17:44:52 EST {0C101586-D87A-4BF1-9DEB-655D97738AA3} NIGMS-funded biologists have discovered the molecular sensor that lets cell feel changes to their shapes and remodel themselves back into symmetry. N/A Thu, 10 September 2009 00:00:00 Engineered Molecule Protects Cells Against HIV http://www.nigms.nih.gov/News/Results/20090817C.htm Mon, 31 August 2009 17:10:55 EST {0C8FB8B6-1991-452B-86D6-1090AFC646A6} A team of NIGMS researchers has created a set of peptide-like molecules that successfully block HIV infection of human cells in laboratory experiments. N/A Mon, 17 August 2009 00:00:00 Solution of Structures Could Lead to Rational Design of Fluorescent Proteins With New Colors http://www.nigms.nih.gov/News/Results/042210b.htm Sat, 1 May 2010 21:10:19 EST {0C903DBD-BD61-4A5F-8174-986601807B95} CellularImaging Thu, 22 April 2010 00:00:00 Cilia Protein Found to Play a Role in Cell Division http://www.nigms.nih.gov/News/Results/20110404.htm Thu, 7 April 2011 18:55:19 EST {0CA1E7D0-26D0-49BC-835D-5D62677F85BD} N/A Mon, 4 April 2011 00:00:00 Clock Gene Plays Role in Weight Gain http://www.nigms.nih.gov/News/Results/051607.htm Thu, 7 June 2007 13:09:31 EST {0CB61518-BFAD-4CBB-B990-065E22DA1200} A gene involved in the regulation of the body's daily biological rhythms also appears to be involved in metabolism and weight gain, report NIGMS-funded biologists. N/A Wed, 16 May 2007 00:00:00 How Cells Regulate Hydrogen Peroxide http://www.nigms.nih.gov/News/Results/010208b.htm Thu, 10 January 2008 14:27:03 EST {0D46A947-026C-4A04-9EDD-4AE7E7094582} A snapshot of how two proteins interact, determined by NIGMS-funded researchers, helps show how cells control levels of hydrogen peroxide. N/A Wed, 2 January 2008 00:00:00 Checkpoint in Cell Cycle Discovered http://www.nigms.nih.gov/News/Results/080608b.htm Mon, 18 August 2008 06:50:30 EST {0D5253DF-573E-47C9-991B-627E32E47224} NIGMS-funded researchers have detailed the role of a newly discovered protein important to controlling cell division. N/A Wed, 6 August 2008 00:00:00 Cholesterol-Reducing Drugs May Lessen Brain Function http://www.nigms.nih.gov/News/Results/022309c.htm Mon, 23 March 2009 15:17:42 EST {0D55DE6F-E01E-476B-8AD8-943F261E7B15} An NIGMS-funded study suggests that by inhibiting the liver from making cholesterol, statins could inhibit brain function. N/A Mon, 23 February 2009 00:00:00 New Chemical Agents May Enable Study of Membrane Protein Structures http://www.nigms.nih.gov/News/Results/110110b.htm Fri, 5 November 2010 18:00:32 EST {0DB6E40D-2763-4E3D-A15A-108EA02B4401} N/A Mon, 1 November 2010 00:00:00 Environment Plays a Large Role in Human Gene Activity http://www.nigms.nih.gov/News/Results/042208b.htm Thu, 20 August 2009 10:18:47 EST {0DC9C9A0-3231-46DE-894F-38C8BCC90D11} An NIGMS-funded study found that up to one-third of genes' expression varies depending on where and how Berbers in Morocco live. N/A Tue, 22 April 2008 00:00:00 Switch Triggers Cancer-Like Response in Stem Cells http://www.nigms.nih.gov/News/Results/101708a.htm Fri, 17 October 2008 17:26:54 EST {0E06BB91-54E5-4A0B-9292-8D2D0CDB7103} NIGMS-funded researchers have shown that electrical signals are a powerful control mechanism for modulating embryonic stem cell behavior. StemCellResearch Fri, 17 October 2008 00:00:00 Same Kinds of Circadian Rhythms Control Cyanobacteria Division and Human Sleep http://www.nigms.nih.gov/News/Results/031910a.htm Tue, 30 March 2010 18:05:39 EST {0E10BFCD-8D59-47DF-AD3F-DA6001001372} ChemHealth Fri, 19 March 2010 00:00:00 Catalyst Mimics Nature's "Hydrogen Economy" http://www.nigms.nih.gov/News/Results/051809c.htm Thu, 4 June 2009 14:23:11 EST {0E91AEF4-85A0-4EC6-8ACB-C1FA2ED5120C} NIGMS-supported chemists have discovered a catalyst that acts like nature's most pervasive hydrogen processor. N/A Mon, 18 May 2009 00:00:00 Major Advance in Use of Microscopy Tracks Movement of RNA Out of Nucleus http://www.nigms.nih.gov/News/Results/091510.htm Tue, 21 September 2010 07:51:30 EST {0F0F823B-E644-4617-9FAF-9C3AD0F86E20} CellularImaging Wed, 15 September 2010 00:00:00 Small Molecules Mimic Natural Gene Regulators http://www.nigms.nih.gov/News/Results/060309a.htm Fri, 12 June 2009 13:41:40 EST {106E1B79-04CE-4894-A196-36FF1054D842} NIGMS-funded researchers have developed small molecules that mimic the behavior and function of large natural regulators of gene expression. N/A Wed, 3 June 2009 00:00:00 Snapshot Clarifies How Materials Enter Cells http://www.nigms.nih.gov/News/Results/113007.htm Mon, 10 December 2007 16:24:52 EST {10999457-F638-4BA1-8C6F-BA5431F70F9D} NIGMS-funded researchers have obtained a snapshot of a tiny protein gate found in cell membranes as material passes through. N/A Fri, 30 November 2007 00:00:00 Twice the Telomere Options in Roundworms http://www.nigms.nih.gov/News/Results/030608a.htm Wed, 12 March 2008 19:48:55 EST {10E7ECD4-4EFA-4833-B1C5-8CCA75572D74} NIGMS-funded researchers have discovered that C. elegans can cap their chromosomes with two different types of telomeres, a finding with implications for aging and cancer. TelomeresAndTelomerase Thu, 6 March 2008 00:00:00 Structure-Building Role for RNAs http://www.nigms.nih.gov/News/Results/030309.htm Thu, 16 September 2010 13:29:23 EST {10EB993D-4B5D-4330-A5BF-E8230B918D99} NIGMS-funded researchers have discovered a unique role for two RNAs; they organize and maintain a compartment within the nucleus. RNAandRNAinterference Tue, 3 March 2009 00:00:00 Discovery of Step in Plant Hormone Synthesis Has Implications for Agriculture http://www.nigms.nih.gov/News/Results/012311.htm Wed, 26 January 2011 16:44:04 EST {11235928-C6F7-41C7-B05F-AA7FF4621789} N/A Sun, 23 January 2011 00:00:00 Migration from Africa Left Mark on European Genetic Diversity http://www.nigms.nih.gov/News/Results/022008b2.htm Fri, 22 February 2008 16:49:44 EST {112B5FA2-4029-41B4-9A17-0E32905394F7} An NIGMS-funded study examining genetic variation found unexpected differences between European-Americans and African-Americans. N/A Wed, 20 February 2008 00:00:00 Probe Can Reveal Protein Interactions http://www.nigms.nih.gov/News/Results/062708b.htm Thu, 10 July 2008 12:32:06 EST {11378746-05FE-44C5-B24E-DBB375018B7D} A new type of probe can be used to see thousands of interactions between proteins in a living cell, report NIGMS-funded researchers. N/A Fri, 27 June 2008 00:00:00 Researchers Image Glycans, Key Regulators of Development, Shortly After Fertilization http://www.nigms.nih.gov/News/Results/052810a.htm Thu, 3 June 2010 13:55:57 EST {11477E2C-1E9F-4DA2-B9AD-9D425CCCB63C} N/A Fri, 28 May 2010 00:00:00 Action of Protein Involved in Stem Cell Maintenance and Cancer Depends on Context http://www.nigms.nih.gov/News/Results/033011.htm Tue, 5 April 2011 17:44:37 EST {11984EDA-3817-4577-8AD3-A26D7048E238} StemCellResearch Wed, 30 March 2011 00:00:00 Method Efficiently Synthesizes Gene Sequences That Code for Repetitive Protein Polymers http://www.nigms.nih.gov/News/Results/012511.htm Tue, 1 February 2011 16:53:57 EST {11A69F21-BBAA-412D-80CF-164EC647DAD9} N/A Tue, 25 January 2011 00:00:00 Disorders May Be Linked to Protein Recycling System http://www.nigms.nih.gov/News/Results/122007a.htm Mon, 7 January 2008 12:07:18 EST {11BF2C17-7B12-44F7-B60B-C35FB26D503E} Failures in a recycling system for Wnt signaling proteins may be responsible for diseases ranging from cancer to birth defects, report NIGMS-funded researchers. N/A Thu, 20 December 2007 00:00:00 Illuminating Protein Networks in One Step http://www.nigms.nih.gov/News/Results/012510a.htm Thu, 4 February 2010 11:47:57 EST {1200ED5A-4337-4BBF-BFB7-791450EE4581} With NIGMS support, researchers have invented a way to examine hundreds of proteins at once. ComplexBiologicalSystemsInitiatives Mon, 25 January 2010 00:00:00 Discovery of 'Overdrive' Protein Could Broaden Drug Design Options http://www.nigms.nih.gov/News/Results/02122008.htm Thu, 14 February 2008 17:00:01 EST {12102581-4733-4B23-B469-80C238301D9D} A team of NIGMS-supported scientists has revealed that a protein called Arr4 can sustain the activity of G-protein signaling pathways, which are targeted by a number of commonly used medicines. N/A Tue, 12 February 2008 00:00:00 Electrons Travel Like Subway Commuters http://www.nigms.nih.gov/News/Results/020107a.htm Tue, 6 February 2007 14:46:22 EST {128B969F-AA4A-40E3-83A7-40EBAAEBF714} A study funded by NIGMS has uncovered details about the varied routes that electrons can take through energy-producing electron-transfer proteins, unifying many years' worth of data. N/A Thu, 1 February 2007 00:00:00 Two-Protein Team Allows Roots to Grow http://www.nigms.nih.gov/News/Results/041907.htm Wed, 25 April 2007 13:23:08 EST {12B1D630-F5CD-4F64-9A07-2551C49DCB8D} Biologists funded by NIGMS have dissected the complex interactions between a pair of proteins that together allow rapid growth in plant root tips. The work sheds light on the interplay between genes and proteins in general. N/A Thu, 19 April 2007 00:00:00 How Translocations Occur at Inception of Lymphoma http://www.nigms.nih.gov/News/Results/121108a.htm Fri, 19 December 2008 10:11:35 EST {12C895B1-F9DF-4772-A231-013EB66E1081} NIGMS-funded researchers have charted biochemical steps leading to chromosomal translocations, mutations that occur frequently in blood cancers. N/A Thu, 11 December 2008 00:00:00 “GO” Grant to Advance Drug Development from Plants http://www.nigms.nih.gov/News/Results/20091105.htm Mon, 9 November 2009 10:44:45 EST {13063BB1-E975-4F3C-BF2A-A568D8920C6E} An NIGMS Grand Opportunities stimulus grant will support research on how several plants make medicinal compounds. ARRA Thu, 5 November 2009 00:00:00 Researchers Tackle Deadly Infections http://www.nigms.nih.gov/News/Results/20081111.htm Mon, 24 November 2008 14:17:13 EST {133100EB-2FAD-4E34-860B-2208242F7090} A team of NIGMS-supported researchers have combined medicine, math and engineering to reveal how sepsis occurs and how to prevent it. TraumaBurnPerioperativeInjuryAndWoundHealing Tue, 11 November 2008 00:00:00 High Doses of Oxygen Linked to Alzheimer's http://www.nigms.nih.gov/News/Results/081109.htm Tue, 18 August 2009 13:03:20 EST {133A341E-65AF-4696-973C-E71EB0715E83} NIGMS-funded researchers showed that oxygen treatment in mice can hasten memory loss like that in Alzheimer's disease. N/A Tue, 11 August 2009 00:00:00 Scientists Uncover New RNA Processing Mechanism http://www.nigms.nih.gov/News/Results/20081126C.htm Thu, 16 September 2010 13:30:58 EST {133F5FED-F7B8-4D8C-B3AD-47FC32A7C4B0} New NIGMS-supported research sheds light on possible functions of abundant 'noncoding' RNA molecules. RNAandRNAinterference Wed, 26 November 2008 00:00:00 Cells Use Water in Nano-Rotors to Power Energy Conversion http://www.nigms.nih.gov/News/Results/080310b.htm Mon, 16 August 2010 17:38:55 EST {1362FBEF-A5F0-4CDA-B9C9-F3F4358EF217} N/A Tue, 3 August 2010 00:00:00 Study Reveals How a Known Pain Reliever Triggers Death of Cancer Cells http://www.nigms.nih.gov/News/Results/20100614.htm Thu, 18 November 2010 12:08:57 EST {13AD45F9-0800-46F3-8021-CBB01C4C867E} N/A Mon, 14 June 2010 00:00:00 The Composition of Centromeric Chromatin http://www.nigms.nih.gov/News/Results/092809a.htm Mon, 5 October 2009 12:35:35 EST {13C91D5A-7CF6-4057-A55A-6CC11695FD56} NIGMS-funded researchers have provided new evidence about structures involved in the faithful separation of chromosomes during cell duplication. N/A Mon, 28 September 2009 00:00:00 Redesign of Snake Proteins Linked to Adaptations http://www.nigms.nih.gov/News/Results/05192008.htm Thu, 29 May 2008 17:43:39 EST {148671EB-2448-4DEF-A8F6-571B3DA707D9} A new NIGMS-supported study suggests that major redesigns of snake metabolic proteins have brought about important biological adaptations. N/A Mon, 19 May 2008 00:00:00 Chromosome Coiling Makes Biological Clock Tick? http://www.nigms.nih.gov/News/Results/112107b.htm Tue, 27 November 2007 14:47:11 EST {15159602-88D1-41E4-8EEE-11EB70BF578A} Working with bacteria, NIGMS-funded researchers discovered a rhythmic day/night cycle in how condensed DNA is. N/A Wed, 21 November 2007 00:00:00 Flowering Plant Sheds Light on Human Clock http://www.nigms.nih.gov/News/Results/041009b.htm Fri, 17 April 2009 17:40:22 EST {153E08CA-C351-4B33-9954-A45BA541107F} NIGMS-funded biologists have solved the structure of a plant protein that is similar to proteins that control the master clock in mammals. N/A Fri, 10 April 2009 00:00:00 A Light Bulb and New Reactions http://www.nigms.nih.gov/News/Results/090408a.htm Wed, 17 September 2008 12:56:37 EST {15641A34-B735-423D-9068-A1EA1D9B3DFA} NIGMS-funded chemists are using light bulbs to propel organic chemical reactions that are efficient, versatile, and environmentally benign. ChemicalMethodologiesAndLibraryDevelopment Thu, 4 September 2008 00:00:00 Nanotech Researchers Develop Artificial Membrane Pore http://www.nigms.nih.gov/News/Results/092809b.htm Mon, 5 October 2009 12:35:12 EST {16107C65-A800-446A-8E33-568AA824E101} Using an RNA-powered nanomoter, NIGMS-funded reseachers have engineered an artificial pore that can transmit material through a membrane. N/A Mon, 28 September 2009 00:00:00 Berg to Step Down as National Institute of General Medical Sciences Director http://www.nigms.nih.gov/News/Results/20101206.htm Tue, 14 December 2010 14:40:02 EST {165C9299-EF15-41DD-969E-B0C621EB256D} N/A Mon, 6 December 2010 00:00:00 Insights into the Evolution of the Human Genome http://www.nigms.nih.gov/News/Results/100807f.htm Fri, 19 October 2007 15:21:31 EST {173E59AC-17C1-4B47-B571-D05C21D1C13B} NIGMS-funded researchers have worked out the evolutionary history of duplications in the human genome that are responsible for both disease and genetic innovations. N/A Mon, 8 October 2007 00:00:00 Molecular Switch Controls the Synthesis of Ribosomes http://www.nigms.nih.gov/News/Results/122210b.htm Mon, 3 January 2011 14:57:58 EST {17592E57-F4A9-48E4-B91B-2A0FB10FDF36} N/A Wed, 22 December 2010 00:00:00 Alternative Splicing and Heart Development http://www.nigms.nih.gov/News/Results/120808c.htm Wed, 17 December 2008 10:07:02 EST {1759A1BD-B86D-4FF4-8A0A-AE84FAFD28A7} NIGMS-funded researchers are exploring how dynamic shifts in proteins prompt alternative splicing in the developing heart. N/A Mon, 8 December 2008 00:00:00 DNA Double Helix Occasionally Exists in an Alternative, Functional Form http://www.nigms.nih.gov/News/Results/20110126A.htm Wed, 2 February 2011 13:58:38 EST {1771DDD0-B9FE-4DDE-B8A1-F20B74465C48} N/A Wed, 26 January 2011 00:00:00 New Insights on Regulation of Key Enzyme http://www.nigms.nih.gov/News/Results/111908c.htm Tue, 25 November 2008 16:43:11 EST {178022F0-1167-48C1-8DE8-F1F577D5D678} A study supported in part by NIGMS is providing new insights on the regulation of calpains, enzymes involved in diseases ranging from diabetes to Alzheimer's. N/A Wed, 19 November 2008 00:00:00 Controlling Embryonic Fate by Association http://www.nigms.nih.gov/News/Results/050408.htm Thu, 8 May 2008 15:23:09 EST {17A046DD-ED6D-4236-A568-946E022A05D8} An NIGMS-funded study explored how two critical embryonic cell proteins help maintain stem cells in their flexible state. StemCellResearch Sun, 4 May 2008 00:00:00 Discovery Shows How to Efficiently Turn Carbon Dioxide into Useful Carbon Monoxide With Light http://www.nigms.nih.gov/News/Results/030510.htm Mon, 15 March 2010 16:25:11 EST {17A3D8D2-F61D-463F-8BE6-E8968DF3B5E7} N/A Fri, 5 March 2010 00:00:00 Technique Identifies Biomarkers for Disease http://www.nigms.nih.gov/News/Results/033108b.htm Mon, 7 April 2008 14:30:02 EST {17AF1D3D-A74E-4826-8136-4799C2DD8062} NIGMS-funded researchers have developed a technique for finding markers for disease without any advance knowledge of the molecules. N/A Mon, 31 March 2008 00:00:00 Epigenetics Model Blurs Nature/Nurture Line http://www.nigms.nih.gov/News/Results/072109b.htm Thu, 30 July 2009 11:04:09 EST {17C346F6-4B88-4643-830A-7329C28037EB} An NIGMS-funded study provides a first step in quantifying the effect of epigenetic changes on disease risk. N/A Tue, 21 July 2009 00:00:00 Study Details Molecular Structure of Major Aspect of Cell Signaling Pathway http://www.nigms.nih.gov/News/Results/102110c.htm Thu, 28 October 2010 17:24:04 EST {17DA7922-1A43-4391-A984-37F29EFBE7CB} N/A Thu, 21 October 2010 00:00:00 Personal Genomes May Lead to Personalized Vitamin Supplements http://www.nigms.nih.gov/News/Results/06022008.htm Fri, 13 June 2008 16:57:52 EST {17F3CE4C-18EF-4EE4-B347-F5031D587645} A team of NIGMS-supported scientists has found a reason to examine a person’s genome: to find the slight genetic flaws that can be fixed with remedies as simple as vitamin or mineral supplements. N/A Mon, 2 June 2008 00:00:00 Understanding Antibiotic Resistance http://www.nigms.nih.gov/News/Results/022508b.htm Wed, 5 March 2008 17:13:54 EST {1800174A-4D7E-4CE0-9FB6-07E1D536AF5F} NIGMS-funded researchers have identified the role of two proteins that allow bacteria to resist some antibiotics. N/A Mon, 25 February 2008 00:00:00 Breaking Enzyme Mimics Genetic Shuffle Seen in Cancer http://www.nigms.nih.gov/News/Results/20081117.htm Mon, 16 March 2009 09:32:24 EST {180A15D9-BAA0-4E50-9C53-027786BBCBBD} A study of how the enzyme, BubR1, helps distribute chromosomes evenly during cell division might explain how the process goes awry in cancer, according to NIGMS-supported researchers. N/A Mon, 17 November 2008 00:00:00 How Enzymes Work http://www.nigms.nih.gov/News/Results/20070619.htm Mon, 2 July 2007 17:08:15 EST {188C3066-AA7C-4B2F-BC06-22F29BB6FC85} NIGMS-supported chemists report the discovery of a central mechanism responsible for the action of the powerful biological catalysts known as enzymes. N/A Tue, 19 June 2007 00:00:00 Plant Biologists Observe Natural Selection In Plants Adapting to Harsh Environments http://www.nigms.nih.gov/News/Results/013111c.htm Thu, 3 February 2011 15:39:10 EST {18928186-2505-465D-985D-2B6D159D39F1} N/A Mon, 31 January 2011 00:00:00 Mechanism Reads Histone Modification Marks http://www.nigms.nih.gov/News/Results/051807.htm Fri, 8 June 2007 17:40:32 EST {18A3D6FC-92B9-45EB-82CC-4D476F924461} NIGMS-funded researchers have figured out how the combined action of two protein domains detects histone modification. N/A Fri, 18 May 2007 00:00:00 Autoimmune Diseases Cluster into Distinct Genomic Groups http://www.nigms.nih.gov/News/Results/20091223.htm Wed, 13 January 2010 13:51:15 EST {18BC48EF-E6DB-4D16-9D4B-9A84BA25A167} Genomic switches can predispose an individual to one set of autoimmune disorders but protect the same person against another set of them, according to an NIGMS-supported study. N/A Wed, 23 December 2009 00:00:00 Motions of Enzyme Allow Correct Copying of DNA http://www.nigms.nih.gov/News/Results/102709.htm Wed, 4 November 2009 13:27:38 EST {18C7687F-FFB5-4AC9-8EF5-EA70F220A635} NIGMS-funded researchers have identified how the motions of an enzyme relate to correct copying of genetic instructions. N/A Tue, 27 October 2009 00:00:00 Human Genes Sing Different Tunes http://www.nigms.nih.gov/News/Results/11022008A.htm Fri, 14 November 2008 09:51:28 EST {18EFA0B9-870F-4FE3-8F20-0D97CFF692F7} NIGMS-supported researchers have shown that a phenomenon known as alternative splicing varies more between tissues than was previously believed. RNAandRNAinterference Sun, 2 November 2008 00:00:00 Purification of BRCA2 Protein Could Lead to New Breast Cancer Drugs http://www.nigms.nih.gov/News/Results/20100822A.htm Fri, 27 August 2010 11:52:34 EST {190C0F4F-3CE6-41F6-BC36-642135ABF66C} N/A Sun, 22 August 2010 00:00:00 Method Identifies Fleetingly Ordered Structures From a Disordered Protein http://www.nigms.nih.gov/News/Results/020811a.htm Wed, 16 February 2011 21:02:56 EST {19131DD3-5D7E-46FA-B091-5E9A3783B710} CellularImaging Tue, 8 February 2011 00:00:00 Fruit Fly Research Sheds Light on Signal Transmission http://www.nigms.nih.gov/News/Results/032707.htm Mon, 2 April 2007 11:57:45 EST {193C22B2-7063-4453-BBE9-F20388BEEF1A} NIGMS-funded geneticists have been studying fruit flies and how they count sex chromosomes to shed light on signal transmission in animals. N/A Tue, 27 March 2007 00:00:00 How Bacteria Divide http://www.nigms.nih.gov/News/Results/041708b.htm Fri, 25 April 2008 13:56:33 EST {195E6A9D-DE9D-42F0-9149-BBFC97F15B0F} In work that could lead to new antibiotics, NIGMS-funded researchers have demonstrated the key role of a protein involved in bacterial cell division. N/A Thu, 17 April 2008 00:00:00 View of Protein Folding Within Chaperonins Provides a Surprise http://www.nigms.nih.gov/News/Results/031511a.htm Mon, 21 March 2011 12:45:57 EST {1AA9D5C6-118C-443F-9268-51C665DB4529} N/A Tue, 15 March 2011 00:00:00 Novel Approach Strips Staph of Virulence http://www.nigms.nih.gov/News/Results/20080214.htm Thu, 21 February 2008 13:52:53 EST {1AE125CD-5A4D-424B-88B9-12D192BB2AAA} An international team of researchers supported by NIH has blocked staph infections in mice using a drug previously tested in clinical trials as a cholesterol-lowering agent. The novel approach could offer a new direction for therapies against a bacterium that’s becoming increasingly resistant to antibiotics. N/A Thu, 14 February 2008 00:00:00 Scientists Develop RNA That Replicates Itself Indefinitely http://www.nigms.nih.gov/News/Results/01092009A.htm Tue, 27 January 2009 16:12:39 EST {1B057D0A-2D2D-4B71-8A9E-FEC8F7D91D19} NIGMS-supported scientists have synthesized for the first time RNA enzymes that can indefinitely replicate themselves without the help of proteins or other cellular components. RNAandRNAinterference Fri, 9 January 2009 00:00:00 Considering the Motion of Proteins http://www.nigms.nih.gov/News/Results/012110b.htm Fri, 29 January 2010 17:07:49 EST {1B098420-2A85-4966-8634-C7B23DC31DA1} NIGMS-funded biochemists are revealing that how proteins move in the immune system and elsewhere affect how they work. N/A Thu, 21 January 2010 00:00:00 Enzyme Keeps Traffic Flowing in the Right Direction in the Nervous System http://www.nigms.nih.gov/News/Results/090810a.htm Wed, 15 September 2010 14:12:52 EST {1B126FAA-79C8-4C08-9921-70BA842E7C5D} N/A Wed, 8 September 2010 00:00:00 Non-Human Ingredient May Limit Effectiveness of Some Biotech Drugs http://www.nigms.nih.gov/News/Results/20100725.htm Fri, 30 July 2010 14:51:29 EST {1B232D8D-BC65-4F99-A023-9A09FE0A4C65} ChemHealth Sun, 25 July 2010 00:00:00 Cooperative Behavior Meshes With Evolutionary Theory http://www.nigms.nih.gov/News/Results/040609b.htm Wed, 15 April 2009 14:36:51 EST {1B41A217-AB7A-440F-B8B5-61C35C85C8A8} NIGMS-funded physicists have used game theory and yeast genetics to understand how cooperative behavior is compatible with evolutionary forces. N/A Mon, 6 April 2009 00:00:00 Prof. Ada Yonath of the Weizmann Institute of Science Awarded the 2009 Nobel Prize in Chemistry http://www.nigms.nih.gov/News/Results/nobel_20091007d.htm Thu, 3 February 2011 08:20:22 EST {1B58B03F-1F5C-48D4-813F-DB98EBE0145E} NIGMS grantee Ada E. Yonath of the Weizmann Institute of Science in Rehovot, Israel, is named a recipient of the 2009 Nobel Prize in chemistry. Nobel Prize Wed, 7 October 2009 00:00:00 Model of Cancer-Preventing Enzyme Gives Clues About Function http://www.nigms.nih.gov/News/Results/051107c.htm Sat, 19 May 2007 17:42:02 EST {1B6519E0-F00C-4734-920E-5110DF81A23E} NIGMS-funded researchers have created a three-dimensional model of an enzyme that helps prevent cancer by allowing appropriate cell death. N/A Fri, 11 May 2007 00:00:00 New Tool Probes History of Genes http://www.nigms.nih.gov/News/Results/091007.htm Mon, 24 September 2007 14:05:23 EST {1B725D9B-5C77-4116-816E-2666CABB5586} A new way of analyzing the ancestry of genes helps show how new genes are groomed over hundreds of millions of years, reports an NIGMS-funded study. N/A Mon, 10 September 2007 00:00:00 Protein Structure Initiative Discovery Points to Drugs for Flu http://www.nigms.nih.gov/News/Results/082508b.htm Tue, 9 September 2008 18:18:10 EST {1B9CC144-4988-4A64-9D71-B3789985CC9F} An NIGMS-funded collaboration has revealed a key binding pocket for flu infection. Disrupting the interaction could treat flu. ProteinStructureInitiative Mon, 25 August 2008 00:00:00 Tiny RNA Enzyme Adds to Notion That LIfe Could Have Begun With an "RNA World" http://www.nigms.nih.gov/News/Results/022210b.htm Mon, 1 March 2010 15:35:47 EST {1BDBA01D-7AE6-4F9F-B105-CB8133DE301C} RNAandRNAinterference Mon, 22 February 2010 00:00:00 NIGMS Invests in Scientific Grand Opportunities with Recovery Act Funds http://www.nigms.nih.gov/News/Results/gogrant_112309.htm Mon, 26 July 2010 11:44:13 EST {1C5D18EA-6B4B-4EC7-B3BA-9A7591B1A793} NIGMS has invested $42.3 million of Recovery Act funds to launch 14 "Grand Opportunities" research projects. N/A Mon, 23 November 2009 00:00:00 Protein Signals Shape Changes That Lead to Cell Division http://www.nigms.nih.gov/News/Results/20101105A.htm Mon, 15 November 2010 15:19:15 EST {1C64A679-2D05-4A23-A63F-C935C1E7FEA7} N/A Fri, 5 November 2010 00:00:00 Protein Suggests Link Between Histones and Apoptosis http://www.nigms.nih.gov/News/Results/102209b.htm Wed, 4 November 2009 13:25:30 EST {1C707B8A-BB4B-4AFD-931C-9C068300BF5D} NIGMS-funded researchers have found that a protein involved in programmed cell death is also required for the proper synthesis of histones, a chief component of chromosomes. N/A Thu, 22 October 2009 00:00:00 Adaptation Drives Human Evolution http://www.nigms.nih.gov/News/Results/011609.htm Thu, 29 January 2009 16:48:01 EST {1C79CA1E-E085-4AE0-B78D-CDB014D1F7AF} An NIGMS-funded study shows that adaptation, rather than neutral change, plays a large role in human evolution. N/A Fri, 16 January 2009 00:00:00 Changes in Protein Shape Influence Drug Binding http://www.nigms.nih.gov/News/Results/20090819A.htm Thu, 3 September 2009 16:22:24 EST {1C9DA1F6-1C8C-4FEB-9FBD-E9121616B133} NIGMS-supported computational biologists have shown that proteins’ intrinsic ability to change shape allows small molecules to interact with the structure that permits the best binding. N/A Wed, 19 August 2009 00:00:00 Basis of 'Bacterial Immune System' Uncovered http://www.nigms.nih.gov/News/Results/20091125.htm Mon, 7 December 2009 17:53:11 EST {1CB4E03E-7171-4557-8624-111067AECEDC} A team of NIGMS-supported scientists has shed light on a mechanism that bacteria use to fend off the viruses that infect them. N/A Wed, 25 November 2009 00:00:00 Chemists Get Grip on Slippery Lipids http://www.nigms.nih.gov/News/Results/083007b.htm Wed, 12 September 2007 10:38:17 EST {1D041D2B-EBA0-47CD-92B5-0D46EA17BE10} NIGMS-funded chemists are figuring out how proteins recognize specific lipids, which play a critical role in cell signaling. N/A Thu, 30 August 2007 00:00:00 Scientists Unravel Structure of Breast Cancer Target Enzyme http://www.nigms.nih.gov/News/Results/01072009.htm Mon, 16 March 2009 08:38:15 EST {1D35BB12-3BE3-44FB-92ED-30B977BC1A7A} NIGMS-supported researchers have revealed the molecular structure of aromatase, the enzyme targeted by Tamoxifen and other, related drugs. N/A Wed, 7 January 2009 00:00:00 Gene Chip Technology Adapted to Perform "Shotgun Glycomics" http://www.nigms.nih.gov/News/Results/120510b.htm Mon, 13 December 2010 15:37:21 EST {1DA0EE20-7917-461C-862E-BA433884206A} N/A Sun, 5 December 2010 00:00:00 Blood Pressure Drug Combination Reduces Heart Attack Deaths http://www.nigms.nih.gov/News/Results/091608.htm Fri, 19 September 2008 15:53:50 EST {1DE00D9D-6DFB-4C84-A5AF-9ABAFEE17B7E} NIGMS-funded researchers are calling into question current treatment guidelines for high blood pressure with a study about the benefits of combining drugs. N/A Tue, 16 September 2008 00:00:00 Hydrodynamic Interactions Affect How Molecules Interact in Cells http://www.nigms.nih.gov/News/Results/101110c.htm Fri, 15 October 2010 16:14:03 EST {1E0E2B2D-ABA4-4329-990E-55915D4912FC} N/A Mon, 11 October 2010 00:00:00 Simple Blood Test Could Help Doctors Halt Organ Rejection Early http://www.nigms.nih.gov/News/Results/092310c.htm Fri, 1 October 2010 15:58:31 EST {1E300384-2C5A-410A-B6AE-83A40ED7FA18} ComputingLife Thu, 23 September 2010 00:00:00 Circadian Rhythms Regulate Fat Metabolism http://www.nigms.nih.gov/News/Results/111510.htm Fri, 19 November 2010 16:06:04 EST {1E66BE54-C77E-471E-8D4F-9F966BFDA03D} N/A Mon, 15 November 2010 00:00:00 Research on the Genetics of Social Behavior Gets Boost from ARRA http://www.nigms.nih.gov/News/Results/20091208B.htm Tue, 22 December 2009 20:28:20 EST {1EC2A82C-62A1-4A51-AA90-115C771E6924} Michelle Arbeitman has received a federal stimulus grant to help advance the understanding of the molecular genetics of reproductive behaviors and physiology in fruit flies. ARRA Tue, 8 December 2009 00:00:00 Scientists Show Why Cells Starved of Iron Burn More Sugar http://www.nigms.nih.gov/News/Results/06062008.htm Wed, 18 June 2008 16:47:07 EST {1ECD7D8C-33E5-44CE-92A1-E0120D32056F} NIGMS-supported scientists have shown that cells starved of iron shut down the iron-dependent, energy-making pathway and switch to a less efficient pathway that burns more sugar. N/A Fri, 6 June 2008 00:00:00 Laser Technique Can Measure Interactions Between Proteins and Other Molecules in Cell Membranes http://www.nigms.nih.gov/News/Results/031411.htm Fri, 18 March 2011 15:51:04 EST {1F59276F-32C4-4D8B-BE86-4FC808F48EF3} N/A Mon, 14 March 2011 00:00:00 The Networks That Regulate Alternative RNA Splicing http://www.nigms.nih.gov/News/Results/091908b.htm Wed, 1 October 2008 13:03:57 EST {1F79F8B5-B4B8-4C5A-81A8-CF55426531E1} NIGMS-funded researchers have traced the biochemical processes that enable alternative proteins to be made from some of the same genes. N/A Fri, 19 September 2008 00:00:00 Without Enzyme Cellular Process Takes 2.3 Billion Years http://www.nigms.nih.gov/News/Results/20081111A.htm Wed, 17 December 2008 09:34:45 EST {1F7B938E-6E19-4EF9-A7DD-D4CDC722DE38} The biosynthesis of hemoglobin and chlorophyll would take 2.3 billion years—half the earth’s age—without a key cellular enzyme. N/A Tue, 11 November 2008 00:00:00 Three Genes Linked to Lou Gehrig's Disease http://www.nigms.nih.gov/News/Results/090909.htm Fri, 18 September 2009 13:45:54 EST {20933F4F-624B-42D6-86CD-3889072D352E} By developing new methods to detect genes involved in complex diseases, NIGMS-funded mathematicians have identified genes linked to ALS. N/A Wed, 9 September 2009 00:00:00 After Dinosaurs, Mammal Genomes Shrink http://www.nigms.nih.gov/News/Results/20090727A.htm Tue, 4 August 2009 14:55:57 EST {20CEA59D-9B47-4BB8-BBC7-2D89EEC55864} Evidence buried in the chromosomes of animals strongly suggests that mammals have seen their genomes shrink following the dinosaurs' extinction, reports an NIGMS-supported team. N/A Mon, 27 July 2009 00:00:00 New Yeast Trick for Eating Favorite Food http://www.nigms.nih.gov/News/Results/073008.htm Thu, 7 August 2008 11:25:23 EST {21129479-78A7-4E92-B8F3-3EC53E8A6037} NIGMS-funded researchers have discovered a new mechanism in much-studied yeast cells that allows them to focus on consuming their favorite sugar. N/A Wed, 30 July 2008 00:00:00 Water Helps Turn the Rotors of the Machine That Makes the Cell’s Chemical Energy http://www.nigms.nih.gov/News/Results/20100818.htm Tue, 24 August 2010 12:28:01 EST {216B11A9-C637-42C0-8617-B9ED48C8CC4E} N/A Wed, 18 August 2010 00:00:00 Developing Cells Consider Their History of Signals http://www.nigms.nih.gov/News/Results/092809c.htm Mon, 5 October 2009 12:34:49 EST {21A912D1-4EA1-4793-B4B7-766BF7647B60} NIGMS-funded researchers have proposed a new model for how animals develop; history of exposure to signals helps cells determine their location. N/A Mon, 28 September 2009 00:00:00 New Role For Mitochondria Could Lead to Targeted Therapies http://www.nigms.nih.gov/News/Results/062508.htm Wed, 2 July 2008 16:33:44 EST {21AA2212-6FC7-4DA7-9ECB-52DA0B87CB32} NIGMS-funded researchers have found that human cells can shift tRNAs into their mitochondria. N/A Wed, 25 June 2008 00:00:00 X-ray Diffraction Microscope Shows Internal Structures of Whole, Unstained Cell http://www.nigms.nih.gov/News/Results/060410a.htm Fri, 11 June 2010 20:16:00 EST {21CA5BBD-F922-4DA7-A5A5-97C9D5EC3DA3} CellularImaging Fri, 4 June 2010 00:00:00 Structure Reveals How Cells 'Sugar-Coat' Proteins http://www.nigms.nih.gov/News/Results/20080311.htm Mon, 23 March 2009 14:56:04 EST {224927BC-69F7-4B8A-9634-4788CAE8F133} A team of NIGMS-supported scientists has deciphered the structure of a large protein complex responsible for adding sugar molecules to newly formed proteins. N/A Tue, 11 March 2008 00:00:00 Researchers Explore Why Cells in the Same Environment Make Different Choices http://www.nigms.nih.gov/News/Results/051410a.htm Fri, 14 May 2010 16:13:01 EST {2264C8F4-C4D3-4030-8F62-2925B09D899F} N/A Fri, 14 May 2010 00:00:00 Researchers Reveal Insights Into How Proteins Fold http://www.nigms.nih.gov/News/Results/06112008.htm Thu, 19 June 2008 16:34:26 EST {226E79E1-173E-415C-9D2A-1ECC48A9E36C} NIGMS-supported researchers have begun to pry open the lid on the inner workings of a molecule called TRiC that helps proteins fold. N/A Wed, 11 June 2008 00:00:00 Scientists Build Complete Metabolic Model http://www.nigms.nih.gov/News/Results/20090917.htm Fri, 18 September 2009 13:41:11 EST {2274F922-0546-4C9F-B63D-5ACD292FE3F9} NIGMS-supported investigators report the construction of a complete model, including three dimensional protein structures, of the central metabolic network of the bacterium Thermotoga maritima. ProteinStructureInitiative Thu, 17 September 2009 00:00:00 Engulfment Receptor Distinguishes Programmed Cell Death From Other Autophagy http://www.nigms.nih.gov/News/Results/062310a.htm Wed, 14 July 2010 11:33:26 EST {22A87D8D-4D3F-4ACD-9F59-DE5310FCCC64} N/A Wed, 23 June 2010 00:00:00 New Therapeutic Target for Melanoma http://www.nigms.nih.gov/News/Results/041609.htm Fri, 1 May 2009 15:29:17 EST {22ECE270-D085-4737-BBCD-15F18A7EA577} NIGMS-funded biologists have discovered that a protein called Mcl-1 plays a critical role in melanoma cells' resistance to death. N/A Thu, 16 April 2009 00:00:00 Transcription Factor Polices Conflicts Between DNA Replication and Transcription Machinery http://www.nigms.nih.gov/News/Results/050610b.htm Mon, 17 May 2010 14:51:39 EST {23163BDB-E56B-4CE7-887D-3E735096DFC9} N/A Thu, 6 May 2010 00:00:00 Anesthetics Shed Light on How the Brain Shifts Between Sleep and Awake States http://www.nigms.nih.gov/News/Results/20100826.htm Thu, 2 September 2010 15:29:20 EST {232153EB-5F9D-432F-8E1F-7AB9A874B2F1} ARRA Thu, 26 August 2010 00:00:00 Two Classes of Chemicals Disrupt Pathway Involved in Diseases http://www.nigms.nih.gov/News/Results/013009a.htm Thu, 5 February 2009 14:39:23 EST {2364B722-2D9C-48E5-A96D-903BE5FA4FF2} An NIGMS-supported chemical library screen identified two new classes of compounds that affect a biochemical system involved in cancer and many diseases. N/A Fri, 30 January 2009 00:00:00 Yeast Biology And How Human Knowledge Expands http://www.nigms.nih.gov/News/Results/031909.htm Fri, 27 March 2009 13:45:29 EST {237C4805-76ED-4627-9D4E-CEBDB527DC3A} NIGMS-funded biologists used temporal network analysis to explore the factors that promote or reduce scientific productivity. BioinformaticsAndComputationalBiology Thu, 19 March 2009 00:00:00 Repairing DNA Damage Unexpectedly Increases Rate of Mutations in Cancer Cells http://www.nigms.nih.gov/News/Results/070110a.htm Sat, 17 July 2010 18:36:09 EST {23D856A6-37D5-48CA-A1AC-7C4A0680BCF7} N/A Thu, 1 July 2010 00:00:00 Device Measures Cellular Forces During Development http://www.nigms.nih.gov/News/Results/20090622.htm Thu, 2 July 2009 14:31:19 EST {24F70139-14D7-4ACD-8299-9D55CA6E46C0} A team of NIGMS-supported bioengineers has created a tiny device that measures forces exerted by individual cells during tissue development. N/A Mon, 22 June 2009 00:00:00 Cell Death and the Ends of Chromosomes http://www.nigms.nih.gov/News/Results/100108c.htm Tue, 21 October 2008 12:29:10 EST {25579411-F2DA-407C-95AB-9335BAB1896A} NIGMS-funded biologists have shown that losing just one telomere can lead to many abnormalities in a cell's chromosomes. TelomeresAndTelomerase Wed, 1 October 2008 00:00:00 Researchers Identify a Potentially Universal Mechanism of Aging http://www.nigms.nih.gov/News/Results/20081126B.htm Mon, 16 March 2009 09:33:49 EST {2632D895-3EE3-4412-9655-5FD294D057F6} NIGMS-supported researchers have discovered that DNA damage decreases a cell's ability to regulate gene activities, which may represent a universal culprit for aging. N/A Wed, 26 November 2008 00:00:00 Scientists Track Protein as it Crosses Energy Barrier http://www.nigms.nih.gov/News/Results/20091210A.htm Fri, 18 December 2009 19:50:05 EST {265608E0-1BC1-400C-A74C-42DDC568865C} In an NIGMS-supported study, researchers reveal computationally and experimentally the molecular pathway that a protein takes to cross the energy barrier between the active and inactive states. N/A Thu, 10 December 2009 00:00:00 Computational Technique Can Predict Drug Side Effects http://www.nigms.nih.gov/News/Results/121107c.htm Mon, 16 March 2009 08:44:29 EST {266F4850-10EB-4A86-9C30-36451253B7EC} Scanning candidate drugs against the Protein Data Bank can be used to predict side effects, NIGMS-funded researchers say. N/A Tue, 11 December 2007 00:00:00 Clock Gene Works Interchangeably in Plant and Human Cells http://www.nigms.nih.gov/News/Results/120110a.htm Mon, 6 December 2010 15:42:17 EST {26AD6BFD-1576-4CE0-9106-2CA8D4CE7F11} N/A Wed, 1 December 2010 00:00:00 Discovery Inches Closer to Possible Diabetes Cure http://www.nigms.nih.gov/News/Results/072009c.htm Tue, 28 July 2009 20:04:11 EST {2716C0CE-78C6-41F0-87F0-F353CEF91841} NIGMS-supported researchers have discovered a master regulator gene for the development of pancreas and other organs. N/A Mon, 20 July 2009 00:00:00 Gastric Bypass Alters Sweet Taste Function in Obese Rats http://www.nigms.nih.gov/News/Results/110210.htm Mon, 8 November 2010 17:19:47 EST {2755E551-2D8F-46D0-828F-3ECEB0630B88} N/A Tue, 2 November 2010 00:00:00 Researchers Able to See Individual mRNA in Living Mammalian Cells http://www.nigms.nih.gov/News/Results/011611.htm Fri, 21 January 2011 17:17:50 EST {2795FB65-B072-43D0-B9D9-65252B0A23B8} CellularImaging Sun, 16 January 2011 00:00:00 Structure of Enzyme Mutated in Many Cancers http://www.nigms.nih.gov/News/Results/010408a.htm Fri, 11 January 2008 15:55:11 EST {279CA184-3900-4E53-BB92-A8CD82F2A8B2} NIGMS-funded researchers have solved the structure of an enzyme (PIK3CA) that is mutated in cancers of the colon, brain, stomach, breast, lung, and others. N/A Fri, 4 January 2008 00:00:00 Sea Lamprey Jettisons Large Chunk of Genome http://www.nigms.nih.gov/News/Results/072009a.htm Fri, 24 July 2009 13:38:25 EST {27E27D8B-B439-473A-AE3F-0E9D9FD8527E} NIGMS-funded researchers have found that the sea lamprey discards one-fifth of its DNA when generating immune receptors. N/A Mon, 20 July 2009 00:00:00 Mapping a Clan of Mobile Selfish Genes http://www.nigms.nih.gov/News/Results/10222008A.htm Mon, 16 March 2009 09:38:13 EST {284FB0D9-F77A-4361-A542-F8DFBB0407AC} Alu retrotransposons are by far the most abundant class of jumping genes in our genome, according to a new NIGMS-supported study. N/A Wed, 22 October 2008 00:00:00 "Dimmer Switch" Regulates Mammalian Genes http://www.nigms.nih.gov/News/Results/072607c.htm Tue, 31 July 2007 14:26:05 EST {28646A2E-C246-4800-AE96-AEC85DF05DC7} NIGMS-funded biomedical engineers have created a genetic dimmer switch that can be used to tune a gene's function. N/A Thu, 26 July 2007 00:00:00 NIGMS Grantee Wins 2007 Hackerman Award http://www.nigms.nih.gov/News/Results/022007.htm Fri, 23 February 2007 12:34:35 EST {28A0552C-757B-4761-8554-B88F622394AB} Patrick Harran, an NIGMS grantee, has received a large prize for his pioneering work in chemistry, which includes the creation of synthetic forms of diazonamide, a natural toxin, with potent anti-cancer properties. N/A Tue, 20 February 2007 00:00:00 Family Size Linked to Risk for Stomach Cancer http://www.nigms.nih.gov/News/Results/011507.htm Fri, 26 January 2007 16:46:38 EST {29038A3F-B537-4682-A11D-8D52AA747445} Early childhood exposure to siblings, especially older ones, increases the risk for developing stomach cancer decades later, report NIGMS-funded researchers, who speculate that early infection with genetically adapted H. pylori may set the stage for future disease. BioinformaticsAndComputationalBiology Mon, 15 January 2007 00:00:00 NIGMS Director Jeremy Berg Receives Award for Public Service http://www.nigms.nih.gov/News/Results/berg_asbmbaward.htm Wed, 29 September 2010 09:37:20 EST {29A1A809-9B4F-4F8A-B034-1F25B368EBA0} N/A Mon, 20 September 2010 00:00:00 RNA-Binding in Myotonic Dystrophy http://www.nigms.nih.gov/News/Results/110707a.htm Tue, 13 November 2007 10:24:31 EST {29AF570D-98B1-41A0-BA5F-43EDB017AA2F} NIGMS-funded researchers have probed the function of an RNA-regulating protein known as muscleblind whose misbehavior can lead to disease. N/A Wed, 7 November 2007 00:00:00 Why Eczema Can Lead to Asthma http://www.nigms.nih.gov/News/Results/051809a.htm Mon, 1 June 2009 13:34:38 EST {2A0BDD21-52B0-4FF4-BAEB-03E311ED292D} NIGMS-funded researchers have discovered that a substance secreted by damaged skin in mice with eczema triggers asthmatic symptoms. N/A Mon, 18 May 2009 00:00:00 New Drug Knocks Out Multiple Enzymes in Cancer Pathway http://www.nigms.nih.gov/News/Results/032509.htm Thu, 18 June 2009 12:23:46 EST {2A2BCA7E-F231-4F07-88D8-D260E7BE2AE1} NIGMS-funded researchers have discovered an effective new anti-cancer agent related to drugs previously used to treat bone diseases. N/A Wed, 25 March 2009 00:00:00 Computer Predicts Anticancer Molecules http://www.nigms.nih.gov/News/Results/061708b.htm Tue, 1 July 2008 17:53:10 EST {2AD1A8F3-EF1C-47DD-9376-DBA8036727B9} A computer-based method of analyzing cell activity is able to predict antitumor activity of naturally occurring metabolites, report NIGMS-funded researchers. BioinformaticsAndComputationalBiology Tue, 17 June 2008 00:00:00 "Disorder" in Protein May Provide Wiggle Room http://www.nigms.nih.gov/News/Results/052609.htm Fri, 5 June 2009 12:23:56 EST {2ADAACFF-4238-424A-B621-218C4BC19121} NIGMS-funded researchers found that sections of a protein previously thought to be disordered may in fact have a biological role. N/A Tue, 26 May 2009 00:00:00 Nanorobotic Device Performs DNA Origami http://www.nigms.nih.gov/News/Results/021509.htm Fri, 20 February 2009 13:43:07 EST {2B800F2C-9FC4-4698-81FF-7849B085F92D} With NIGMS support, chemists have developed a two-armed nanorobotic device that can manipulate molecules in a device built from DNA. N/A Sun, 15 February 2009 00:00:00 Blood Component Turns Bacteria Virulent http://www.nigms.nih.gov/News/Results/20081120.htm Tue, 25 November 2008 16:51:00 EST {2B98438F-F8C9-425D-84AC-D0EE7006A63F} NIGMS-supported scientists have discovered the key chemical that signals Bacillus anthracis, the bacterium that causes anthrax, to become lethal. N/A Thu, 20 November 2008 00:00:00 Mechanical Forces as Well as Biochemistry Appear to Affect Gene Expression http://www.nigms.nih.gov/News/Results/020210.htm Fri, 12 February 2010 08:50:03 EST {2BAF620F-8D7E-487F-9F8C-F376CA85A5CA} N/A Tue, 2 February 2010 00:00:00 New Map of Recombination Hotspots Could Help Uncover the Roots of Genetic Diseases http://www.nigms.nih.gov/News/Results/20110405.htm Fri, 8 April 2011 10:55:21 EST {2BDC55E8-0DF1-433E-AA93-93957564D8A5} N/A Tue, 5 April 2011 00:00:00 Glucose-Regulating Protein Linked to Diabetes http://www.nigms.nih.gov/News/Results/052809a.htm Mon, 8 June 2009 14:36:01 EST {2BE96B1E-0298-4AA1-83DB-F0BDA4CFB094} NIGMS-funded researchers have linked a protein found in human muscles, but not found in mice, to type 2 diabetes. N/A Thu, 28 May 2009 00:00:00 New Protein Structure Could Spur Research on Metabolism, Cell Death http://www.nigms.nih.gov/News/Results/20080904_announce.htm Thu, 4 September 2008 13:19:53 EST {2BFF72B9-3F1F-4169-B007-26F95258BA97} Scientists have determined the structure of a human membrane protein involved in metabolism and the self-destruction of cells. N/A Thu, 4 September 2008 00:00:00 New Checkpoint in Cell Division http://www.nigms.nih.gov/News/Results/070108b.htm Thu, 10 July 2008 12:32:54 EST {2C418B12-D3BC-4785-9553-82ACBE56F89F} NIGMS-funded researchers have discovered a previously unknown checkpoint that helps cells divide only when they're ready. N/A Tue, 1 July 2008 00:00:00 The Nobel Prize in Chemistry 2010 http://www.nigms.nih.gov/News/Results/nobel_101006b.htm Wed, 6 October 2010 16:42:52 EST {2C43FE29-FB69-41FF-8CD5-3C0A8857AEDE} Nobel Prize Wed, 6 October 2010 00:00:00 Why Obama's Dog Has Curly Hair http://www.nigms.nih.gov/News/Results/20090827.htm Thu, 27 August 2009 17:09:47 EST {2C883FDA-01B7-4B17-85AB-5505B9DCB928} A team of researchers partly supported by NIGMS used data from Portuguese water dogs—the breed of President Barack Obama's dog Bo—to help find a gene that gives some dogs curly hair and others long, wavy hair. N/A Thu, 27 August 2009 00:00:00 Charcot-Marie-Tooth Disorder Gene Identified http://www.nigms.nih.gov/News/Results/20070621.htm Tue, 3 July 2007 17:26:49 EST {2D078BA2-30AB-44E1-94E9-BB5D751B60A0} Thanks to the chance appearance of a strain of impaired mice in a university laboratory, a team of NIGMS-supported scientists has identified the gene responsible for one type of a common inherited neurological disease. N/A Thu, 21 June 2007 00:00:00 Sponges Inspire Synthesis of Potential New Cancer Drugs http://www.nigms.nih.gov/News/Results/083010b.htm Wed, 8 September 2010 16:55:47 EST {2D777A08-B9FC-4465-83CC-A55D7E63F938} ChemHealth Mon, 30 August 2010 00:00:00 How Cells Defend Against Genetic Mistakes http://www.nigms.nih.gov/News/Results/041708a.htm Fri, 25 April 2008 09:44:27 EST {2E398FEC-83D9-4884-88D0-5792F602102F} NIGMS-funded researchers have discovered a step whereby cells find flawed mRNAs to prevent the production of damaged proteins. N/A Thu, 17 April 2008 00:00:00 How Evolution Can Allow Large Leaps http://www.nigms.nih.gov/News/Results/072009b.htm Tue, 28 July 2009 20:03:00 EST {2E969228-06E8-43FB-83F5-8E503CA853E1} Random fluctuations working alongside partial penetrance can lead to developmental leaps, report NIGMS-funded researchers. N/A Mon, 20 July 2009 00:00:00 Microfluidic Device Gently Collects Neutrophils, Allowing for Study of Immune Response http://www.nigms.nih.gov/News/Results/083010a.htm Wed, 8 September 2010 16:55:13 EST {2EE73126-A9D4-4CF6-82DA-3B0050B471D3} GlueGrants Mon, 30 August 2010 00:00:00 Study Canvasses Human Genetic Variation Around Globe http://www.nigms.nih.gov/News/Results/022008a.htm Thu, 28 February 2008 11:07:39 EST {2EF31F46-DD17-438E-9A5C-A5EF9A1E6F9D} NIGMS-funded researchers have helped produce the largest and most detailed worldwide survey of human genetic variation, uncovering clues to human origins. N/A Wed, 20 February 2008 00:00:00 Why H1N1 Flu Spreads Inefficiently http://www.nigms.nih.gov/News/Results/070209a.htm Tue, 14 July 2009 14:06:19 EST {2F31B89C-9803-4C24-B4D3-0C26B35EDDEC} NIGMS-funded researchers have found that H1N1 spreads inefficiently because it doesn't bind strongly to human respiratory tract receptors. N/A Thu, 2 July 2009 00:00:00 New Technique Inactivates Targeted Genes in Zebrafish http://www.nigms.nih.gov/News/Results/05252008.htm Mon, 16 March 2009 09:45:19 EST {2F4F07FB-13E4-4D61-9EA6-4B5871142354} NIGMS-supported researchers have devised a method to target individual genes for inactivation—a technique with broad potential implications for both basic science research and human disease. N/A Sun, 25 May 2008 00:00:00 Fly Cells Reveal Host Genes Required for Flu Infection http://www.nigms.nih.gov/News/Results/070908a.htm Fri, 25 July 2008 15:53:35 EST {2F6067C8-F59E-4653-9827-DC8898E0EABC} NIGMS-funded biologists have demonstrated a rapid way to identify host factors needed for a virus to infect a cell. N/A Wed, 9 July 2008 00:00:00 Which Genome Variants Matter http://www.nigms.nih.gov/News/Results/020807.htm Fri, 9 February 2007 14:03:24 EST {2F6BAF44-7A81-4330-ACA8-713DF11B14BC} Researchers funded in part by NIGMS have constructed a map charting which variations in the human genome affect gene activity. N/A Thu, 8 February 2007 00:00:00 Glowing Sugars in Live Fish http://www.nigms.nih.gov/News/Results/050208a.htm Mon, 16 March 2009 09:20:49 EST {2FA1B60D-CE69-497F-8AE0-DE9AFE3FBD1D} NIGMS-funded chemists have created glow-in-the-dark zebrafish whose cell-surface carbohydrates are tagged with dyes, a technique that can be used to track development. N/A Fri, 2 May 2008 00:00:00 Cytoskeleton Directs Chromosome Dance in Meiosis http://www.nigms.nih.gov/News/Results/20091112C.htm Fri, 20 November 2009 17:21:55 EST {2FD5670B-4403-4B6D-9ED9-42531D8A6270} New findings by NIGMS-supported scientists show that the cell's cytoskeleton, which moves things around in the cell, plays a critical role in helping chromosomes find mates and pair up during meiosis. N/A Thu, 12 November 2009 00:00:00 Switch Triggers Circadian Rhythms http://www.nigms.nih.gov/News/Results/121207.htm Sat, 22 December 2007 13:04:55 EST {2FFECFDC-49A7-4D7A-B55A-362D744C7B8D} NIGMS-funded researchers have discovered that the modification of a single amino acid triggers the genetic chain of events involved with circadian rhythms. N/A Wed, 12 December 2007 00:00:00 Protein Called Rictor Could be a Drug Target for Certain Cancers http://www.nigms.nih.gov/News/Results/102810d.htm Wed, 3 November 2010 14:39:38 EST {3013408D-6BF2-404C-97D9-99875531FEB7} N/A Thu, 28 October 2010 00:00:00 What Makes a Simple Biological Clock Tick http://www.nigms.nih.gov/News/Results/032607.htm Fri, 30 March 2007 12:37:07 EST {308C2CD0-966A-4DF4-BFB0-2C22DC52528B} NIGMS-funded researchers have worked out molecular details about how a set of three proteins in a test tube can establish and maintain a steady 24-hour rhythm. N/A Mon, 26 March 2007 00:00:00 Altering Motor Proteins Could Deliver Drugs, Inhibit Cancer http://www.nigms.nih.gov/News/Results/032009.htm Wed, 1 April 2009 11:38:49 EST {309312CF-8567-4E14-8995-75174DE8D4BE} NIGMS-funded study of the motor protein kinesin-2 sheds light on the important process of cell transport and how it could be recruited to fight disease. N/A Mon, 23 March 2009 00:00:00 Location on Chromosome Shapes How Genes Evolve http://www.nigms.nih.gov/News/Results/101410a.htm Wed, 20 October 2010 15:36:27 EST {30948D14-42AB-4066-9C09-388FB89AD6A5} N/A Thu, 14 October 2010 00:00:00 NIH Recovery Act Grants to Foster Scientific Workforce Diversity http://www.nigms.nih.gov/News/Results/20101026.htm Tue, 2 November 2010 16:46:50 EST {30FE104D-9B16-4438-B0E5-5F5EC2782683} N/A Tue, 26 October 2010 00:00:00 Scientists Zero In On Protein Critical to Fruit Fly Eggshell Formation http://www.nigms.nih.gov/News/Results/05292008.htm Fri, 13 June 2008 08:15:31 EST {3110ADF2-F5BF-4767-A22D-C5818FF5EB50} The NIGMS-supported advance gives scientists a better understanding of how the innermost protective eggshell layer forms and suggests a target for pesticide development. N/A Thu, 29 May 2008 00:00:00 Protein May Allow Breast Cancer to Spread http://www.nigms.nih.gov/News/Results/040109.htm Sun, 5 April 2009 17:00:21 EST {3165AAEA-8489-4C7A-8A3B-B3CD3168D066} NIGMS-funded researchers suspect that a protein called Muc4 may promote metastasis and inhibit cancer cells' death. N/A Wed, 1 April 2009 00:00:00 Protein That Promotes Cell Death Also Regulates Mitochondrial Fusion http://www.nigms.nih.gov/News/Results/012411.htm Fri, 28 January 2011 18:03:40 EST {31ADABA0-995A-49AA-918F-53E993ED5B04} N/A Mon, 24 January 2011 00:00:00 New Hepatitis C Inhibitors http://www.nigms.nih.gov/News/Results/20091216A.htm Thu, 31 December 2009 11:33:16 EST {32241FD7-310C-48FB-ABEF-8FE9F682C0DF} NIGMS-supported scientists have described their discovery of several novel drug-like inhibitors of the hepatitis C virus. ChemicalMethodologiesAndLibraryDevelopment Wed, 16 December 2009 00:00:00 NIGMS ‘Glue Grant’ Creates International Team to Study Membrane Proteins http://www.nigms.nih.gov/News/Results/081010.htm Fri, 20 August 2010 15:13:52 EST {322BE84A-10CA-4824-8DBE-8A48CC6D52D7} GlueGrants Tue, 10 August 2010 00:00:00 Molecule Keeps Pathogens Like Salmonella in Check http://www.nigms.nih.gov/News/Results/082108.htm Wed, 3 September 2008 10:11:26 EST {32E63D3E-EBA3-4F84-8AD2-2D1434999EA6} Researchers funded in part by NIGMS have found a potential new way to stop bacteria that cause digestive problems. N/A Thu, 21 August 2008 00:00:00 Smaller Fluorescent Probe Allows Proteins to Continue Working Normally http://www.nigms.nih.gov/News/Results/060110c.htm Mon, 14 June 2010 10:25:22 EST {3308CDBC-69BC-41F0-9EA6-D24A3F0B52EC} CellularImaging Mon, 7 June 2010 00:00:00 Chemists Get Closer to Designing Catalysts http://www.nigms.nih.gov/News/Results/081808b.htm Thu, 28 August 2008 10:26:11 EST {3345F951-4EA1-45AC-B702-D31C0F89780E} An NIGMS-funded study challenges entrenched ideas about the working of catalysts and suggests a way to design new ones. N/A Mon, 18 August 2008 00:00:00 Structure Sheds Light on Virus Assembly http://www.nigms.nih.gov/News/Results/020809.htm Wed, 18 February 2009 16:33:14 EST {3386FE0C-1A77-4500-AF2C-C4C477A49524} NIGMS-funded researchers have solved the crystal structure of an intermediate particle in virus assembly. N/A Sun, 8 February 2009 00:00:00 Study Links Oncogene and Tumor Suppressor http://www.nigms.nih.gov/News/Results/012909.htm Wed, 4 February 2009 11:10:52 EST {3444B7CC-1371-4BAD-939F-C730E8132D72} NIGMS-funded researchers have found a connection between two signaling pathways associated with cancer. N/A Thu, 29 January 2009 00:00:00 Keeping Insulin Receptor Revved Up Keeps Stem Cells Alive in Adult Fruit Fly Brains http://www.nigms.nih.gov/News/Results/032510a.htm Fri, 9 April 2010 15:00:52 EST {3492D643-81EF-4DBA-84D5-215FBB8A541E} N/A Thu, 25 March 2010 00:00:00 Protein Structure Initiative Study Provides Insights to Medically Important Protein Family http://www.nigms.nih.gov/News/Results/031011a.htm Fri, 18 March 2011 15:50:36 EST {34B1B1F8-600C-4BC9-B1CA-3928E8381FA7} ProteinStructureInitiative Thu, 10 March 2011 00:00:00 Study Sheds Light on How Cells Proofread Proteins http://www.nigms.nih.gov/News/Results/20091209A.htm Wed, 16 December 2009 16:34:13 EST {34DB26D0-53E9-4529-87E8-93C3771731BC} NIGMS-supported scientists have discovered the basis for why cells have developed two mechanisms to make sure that the amino acid, alanine, is used correctly. N/A Wed, 9 December 2009 00:00:00 Motors and Brakes Organize Microtubules http://www.nigms.nih.gov/News/Results/013007.htm Tue, 6 February 2007 14:38:02 EST {34E0711D-A274-464D-B9A5-0FBE29E21510} NIGMS-funded researchers have shown that a balance between the workings of molecular motors and brakes keeps microtubules stable. Microtubule structures are like cells' skeletons and essential for cell division and transport. N/A Tue, 30 January 2007 00:00:00 New Technique Allows Researchers to Switch Kinases On and Off http://www.nigms.nih.gov/News/Results/062710.htm Mon, 19 July 2010 08:34:26 EST {35C1775E-BE03-4700-ABFA-E60971662F3C} N/A Sun, 27 June 2010 00:00:00 Carbenes Created in Lab Have Wide Applications http://www.nigms.nih.gov/News/Results/102209a.htm Tue, 3 November 2009 14:09:20 EST {35E2D4C0-78B9-4674-9EB3-EC93FF3E3615} NIGMS-funded chemists have successfully synthesized carbenes, a class of unusually unstable molecules used to make catalysts. N/A Thu, 22 October 2009 00:00:00 An Immune Target For a Wide Range of Flu Viruses http://www.nigms.nih.gov/News/Results/022609.htm Fri, 13 March 2009 17:57:09 EST {35FDDD89-C53B-4D2C-92B0-9D0541F00A58} An NIGMS-funded study has discovered that a single antibody can target a wide range of flu viruses, a finding that could lead to a universal flu vaccine or treatment. N/A Thu, 26 February 2009 00:00:00 Questions About Statistical Methods in Natural Selection Studies http://www.nigms.nih.gov/News/Results/033009.htm Fri, 3 April 2009 18:16:58 EST {3661A304-4664-487E-8510-46DCB0FE5870} NIGMS-funded researchers say that scientists who examine human evolution have used faulty statistical methods. N/A Mon, 30 March 2009 00:00:00 Enzyme Involved in Protein Degradation Linked to Cellular Senescence http://www.nigms.nih.gov/News/Results/05222008.htm Thu, 29 May 2008 17:48:06 EST {367C1566-E86E-464B-AF18-667012923AF6} A new NIGMS-supported study identifies a pivotal role for the CUL7 E3 ubiquitin ligase in growth control. N/A Thu, 22 May 2008 00:00:00 Scientists Synthesize Memory in Yeast Cells http://www.nigms.nih.gov/News/Results/091407.htm Tue, 25 September 2007 10:01:32 EST {36A7C626-65D3-435E-B9FE-84D70D90BAD8} NIGMS-funded synthetic biologists have engineered a DNA-based memory loop in yeast cells. N/A Fri, 14 September 2007 00:00:00 Potential New Target for Chemotherapy http://www.nigms.nih.gov/News/Results/110107.htm Tue, 13 November 2007 10:22:17 EST {36B6DCD7-68D0-4FCA-92FA-31E87D9A2B23} NIGMS-funded researchers have identified an enzyme as a new target for treating colon and breast cancer. N/A Thu, 1 November 2007 00:00:00 Link Between Circadian Rhythm and Metabolism http://www.nigms.nih.gov/News/Results/072408c.htm Tue, 5 August 2008 12:59:23 EST {36D8225C-74DB-467B-A84C-3CA1AD8A95ED} NIGMS-funded researchers have discovered that a protein that regulates circadian rhythms works with a protein linked to aging to modulate energy use. N/A Thu, 24 July 2008 00:00:00 Repeats Lead to DNA Fragility, Neurological Disorders http://www.nigms.nih.gov/News/Results/011109.htm Tue, 27 January 2009 16:12:58 EST {372027CA-BFC3-4BB1-A231-00C36286527E} NIGMS-funded researchers have found that repeating CGG sequences in DNA, which are associated with inherited neurological disorders, stall DNA replication. N/A Sun, 11 January 2009 00:00:00 Secrets of a Life-Giving Amino Acid Revealed http://www.nigms.nih.gov/News/Results/20090716B.htm Fri, 24 July 2009 13:38:07 EST {379D28B1-98D2-4F2B-B9E1-54FE4A3DDF10} NIGMS-supported researchers report on the molecular mechanisms that govern the metabolism of selenium, a trace element crucial to life. N/A Thu, 16 July 2009 00:00:00 Elderly Patients Less Likely to be Transported to Trauma Centers http://www.nigms.nih.gov/News/Results/081808a.htm Wed, 27 August 2008 10:58:57 EST {3895978B-18FE-49C5-8C3C-2D6C0BE9D5D0} An NIGMS-supported study found an apparent age bias in the treatment of elderly trauma patients. TraumaBurnPerioperativeInjuryAndWoundHealing Mon, 18 August 2008 00:00:00 Clues About Large-Scale Gene Silencing http://www.nigms.nih.gov/News/Results/120408b.htm Fri, 12 December 2008 12:07:55 EST {38B49B95-40AF-4460-A610-B2AF8FEFDBE3} NIGMS-funded researchers are closer to understanding nucleolar dominance, the phenomenon whereby an entire set of ribosomal RNA genes from one parent is silenced. N/A Thu, 4 December 2008 00:00:00 Dark-Skinned Mice Shed Light on Bone Marrow Failure in Humans http://www.nigms.nih.gov/News/Results/072008.htm Thu, 31 July 2008 11:15:52 EST {3910B8DE-0A80-46FD-83A2-56AE84CEEF4B} NIGMS-funded researchers have discovered that p53, long known for its role in cancer, appears to be involved in skin color and anemia too. N/A Sun, 20 July 2008 00:00:00 New Way to Stabilize Proteins Has Implications for Drug Development http://www.nigms.nih.gov/News/Results/020311c.htm Wed, 9 February 2011 14:27:46 EST {39288B82-4B9A-4665-A45A-6894F0F6E8B8} N/A Thu, 3 February 2011 00:00:00 Why Some Drugs Pack a Punch http://www.nigms.nih.gov/News/Results/20090820.htm Wed, 9 September 2009 14:51:24 EST {393F49BA-FB9E-49F7-81D0-791B60D8B210} By studying the intricate mechanisms at work in protein production, a team of NIGMS-supported researchers has discovered why certain kinds of antibiotics are so effective. N/A Thu, 20 August 2009 00:00:00 Method Detects Movement in Ion Channels http://www.nigms.nih.gov/News/Results/121808a.htm Fri, 9 January 2009 17:21:45 EST {3983C11D-E39B-4473-9512-B670A97DEEB4} A study supported in part by NIGMS developed a way to detect movement within ion channels, which are major drug targets. N/A Thu, 18 December 2008 00:00:00 Physicists Manipulate DNA-Drug Interactions http://www.nigms.nih.gov/News/Results/05192008A.htm Wed, 28 May 2008 11:47:16 EST {39D94BE3-04C2-4F37-8D36-806AD4FD444F} NIGMS-supported researchers have developed a method using optical tweezers to better understand how DNA-drug interactions occur. SingleMoleculeDetectionAndManipulation Mon, 19 May 2008 00:00:00 Visualizing the Machinery of mRNA Splicing http://www.nigms.nih.gov/News/Results/040408a.htm Mon, 14 April 2008 11:16:02 EST {3A807680-8287-48A8-9C91-CCE80D718C5A} NIGMS-funded researchers have solved the crystal structure of a a self-splicing region of RNA, providing a glimpse of an ancient mechanism. N/A Fri, 4 April 2008 00:00:00 Close-Up Views Suggest How Cells Sense Zinc http://www.nigms.nih.gov/News/Results/20090913.htm Wed, 23 September 2009 18:53:50 EST {3AB26759-CD95-46E7-B6B9-4F1A3E2B126B} New, high-resolution views of a zinc transporter protein deciphered by NIGMS-supported scientists suggest a mechanism for how cells sense and regulate zinc, an element that is essential for life. N/A Sun, 13 September 2009 00:00:00 Discovery Could Help Treat Roundworm Infections http://www.nigms.nih.gov/News/Results/081009.htm Tue, 18 August 2009 13:04:15 EST {3AE499AA-C10F-4E0B-A944-D50E5D7CEEB8} NIGMS-funded biologists have discovered how a drug that kills parasitic roundworms works. N/A Mon, 10 August 2009 00:00:00 RNA Editing Enhances Effectiveness of DNA Repair Enzyme http://www.nigms.nih.gov/News/Results/20101108.htm Tue, 16 November 2010 15:38:45 EST {3B034B93-0BE0-4EC3-B1D6-446056E32EB5} N/A Mon, 8 November 2010 00:00:00 How Cells Fend Off Damaging Genetic Alterations http://www.nigms.nih.gov/News/Results/080609b.htm Tue, 18 August 2009 13:05:52 EST {3B052F84-5A60-48C2-8D40-F3311506863E} Using yeast cells, NIGMS-funded researchers found genes that can prevent a type of genetic rearrangement that may lead to cancer and other diseases. N/A Thu, 6 August 2009 00:00:00 Complex of Proteins Guides Amoebae and Mammalian Immune Cells to Prey http://www.nigms.nih.gov/News/Results/051710b.htm Fri, 21 May 2010 16:55:24 EST {3B8FEAD6-3F8B-42BD-87F5-75B2DE4D21DC} N/A Mon, 17 May 2010 00:00:00 How Different Species Develop Using Same Genes With Distinct Features http://www.nigms.nih.gov/News/Results/033007b.htm Tue, 10 April 2007 23:13:12 EST {3BA270BA-97B8-4B2A-958E-ADC884394A6B} NIGMS-funded biologists have identified how different species--in this case, wasps and fruit flies--use the same mechanisms to control their development but with specific alterations. N/A Fri, 30 March 2007 00:00:00 Enzyme That Helps Power the Cholera Bacterium Uses an Unusual Mechanism http://www.nigms.nih.gov/News/Results/20100728.htm Wed, 4 August 2010 13:52:24 EST {3BF19A65-30AE-4EA0-8170-09A6E1E61055} N/A Wed, 28 July 2010 00:00:00 Study Reveals Rich Mosaic of African-American Ancestry http://www.nigms.nih.gov/News/Results/20091221A.htm Fri, 8 January 2010 11:54:25 EST {3C28ABCA-7BC1-4987-9819-27DF0BD16C22} A team of NIGMS-supported scientists has collected and analyzed genetic data from 365 African-Americans, 203 West Africans and 400 Europeans to provide a genome-wide perspective of African and African-American ancestry. N/A Mon, 21 December 2009 00:00:00 Antioxidant Has Implications for Treating Cystic Fibrosis http://www.nigms.nih.gov/News/Results/20091116.htm Tue, 24 November 2009 17:01:08 EST {3C7D3C80-ABF7-4F96-8E3F-321F2E7D2ED2} An antioxidant found in vegetables may help treat inflammation-based disorders like cystic fibrosis, according to a new NIGMS-supported study. N/A Mon, 16 November 2009 00:00:00 A DNA Barrier Silences Genes in Herpes Virus http://www.nigms.nih.gov/News/Results/050207a.htm Fri, 11 May 2007 12:18:38 EST {3C95C2E7-E1D0-40A8-9C77-247269D32318} A stretch of DNA acts as a physical barrier between active and inactive parts of the herpes virus genome, allowing the virus to remain dormant, report NIGMS-funded researchers. N/A Wed, 2 May 2007 00:00:00 Fossil Finger Bone Yields Genome of Previously Unknown Human Relative http://www.nigms.nih.gov/News/Results/122210a.htm Wed, 29 December 2010 16:20:51 EST {3CBC1FCD-6B02-439C-A50A-2021608C4064} N/A Wed, 22 December 2010 00:00:00 New Actions of Neurochemicals http://www.nigms.nih.gov/News/Results/070209b.htm Tue, 14 July 2009 13:56:52 EST {3CDA239F-5BE0-4E91-AD0C-A86C4519C164} An NIGMS-funded study has found novel neurochemical receptors in C. elegans. N/A Thu, 2 July 2009 00:00:00 New Findings Shift Fruit Fly Development Paradigm http://www.nigms.nih.gov/News/Results/20091217A.htm Wed, 6 January 2010 20:11:15 EST {3D6BACE4-4EF8-4557-BC89-1B3C31EC5F76} NIGMS-supported researchers have found that a key transcription factor is less influential than thought, revealing a tale that is more complicated and potentially more interesting. N/A Thu, 17 December 2009 00:00:00 NIGMS Funds New Systems Biology Centers http://www.nigms.nih.gov/News/Results/080107a.htm Tue, 21 August 2007 11:46:41 EST {3DB6810E-8175-4F51-BD9E-5EB417934E43} With NIGMS support, centers to study complex biological systems are arising around the country. A center in California will focus on how biological systems control what happens not just over time, but over space. ComplexBiologicalSystemsInitiatives Wed, 1 August 2007 00:00:00 Newly Identified Proteins Override Cellular Roadblock to Viruses http://www.nigms.nih.gov/News/Results/20100814.htm Wed, 18 August 2010 18:50:04 EST {3DEF5987-B122-4EEB-8285-E1857B09427D} N/A Sat, 14 August 2010 00:00:00 Crystal Structure Shows How Catalytic RNA Cleaves tRNA http://www.nigms.nih.gov/News/Results/111410b.htm Fri, 19 November 2010 16:05:28 EST {3E49ACEE-6D51-45E3-A793-955AD8D4F56F} N/A Sun, 14 November 2010 00:00:00 Scientists Develop Novel Method for Understanding Gene Function http://www.nigms.nih.gov/News/Results/20080806B.htm Mon, 18 August 2008 06:46:31 EST {3E7EF1C7-8E68-4433-B959-0B6078C48893} A team of NIGMS-supported researchers has devised a new method that enables the rapid and large-scale study of E. coli genes. N/A Wed, 6 August 2008 00:00:00 Missing Link in Plant Steroid Hormone Synthesis http://www.nigms.nih.gov/News/Results/090809.htm Thu, 17 September 2009 15:01:56 EST {3EC464EA-E783-4BD3-8414-F61F11B4A294} NIGMS-funded researchers have discovered a key missing link in the signaling pathway for plant steroid hormones. N/A Tue, 8 September 2009 00:00:00 How Males Boost Gene Expression From Their X Chromosomes http://www.nigms.nih.gov/News/Results/030211.htm Fri, 11 March 2011 14:50:42 EST {3EDA7A1E-8149-4B03-9063-5512C8F07F7C} N/A Wed, 2 March 2011 00:00:00 SUMO Teams Up With Replication Protein A to Repair DNA http://www.nigms.nih.gov/News/Results/20100812.htm Mon, 16 August 2010 17:30:57 EST {3FD6F110-C093-4784-A8E7-F7CEA4AC9AD0} N/A Thu, 12 August 2010 00:00:00 Chronically High Blood Sugar Levels Dull Insulin Response http://www.nigms.nih.gov/News/Results/030608b.htm Wed, 12 March 2008 19:44:08 EST {3FEBCB3B-A406-4A68-A413-55723F3C1907} An NIGMS-funded study explores the biochemical vicious circle in which high blood sugar levels disable the body's response to rising levels of insulin. N/A Thu, 6 March 2008 00:00:00 Fluorescent Anesthetic May Expedite Drug Discovery http://www.nigms.nih.gov/News/Results/040309b.htm Sat, 11 April 2009 20:15:13 EST {40A71ADA-E343-4BE0-B1EE-61DC20A0CE27} NIGMS-funded researchers have identified a fluorescent anesthetic that should help in future research to discover and understand anesthetics. N/A Fri, 3 April 2009 00:00:00 Computational Approach Could Help Identify Drug Targets http://www.nigms.nih.gov/News/Results/20080201.htm Thu, 14 February 2008 10:32:53 EST {40DFF3E0-3489-49ED-BB90-00504F3F26F6} NIGMS-supported researchers have analyzed the proteins targeted by nearly a thousand FDA-approved drugs and identified characteristics shared among successful drug targets. N/A Fri, 1 February 2008 00:00:00 Scientists Uncover New Roles for Small RNAs http://www.nigms.nih.gov/News/Results/05132008A.htm Mon, 25 October 2010 13:34:35 EST {418B4046-F794-418B-BEE0-9816DDC3C376} NIGMS-supported scientists have uncovered a new class of small RNAs that modify gene activity and suppress transposable elements. They have also revealed a new source of small RNAs: pseudogenes. N/A Tue, 13 May 2008 00:00:00 Beneficial Mutant Prions Can Help Cells Foil Harmful Protein Misfolding http://www.nigms.nih.gov/News/Results/032011.htm Fri, 25 March 2011 15:48:57 EST {4198819C-38E4-494B-A3FC-6D1408716F34} N/A Sun, 20 March 2011 00:00:00 A Glimpse of How the Genetic Coding of Life May Have Emerged http://www.nigms.nih.gov/News/Results/032311b.htm Tue, 5 April 2011 17:37:30 EST {41CA4348-8C56-4946-9D9F-16477868DF57} N/A Wed, 23 March 2011 00:00:00 Little-Known Protein Found to Be Key Player http://www.nigms.nih.gov/News/Results/20090729A.htm Fri, 7 August 2009 15:34:23 EST {41F3E8C5-5ED9-46A6-B63C-C14240A14AAC} A team of NIGMS-supported biologists report that a little-understood protein previously implicated in a rare genetic disorder plays an unexpected and critical role in building and maintaining healthy cells. N/A Wed, 29 July 2009 00:00:00 Number of Motors Doesn't Regulate Organelle Transport http://www.nigms.nih.gov/News/Results/121108b.htm Fri, 19 December 2008 10:11:12 EST {41FA0072-158B-4B9D-8574-617DD6650D55} NIGMS-funded biologists have found that the mechanisms that control molecular motors are different from what biologists have previously believed. N/A Thu, 11 December 2008 00:00:00 Informatics Specialists Helped Reveal Structure of Membrane Protein http://www.nigms.nih.gov/News/Results/102710c.htm Thu, 28 October 2010 17:28:52 EST {422744B4-515A-4A6B-9442-5DEDA2947EA3} ProteinStructureInitiative Wed, 27 October 2010 00:00:00 Molecules Designed to Probe Proteins Inside Membranes http://www.nigms.nih.gov/News/Results/033007a.htm Fri, 6 April 2007 15:10:18 EST {42DF95C9-46C9-46DF-9F2C-A18643412CBA} To probe the secrets of proteins embedded within cell membranes, NIGMS-funded researchers have designed peptides that are able to bind to specific regions of the proteins. N/A Fri, 30 March 2007 00:00:00 Scientists Visualize Bacteria Talking to One Another http://www.nigms.nih.gov/News/Results/20091108.htm Mon, 9 November 2009 11:55:49 EST {4324C9D4-1522-4467-9762-99BF64628249} NIGMS-supported researchers have developed tools that enable them to visualize how different populations of cells communicate. N/A Sun, 8 November 2009 00:00:00 Supercharged Proteins Could Help Draw Potential Drugs Inside Cells http://www.nigms.nih.gov/News/Results/071410b.htm Wed, 14 July 2010 21:40:39 EST {432642AE-6977-45E0-9984-0387FA5BD066} N/A Wed, 14 July 2010 00:00:00 Security System Protects Cells From Foreign DNA http://www.nigms.nih.gov/News/Results/20100111.htm Thu, 21 January 2010 13:50:22 EST {432A5F5C-1EDB-4984-8A25-CF576586AB9E} NIGMS-supported researchers have discovered a molecular security system in human cells that deactivates and degrades potentially harmful, foreign DNA. N/A Mon, 11 January 2010 00:00:00 Molecular Switch Helps Decide Cell Type in Embryo Development http://www.nigms.nih.gov/News/Results/20080811.htm Wed, 20 August 2008 09:36:21 EST {432E9F35-9549-46A3-BA6A-602E87C2A32C} NIGMS-supported researchers have discovered a central molecular switch in fruit fly embryos that opens new avenues for studying the causes of birth defects and cancer in humans. N/A Mon, 11 August 2008 00:00:00 Brain Protein Required for Neural Connections http://www.nigms.nih.gov/News/Results/090507a.htm Tue, 18 September 2007 10:16:01 EST {432F1B99-E334-420A-95B4-C98F7C27AD97} NIGMS-funded researchers are working to identify the effects of mutating neurexin, a brain protein identified as a genetic risk factor for autism. N/A Wed, 5 September 2007 00:00:00 Infrared Tags Allow Whole-Body Imaging http://www.nigms.nih.gov/News/Results/050509b.htm Thu, 28 May 2009 11:55:49 EST {43783F9D-001F-4C77-B82B-DD2422DFE86A} NIGMS-funded researchers have shown that phytochromes from bacteria can be engineered into infrared-emitting tags for whole-body imaging. CellularImaging Tue, 5 May 2009 00:00:00 Molecular Probes Detect Subtle Leukemia DIfferences http://www.nigms.nih.gov/News/Results/071907.htm Thu, 26 July 2007 11:55:43 EST {43AFE520-3ECA-45F2-891D-1529A01FC5FD} NIGMS-funded chemists have successfully engineered short strands of DNA or RNA that are able to distinguish among subcategories of adult T-cell leukemia. N/A Thu, 19 July 2007 00:00:00 Safe New Probe Is Based on Luciferase, the Firefly Enzyme http://www.nigms.nih.gov/News/Results/021111.htm Mon, 28 February 2011 15:40:26 EST {43F040F2-0820-44EA-A83F-34E623DE6087} CellularImaging Fri, 11 February 2011 00:00:00 Calcium Channel Helps Trigger Allergic Reactions http://www.nigms.nih.gov/News/Results/20080114.htm Thu, 24 January 2008 11:39:33 EST {441C08DF-B670-47B6-8912-CA3E8DB552DD} Mice lacking the CRACM1 calcium channel are resistant to stimuli that typically elicit severe allergic reactions, according to an NIGMS-supported study. N/A Mon, 14 January 2008 00:00:00 Modifying RNA Makes Molecule Impervious to Pervasive Enzyme http://www.nigms.nih.gov/News/Results/011911a.htm Mon, 24 January 2011 14:07:35 EST {44384EEF-AAAB-4FFA-91CC-7F3C364EA476} N/A Wed, 19 January 2011 00:00:00 Mechanism Disposes of Faulty Proteins http://www.nigms.nih.gov/News/Results/120607c.htm Fri, 14 December 2007 11:01:22 EST {4464C277-65DF-4B33-96F5-10A8319C0BD1} NIGMS-funded researchers have identified cellular components that help dispose of defective proteins, potentially revealing targets for future cancer drugs. N/A Thu, 6 December 2007 00:00:00 Skin Defects Can Set Off Alarm With Potentially Harmful Effects http://www.nigms.nih.gov/News/Results/05272008.htm Fri, 6 June 2008 13:06:53 EST {44F2129C-1928-4918-9327-041D8A077FFD} A team of NIGMS-supported researchers has found that irritated skin can trigger a natural inflammatory substance that launches a massive overproduction of white blood cells in mice. N/A Tue, 27 May 2008 00:00:00 Early Evolution of Protein Editing http://www.nigms.nih.gov/News/Results/080609a.htm Tue, 18 August 2009 13:09:11 EST {4522D5DF-C94A-48DD-82CF-1C718ED97E78} NIGMS-funded research demonstrates how enzyme functions have evolved, particularly in proofreading the sequences of newly made proteins. N/A Thu, 6 August 2009 00:00:00 NIGMS ‘Challenge’ Areas Get Millions in Recovery Act Funds http://www.nigms.nih.gov/News/Results/20091119.htm Mon, 26 July 2010 11:44:44 EST {452CFB98-41AD-46D2-9826-BEE1B0EAF915} NIGMS has invested $16.4 million of Recovery Act funds to support 19 two-year research projects that address critical gaps in the basic biomedical and behavioral sciences. N/A Thu, 19 November 2009 00:00:00 Novel Genes ‘Notch’ Glucose into Place http://www.nigms.nih.gov/News/Results/20080125.htm Fri, 1 February 2008 14:06:11 EST {456CCDE4-887C-4F14-9365-77E8E5F8905B} A novel gene called Rumi regulates the Notch protein by adding a glucose molecule to the part of Notch that extends outside the cell, according to a new NIGMS-supported study. N/A Fri, 25 January 2008 00:00:00 Mutant Testis Cells Pass Themselves On http://www.nigms.nih.gov/News/Results/071408b.htm Fri, 25 July 2008 15:54:49 EST {4591AAB1-C93B-411F-8598-8153D45BF87B} NIGMS-funded biologists have shown that testis cells carrying a mutation for Apert's syndrome have a survival advantage. N/A Mon, 14 July 2008 00:00:00 New Way Protein Kinase Pathway Suppresses Tumors http://www.nigms.nih.gov/News/Results/012507b.htm Fri, 26 January 2007 16:42:12 EST {45F096A8-C691-48F1-93DD-6A017D491C29} NIGMS-supported researchers have identified a way that mammalian cells protect against tumors. A kinase called PRAK is involved in inducing senescence and tumor suppression. N/A Thu, 25 January 2007 00:00:00 A Route for Heredity Bypassing DNA http://www.nigms.nih.gov/News/Results/010408b.htm Mon, 14 January 2008 13:29:01 EST {4605E798-990E-4383-A66D-D7977D80F089} Using a single-celled ciliate, NIGMS-funded biologists have discovered a mechanism whereby genetic information can be passed on through generations via RNA. N/A Fri, 4 January 2008 00:00:00 How Cells Change State http://www.nigms.nih.gov/News/Results/20091209.htm Thu, 17 December 2009 11:09:35 EST {461CE9E1-0675-4F43-A261-819FE96FDD68} By looking at yeast cells, NIGMS-supported researchers have figured out one way in which cells can transform themselves: a cellular “machine” removes a regulatory “lid.” N/A Wed, 9 December 2009 00:00:00 Tool Offers Zoomable View of Genome http://www.nigms.nih.gov/News/Results/080408.htm Wed, 3 September 2008 13:12:26 EST {462A3B30-298B-4175-A1B3-2C7F573F4F98} NIGMS-funded computational biologists have developed a publicly available tool that integrates diverse data about the genome. BioinformaticsAndComputationalBiology Mon, 4 August 2008 00:00:00 A Trio of Signals Guide Early Cell Differentiation http://www.nigms.nih.gov/News/Results/20090625A.htm Tue, 7 July 2009 14:38:00 EST {469C3ACD-73ED-4094-B4F5-220DA275A38D} In a new NIGMS-supported study, researchers investigated a trio of cell-signaling pathways that work to direct pancreas and liver progenitor cells to mature into their final state. N/A Thu, 25 June 2009 00:00:00 Newly Discovered Compounds Help Protect Nerve Cells http://www.nigms.nih.gov/News/Results/20100119A.htm Tue, 26 January 2010 16:08:37 EST {46E4BCC1-391B-4C7A-9DE3-5385B897003B} NIGMS-supported scientists have identified compounds that could lead to promising drugs for degenerative nerve diseases like Alzheimer's and Parkinson's. ChemHealth Tue, 19 January 2010 00:00:00 Chromatin Reconstituted in Lab to Study Dynamics of Gene Activation http://www.nigms.nih.gov/News/Results/040810.htm Thu, 15 April 2010 14:21:46 EST {46FFF140-14BA-4C5A-8F6F-3CC110689A2B} N/A Thu, 8 April 2010 00:00:00 Technique Can Nudge Genes Awake http://www.nigms.nih.gov/News/Results/012807.htm Fri, 2 February 2007 14:08:35 EST {472C0C33-1952-4B88-BD16-8AC227A3B554} A new technique using RNA can turn on genes at will, report NIGMS-funded researchers. The novel tool could lead to new medicines. N/A Sun, 28 January 2007 00:00:00 Snapshot Catches Protein Motor in Action http://www.nigms.nih.gov/News/Results/20091119C.htm Thu, 3 December 2009 20:20:18 EST {4814162F-D67E-4149-AD8F-73001074BBD2} NIGMS-supported researchers have captured a critical action snapshot of an enzyme that is vital to the survival of all biological cells. N/A Thu, 19 November 2009 00:00:00 Protein Quality Control and the Link to Neurodegenerative Diseases http://www.nigms.nih.gov/News/Results/091210.htm Fri, 17 September 2010 18:06:41 EST {48889664-0D4B-40D3-8FC6-B840E236494A} N/A Sun, 12 September 2010 00:00:00 Genes Lead to New Insights on Early Native American Horticultural Practices http://www.nigms.nih.gov/News/Results/20100402.htm Mon, 12 April 2010 15:45:46 EST {48A3DDFB-2637-4E80-BB87-80E1E8EE855C} N/A Fri, 2 April 2010 00:00:00 Starvation Hormone Makes Mice Small http://www.nigms.nih.gov/News/Results/062608.htm Fri, 4 July 2008 09:21:13 EST {48ACED5A-8946-4841-8713-D4E5BD7FDD9E} NIGMS-funded researchers have discovered that high levels of a starvation hormone stunt the growth of mice. N/A Thu, 26 June 2008 00:00:00 Hidden System of Retinal Cells May be a Simpler Way for Animals to See http://www.nigms.nih.gov/News/Results/071410a.htm Wed, 28 July 2010 19:46:56 EST {4926A2F9-5812-486C-9B0A-D0307076219A} N/A Wed, 14 July 2010 00:00:00 Enzyme Structures Shed Light on DNA Packaging http://www.nigms.nih.gov/News/Results/20091220.htm Thu, 7 January 2010 12:46:40 EST {4928879D-1DD2-4C4A-9166-B1F2FA443400} NIGMS-supported researchers have determined the structures of two enzymes that customize histones, the spool-like proteins around which DNA coils inside the cell. N/A Sun, 20 December 2009 00:00:00 "Nanosyringe" Could Deliver Drugs to Tumors http://www.nigms.nih.gov/News/Results/050107b.htm Fri, 4 May 2007 14:05:00 EST {494A1F04-2D15-4E0C-863B-66AEE5196F5B} NIGMS-funded researchers have developed a new way to target and potentially treat tumors using a short piece of protein that delivers therapy to specific cells. N/A Tue, 1 May 2007 00:00:00 How Sleep May Refresh Synapses http://www.nigms.nih.gov/News/Results/040209d.htm Sat, 11 April 2009 20:14:31 EST {4A1B7DD8-40FC-4162-A166-36F6234FCCD2} An NIGMS-funded study suggests that sleep refreshes the brain by lowering levels of proteins that build up in the synapses. N/A Thu, 2 April 2009 00:00:00 Role of Ronin, Protein Crucial to Renewal of Embryonic Stem Cells http://www.nigms.nih.gov/News/Results/062510b.htm Thu, 1 July 2010 14:26:54 EST {4A51E64E-C451-444F-8C2C-0B1865CD2004} StemCellResearch Fri, 25 June 2010 00:00:00 Control of Stem Cell Aging http://www.nigms.nih.gov/News/Results/101007.htm Fri, 19 October 2007 15:31:38 EST {4A5F5273-F0D1-4702-837E-FD3B6DD64E48} Using fruit fly ovarian cells, NIGMS-funded researchers examined the factors that control stem cell function. The declining function of stem cells may be a primary cause of aging. N/A Wed, 10 October 2007 00:00:00 Survey of Immune Systems Shows Similarities in Plants and Animals http://www.nigms.nih.gov/News/Results/111810d.htm Wed, 1 December 2010 15:41:52 EST {4A76C736-EB4F-47D3-B995-2BDB9614C955} N/A Thu, 18 November 2010 00:00:00 Levels of a Protein Called Arrestin Determine How Long Roundworms Live http://www.nigms.nih.gov/News/Results/050710a.htm Fri, 14 May 2010 16:06:03 EST {4B294EBE-B04C-4BD0-8822-16EC7971F95D} N/A Fri, 7 May 2010 00:00:00 How Cells Copy Epigenetic Markers http://www.nigms.nih.gov/News/Results/090309.htm Thu, 11 September 2008 13:47:28 EST {4B942E1C-3F61-415F-A5DA-0EF793CCDFA5} NIGMS-funded researchers have caught in action one of the tools mammalian cells use to maintain the pattern of methylation in DNA. N/A Wed, 3 September 2008 00:00:00 Time Needed to Create Life Might be Less Than Thought in Heat http://www.nigms.nih.gov/News/Results/120210b.htm Thu, 9 December 2010 15:30:27 EST {4B9835B5-B9F0-4DB7-BCB6-66ED383F8390} N/A Thu, 2 December 2010 00:00:00 Delicate Balance Regulates Important Class of Molecular Switches, the Rho Proteins http://www.nigms.nih.gov/News/Results/041910a.htm Fri, 23 April 2010 13:34:41 EST {4BECA4AC-F191-47A2-ABFA-DA068125F0FF} N/A Mon, 19 April 2010 00:00:00 Chemists Create 3-D DNA Crystals http://www.nigms.nih.gov/News/Results/090209a.htm Wed, 16 September 2009 12:10:22 EST {4BF0AE6B-3A84-42EC-B30A-A1737C69AAEA} NIGMS-funded chemists have created three-dimensional DNA crystals, a process with many potential applications. N/A Wed, 2 September 2009 00:00:00 Three Grantees Win Prize for Biomedical Research http://www.nigms.nih.gov/News/Results/043007.htm Wed, 2 May 2007 07:12:38 EST {4C6FC465-0003-452F-A5B1-5C2F72520D29} Three NIGMS grantees--David Allis, Harry Noller, and Thomas Steitz--are among the five winners of the 2007 Gairdner awards, which recognize outstanding contributions of biomedical scientists worldwide. N/A Mon, 30 April 2007 00:00:00 Watching Cells Pinch in Two http://www.nigms.nih.gov/News/Results/121108c.htm Mon, 16 March 2009 09:39:46 EST {4CA3CCE0-F143-4305-83E2-019A9BE5CFDD} Using a technique that allowed them to watch cells divide in real time, NIGMS-funded researchers have discovered details about how cell membranes allow fission. N/A Thu, 11 December 2008 00:00:00 Study Helps Explain Tumor Growth http://www.nigms.nih.gov/News/Results/03132008.htm Tue, 25 March 2008 09:49:27 EST {4CAEF185-C54C-452A-A9EC-E5932DF6FF92} NIGMS-supported researchers have discovered that a metabolic process known as the Warburg effect is essential for tumors’ rapid growth, and involves an enzyme called pyruvate kinase M2. N/A Thu, 13 March 2008 00:00:00 Researchers Detail New Class of Catalysts http://www.nigms.nih.gov/News/Results/20081116A.htm Mon, 24 November 2008 20:43:12 EST {4CCED818-7EF2-4B76-A074-D711E2898696} A new class of exceptionally effective catalysts that promote the powerful olefin metathesis reaction has been discovered by a team of NIGMS-supported scientists. ChemicalMethodologiesAndLibraryDevelopment Sun, 16 November 2008 00:00:00 Programmed Cell Death Contributes Force to Cell http://www.nigms.nih.gov/News/Results/091808a.htm Mon, 29 September 2008 12:16:11 EST {4CD8B303-0C5F-4A94-95FC-BC1BD8A4FBBC} NIGMS-funded biophysicists have discovered that apoptosis can exert substantial mechanical force on surrounding cells. N/A Thu, 18 September 2008 00:00:00 Scientists Discover New Mode of Epigenetic Inheritance http://www.nigms.nih.gov/News/Results/20081126A.htm Wed, 3 December 2008 16:04:01 EST {4CDFA079-FAC2-44B7-9F14-A0125D8288CF} A team of NIGMS-supported scientists has discovered that a class of small RNAs carries epigenetic information and passes on the trait of fertility from mother to offspring in fruit flies. RNAandRNAinterference Wed, 26 November 2008 00:00:00 Roadblock to Gene Expression http://www.nigms.nih.gov/News/Results/050908.htm Wed, 21 May 2008 17:30:09 EST {4CFA3C39-93D4-490A-9893-7AE220D6185A} NIGMS-funded researchers have discovered a key stop sign for transcription based on nucleosome organization. N/A Fri, 9 May 2008 00:00:00 How Molecular Motor Works http://www.nigms.nih.gov/News/Results/070908b.htm Tue, 22 July 2008 09:14:49 EST {4D66A513-2DD9-444F-9B31-ED6A805D7AB2} NIGMS-funded researchers have discovered that molecular motors in the cell work by detecting minor changes in force. N/A Wed, 9 July 2008 00:00:00 Nanotechnology Technique Identifies Single Transcripts http://www.nigms.nih.gov/News/Results/012407.htm Thu, 25 January 2007 14:08:20 EST {4D7975B3-C6FA-45B2-B012-59C424545A33} NIGMS-supported researchers have helped develop a new nanotechnology that can isolate and identify individual transcripts--an extremely sensitive test of gene expression. N/A Wed, 24 January 2007 00:00:00 Straightforward Answer to How Plants Coordinate Development and Growth http://www.nigms.nih.gov/News/Results/063010.htm Tue, 13 July 2010 22:03:37 EST {4DBB3BBD-6EC7-49B0-99E8-2EEE0A467289} N/A Wed, 30 June 2010 00:00:00 Mechanical Forces Could Differentiate ES Cells http://www.nigms.nih.gov/News/Results/101909.htm Wed, 28 October 2009 12:31:22 EST {4E69B783-F235-46B7-AF7E-7A38A623EE2B} An NIGMS-funded study suggests that small mechanical forces on embryonic stem cells can coax them to develop in specific ways. StemCellResearch Mon, 19 October 2009 00:00:00 The Genes Behind Gray Mold's Killer Arsenal http://www.nigms.nih.gov/News/Results/120108.htm Wed, 10 December 2008 10:23:23 EST {4EB410CA-74CB-49E4-943F-94512D4E267D} NIGMS-funded researchers have identified the genetic sequence behind how gray mold kills plants, including many agricultural staples. N/A Mon, 1 December 2008 00:00:00 ‘Kitchen Chemistry’ Used in Complex Synthesis http://www.nigms.nih.gov/News/Results/20091203A.htm Mon, 14 December 2009 12:31:59 EST {4F5F59B0-A4D1-4B27-A754-C9A34F2F27EE} An NIGMS-supported team has revealed how best to break carbon-hydrogen bonds and then to create new bonds to join molecules together, a problem that has plagued chemists for years. ChemHealth Thu, 3 December 2009 00:00:00 Technique Could Make Malaria Treatment Less Costly http://www.nigms.nih.gov/News/Results/092608a.htm Mon, 6 October 2008 13:03:49 EST {4F85122C-7A12-4CC2-99EF-E8EAB451E8A8} NIGMS-funded researchers have developed a way to mass-produce an antimalarial compound. Related molecules have antibiotic properties. N/A Fri, 26 September 2008 00:00:00 Recently Identified Protein Drives Breast Cells Toward Cancer http://www.nigms.nih.gov/News/Results/20101215A.htm Tue, 21 December 2010 14:40:35 EST {4FABCE90-C7A2-41FB-BCD3-20F1F501BCF4} N/A Wed, 15 December 2010 00:00:00 How Mold Tells Time http://www.nigms.nih.gov/News/Results/060809b.htm Wed, 24 June 2009 17:24:38 EST {4FEE7102-32F9-4B96-9507-2A72469C184B} NIGMS-funded researchers are using Neurospora fungus to study the biochemistry and genetics of circadian rhythms. N/A Mon, 8 June 2009 00:00:00 Previously Unknown Layer Protects Tough Bacterial Spores http://www.nigms.nih.gov/News/Results/050610a.htm Fri, 14 May 2010 16:05:28 EST {4FFEC7EC-CB4D-46CF-AE15-8F1AA9C00D3C} N/A Thu, 6 May 2010 00:00:00 Continual Fusion of Mitochondria Protects Them From DNA Mutations http://www.nigms.nih.gov/News/Results/041410.htm Fri, 23 April 2010 09:43:14 EST {50129867-B0B4-4705-94EB-9F0A6E5DAA1D} N/A Wed, 14 April 2010 00:00:00 Worms Sense Light Without Eyes http://www.nigms.nih.gov/News/Results/080508.htm Sat, 16 August 2008 16:20:25 EST {5085F9C6-37D3-4BC9-90A0-4E4A98A1364D} NIGMS-funded biologists have discovered a way that worms can sense light, pointing to a tool for understanding how nerves communicate. N/A Tue, 5 August 2008 00:00:00 Pheromone Tells Fly Suitors to 'Buzz Off' http://www.nigms.nih.gov/News/Results/20090716.htm Wed, 22 July 2009 23:11:37 EST {508606FC-8E7D-4163-9A89-D7FEED32D1F0} A team of NIGMS-supported scientists has identified a pheromone that when transferred from males to females during the mating process wards off male suitors for at least a week. N/A Thu, 16 July 2009 00:00:00 Hormone Brings Together Proteins, Bolsters Plant Immune Systems http://www.nigms.nih.gov/News/Results/100610.htm Thu, 14 October 2010 15:47:09 EST {513377E1-D3A5-42FD-BB08-E451108196D4} N/A Wed, 6 October 2010 00:00:00 Sneaky Cancer Gene http://www.nigms.nih.gov/News/Results/091707a.htm Fri, 28 September 2007 15:40:28 EST {514BC02F-BA3E-4E49-9103-0EA7D351CB33} Epigenetic changes can be passed from parents to offspring, affecting their risk for cancer, report NIGMS-funded geneticists. N/A Mon, 17 September 2007 00:00:00 Protein That Marks Molecules for Destruction Also Triggers Immune Defense When Viruses Infect http://www.nigms.nih.gov/News/Results/042110c.htm Fri, 23 April 2010 13:35:01 EST {51B619AD-E6E0-4300-81EF-24DFEFB5275B} N/A Wed, 21 April 2010 00:00:00 Lab Mice More Varied Than Thought http://www.nigms.nih.gov/News/Results/072907a.htm Tue, 31 July 2007 14:16:57 EST {51E0A7AD-35AF-400A-9E63-17C5EDE17BC0} A collaborative study funded by an NIGMS systems biology grant shows that strains of laboratory mice have many more genetic variations than previously thought. ComplexBiologicalSystemsInitiatives Sun, 29 July 2007 00:00:00 Paternal Diet Affects Gene Expression in Offspring http://www.nigms.nih.gov/News/Results/122310.htm Fri, 14 January 2011 12:59:58 EST {51E290AF-CF39-400E-86A8-59513795953B} N/A Thu, 23 December 2010 00:00:00 Researchers Find New Way Protein Can Function http://www.nigms.nih.gov/News/Results/01092009.htm Mon, 16 March 2009 09:30:39 EST {52419EB5-C616-47C4-8919-1BCC92C5D8BB} A group of NIGMS-supported researchers has found a new function for one of the proteins involved with chromosome segregation during cell division. N/A Fri, 9 January 2009 00:00:00 How Dividing Cells Find Their Middle http://www.nigms.nih.gov/News/Results/063008.htm Thu, 10 July 2008 12:32:30 EST {526CA077-B84C-452F-98B4-BDD8324A859D} NIGMS-funded researchers have discovered a self-organizing system that ensures accurate cell division. N/A Mon, 30 June 2008 00:00:00 Disrupted Copper Regulation Linked to Prion Disease http://www.nigms.nih.gov/News/Results/041709a.htm Fri, 1 May 2009 15:29:54 EST {5297AE95-DBEC-4FB7-87B9-B672849BA859} NIGMS-funded researchers have found hints that copper regulation is disrupted in prion disease. N/A Fri, 17 April 2009 00:00:00 New Images Capture Ribosomes at Work http://www.nigms.nih.gov/News/Results/20090820A.htm Thu, 3 September 2009 16:22:45 EST {52A91D68-3824-40C0-AB25-3DE243131061} NIGMS-supported researchers have for the first time captured elusive movements of ribosomes at work, shedding light on how these cellular factories take in genetic instructions and churn out proteins. N/A Thu, 20 August 2009 00:00:00 Insulin-Control System Resets Body’s Clock http://www.nigms.nih.gov/News/Results/20090917B.htm Tue, 29 September 2009 19:10:59 EST {52DDECB2-BD49-4C4D-9570-B607C6CAAAE7} Many of the genes that regulate insulin also alter the timing of the circadian clock, according to a new NIGMS-supported study. N/A Thu, 17 September 2009 00:00:00 Gene Mutation Leads to Neuroendocrine Cancer http://www.nigms.nih.gov/News/Results/072309.htm Thu, 30 July 2009 11:05:52 EST {531513C9-DD91-40A0-9FDF-62AD54EB1217} NIGMS-funded researchers have identified the gene that is mutated in an inherited form of a rare neuroendocrine tumor. N/A Thu, 23 July 2009 00:00:00 Circadian Clock Genes Control Plant Growth http://www.nigms.nih.gov/News/Results/091508.htm Fri, 19 September 2008 15:53:09 EST {531AE1DF-5ABE-49E5-AA30-602494D9FF34} Biologists funded by NIGMS have identified genes that permit plants to grow in spurts at night. N/A Mon, 15 September 2008 00:00:00 Genetic Origins of Muscular Dystrophy http://www.nigms.nih.gov/News/Results/012410.htm Fri, 29 January 2010 17:08:04 EST {53238D1F-CFB0-4D14-B4CB-CF2937BA1186} NIGMS-funded researchers have traced how the loss of one or two proteins can lead to myotonic muscular dystrophy. N/A Sun, 24 January 2010 00:00:00 Gene Linked to Bardet-Biedl Syndrome Helps Shape Development in Frogs http://www.nigms.nih.gov/News/Results/20100730.htm Fri, 6 August 2010 15:16:39 EST {5334C020-6445-41D0-8E92-010604D67889} N/A Fri, 30 July 2010 00:00:00 Supercomputer Helps Explain How Swivel Movement in Ribosomes Allows Protein Synthesis http://www.nigms.nih.gov/News/Results/120210a.htm Wed, 8 December 2010 13:45:33 EST {53BF7602-46BD-48C8-97CE-DAF48EA246B3} N/A Thu, 2 December 2010 00:00:00 Finding Could Lead to Water-Wise Crops http://www.nigms.nih.gov/News/Results/20091213.htm Tue, 29 December 2009 14:34:10 EST {5492A997-D41B-4615-AD09-667187632D7F} NIGMS-supported biologists have identified plant enzymes that may help to engineer plants that take advantage of elevated carbon dioxide to use water more efficiently. N/A Sun, 13 December 2009 00:00:00 How Plant Cells Protect Sperm DNA http://www.nigms.nih.gov/News/Results/020609a.htm Fri, 13 February 2009 16:24:35 EST {54BEA443-8322-460D-92BB-89D83DC973AC} NIGMS-funded researchers have discovered that companion cells in plant pollen protect DNA in sperm cells from damage with small RNA molecules. N/A Fri, 6 February 2009 00:00:00 Discovery of Enzyme Completes Pathway for Making Vitamin C http://www.nigms.nih.gov/News/Results/042707b.htm Tue, 1 May 2007 22:06:45 EST {554799C5-421A-427A-B757-4CD32DCD9F14} NIGMS-funded biochemists have discovered the last unknown enzyme involved in making vitamin C in plants. N/A Fri, 27 April 2007 00:00:00 Potential Drug Candidates For "Bird Flu" http://www.nigms.nih.gov/News/Results/070208.htm Fri, 11 July 2008 14:16:10 EST {55B720EC-1CE6-4081-AD06-443F24134C29} Looking to prepare for a possible outbreak of drug-resistant avian flu, NIGMS-funded researchers have identified more than two dozen new candidate drugs. N/A Wed, 2 July 2008 00:00:00 Proof of Concept for Comprehensive Proteome Analysis http://www.nigms.nih.gov/News/Results/040809.htm Thu, 16 April 2009 14:25:20 EST {5602935D-DB48-4321-A2C0-56A6FBC686EF} NIGMS-funded investigators have deciphered a large proportion of the total protein complement in a species of yeast. N/A Wed, 8 April 2009 00:00:00 Cells Don't Always Respond According to Genetics http://www.nigms.nih.gov/News/Results/041209.htm Fri, 17 April 2009 17:40:50 EST {564FE32A-55C8-4219-A245-781FD0A125C7} NIGMS-funded researchers have studied how genetically identical cells have different amounts of proteins that can affect their response to drugs. ComplexBiologicalSystemsInitiatives Sun, 12 April 2009 00:00:00 More Regulatory DNA in Genome Than Expected http://www.nigms.nih.gov/News/Results/121107b.htm Mon, 17 December 2007 14:50:59 EST {56581364-30F9-4466-884B-D39AC1D6A771} Current computer programs that scan the genome for regulatory DNA can miss more than half of these regions, report NIGMS-funded researchers. N/A Tue, 11 December 2007 00:00:00 Redefining What it Means to be a Prion http://www.nigms.nih.gov/News/Results/040209b.htm Wed, 8 April 2009 11:45:12 EST {56643108-5419-4AD5-BB6F-CE99A1D23F41} NIGMS-funded researchers have found many new prions in yeast to better address whether they have a beneficial role in nature. N/A Thu, 2 April 2009 00:00:00 Flu Virus Trots Globe in Off Season http://www.nigms.nih.gov/News/Results/092007b.htm Tue, 2 October 2007 14:24:02 EST {56A50E30-7F4B-49F6-B12C-197A952DEA46} An NIGMS-funded study shows that flu viruses migrate globally and evolve between successive winters. N/A Thu, 20 September 2007 00:00:00 The Robustness of Metabolic Networks http://www.nigms.nih.gov/News/Results/090408b.htm Mon, 15 September 2008 17:09:51 EST {56B8B153-32D2-4828-95F7-BBD8CF501ECE} An NIGMS-funded team has found that metabolic networks are evolved to handle potentially harmful changes like gene deletions and mutations. BioinformaticsAndComputationalBiology Thu, 4 September 2008 00:00:00 Antibiotic Sets Up Road Block to Kill Bacteria http://www.nigms.nih.gov/News/Results/10222008.htm Wed, 5 November 2008 13:49:47 EST {57219F8B-F122-461A-B159-073D4B5E7CC4} NIGMS-supported scientists have moved toward developing more effective antibacterials by pinpointing how a specific antibiotic blocks bacterial growth. N/A Wed, 22 October 2008 00:00:00 Researchers Discover Variants of Tumor Suppressor Enzyme http://www.nigms.nih.gov/News/Results/040907.htm Mon, 23 April 2007 11:37:22 EST {572423CA-7F54-4F3C-B09C-2285F7915EB7} NIGMS-funded researchers have discovered two variants of a natural tumor suppressor enzyme that could provide new targets for therapies to treat diabetes and heart and neurological diseases. N/A Mon, 9 April 2007 00:00:00 New Method Could Speed Discovery of Psychoactive Drugs http://www.nigms.nih.gov/News/Results/20100117.htm Tue, 26 January 2010 15:48:33 EST {576C73FC-530B-4E29-937C-D0F056B3C4A5} A team of researchers partly supported by NIGMS has developed a system that captures on video and barcodes the behavioral responses of zebrafish to thousands of chemical compounds. ChemHealth Sun, 17 January 2010 00:00:00 Chemists Synthesize Herbal Alkaloid http://www.nigms.nih.gov/News/Results/041509.htm Thu, 30 April 2009 14:25:12 EST {578FE0A0-97F9-458B-9B73-983A8ECFF281} Chemists funded by NIGMS have created an efficient way to make a complex alkaloid found in club moss that has medical potential. N/A Wed, 15 April 2009 00:00:00 Stimulus Grant Funds Image Library of the Cell http://www.nigms.nih.gov/News/Results/100109b.htm Mon, 7 December 2009 12:56:14 EST {57AEA1D6-A074-4BDA-940E-740958C785EA} NIGMS has awarded a "Grand Opportunities" grant to create an online image gallery of the cell that will be accessible to researchers, schools and the public. ARRA Thu, 1 October 2009 00:00:00 How a Mutation Leads to a Deadly Protein Misfolding Disease, Amyloidosis http://www.nigms.nih.gov/News/Results/051010a.htm Fri, 14 May 2010 16:06:28 EST {57B94956-F907-49FA-8FD6-45397407C6F9} N/A Mon, 10 May 2010 00:00:00 Genetic Trait Could Increase Susceptibility to Cocaine Abuse http://www.nigms.nih.gov/News/Results/122010b.htm Mon, 27 December 2010 16:48:44 EST {57FE7B74-85CB-4152-9DEA-3898A94EA84D} N/A Mon, 20 December 2010 00:00:00 Scientists Excise Excess DNA From Induced Stem Cells http://www.nigms.nih.gov/News/Results/032609b.htm Fri, 27 March 2009 13:40:46 EST {583661BF-5150-47B6-BBBE-C1583366C177} NIGMS-funded researchers report that they have created induced human pluripotent stem cells free of viral vectors and exotic genes. StemCellResearch Thu, 26 March 2009 00:00:00 Unraveling the Mechanisms of Friedreich's Ataxia http://www.nigms.nih.gov/News/Results/20090708A.htm Fri, 17 July 2009 12:27:41 EST {587F4FC7-90FF-40AA-9A59-AA783ABAB091} A team supported by NIGMS has analyzed the GAA repeat expansions that characterize Friedreich's Ataxia and identified cellular proteins that promote the elongated sequence. N/A Wed, 8 July 2009 00:00:00 Scientists Create Model of Energy Enzyme http://www.nigms.nih.gov/News/Results/031507.htm Fri, 23 March 2007 13:00:25 EST {5880FF13-A70F-41CD-B652-48A20ABBB227} NIGMS-funded scientists have built a model of the active site of cytochrome c oxidase, a crucial component of cells' energy-generating machinery. N/A Thu, 15 March 2007 00:00:00 Watching Protein Synthesis http://www.nigms.nih.gov/News/Results/032107a.htm Wed, 28 March 2007 11:05:35 EST {58F6BB2B-413F-4CC0-B890-EDE32FB04B2B} A technological advance supported by NIGMS funding has enabled scientists to observe, at the molecular level, real-time movies of key parts of the cells' protein-making machinery. N/A Wed, 21 March 2007 00:00:00 Model Simulates Wound Healing http://www.nigms.nih.gov/News/Results/20090921.htm Fri, 2 October 2009 11:55:04 EST {59AD7972-E6E2-4ADB-9AD8-579A8301984B} NIGMS-supported scientists have devised a mathematical model of wound healing that could replace intuition with clear guidance in treating chronic wounds. TraumaBurnPerioperativeInjuryAndWoundHealing Mon, 21 September 2009 00:00:00 New Method Can Determine Molecular Structure From Protein Nanocrystals http://www.nigms.nih.gov/News/Results/020311a.htm Mon, 7 February 2011 14:41:34 EST {5A74540E-DC21-40A3-AFE9-C1C0DA5AA904} ProteinStructureInitiative Thu, 3 February 2011 00:00:00 Promising Model Organisms Shed Light on Plant-Insect Arms Race http://www.nigms.nih.gov/News/Results/111810c.htm Fri, 19 November 2010 16:15:31 EST {5A99548A-BF10-4252-96C3-E8950027B1A3} N/A Thu, 18 November 2010 00:00:00 Less Labor-Intensive Approach to Engineer Zinc-Finger Nucleases http://www.nigms.nih.gov/News/Results/121210a.htm Thu, 16 December 2010 17:43:15 EST {5AB5C57B-3AB1-4B19-8199-50616E9513B2} N/A Sun, 12 December 2010 00:00:00 Technique Reveals Motions of Individual Enzymes in Nearly Real Time http://www.nigms.nih.gov/News/Results/021210a.htm Wed, 17 February 2010 13:22:11 EST {5B6F8C6A-3B1D-4308-9248-0818EA632156} N/A Fri, 12 February 2010 00:00:00 Mechanism Behind Antimicrobial "Hole Punchers" http://www.nigms.nih.gov/News/Results/092007a.htm Fri, 21 September 2007 15:57:54 EST {5BBCC59C-7A0C-432C-9EF5-15B5BF1BE535} With NIGMS funding, researchers have discovered how a class of antimicrobial compounds works to punch holes in the membranes of bacteria. N/A Thu, 20 September 2007 00:00:00 History of Dividing Cells Explains Cycle DIfferences http://www.nigms.nih.gov/News/Results/101909b.htm Fri, 23 October 2009 17:19:32 EST {5BF9C3D8-6359-4FE6-8641-A0661470FB47} NIGMS-funded researchers found that both mother and daughter cells control and sense their size before committing to divide but that the levers and gears that they use to make that commitment are different. N/A Mon, 19 October 2009 00:00:00 Computers Analyze Environmental Factors in Diabetes http://www.nigms.nih.gov/News/Results/20100520.htm Thu, 3 June 2010 12:12:03 EST {5C009E90-4286-4DD4-B467-285F68BEEB50} N/A Thu, 20 May 2010 00:00:00 Light Used to Manipulate Cell Movement http://www.nigms.nih.gov/News/Results/20090819.htm Thu, 5 November 2009 12:10:36 EST {5C80DE66-5889-4D1C-9FC2-C62A5DDB6E7A} A new technique developed by a team of NIGMS-supported scientists uses light to manipulate the activity of a protein that initiates cell movement, providing a new tool for scientists who study the fundamentals of protein function. N/A Wed, 19 August 2009 00:00:00 Chemists Build First Synthetic Antibodies That Work in Live Organisms http://www.nigms.nih.gov/News/Results/062110a.htm Mon, 28 June 2010 13:00:04 EST {5CC76605-B48F-455D-B648-31949BAEF2BD} ChemHealth Tue, 22 June 2010 00:00:00 Four New Members Appointed to NAGMS Council http://www.nigms.nih.gov/News/Results/councilmembers_20100921.htm Fri, 24 September 2010 17:23:00 EST {5D315C4C-CC79-4F84-93A5-21639A6C0859} AdvisoryCouncil Tue, 21 September 2010 00:00:00 Mechanism Underlying Multidrug Resistance in Fungi http://www.nigms.nih.gov/News/Results/040208.htm Wed, 9 April 2008 11:56:33 EST {5D51A414-583A-4E19-AFA7-18480B2BDB30} An NIGMS-funded study has identified a molecular switch that causes drug-resistance in fungi, which can plague people with compromised immunity. N/A Wed, 2 April 2008 00:00:00 Biologists Identify the Chain That Enables Light to Control Genes in Plants http://www.nigms.nih.gov/News/Results/062410b.htm Wed, 30 June 2010 21:31:45 EST {5D74122F-A777-4A69-BD4E-774F901B8A12} N/A Thu, 24 June 2010 00:00:00 Sources of Hispanic Ancestry Vary Between and Within Communities http://www.nigms.nih.gov/News/Results/050310b.htm Fri, 14 May 2010 16:04:54 EST {5D757C9F-10D3-4E19-B797-D9A36FBC4A31} N/A Mon, 3 May 2010 00:00:00 Researchers Observe 'Ratcheting' of Ribosome Molecules http://www.nigms.nih.gov/News/Results/06052008A.htm Wed, 18 June 2008 16:46:19 EST {5D8EB81D-5354-4DC0-9903-320F942C56E5} NIGMS-supported researchers are the first to observe the dynamic, ratchet-like movements of single ribosomal molecules in the act of building proteins from genetic blueprints. SingleMoleculeDetectionAndManipulation Thu, 5 June 2008 00:00:00 New Boron Compounds Could Lead to Drugs http://www.nigms.nih.gov/News/Results/090209b.htm Fri, 11 September 2009 16:21:25 EST {5DB41B29-0089-4866-8ED4-12547B518E74} NIGMS-funded chemists and biologists have demonstrated that specially synthesized boron compounds are readily accepted in biologically active enzymes. N/A Wed, 2 September 2009 00:00:00 Researchers Identify MicroRNA Targets http://www.nigms.nih.gov/News/Results/20100110.htm Thu, 21 January 2010 12:44:18 EST {5DCF799A-1D5F-434A-A61E-596678B44714} NIGMS-supported researchers have identified the binding sites of microRNAs in one of the foremost model organisms, C. elegans, using biochemical means to capture targeted mRNA sequences in vivo. RNAandRNAinterference Sun, 10 January 2010 00:00:00 Stimulus Funds Go to Stem Cell Research in Nebraska http://www.nigms.nih.gov/News/Results/20091115A.htm Mon, 26 July 2010 10:36:18 EST {5EF85F9F-C904-4734-B9EA-70DBC79E0470} A Nebraska researcher was recently selected to receive federal stimulus funds to extend his work on induced pluripotent stem cells. ARRA Sun, 15 November 2009 00:00:00 How DNA Replication Works As Stem Cells Differentiate http://www.nigms.nih.gov/News/Results/101308a.htm Tue, 14 October 2008 13:37:58 EST {5F106412-960A-4A48-980E-574050979C92} NIGMS-funded researchers have tracked how DNA copying gets reorganized as embryonic stem cells become specialized. StemCellResearch Mon, 13 October 2008 00:00:00 Sea Squirt Toxin Could Lead to Cancer Treatment http://www.nigms.nih.gov/News/Results/020507.htm Thu, 15 February 2007 15:40:11 EST {5F538DD6-4CA8-4096-A6F3-440DBDEF7D37} NIGMS-funded researchers have discovered that a natural toxin called diazonamide can block the reproduction of cultured human cancer cells while leaving healthy cells unaffected. In mice, the toxin curbed tumors without side effects seen with other drugs. N/A Mon, 5 February 2007 00:00:00 Gene Thought to Cause Cancer is Critical for Stem Cell Maintenance http://www.nigms.nih.gov/News/Results/090210a.htm Mon, 13 September 2010 15:40:50 EST {5FB024C6-8096-41C9-9D69-463C99D6DAF3} StemCellResearch Thu, 2 September 2010 00:00:00 Compstatin Found to Inhibit Formation of Blood Clotting Factors http://www.nigms.nih.gov/News/Results/20100616.htm Fri, 25 June 2010 18:21:28 EST {5FE8DD79-FC6F-4B72-B949-FB8DC23386FE} N/A Wed, 16 June 2010 00:00:00 Model Reveals Mechanism Behind Blood Clot Elasticity http://www.nigms.nih.gov/News/Results/022508.htm Wed, 5 March 2008 17:11:35 EST {6001625C-5948-4D7A-97C4-EAD1E93F0E9E} Using a detailed computational approach, NIGMS-funded researchers have modeled why the clotting protein fibrinogen is so elastic. N/A Mon, 25 February 2008 00:00:00 Sex is Irrelevant to Many Cells in the Bodies of Flies http://www.nigms.nih.gov/News/Results/050410.htm Tue, 11 May 2010 13:11:28 EST {60683746-C663-4AD4-8994-C1BE0D94BA3E} N/A Tue, 4 May 2010 00:00:00 Target for Inhibiting Necrosis http://www.nigms.nih.gov/News/Results/041108.htm Fri, 18 April 2008 12:17:19 EST {60A89C7F-28E6-4B6F-A29E-94E14854CD32} A study funded in part by NIGMS reveals that a kinase protein can direct cells into cell death, for example after a heart attack or stroke. N/A Fri, 11 April 2008 00:00:00 Activation of Related Genes Isn't Always Coordinated http://www.nigms.nih.gov/News/Results/120510c.htm Fri, 10 December 2010 12:09:20 EST {60AD9427-C777-4F44-A2BE-1F15770FE7A5} N/A Sun, 5 December 2010 00:00:00 Protein Linked to Alzheimer's Disease Also Found in Eyes of Those With Down Syndrome http://www.nigms.nih.gov/News/Results/052010b.htm Thu, 27 May 2010 10:57:09 EST {60F394EA-9521-4673-AF4A-0BD86F730A0E} N/A Thu, 20 May 2010 00:00:00 Map Shows How Protein Spools Control Genes http://www.nigms.nih.gov/News/Results/032907a.htm Tue, 3 April 2007 11:55:39 EST {613ED688-ED69-46CC-B312-AD4C4DEB38D9} NIGMS-funded scientists have created a map identifying where and how nucleosomes--packaging material for DNA--interact with genes. The interaction is important in regulating gene expression. N/A Thu, 29 March 2007 00:00:00 Anti-Dandruff Compound May Help Fight Epilepsy http://www.nigms.nih.gov/News/Results/042707a.htm Thu, 3 May 2007 13:11:38 EST {618AF372-E1C1-4545-94F7-793447C0F6C2} The active ingredient in many dandruff shampoos shows promise as a potential treatment for seizures, report NIGMS-funded researchers. N/A Fri, 27 April 2007 00:00:00 Molecules Could Block Huntington's Disease http://www.nigms.nih.gov/News/Results/050309.htm Tue, 19 May 2009 14:27:21 EST {61D14D8D-5E36-4E59-B5C6-5B3DF6D3B8F4} NIGMS-funded researchers are working to create molecules that selectively interfere with the production of mutant proteins that cause Huntington's disease. N/A Sun, 3 May 2009 00:00:00 Computers Help Predict Protein Function http://www.nigms.nih.gov/News/Results/071107a.htm Thu, 19 July 2007 12:52:35 EST {61D6AB75-F801-415D-8A12-C846C7440AD9} NIGMS-funded researchers have developed a promising strategy for predicting the functions of proteins based on their amino acid sequence. N/A Wed, 11 July 2007 00:00:00 Structural Biology Scores With Protein Snapshot http://www.nigms.nih.gov/News/Results/20090625.htm Tue, 7 July 2009 14:36:41 EST {6218922B-40E8-42C0-9C66-8D576D199446} In a landmark technical achievement, NIGMS-supported investigators have determined the structure of the largest membrane-spanning protein to date. N/A Thu, 25 June 2009 00:00:00 New Chemistry Approach Promises Cheaper Drugs http://www.nigms.nih.gov/News/Results/032907b.htm Fri, 6 April 2007 15:08:04 EST {623003C5-1A69-4CDA-A56C-EB7B100118CC} A new approach taken by NIGMS-funded chemists allows the creation of specific asymmetric molecules using cheap, environmentally friendly organic molecules as catalysts. N/A Thu, 29 March 2007 00:00:00 Protein Found That Prevents Stem Cells From Turning Cancerous http://www.nigms.nih.gov/News/Results/101410c.htm Thu, 21 October 2010 15:38:04 EST {62AD56C6-CCC8-4109-9B75-663E4B4B264F} StemCellResearch Thu, 14 October 2010 00:00:00 Magnetic Nano-Shepherds Organize Cells http://www.nigms.nih.gov/News/Results/033109.htm Sun, 5 April 2009 16:59:48 EST {62FBD86D-C1C0-4BDB-9129-2C0A1FDBB52C} NIGMS-funded researchers have used magnetic particles like molecular sheep dogs, a strategy that could be used to build human tissues. N/A Tue, 31 March 2009 00:00:00 Green Tea Ingredient Cures Sepsis in Mice http://www.nigms.nih.gov/News/Results/110807.htm Mon, 16 March 2009 09:46:21 EST {6311D3F0-72AD-4EE5-9E5D-4A37CF536DDE} NIGMS-funded researchers have found that a substance in green tea greatly improves the chance for survival in mice with sepsis, paving the way for clinical trials. N/A Thu, 8 November 2007 00:00:00 New Gene Silencing Pathway Found in Plants http://www.nigms.nih.gov/News/Results/20081114.htm Fri, 21 November 2008 16:42:42 EST {632199CB-625A-4C69-A0E3-D9C6E64DC0A9} NIGMS-supported biologists have made headway in explaining a mechanism by which plant cells silence potentially harmful genes. RNAandRNAinterference Fri, 14 November 2008 00:00:00 The Roles of HIV Reverse Transcriptase http://www.nigms.nih.gov/News/Results/050708b.htm Thu, 15 May 2008 18:17:56 EST {634A0234-FF9C-4226-A91E-FE1C0746F13B} An NIGMS-funded study used single-molecule fluorescent imaging to trace the role of reverse transcriptase in real time. SingleMoleculeDetectionAndManipulation Wed, 7 May 2008 00:00:00 "Glue" Grant Study Details Lipids in Mouse Macrophages http://www.nigms.nih.gov/News/Results/120110b.htm Mon, 6 December 2010 15:24:02 EST {6384597A-FCD8-40EB-82FE-34A01CCB2FCB} GlueGrants Wed, 1 December 2010 00:00:00 Biochemists to Study How Chromosomes Unravel to Let Genes Do Their Jobs http://www.nigms.nih.gov/News/Results/050310.htm Tue, 4 May 2010 11:01:56 EST {639E3908-2301-418A-9220-9E5DC11A83CB} N/A Mon, 3 May 2010 00:00:00 New Way to Make Stem Cells Avoids Risk of Cancer http://www.nigms.nih.gov/News/Results/StemCells03262009.htm Mon, 23 August 2010 15:47:27 EST {63AE5A7D-ED62-4AAA-A7F0-83B624C73A39} A team of scientists has advanced stem cell research by finding a way to endow human skin cells with embryonic stem cell-like properties without inserting potentially problematic new genes into their DNA. StemCellResearch Thu, 26 March 2009 00:00:00 Model Helps Explain Major Transitions in Evolution of Complex Organisms http://www.nigms.nih.gov/News/Results/20100610A.htm Thu, 17 June 2010 16:28:40 EST {63D5DB10-897F-4B58-8A39-9D653ADDC8BA} BioinformaticsAndComputationalBiology Thu, 10 June 2010 00:00:00 NIH Funds New Educational Grants to Enhance Diversity in the Neurosciences http://www.nigms.nih.gov/News/Results/20100924.htm Thu, 7 October 2010 13:27:36 EST {641D9563-56CF-4E7D-89E1-93976469183A} N/A Fri, 24 September 2010 00:00:00 Cells That Line Blood Vessels Get Stronger When They Face Mechanical Force http://www.nigms.nih.gov/News/Results/051210b.htm Fri, 14 May 2010 16:18:57 EST {64294F8D-F032-476B-AB84-A04FB8AD4F19} N/A Wed, 12 May 2010 00:00:00 Genetic Test Sorts Similar Gastrointestinal Cancers http://www.nigms.nih.gov/News/Results/021207b.htm Thu, 22 February 2007 11:44:16 EST {64675FCB-73D1-48E2-9E70-EDD836352148} A two-gene test can distinguish between gastrointestinal cancers that require radically different courses of treatment, report NIGMS-funded researchers. N/A Mon, 12 February 2007 00:00:00 How a Key Enzyme Repairs Sun-Damaged DNA http://www.nigms.nih.gov/News/Results/20100725A.htm Thu, 29 July 2010 16:17:08 EST {646C8A7E-B1E5-4F90-8960-7266F11FBE87} N/A Sun, 25 July 2010 00:00:00 The Physics of DNA's Double Helix http://www.nigms.nih.gov/News/Results/071207.htm Fri, 20 July 2007 13:42:08 EST {64701819-261B-4A4D-9E5F-1B0024FCFBDB} A study funded by NIGMS reports the first direct measurements of forces within single strands of DNA--forces that largely reflect the chemical attraction between stacked bases. N/A Thu, 12 July 2007 00:00:00 Researchers Program Cells to Respond to Light http://www.nigms.nih.gov/News/Results/20090913A.htm Wed, 23 September 2009 14:07:12 EST {647C874D-CEEE-46CA-90A6-83586276FC42} NIGMS-supported researchers have genetically encoded mouse cells to respond to light, creating cells that can be trained to follow a beam or stop on command like microscopic robots. N/A Sun, 13 September 2009 00:00:00 Atomic-Level Look at Bone http://www.nigms.nih.gov/News/Results/20091202B.htm Wed, 9 December 2009 19:37:11 EST {6501A243-5FCF-4360-82DA-254DC61E2668} A new NIGMS-supported study used solid-state NMR spectroscopy to analyze intact bone, paving the way for explorations of how disease and aging affect bone. N/A Wed, 2 December 2009 00:00:00 Cell Movements Found to Be Modular http://www.nigms.nih.gov/News/Results/20081130.htm Mon, 16 March 2009 09:31:08 EST {652BF0AC-87F1-4845-A790-A09905FD7D22} NIGMS-supported researchers have shown that distinct groups of proteins each control one of four simple activities involved in the collective migration of cells. N/A Sun, 30 November 2008 00:00:00 Hormone Associated With Obesity Also Helps Immune System Fight Sepsis http://www.nigms.nih.gov/News/Results/043010.htm Fri, 7 May 2010 16:48:11 EST {6587BBDA-A28D-44D2-B108-DB18E8776022} N/A Fri, 30 April 2010 00:00:00 Acetylation Tags on Metabolic Enzymes Appear to Regulate Metabolism and Differ in Cancer Cells http://www.nigms.nih.gov/News/Results/021810.htm Tue, 23 February 2010 14:49:33 EST {65F978F3-22D5-4757-8420-DA4B19812515} N/A Thu, 18 February 2010 00:00:00 E. coli Engineered to Produce Important Drugs http://www.nigms.nih.gov/News/Results/122208.htm Fri, 9 January 2009 17:31:12 EST {661A865F-0252-40E8-84D6-A8D55D541423} NIGMS-funded researchers have successfully used E. coli to synthesize natural products known as bacterial aromatic polyketides. N/A Mon, 22 December 2008 00:00:00 New Computational Languages to Describe Biology http://www.nigms.nih.gov/News/Results/072208.htm Fri, 1 August 2008 15:53:57 EST {661CD75B-93AD-4C20-BB90-489709F949BA} An NIGMS-funded mathematician is helping integrate engineering concepts like artificial intelligence into computational descriptions of cells. BioinformaticsAndComputationalBiology Tue, 22 July 2008 00:00:00 E. Coli Enzyme Must Move to Function http://www.nigms.nih.gov/News/Results/20110407.htm Wed, 13 April 2011 09:50:26 EST {66538FFF-9BCF-477F-8A6A-B879E0DEC182} ProteinStructureInitiative Thu, 7 April 2011 00:00:00 Distinct Evolutionary Genetic Processes Shape an Organism's Form and Function http://www.nigms.nih.gov/News/Results/20100405A.htm Thu, 15 April 2010 14:21:20 EST {66A4EE05-FC5E-4263-B4E2-0CEAE7DEE1C1} N/A Mon, 5 April 2010 00:00:00 Ozone-Resistance Gene Could Lead to Drought-Resistant Crops http://www.nigms.nih.gov/News/Results/022708.htm Thu, 6 March 2008 12:29:22 EST {66A6ED97-96D2-4D2D-9D03-733B9F06D6A9} NIGMS-funded researchers have elucidated the mechanism of a plant gene that controls the amount of ozone that enters a plant's leaves. N/A Wed, 27 February 2008 00:00:00 Purdue Professor Wins Nobel Prize in Chemistry http://www.nigms.nih.gov/News/Results/nobelprize_101006b.htm Wed, 6 October 2010 16:42:44 EST {674107E3-9CAA-4A1A-AAF8-6B908DED5A53} Nobel Prize Wed, 6 October 2010 00:00:00 Genome-Wide Methods Locate Genes Behind Physical Traits in Plants http://www.nigms.nih.gov/News/Results/032410a.htm Tue, 6 April 2010 20:18:12 EST {6790C262-D6A2-4F98-89C8-A4509CF6307C} N/A Wed, 24 March 2010 00:00:00 Chloride Channel May Contribute to Diabetes http://www.nigms.nih.gov/News/Results/102609a.htm Wed, 4 November 2009 13:26:40 EST {6794C3E8-2207-49F0-8FFD-5F82439D1720} NIGMS-supported researchers found that mice lacking a particular chloride ion channel do not secrete insulin properly. N/A Mon, 26 October 2009 00:00:00 Loss of Protein Found to Be Key in ALS Neuron Loss http://www.nigms.nih.gov/News/Results/030411a.htm Tue, 15 March 2011 14:30:58 EST {67A71EFF-B4A9-48FC-8D2F-FB2BE7287B81} N/A Fri, 4 March 2011 00:00:00 DNA Device Mimics Cell's Transportation System http://www.nigms.nih.gov/News/Results/040209c.htm Wed, 8 April 2009 11:44:55 EST {67C8FD65-3851-4804-9BC5-8B872801D3AE} NIGMS-funded researchers have created a bipedal, autonomous DNA "walker" to better understand molecular motor systems. N/A Thu, 2 April 2009 00:00:00 Mitochondria Drive Cell Division http://www.nigms.nih.gov/News/Results/042508.htm Thu, 8 May 2008 15:14:24 EST {67E019C1-624E-4A33-A2DD-162C89AEF522} Studying yeast cells, NIGMS-funded researchers have discovered that mitochondria trigger nuclear DNA to replicate, instigating cell division. N/A Fri, 25 April 2008 00:00:00 Clearer View on Eye Lens Proteins http://www.nigms.nih.gov/News/Results/110309a.htm Mon, 16 November 2009 19:12:12 EST {6817AD25-20C0-4713-9F01-C479589DC3CA} An NIGMS-funded study reveals how proteins critical for the transparency of the eye lens are properly sorted and located. N/A Tue, 3 November 2009 00:00:00 Detailed Picture of Brain Receptor Reveals Potential New Target for Antidepressants http://www.nigms.nih.gov/News/Results/053110a.htm Tue, 8 June 2010 12:36:31 EST {68746FC2-62F5-4330-B95D-EEDBF22BA332} N/A Mon, 31 May 2010 00:00:00 First Detailed Structure of Light-Sensing Phytochrome http://www.nigms.nih.gov/News/Results/053110c.htm Mon, 7 June 2010 13:44:05 EST {68925F46-67CD-43D3-97C6-C5F84652B683} N/A Mon, 31 May 2010 00:00:00 Scientists Launch EcoliHub http://www.nigms.nih.gov/News/Results/050708.htm Wed, 25 March 2009 13:18:40 EST {68A9B704-DDC5-40FB-8743-330DF5145751} With support from NIGMS, scientists have launched a comprehensive online information hub about the E. coli bacterium, one of the most valuable model organisms for biomedical research. N/A Wed, 7 May 2008 00:00:00 Senescent Cells Drawn to a Wound Act to Limit Scar Formation http://www.nigms.nih.gov/News/Results/20100610E.htm Wed, 16 June 2010 18:11:27 EST {6900A384-1E30-4F5C-A0F7-B489659A872E} TraumaBurnPerioperativeInjuryAndWoundHealing Thu, 10 June 2010 00:00:00 Structure of Promising New Antibiotic http://www.nigms.nih.gov/News/Results/080409.htm Tue, 18 August 2009 13:07:40 EST {693D4BB0-EEFC-4461-876B-A654ED706684} An NIGMS-funded study shows how a promising new "last resort" antibiotic called ramoplanin can kill bacteria. N/A Tue, 4 August 2009 00:00:00 Molecular Gymnastics in Gene Regulation http://www.nigms.nih.gov/News/Results/092908.htm Wed, 8 October 2008 10:39:22 EST {696A8A0C-5F88-4624-B414-E1E46FD0A65D} An NIGMS-funded study shows how a protein bends DNA into tight loops to regulate gene expression. N/A Mon, 29 September 2008 00:00:00 Team Coaxes Plants to Reproduce Asexually, Which Could be Applied in Agriculture http://www.nigms.nih.gov/News/Results/030710.htm Fri, 12 March 2010 16:25:19 EST {69A74706-71F4-457A-B74D-932956A93A60} N/A Sun, 7 March 2010 00:00:00 Combination of Methods Reveals Structure of Protein Complex Essential to Mitosis http://www.nigms.nih.gov/News/Results/101310.htm Fri, 15 October 2010 16:14:47 EST {69CA728D-0848-48A6-A891-BD89933D8765} N/A Wed, 13 October 2010 00:00:00 Protein Wavers Between Two Forms http://www.nigms.nih.gov/News/Results/06192009.htm Tue, 30 June 2009 22:24:36 EST {6ACE20E5-9B65-4847-AFE2-424A8F9EC862} NIGMS-supported researchers have found that a bacterial protein thought to exist in a single three-dimensional structure can twist itself into a second form. N/A Fri, 19 June 2009 00:00:00 How Gene-Regulating Protein Alters Chromatin Structure http://www.nigms.nih.gov/News/Results/042709.htm Wed, 6 May 2009 10:02:09 EST {6B150247-848F-4BCB-A5B6-70C1F2FD40F0} An NIGMS-supported study explored how a protein called SUMO alters the structure of chromatin to regulate genetic activity. N/A Mon, 27 April 2009 00:00:00 DNA Knot Keeps Viral Genes Corked http://www.nigms.nih.gov/News/Results/061708.htm Mon, 16 March 2009 08:43:35 EST {6B1AFCB3-6A25-4A45-871E-7FEE848DD3E9} NIGMS-funded researchers have discovered that DNA is coiled into a highly distorted structure under tremendous pressure in a virus shell. N/A Tue, 17 June 2008 00:00:00 Defective Protein in a Form of Ataxia Gives Nerve Cells a Double Hit http://www.nigms.nih.gov/News/Results/20100405.htm Wed, 14 April 2010 21:18:58 EST {6B3E1BC6-48B4-4820-AFB0-8897CBCB4291} N/A Mon, 5 April 2010 00:00:00 How Notorious Cancer Gene Works http://www.nigms.nih.gov/News/Results/031907.htm Mon, 26 March 2007 11:58:40 EST {6B85C4C2-C927-4C4C-88F7-336C39B1552A} NIGMS-funded researchers have shed light on how Src, a cancer gene discovered in 1977, may contribute to tumor growth. N/A Mon, 19 March 2007 00:00:00 Scientists Assemble Artificial Golgi http://www.nigms.nih.gov/News/Results/20090729C.htm Fri, 7 August 2009 15:34:02 EST {6C411B49-5B02-4DED-997B-12C23942F01E} NIGMS-supported scientists report assembly of the first functioning prototype of an artificial Golgi, a key structure inside cells that helps process and package hormones, enzymes, and other substances. N/A Wed, 29 July 2009 00:00:00 Techniques Probe Folding of Individual Prion Molecules http://www.nigms.nih.gov/News/Results/021207a.htm Wed, 21 February 2007 10:41:53 EST {6C6C3481-04EF-401B-9B91-F1B786B8954E} Using innovative techniques, NIGMS-funded researchers have studied the folding of prion proteins, which cause neurodegenerative disease when they misfold. N/A Mon, 12 February 2007 00:00:00 Researchers Target Receptor on B Cells as a Potential Approach to Treat Cancer http://www.nigms.nih.gov/News/Results/060710a.htm Tue, 8 June 2010 12:41:27 EST {6C707431-AB74-4BDF-9175-703E4F5937C1} N/A Mon, 7 June 2010 00:00:00 A Little Squeeze Is Enough For Proteins to Assess DNA http://www.nigms.nih.gov/News/Results/121608.htm Mon, 16 March 2009 08:38:36 EST {6D79D822-B1B3-45E3-8522-483BAFFD9961} An NIGMS-funded study shows that DNA-binding proteins don't need to give full-body hugs to accurately read DNA sequence. N/A Tue, 16 December 2008 00:00:00 Lasers, Custom Microscope Show Splicing in Real Time http://www.nigms.nih.gov/News/Results/031011c.htm Wed, 16 March 2011 16:31:12 EST {6DD71D26-15D7-4359-BF15-4B6526DAA357} CellularImaging Thu, 10 March 2011 00:00:00 Protein Family is Key to Brain Function http://www.nigms.nih.gov/News/Results/111907a.htm Fri, 30 November 2007 17:02:41 EST {6DF6BEC1-58C3-4682-A798-DE0089798411} NIGMS-funded biologists have discovered a family of proteins that helps direct the formation of axons and dendrites, allowing communication between neurons. N/A Mon, 19 November 2007 00:00:00 HIV Protein Makes Cell Membranes Bend More Easily http://www.nigms.nih.gov/News/Results/072507a.htm Fri, 27 July 2007 14:51:39 EST {6E5810B3-6558-4873-818D-F3F08C16D64E} An NIGMS-funded discovery helps reveal how HIV enters immune cells. HIV fusion peptide helps cell membranes curve, allowing HIV to fuse with human cells. N/A Wed, 25 July 2007 00:00:00 Genome Sequence for Biofuels Yeast http://www.nigms.nih.gov/News/Results/100609e.htm Thu, 8 October 2009 14:32:09 EST {6E5DB995-4142-46FD-A079-35AA585809A7} NIGMS-funded researchers have sequenced the genome of a yeast that can convert tough grasses into ethanol, a biofuel. N/A Tue, 6 October 2009 00:00:00 Deaths of Nearby Relatives Cause Bacteria to Flee http://www.nigms.nih.gov/News/Results/062910.htm Wed, 14 July 2010 21:46:31 EST {6E73C07E-2C1B-47E5-BDFB-F9571FC860F0} N/A Tue, 29 June 2010 00:00:00 Coaxing Banked Tissue to Become ES-Like, Researchers Could Observe the Onset of Cancer http://www.nigms.nih.gov/News/Results/020411.htm Thu, 10 February 2011 15:17:22 EST {6E8C57E4-A184-4851-BCEB-AEF634A13470} StemCellResearch Fri, 4 February 2011 00:00:00 RNA Interference and Epigenetic Inheritance http://www.nigms.nih.gov/News/Results/042208a.htm Thu, 16 September 2010 13:32:41 EST {6E9A3EC2-B7C9-4FCC-8023-A7047A808E47} An NIGMS-funded study probes how interfering RNA molecules allow DNA expression patterns to be inherited. RNAandRNAinterference Tue, 22 April 2008 00:00:00 Researchers Discover Protein That Leads to Biofilms of Bacteria That Cause Cholera http://www.nigms.nih.gov/News/Results/021110.htm Wed, 17 February 2010 13:11:24 EST {6F0B7B0C-F658-421A-BD29-8D8CFFC7BC57} N/A Thu, 11 February 2010 00:00:00 New Genes Are As Essential As Ancient Ones http://www.nigms.nih.gov/News/Results/20101216.htm Fri, 24 December 2010 12:32:57 EST {6F9C3A2E-9C9F-44E2-8139-5887C2A32E67} N/A Thu, 16 December 2010 00:00:00 A Nanoscale Mass Spectrometer http://www.nigms.nih.gov/News/Results/072109d.htm Thu, 30 July 2009 11:03:31 EST {6FBE4C60-D249-4CA9-8E64-954844A7F759} NIGMS-funded physicists have created tiny devices that can determine the mass of a single molecule in real time. SingleMoleculeDetectionAndManipulation Tue, 21 July 2009 00:00:00 New Approach May Help Tame Drugs’ Side Effects http://www.nigms.nih.gov/News/Results/20100106A.htm Thu, 14 January 2010 16:44:10 EST {6FE78257-86FA-4202-BD28-1A712B07A517} NIGMS-supported researchers have taken an early step toward identifying a new approach to drug discovery that may eventually yield drugs with fewer side effects. N/A Wed, 6 January 2010 00:00:00 New Map of Genomic Variation http://www.nigms.nih.gov/News/Results/20090715.htm Fri, 24 July 2009 13:29:58 EST {6FEDFA7C-F0AE-4A6F-993C-B24E285E4680} NIGMS-supported researchers have unveiled a powerful new resource for scientists studying human illnesses—a reference standard of deletions and duplications of DNA found in the human genome. N/A Wed, 15 July 2009 00:00:00 Manufactured 3-D RNAs Could Fight Cancer, Other Illnesses http://www.nigms.nih.gov/News/Results/083110a.htm Wed, 8 September 2010 16:56:07 EST {700090D7-FA40-46B1-8424-1B7916A8B829} ARRA Tue, 31 August 2010 00:00:00 Findings May Lead to Broad-Spectrum Antibiotics http://www.nigms.nih.gov/News/Results/101608a.htm Fri, 17 October 2008 13:38:31 EST {7097D07B-C6F6-48CD-A290-43014309C1E2} NIGMS-funded scientists have shown how three antibiotics block the action of RNA polymerase, paving the way for more potent antibiotics. N/A Thu, 16 October 2008 00:00:00 Super Fruit Fly May Lead to Healthier Humans http://www.nigms.nih.gov/News/Results/20070607.htm Tue, 19 June 2007 17:55:44 EST {7098F0B6-2B77-4B6F-8069-91A4C8374429} NIGMS-supported scientists have figured out how to make the fruit fly live longer. The discovery holds implications for human longevity and for treatment of some of the world’s most feared diseases. N/A Thu, 7 June 2007 00:00:00 Chemists Achieve Landmark Synthesis of Medicinal Compound http://www.nigms.nih.gov/News/Results/20100107C.htm Wed, 20 January 2010 14:53:14 EST {70E12DE9-E1FD-4D82-BF77-399DADF2C848} A team of NIGMS-supported chemists has achieved the landmark synthesis of a structurally complex natural product first discovered in a sponge off the coast of Palau. N/A Thu, 7 January 2010 00:00:00 New Analysis Method Advances Structural Biology http://www.nigms.nih.gov/News/Results/043007b.htm Thu, 3 May 2007 13:12:15 EST {717BC073-AB07-4106-9BBF-88A9F404FAB5} A new computational method developed by NIGMS-funded scientists is being hailed as a large technical leap forward in the field of protein structure study. N/A Mon, 30 April 2007 00:00:00 Discovery of Mechanism That Enables Move to New Cells Could Block Toxoplasmosis http://www.nigms.nih.gov/News/Results/092010.htm Fri, 24 September 2010 17:21:55 EST {72117680-BA3E-4A4F-8D4E-CA1E823C5DBE} N/A Mon, 20 September 2010 00:00:00 Gene Thought to Fight Microbes Determines Coat Color in Dogs http://www.nigms.nih.gov/News/Results/103007.htm Fri, 9 November 2007 16:44:43 EST {725C1D19-C9A1-40A7-B97C-221EA30BDC04} NIGMS-funded geneticists have discovered a gene that determines coat color in dogs. Surprisingly, the gene is part of a family involved in fighting infections. N/A Tue, 30 October 2007 00:00:00 Discovery of New Prion in Yeast Raises Questions About Role http://www.nigms.nih.gov/News/Results/031309.htm Thu, 26 March 2009 14:13:21 EST {7268AA58-5623-4CB8-904C-3A15DFA456E1} NIGMS-funded researchers who discovered a prion in yeast are testing whether it could have a natural role in gene regulation. N/A Fri, 13 March 2009 00:00:00 Cell Migration Data Accessible Via New Database http://www.nigms.nih.gov/News/Results/20080810.htm Mon, 25 August 2008 13:27:03 EST {732AFDE2-B449-4329-99DF-02BDAB890E5D} A team funded by the NIGMS has developed a user-friendly, interactive database, granting unprecedented access to information on genes involved in cell migration. GlueGrants Sun, 10 August 2008 00:00:00 Microbiologists Uncover Key Step in Metabolic Pathway Linked to Diabetes http://www.nigms.nih.gov/News/Results/20101105.htm Wed, 10 November 2010 17:20:49 EST {734450F2-C096-422B-BE00-D472716CFE8D} N/A Fri, 5 November 2010 00:00:00 NIGMS Grantees Win Nobel for Gene Targeting http://www.nigms.nih.gov/News/Results/10082007a.htm Fri, 14 November 2008 15:17:25 EST {73B9315E-659C-4801-AFB5-43F5B577151B} The Nobel Prize in physiology or medicine was awarded to three scientists, including NIGMS grantees Mario R. Capecchi and Oliver Smithies, "for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells." Nobel Prize Mon, 8 October 2007 00:00:00 Functioning Human Intestinal Tissue Created From Stem Cells http://www.nigms.nih.gov/News/Results/121210b.htm Thu, 16 December 2010 17:36:10 EST {73E5E2F3-896D-4DF7-83C9-D3A1FF40C516} StemCellResearch Sun, 12 December 2010 00:00:00 Gene Expression Pattern Linked to Pediatric Septic Shock http://www.nigms.nih.gov/News/Results/072607b.htm Fri, 3 August 2007 14:26:19 EST {740B9288-2E56-41A3-86BC-90940F8ACF07} Adverse outcomes in children with septic shock appear to be linked with decreased expression of proteins involved in zinc regulation, reports an NIGMS-funded study. N/A Thu, 26 July 2007 00:00:00 New Evidence Supports the Idea that Human Cells Can Copy RNA http://www.nigms.nih.gov/News/Results/20100810C.htm Tue, 17 August 2010 09:43:09 EST {742A7F08-4752-4424-B0F7-B85280E26671} N/A Tue, 10 August 2010 00:00:00 Cells Are Like Robust Computational Systems http://www.nigms.nih.gov/News/Results/20090616A.htm Fri, 26 June 2009 16:37:53 EST {743D2512-6488-4E04-83DD-F8AB550D9C71} Gene regulatory networks keep working despite the failure of individual components, according to a new NIGMS-funded study. ComplexBiologicalSystemsInitiatives Tue, 16 June 2009 00:00:00 Why Animals Sleep http://www.nigms.nih.gov/News/Results/082508a.htm Fri, 5 September 2008 14:30:15 EST {743F7C5B-9DBB-4B8E-9204-D24C16FC8D8C} NIGMS-funded researchers are asking why all animals sleep and speculate that sleep gives synapses a chance to slow down. N/A Mon, 25 August 2008 00:00:00 Newly Discovered Protein Helps Maintain and Repair Cells' Skeleton http://www.nigms.nih.gov/News/Results/092110b.htm Mon, 27 September 2010 13:10:38 EST {7456651F-7D28-4ACB-A36C-719AE24DFB66} N/A Tue, 21 September 2010 00:00:00 Genomes of Large Utah Family Sequenced as Part of 1000 Genomes Project http://www.nigms.nih.gov/News/Results/102710.htm Thu, 28 October 2010 17:25:01 EST {74CE52A9-8AA5-4B9A-9026-7B54B4E270B5} N/A Wed, 27 October 2010 00:00:00 Targeted Approach To Pain Management http://www.nigms.nih.gov/News/Results/100307.htm Mon, 8 October 2007 11:06:29 EST {75C5C39A-6472-45A9-B601-6642B7A48BF5} NIGMS-funded researchers have developed a way to block pain-sensing neurons without interfering with the action of other neurons. N/A Wed, 3 October 2007 00:00:00 Fast-Replicating Bacterial Viruses Help Speed the Evolution of Biomolecules in the Lab http://www.nigms.nih.gov/News/Results/20110410.htm Wed, 13 April 2011 12:33:29 EST {75E5F77C-5D70-437E-91F8-E8D814AD5190} N/A Sun, 10 April 2011 00:00:00 Break-Induced DNA Repair Causes Genetic Mutations http://www.nigms.nih.gov/News/Results/021611.htm Fri, 4 March 2011 16:12:12 EST {76244711-9488-48A9-A571-AA3180D291C5} N/A Wed, 16 February 2011 00:00:00 Quantitative Techniques Show Precision of Biological Processes http://www.nigms.nih.gov/News/Results/071807a.htm Mon, 23 July 2007 12:21:53 EST {7625CBB0-2A21-4D52-B67B-3DB7EA58A5B0} By combining experimental methods from physics and molecular biology, NIGMS-funded researchers have developed sophisticated ways to study fruit fly development and other biological puzzles. BioinformaticsAndComputationalBiology Wed, 18 July 2007 00:00:00 A Clue to Epigenetic Regulation http://www.nigms.nih.gov/News/Results/082207b.htm Wed, 29 August 2007 10:18:00 EST {7651127C-320D-496F-BD75-9438CF0ABF26} NIGMS-funded biochemists have discovered cues in DNA sequence that appear to signal a chemical modification that can differ depending on whether a gene is inherited from one's mother or father. N/A Wed, 22 August 2007 00:00:00 Cancer Cells Need Normal Genes to Survive http://www.nigms.nih.gov/News/Results/052809b.htm Tue, 9 June 2009 18:57:30 EST {76806430-B13C-420A-A996-CBA2A5C85D75} An NIGMS-supported study suggests that normally functioning genes, not just mutated ones, could be important targets for cancer drugs. N/A Thu, 28 May 2009 00:00:00 Protein That Acts as a Motor to Shuttle Cargo and Help Cells Divide Moves Like a Seesaw http://www.nigms.nih.gov/News/Results/021710c.htm Tue, 23 February 2010 14:44:43 EST {76B0AF52-D772-4966-A805-D81A2CC39B06} SingleMoleculeDetectionAndManipulation Wed, 17 February 2010 00:00:00 Researchers Discover Ebola’s Deadly Secret http://www.nigms.nih.gov/News/Results/20100119.htm Wed, 27 January 2010 16:27:10 EST {76C93CA9-08BC-42B5-A247-01F30B128419} A research team partly supported by NIGMS has revealed how VP35, a critical part of an Ebola virus protein, helps suppress the host immune response. N/A Tue, 19 January 2010 00:00:00 University of Wisconsin, Madison to Share in Stem Cell Funding http://www.nigms.nih.gov/News/Results/103009a.htm Mon, 26 July 2010 10:36:42 EST {76CB0F9A-FFAF-4FC0-898F-515D1C8885D5} Part of NIGMS' stimulus funds to study induced pluripotent stem cells will go to researchers in Wisconsin. ARRA Fri, 30 October 2009 00:00:00 More on the Molecular Basis of Childhood Leukemia http://www.nigms.nih.gov/News/Results/050409.htm Wed, 20 May 2009 14:03:56 EST {76E59B34-EF12-4512-9717-9DFBE55D048A} An NIGMS-funded laboratory has provided new insight on how chromosomal translocations in a gene lead to leukemia. N/A Mon, 4 May 2009 00:00:00 Nanoneedle Releases Quantum Dots Into Nucleus of Living Cell http://www.nigms.nih.gov/News/Results/092710a.htm Wed, 6 October 2010 16:25:47 EST {77869BA1-9721-4C88-8CB8-D3F22F0213F6} N/A Mon, 27 September 2010 00:00:00 Cell-Killing Enzymes Make Sperm Trim http://www.nigms.nih.gov/News/Results/91707b.htm Fri, 28 September 2007 15:39:45 EST {77CF223C-D552-44FA-905B-0DDF322689F0} NIGMS-funded biologists have discovered that caspases, enzymes known to cause cell death, also work to whittle sperm cells into their sleek shape. N/A Mon, 17 September 2007 00:00:00 Dance of Structural Component in Neurons Involved in Long-Term Potentiation http://www.nigms.nih.gov/News/Results/091310b.htm Fri, 17 September 2010 18:07:04 EST {77F97F31-5DF7-4CE0-90AE-DB35F3EE32C3} N/A Mon, 13 September 2010 00:00:00 Watching Membrane Fusion http://www.nigms.nih.gov/News/Results/012607.htm Fri, 2 February 2007 14:04:44 EST {781D0B2A-0A3A-4E7A-AEDD-95F0CAAA3F20} NIGMS-funded researchers have developed a way to see the fusion of biological membranes in unprecedented detail. N/A Fri, 26 January 2007 00:00:00 New Drugs Faster From Natural Compounds http://www.nigms.nih.gov/News/Results/20090713.htm Tue, 21 July 2009 22:40:55 EST {78A76D39-10C4-44F5-9831-A66A412B72E7} A new NIGMS-supported advance will enable scientists to rapidly characterize ring-shaped nonribosomal peptides, a class of natural compounds with a high potential to yield new pharmaceuticals. N/A Mon, 13 July 2009 00:00:00 Researchers Watch Neural Proteins Change Shape http://www.nigms.nih.gov/News/Results/031609.htm Fri, 27 March 2009 13:35:05 EST {78B06C24-C86C-4606-8F75-D66D25070C00} NIGMS-funded researchers have been able to follow the changing shape of individual alpha-synuclein proteins, which are linked to Parkinson's and Alzheimer's diseases. SingleMoleculeDetectionAndManipulation Mon, 16 March 2009 00:00:00 Biologists Identify Key Protein in Cell’s “Self-Eating” Function http://www.nigms.nih.gov/News/Results/20080311A.htm Tue, 18 March 2008 16:28:58 EST {78E4FE36-A045-4A83-95EB-147992BA093E} NIGMS-supported molecular biologists have found one piece of the complex puzzle of autophagy, the process of “self-eating” performed by all eukaryotic cells to keep themselves healthy. N/A Tue, 11 March 2008 00:00:00 Gene Chips Used to Recognize Ventilator-Associated Pneumonia http://www.nigms.nih.gov/News/Results/02122008A.htm Thu, 14 February 2008 14:10:35 EST {79073BFF-FE26-40D4-ACDD-B00C138B27D5} Using gene chip technology, a team of NIGMS-supported scientists has distinguished pneumonia associated with ventilator use from other serious illnesses. N/A Tue, 12 February 2008 00:00:00 Chemical Could Improve Drought Tolerance in Crops http://www.nigms.nih.gov/News/Results/043009a.htm Fri, 15 May 2009 10:52:06 EST {79386BE1-1B4D-4073-AA3F-7F85B91E17EA} NIGMS-funded researchers have shown that artificial mimics of a plant hormone could help crops survive drought. N/A Thu, 30 April 2009 00:00:00 Structures of Two Key Transient Enzyme Complexes in Old Branch of Immune Response http://www.nigms.nih.gov/News/Results/122310b.htm Tue, 4 January 2011 15:38:20 EST {793A0562-CA08-4B75-B592-9BB58632183E} N/A Thu, 23 December 2010 00:00:00 In Elementary School Swine Flu Spreads From Boys to Boys, Girls to Girls http://www.nigms.nih.gov/News/Results/013111b.htm Thu, 3 February 2011 15:38:49 EST {795FDA03-70C4-4245-A248-580BEF518202} ModelingInfectiousDiseases Mon, 31 January 2011 00:00:00 Scientists Challenge RNA Decay Model http://www.nigms.nih.gov/News/Results/20080118.htm Mon, 28 January 2008 17:40:16 EST {796224F7-F305-400C-8011-6DCC04A8D408} A new NIGMS-supported study challenges molecular biology’s widely-accepted model for nonsense-mediated messenger ribonucleic acid (mRNA) decay. N/A Fri, 18 January 2008 00:00:00 Scientists Uncover Role of Gene Linked to Aggressive Cancer http://www.nigms.nih.gov/News/Results/20080117.htm Fri, 25 January 2008 09:49:41 EST {7987A7D5-346E-428C-9476-6845A077719B} NIGMS-supported researchers have revealed the function of a gene previously shown to be part of an 11-gene “signature” that can predict which tumors will be aggressive and likely to spread. N/A Thu, 17 January 2008 00:00:00 Slicing Chromosomes to Understand Their Movement http://www.nigms.nih.gov/News/Results/052909.htm Thu, 11 June 2009 11:20:55 EST {79C59380-AB35-4721-B248-0B3126704C71} NIGMS-funded researchers used laser pulses to slice off pieces of chromosomes to better understand the forces that move them during mitosis. N/A Fri, 29 May 2009 00:00:00 How Chronic Wounds Trigger Tumors http://www.nigms.nih.gov/News/Results/20090706.htm Tue, 14 July 2009 14:08:53 EST {79DF8902-F6BF-4CAC-8A84-3CDB08D3DBA8} A team of NIGMS-supported researchers has shed light on the tumor-promoting effects of long-standing wounds and injuries using mice engineered to have a persistent wound-like skin condition. N/A Mon, 6 July 2009 00:00:00 Technique Can Control Protein Activity http://www.nigms.nih.gov/News/Results/092808.htm Tue, 7 October 2008 13:24:19 EST {7A0B647A-967B-4683-B4B2-3559C26DD7A1} NIGMS-funded researchers have developed a way to pair proteins with a drug that prevents proteins from being degraded. N/A Sun, 28 September 2008 00:00:00 Assembly of Fly Mitochondrial DNA for Landmark Project http://www.nigms.nih.gov/News/Results/110707b.htm Thu, 15 November 2007 11:57:35 EST {7A0E9E32-EC38-4C9D-A08D-CB7937EA4F12} As part of an immense project cataloging the DNA sequences of a dozen species of fruit fly, NIGMS-funded biologists assembled the mitochondrial DNA sequences of the flies. N/A Wed, 7 November 2007 00:00:00 Crystal Structure of Donut-Shaped Enzyme That Degrades Proline, Creates Tunnel Between Catalytic Sites http://www.nigms.nih.gov/News/Results/021510.htm Fri, 19 February 2010 12:43:17 EST {7A23F8B0-E0CA-4D4D-A11C-1C6B62499A23} N/A Mon, 15 February 2010 00:00:00 Convergent Evolution in Snake and Lizard Proteins http://www.nigms.nih.gov/News/Results/042109.htm Mon, 4 May 2009 13:27:58 EST {7A868794-5842-4C22-843E-7391E0E551E2} NIGMS-funded research has discovered widespread convergent molecular evolution across mitochondrial proteins. N/A Tue, 21 April 2009 00:00:00 A General Method for Detecting Trace Chemicals http://www.nigms.nih.gov/News/Results/022509.htm Fri, 13 March 2009 17:55:13 EST {7AA32F3C-582A-4218-918B-51AA05C1551F} NIGMS-funded researchers have discovered a method that uses RNA replicator molecules to detect specific chemicals. RNAandRNAinterference Wed, 25 February 2009 00:00:00 Nanobubbles Generated Around Gold Nanoparticles Can Detect and Destroy Cancer Cells http://www.nigms.nih.gov/News/Results/092710b.htm Fri, 1 October 2010 16:14:53 EST {7B2A942F-AB3F-42B6-B14E-C457E5A3636D} N/A Mon, 27 September 2010 00:00:00 The Motions of Proteins--Random or Controlled? http://www.nigms.nih.gov/News/Results/082708.htm Fri, 5 September 2008 14:30:33 EST {7B54515A-5388-47C4-B37B-949D60F66B21} NIGMS-funded researchers have found that protein motions appear to be more restricted and controlled than many expected. N/A Wed, 27 August 2008 00:00:00 Structure Crucial to Chromosome Segregation http://www.nigms.nih.gov/News/Results/122007b.htm Thu, 3 January 2008 11:25:57 EST {7BDE346C-2A43-48E0-B856-D6833EE8BFCD} NIGMS-funded researchers have solved the structure of a DNA-protein complex necessary for chromosome separation and involved in the spread of antibiotic resistance. N/A Thu, 20 December 2007 00:00:00 Three-Dimensional View of Core Replication Machinery http://www.nigms.nih.gov/News/Results/120908.htm Mon, 16 March 2009 08:42:05 EST {7C09C09F-C3D7-4D03-84D0-6E0770C8D10B} NIGMS-funded researchers have obtained a detailed structure for the core of the replisome, molecular machinery assembled to copy DNA. N/A Tue, 9 December 2008 00:00:00 Magnets Used to Turn Drugs On and Off http://www.nigms.nih.gov/News/Results/20090918.htm Tue, 29 September 2009 19:11:20 EST {7C357D6C-834C-4FDB-84AD-725524E80218} A team of NIGMS-supported researchers has created a small implantable device that releases drugs into the body when a magnetic field is applied. N/A Fri, 18 September 2009 00:00:00 Chemists Expand Plants' Pharmaceutical Repertoire http://www.nigms.nih.gov/News/Results/110310a.htm Tue, 9 November 2010 14:43:13 EST {7C572A68-736B-48C8-BF53-49DF649A3032} N/A Wed, 3 November 2010 00:00:00 Bacteria From Hot Springs Shed Light on Early Evolution of Life http://www.nigms.nih.gov/News/Results/20090608.htm Mon, 14 June 2010 11:07:32 EST {7C7C32AA-810F-401C-9A41-40BFC1DEA05F} N/A Tue, 8 June 2010 00:00:00 Genetic Variation Tied to Risk of Relapse in Childhood Leukemia http://www.nigms.nih.gov/News/Results/020611a.htm Thu, 10 February 2011 15:17:53 EST {7C813E1C-2463-4483-9393-93DB0C93EB28} PharmacogeneticsResearchNetwork Sun, 6 February 2011 00:00:00 Researchers Uncover New Way to Target Flu http://www.nigms.nih.gov/News/Results/20080130.htm Mon, 4 February 2008 11:51:08 EST {7D1334C7-D5BC-4B8B-90DB-6F06BFAFFF2D} A team of researchers supported by NIGMS has solved the three-dimensional structure of an influenza protein called M2. The findings offer new ways to target drug-resistant influenza. N/A Wed, 30 January 2008 00:00:00 Newly Discovered Method to Regulate Genes is Unique to Primates http://www.nigms.nih.gov/News/Results/020911a.htm Fri, 25 February 2011 11:21:01 EST {7D2697DA-6E59-4A6B-A236-C1086CD4F7B2} N/A Wed, 9 February 2011 00:00:00 Inactivating a Protein May Protect Against MS http://www.nigms.nih.gov/News/Results/042307c.htm Mon, 30 April 2007 13:36:13 EST {7D54EC87-4A78-40B4-BDC9-8BB8475536D8} NIGMS-funded neuroscientists have discovered that deactivating a protein protects nerve fibers from damage, suggesting the protein could serve as a target for drugs to treat multiple sclerosis. N/A Mon, 23 April 2007 00:00:00 Unlocking the Function of Enzymes http://www.nigms.nih.gov/News/Results/110607.htm Thu, 15 November 2007 10:24:06 EST {7DC3B12D-B23A-40C4-97CC-48F42C18F38F} Without knowing an enzyme's function, NIGMS-funded researchers were able to predict its substrate based on the enzyme's structure. N/A Tue, 6 November 2007 00:00:00 Yale’s Thomas Steitz Shares 2009 Nobel Prize in Chemistry http://www.nigms.nih.gov/News/Results/nobel_20091007c.htm Wed, 21 October 2009 12:54:54 EST {7DFA2C30-12A6-44A6-8D5A-5AC650667D35} NIGMS grantee Thomas A. Steitz of Yale University is named a recipient of the 2009 Nobel Prize in chemistry. Nobel Prize Wed, 7 October 2009 00:00:00 Scientists Reveal How Cell's Transcribing Machine Achieves Near Perfection http://www.nigms.nih.gov/News/Results/06052008.htm Mon, 16 March 2009 09:38:48 EST {7E7F2962-7DFB-47A4-9022-55076142F549} NIGMS-supported researchers have discovered new details of how the cell's major transcriptional enzyme, RNA polymerase II, functions with such exquisite precision. N/A Thu, 5 June 2008 00:00:00 Bacteria Use Toxic Darts to Disable Each Other http://www.nigms.nih.gov/News/Results/111810b.htm Fri, 19 November 2010 16:14:02 EST {7EB8A8D2-91D3-49F5-AEE4-398415583871} N/A Thu, 18 November 2010 00:00:00 Form of Vitamin B1 Could Treat Blindness http://www.nigms.nih.gov/News/Results/042309.htm Tue, 5 May 2009 11:35:49 EST {7F0430CB-40F1-4393-908C-4FB758021D73} An NIGMS-funded study has found that a type of vitamin B1 could treat the inflammation that is a common cause of blindness. N/A Thu, 23 April 2009 00:00:00 A Tunable Circuit in Pancreatic Beta Cells Appears to Control Insulin Release http://www.nigms.nih.gov/News/Results/120710b.htm Mon, 13 December 2010 15:38:37 EST {7F108571-0C8D-42C1-A44E-CB9A83D78BC9} N/A Tue, 7 December 2010 00:00:00 Enzyme Promotes Cell Proliferation http://www.nigms.nih.gov/News/Results/092507.htm Fri, 5 October 2007 16:17:27 EST {7F26B0F5-7605-4F94-9227-67F84DDB1F90} NIGMS-funded researchers have discovered that an enzyme called PLC-epsilon is required for cell growth, which, if unchecked, can lead to inflammation and cancer. N/A Tue, 25 September 2007 00:00:00 Scientists Develop Tools to Breed Maize Rich in Provitamin A http://www.nigms.nih.gov/News/Results/20080124.htm Tue, 29 January 2008 17:00:38 EST {7F3CA622-D704-4BE2-96A8-E9BD77C1B411} A team of NIGMS-supported scientists has identified DNA-based indicators for high provitamin A production that breeders can use in maize breeding programs. N/A Thu, 24 January 2008 00:00:00 Tinkering With Circadian Clock Can Suppress Cancer http://www.nigms.nih.gov/News/Results/020309b.htm Thu, 6 August 2009 13:20:32 EST {7F696AEF-9641-45D0-9EAA-A182E8849983} NIGMS-funded researchers found that altering four "clock" genes suppressed cancer growth in a mouse model. N/A Tue, 3 February 2009 00:00:00 Replacing microRNAs Could Treat Cancer http://www.nigms.nih.gov/News/Results/033108d.htm Mon, 7 April 2008 14:29:42 EST {7F966F05-C13D-45EB-AB52-A8E5D3BF1B24} Small, non-coding RNAs appear to be a master regulator without which many types of cells become cancerous, reports an NIGMS-funded study. N/A Mon, 31 March 2008 00:00:00 How Membrane Proteins Self-Organize http://www.nigms.nih.gov/News/Results/20090706A.htm Tue, 14 July 2009 14:07:33 EST {7FDCD9F3-8415-4D8F-851E-5D8BBAB8D34A} A team of NIGMS-supported scientists has taken a unique look at how thousands of bacterial membrane proteins assemble into clusters that direct cell movement to select chemicals in their environment. N/A Mon, 6 July 2009 00:00:00 New Catalytic Method Makes Important Class of Carbon-Carbon Double Bonds http://www.nigms.nih.gov/News/Results/032311.htm Fri, 1 April 2011 16:40:15 EST {803CC861-D63F-454A-9F96-08717BF18BB3} N/A Wed, 23 March 2011 00:00:00 Mystery of Glowing Antibody Solved http://www.nigms.nih.gov/News/Results/022808a.htm Mon, 10 March 2008 14:09:10 EST {804DD4A1-F90D-4213-93E7-B363B40CD1C4} NIGMS-funded scientists have discovered the rare and rather surprising mechanism behind the bright blue glow of a fluorescent antibody, which could be applied to the development of biosensors. N/A Thu, 28 February 2008 00:00:00 Click Chemistry in Live Cells http://www.nigms.nih.gov/News/Results/102507b.htm Thu, 8 November 2007 15:37:53 EST {80D15685-93FE-4F9F-B11B-B80A3FA5EC32} NIGMS-funded chemists have extended click chemistry, a technique for labeling biomolecules, to live cells, opening the way for probing molecular dynamics in many contexts. N/A Thu, 25 October 2007 00:00:00 Honeybee Venom Leads to New Tool for Studying Hypertension http://www.nigms.nih.gov/News/Results/091608b.htm Fri, 19 September 2008 15:53:30 EST {813A1733-7C9B-414E-B03B-3FB4E974B80D} NIGMS-funded researchers have modified a honeybee venom toxin to use it as a tool to study ion channels that control heart rate and salt recycling. N/A Tue, 16 September 2008 00:00:00 Mahjong Gene Underlies Life-Death Competition Between Cancer and Normal Cells http://www.nigms.nih.gov/News/Results/071310.htm Fri, 23 July 2010 11:33:19 EST {814D3E8F-32E5-45C2-8410-901A26E88D54} N/A Tue, 13 July 2010 00:00:00 Many Genetic Variations Linked to Leukemia Treatment http://www.nigms.nih.gov/News/Results/012709b.htm Fri, 30 January 2009 13:46:06 EST {8162E9BA-45E2-4EA6-AE2D-366E08F2314A} Scientists in the NIGMS-funded Pharmacogenetics Research Network have linked scores of genetic variations with how children respond to leukemia drugs. PharmacogeneticsResearchNetwork Tue, 27 January 2009 00:00:00 Tiny Protein Provokes Bonding Between Cells http://www.nigms.nih.gov/News/Results/20081125.htm Tue, 2 December 2008 10:33:48 EST {81E9B851-BBC5-4B12-B623-F53F7F2B57CA} Alpha-catenin allows cells to recognize neighboring cells as ‘friends’, leading to strong bonds that are hard to break, according to a new NIGMS-supported study. N/A Tue, 25 November 2008 00:00:00 Tailor-Made Recombinant Proteins in Mammals http://www.nigms.nih.gov/News/Results/020909b.htm Wed, 18 February 2009 16:53:09 EST {81ED8202-B3F6-4B16-9884-793B34BA6931} NIGMS-funded researchers have developed a way to direct chemical modifications to specific sites on recombinant proteins. N/A Mon, 9 February 2009 00:00:00 Hints for Better Care of Leukemia Survivors http://www.nigms.nih.gov/News/Results/032007.htm Tue, 29 July 2008 13:33:32 EST {8252E23A-CB99-4D43-8F8D-DDBDD9FD9073} The longest follow-up study ever done on children with acute lymphoblastic leukemia, supported in part by NIGMS, identifies risks for survivors later in life. PharmacogeneticsResearchNetwork Tue, 20 March 2007 00:00:00 Engineering Heart Repair Patches From Stem Cells http://www.nigms.nih.gov/News/Results/100709e.htm Thu, 8 October 2009 14:34:10 EST {82776BD7-4DF8-407D-BB64-1076FBE17656} NIGMS-funded bioengineers have succeeded in building human tissue patches with supply lines for the oxygen and nutrients that living cells require. StemCellResearch Wed, 7 October 2009 00:00:00 How Cells Shuttle Proteins to Their Destinations http://www.nigms.nih.gov/News/Results/021009.htm Wed, 18 February 2009 16:53:35 EST {838D11FC-CD30-4ACB-81FB-05C4DC7C5AD2} NIGMS-funded researchers have shed light on the process of intracellular protein delivery. N/A Tue, 10 February 2009 00:00:00 New $8.9 Million Project Aims to Unlock Stem Cell Secrets http://www.nigms.nih.gov/News/Results/20080804A.htm Tue, 5 August 2008 10:20:44 EST {83DE0ECC-0E00-42DD-AC10-4A9B73BFC445} University of Wisconsin researcher James Thomson has been awarded an NIGMS grant to pursue a research program that addresses some of the most fundamental questions about stem cells. StemCellInitiatives Mon, 4 August 2008 00:00:00 Pictures Show the Intermediate Steps in Ribosome Creation http://www.nigms.nih.gov/News/Results/110110a.htm Thu, 4 November 2010 11:31:40 EST {841DA93D-95B9-4EAB-A35D-175B9701D56A} N/A Mon, 1 November 2010 00:00:00 Roles of DNA Packaging Protein Revealed http://www.nigms.nih.gov/News/Results/021209c.htm Fri, 20 February 2009 13:42:44 EST {8439DF8A-BEC9-4576-AC5C-6D6C341CC140} NIGMS-funded scientists have found that linker histones, a class of chromatin proteins, are crucial for chromosome packaging and gene regulation. N/A Thu, 12 February 2009 00:00:00 Scientists Give Bacteria New Goals http://www.nigms.nih.gov/News/Results/051107.htm Tue, 5 June 2007 21:50:19 EST {8457587D-02A9-4BD0-9EEB-87A080761165} NIGMS-funded researchers have used an innovative method to reprogram bacteria to detect and follow specific chemical signals. N/A Fri, 11 May 2007 00:00:00 How Protein Detects Viruses and Sparks Immune Response http://www.nigms.nih.gov/News/Results/021909b.htm Thu, 18 June 2009 12:21:16 EST {84A4914C-A031-484E-9A71-5B802E08176A} NIGMS-funded researchers have revealed how a cell protein recognizes an invading virus and alerts the body to the infection. N/A Thu, 19 February 2009 00:00:00 Brain Responses During Anesthesia Mimic Those During Natural Deep Sleep http://www.nigms.nih.gov/News/Results/012710b.htm Tue, 2 February 2010 16:11:21 EST {84E034A3-8AA6-41FA-B272-2177ACF4E696} N/A Wed, 27 January 2010 00:00:00 Cooperating Proteins Could Be Cancer Drug Targets http://www.nigms.nih.gov/News/Results/011609b.htm Wed, 28 January 2009 17:57:00 EST {84FBFC34-9926-4C87-AB23-835DED9627BA} NIGMS-funded biochemists have found two proteins that work together to ensure proper chromosome segregation during cell division. N/A Fri, 16 January 2009 00:00:00 New, Improved Light-Driven Nanomotor http://www.nigms.nih.gov/News/Results/060409.htm Mon, 15 June 2009 13:54:33 EST {855148FB-E25E-4B82-8A37-7BA48571FC64} An NIGMS-supported study reports the building of a new type of nanomotor made from a molecule of DNA and driven only by particles of light. N/A Thu, 4 June 2009 00:00:00 Stem-Cell Like Properties in Plant Cells http://www.nigms.nih.gov/News/Results/012809c.htm Mon, 2 February 2009 14:45:22 EST {8560E51D-1383-4851-9393-04DB880B03CD} NIGMS-funded biologists have discovered that ordinary plants cells have the ability to replace lost organs in plants. N/A Wed, 28 January 2009 00:00:00 Technique Uses Light to Control Activity of a Protein in Living Cell http://www.nigms.nih.gov/News/Results/051710a.htm Thu, 1 July 2010 15:14:08 EST {85650FBC-0474-4941-98A0-6B85BB7E416A} N/A Mon, 17 May 2010 00:00:00 Evolutionary Battle Between Plants and Pathogens http://www.nigms.nih.gov/News/Results/071807b.htm Thu, 26 July 2007 11:51:37 EST {863304C4-B397-45C9-8482-EEA074A5D87A} NIGMS-funded scientists have explored how tomato plant pathogens evolve to escape detection and the countermeasures mounted in response by the plant. N/A Wed, 18 July 2007 00:00:00 How a Virus Infects Bacteria http://www.nigms.nih.gov/News/Results/120808a.htm Wed, 10 December 2008 10:38:43 EST {86AA0BC4-39C6-41A6-918F-292377A24054} A study supported by NIGMS reveals how some viruses infect E. coli bacteria. N/A Mon, 8 December 2008 00:00:00 TB-Drugome Provides New Targets for Anti-Tuberculosis Drug Discovery http://www.nigms.nih.gov/News/Results/20101108A.htm Mon, 15 November 2010 15:27:58 EST {86E48EEB-A048-4B6E-BC5B-B4888C220C9E} N/A Mon, 8 November 2010 00:00:00 Genetic Region Linked to Anesthesia Sensitivity http://www.nigms.nih.gov/News/Results/091009b.htm Mon, 21 September 2009 13:34:21 EST {86E9A3F6-264A-431C-91BF-83446901B97C} Studying rats, NIGMS-funded researchers have discovered a genetic region responsible for cardiovascular collapse during anesthesia. N/A Thu, 10 September 2009 00:00:00 Protein Called Reaper Triggers Apoptosis by Striking at Mitochondria http://www.nigms.nih.gov/News/Results/101910.htm Fri, 22 October 2010 14:46:20 EST {86F453A8-1312-40B4-8201-364E29525AEA} N/A Tue, 19 October 2010 00:00:00 Computational Method Uncovers Close to a Thousand Distinct Protein-Protein Interfaces http://www.nigms.nih.gov/News/Results/20101215.htm Mon, 20 December 2010 16:54:07 EST {87A6A41C-73AE-48AC-846D-A7036616D9BF} N/A Wed, 15 December 2010 00:00:00 Marine Worm Sheds Light on How Organisms Develop http://www.nigms.nih.gov/News/Results/20070702.htm Mon, 16 July 2007 11:33:36 EST {87F4D59C-225B-45B3-B754-E22E8A20D49E} NIGMS-supported biologists studying a common ocean-dwelling worm have uncovered potentially fundamental insights into how different cell types are produced during animal development. N/A Mon, 2 July 2007 00:00:00 Kinase Regulates Cytoskeleton and Could be a Target for Future Cancer Therapies http://www.nigms.nih.gov/News/Results/053110b.htm Thu, 3 June 2010 17:06:02 EST {88A2A848-E0CD-4C18-8F59-2A2B4A540F4A} N/A Mon, 31 May 2010 00:00:00 Non-Invasive Way to Monitor for Sepsis in Newborns http://www.nigms.nih.gov/News/Results/020807b.htm Mon, 16 March 2009 09:47:12 EST {895A55A4-30B0-4B9E-B531-6C996A6637C9} NIGMS-funded researchers have developed a way to monitor babies in neonatal intensive care units to predict sepsis before it hits. Continuous monitoring of heartbeat patterns can detect infants at risk. N/A Thu, 8 February 2007 00:00:00 Blocking Termites' Defense Mechanisms http://www.nigms.nih.gov/News/Results/060809a.htm Mon, 22 June 2009 11:49:40 EST {89704C47-714F-40F4-A280-3B88447534F5} NIGMS-funded researchers find that targeting insects' immune systems, thereby making them more susceptible to infection, could offer a sustainable method of pest control. N/A Mon, 8 June 2009 00:00:00 New Way of "Stapling" Peptide Helices Could Help Them Keep Their Shape http://www.nigms.nih.gov/News/Results/020811c.htm Mon, 14 February 2011 13:15:48 EST {89CE1BE6-8738-43B7-B711-8A613FF324C9} N/A Tue, 8 February 2011 00:00:00 Mechanism Links Aging and Cancer http://www.nigms.nih.gov/News/Results/020507c.htm Tue, 29 July 2008 13:53:33 EST {89DAE4AF-B75A-49A8-A1F0-E99DA8AA91DE} In studying the chromosomes of patients with the premature aging disease Werner Syndrome, NIGMS-funded researchers have shown that rebuilding the chromosome tips blocks genetic damage associated with both aging and cancer. TelomeresAndTelomerase Mon, 5 February 2007 00:00:00 Structure of Plant Hormone Receptor http://www.nigms.nih.gov/News/Results/20091203B.htm Fri, 11 December 2009 15:59:03 EST {89F10249-4926-4354-912E-12CD12404166} A team of NIGMS-supported researchers has determined the structure of a key plant hormone receptor. The findings could help scientists engineer hardier plants. N/A Thu, 3 December 2009 00:00:00 Fluorescent Proteins Tag Structures in Living Cells http://www.nigms.nih.gov/News/Results/012509.htm Thu, 29 January 2009 16:49:37 EST {8A6862B4-7317-42B5-AC4C-C3C66E4EA727} NIGMS-funded researchers are developing advanced fluorescent probes to watch structures and processes in living cells. CellularImaging Sun, 25 January 2009 00:00:00 Study Reveals H1N1 Weakness http://www.nigms.nih.gov/News/Results/20091210C.htm Thu, 17 December 2009 11:11:17 EST {8AC22CE8-996C-4366-9BFE-3FC6D47EBF32} A team of NIGMS-supported researchers has uncovered a weakness in H1N1's method for evading detection by the immune system. N/A Thu, 10 December 2009 00:00:00 New Understanding of How Nodes of Ranvier Keep Nerve Impulses Hopping http://www.nigms.nih.gov/News/Results/012611.htm Wed, 2 February 2011 13:58:13 EST {8B34780C-0D4C-436E-B7BC-5B75EF8DE8D5} N/A Wed, 26 January 2011 00:00:00 So-Called Junk DNA Supports Healthy Embryonic Development http://www.nigms.nih.gov/News/Results/071610c.htm Wed, 28 July 2010 19:47:20 EST {8B40E877-260D-4F6D-88DC-C338158F65D0} N/A Fri, 16 July 2010 00:00:00 Fruit Fly Nervous Systems Could Serve as Model for More Effective Distributed Computing Applications http://www.nigms.nih.gov/News/Results/011311a.htm Thu, 20 January 2011 14:51:20 EST {8B470B5E-D948-4621-A48A-8658C75F8B9A} N/A Thu, 13 January 2011 00:00:00 Protein Shows Surprising Range of Functions http://www.nigms.nih.gov/News/Results/081309.htm Tue, 18 August 2009 13:10:37 EST {8B55BE7C-7C0B-4CC1-85E2-F0243417F33B} A protein known to regulate gene expression also protects the tips of chromosomes and is involved in protein stability, NIGMS-funded researchers report. TelomeresAndTelomerase Thu, 13 August 2009 00:00:00 Molecular Structure Helps Explain Drought Tolerance http://www.nigms.nih.gov/News/Results/102109a.htm Thu, 29 October 2009 15:55:43 EST {8B6B0E81-1C8A-41E2-867C-F807E01E392F} A team of biologists supported by NIGMS has solved the structure of a molecule that helps plants survive droughts. N/A Wed, 21 October 2009 00:00:00 Courtship Pattern Linked to Gene in Fruit Flies http://www.nigms.nih.gov/News/Results/05262008.htm Mon, 16 March 2009 08:32:20 EST {8B7786DD-E600-49B7-841E-6C667F8BCE9F} When a gene known as sphinx is inactivated in the common fruit fly, it leads to increased male-male courtship, according to a new NIGMS-supported study. N/A Mon, 26 May 2008 00:00:00 Biology Majors’ Research Helps Advance Fungal Functional Genomics Studies http://www.nigms.nih.gov/News/Results/biology_03262010.htm Thu, 1 April 2010 13:50:06 EST {8C08FC72-8EFD-417C-8D30-0E56214D028D} N/A Fri, 26 March 2010 00:00:00 Long-Time NIGMS Grantees Win Albany Medical Prize http://www.nigms.nih.gov/News/Results/050208.htm Thu, 8 May 2008 15:15:08 EST {8C0FF9E1-4D3C-4EE4-A1DD-09A199285485} Joan Steitz of Yale University and Elizabeth Blackburn of the University of California, San Francisco, are the first women to win the Albany Medical Center Prize in Medicine and Biomedical Research, America’s largest prize in medicine. N/A Fri, 2 May 2008 00:00:00 Blocking the Spread of Antibiotic Resistance http://www.nigms.nih.gov/News/Results/121808b.htm Thu, 8 January 2009 17:46:33 EST {8C880ED4-FF5F-43CC-AE43-66B2060124B8} NIGMS-funded researchers discovered that a special DNA sequence in certain bacteria can impede the spread of antibiotic resistance in Staphylococcus. N/A Thu, 18 December 2008 00:00:00 Researchers Synchronize Blinking "Genetic Clocks" http://www.nigms.nih.gov/News/Results/20100120.htm Wed, 27 January 2010 16:27:39 EST {8CB3CC55-9B68-428D-BD00-12F023CA07AB} NIGMS-supported researchers have synchronized bacterial “genetic clocks” to blink in unison and to alter their blinking rates when environmental conditions change. N/A Wed, 20 January 2010 00:00:00 Protein Key to Spread of Prions http://www.nigms.nih.gov/News/Results/012307.htm Wed, 31 January 2007 14:38:42 EST {8CC60E34-B848-4678-973D-51673DCEAA8A} A single protein plays a major role in brain-wasting prion diseases by smashing up clusters of the infectious proteins, allowing the fatal illness to spread quickly, report NIGMS-funded researchers. N/A Tue, 23 January 2007 00:00:00 Fruit Flies Lead to Leukemia Target http://www.nigms.nih.gov/News/Results/031107b.htm Tue, 20 March 2007 12:42:55 EST {8D55FD96-F929-4F0A-B1A7-E8303345056A} In finding the related gene in flies, an NIGMS-funded study has identified a possible treatment target for certain types of leukemia. N/A Sun, 11 March 2007 00:00:00 Tiny Segments of RNA May Play an Important Role in Regulating Cholesterol and Lipids http://www.nigms.nih.gov/News/Results/051310b.htm Fri, 21 May 2010 10:42:54 EST {8D9924AD-5E10-4F7F-8EA1-EC85E1C434C4} N/A Thu, 13 May 2010 00:00:00 Computer Model Suggests Genetic Mechanism For Tuberculosis Dormancy http://www.nigms.nih.gov/News/Results/091710.htm Tue, 21 September 2010 10:11:51 EST {8D9C9FCE-A9D7-40A3-84E0-1346713BDF29} ComputingLife Fri, 17 September 2010 00:00:00 How Cells Accessorize Their Proteins http://www.nigms.nih.gov/News/Results/091808b.htm Fri, 26 September 2008 11:25:12 EST {8DF36DE3-08B7-48B6-AD6D-2103581234A7} Researchers supported in part by NIGMS have determined how an enzyme that stitches important molecular adjustments onto proteins regulates its own function. N/A Thu, 18 September 2008 00:00:00 Genetic Links Between Nervous and Immune Systems http://www.nigms.nih.gov/News/Results/091908.htm Mon, 29 September 2008 12:16:49 EST {8DFC5FE0-6BEF-405B-8D61-331B8A8E60E5} NIGMS-funded researchers have discovered evidence of cross talk between the nervous system and the immune system in roundworms. N/A Fri, 19 September 2008 00:00:00 A New Method For Studying Binding of Molecules to DNA http://www.nigms.nih.gov/News/Results/060407.htm Mon, 11 June 2007 14:17:07 EST {8E3190BC-97B9-4417-A950-973D9D66DBB6} NIGMS-funded researchers have discovered a new way to study the binding of small molecules to DNA by intercalation. The method may be a useful tool for rational drug design. N/A Mon, 4 June 2007 00:00:00 Viruses Affect Important Cell Stress Response http://www.nigms.nih.gov/News/Results/111507.htm Tue, 27 November 2007 14:39:59 EST {8ECFD20D-11E9-454D-B3C7-EFC9F474DC1B} NIGMS-funded researchers are exploring how viral infection affects mammalian cells' formation of stress granules, which shelter RNA. N/A Thu, 15 November 2007 00:00:00 Better Predicting Drug Success or Failure http://www.nigms.nih.gov/News/Results/051409b.htm Thu, 28 May 2009 11:59:27 EST {8F0C14DC-C71B-4AC6-9358-A0FE6B850D43} NIGMS-funded researchers are exploring the complex network of interactions between drugs and proteins to explain adverse drug effects. N/A Thu, 14 May 2009 00:00:00 Twinkling Nanostars Serve Imaging Role http://www.nigms.nih.gov/News/Results/072109c.htm Thu, 30 July 2009 11:05:26 EST {8F0F91A4-D326-486B-8009-314E0738BCA8} NIGMS-funded researchers have created gyrating nanostars whose twinkling allows for a new, improved imaging technique. N/A Tue, 21 July 2009 00:00:00 NIH Grantees Win 2007 Nobel Prize in Physiology or Medicine for Developing Techniques to Target Specific Genes in Mice http://www.nigms.nih.gov/News/Results/10092007.htm Fri, 14 November 2008 15:16:31 EST {8F26901C-C7BC-4CA0-9195-CFBC52FD228F} Statement from NIH Director Elias A. Zerhouni on Nobel Prize in physiology or medicine to grantees Mario R. Capecchi and Oliver Smithies. Nobel Prize Tue, 9 October 2007 00:00:00 Gene Expression Differences Affect Response to Drugs, Infections http://www.nigms.nih.gov/News/Results/022808b.htm Fri, 7 March 2008 13:57:29 EST {8F526531-9E0A-4204-973F-B6B888DBD422} Researchers in the NIGMS-funded Pharmacogenetics Research Network have found that differences in gene expression levels between population groups can affect how they respond to drugs or fight off specific infections. PharmacogeneticsResearchNetwork Thu, 28 February 2008 00:00:00 Detailed Structure of Multidrug Resistance Pump http://www.nigms.nih.gov/News/Results/092210.htm Tue, 28 September 2010 13:57:04 EST {8F8B3B9C-FE9C-483D-B77D-84AA893B232A} N/A Wed, 22 September 2010 00:00:00 Gene That Controls Circadian Rhythms Can Improve the Health of Aging Fruit Flies http://www.nigms.nih.gov/News/Results/030110b.htm Mon, 8 March 2010 15:51:49 EST {8FA40A01-249A-4681-9187-27044C997729} N/A Mon, 1 March 2010 00:00:00 Grant Will Help People With Disabilities Study Science http://www.nigms.nih.gov/News/Results/102510d.htm Tue, 2 November 2010 16:54:36 EST {8FB326AB-EEAD-4D5D-942F-9544E927612D} ARRA Mon, 25 October 2010 00:00:00 Ant Guts Could Show Way for Better Drugs http://www.nigms.nih.gov/News/Results/032508b.htm Thu, 3 April 2008 12:25:34 EST {8FC3EFCF-E3BA-4143-8EA5-8176D6900C45} By studying microbes from the guts of carpenter ants, NIGMS-funded researchers discovered two proteins that help form bacteria's outer shells. N/A Tue, 25 March 2008 00:00:00 How Microtubules Grow in Neurons and Help Them Regenerate Missing Parts http://www.nigms.nih.gov/News/Results/120910.htm Tue, 14 December 2010 14:44:46 EST {9086EAD1-2317-48D4-BA60-4D03185B6434} N/A Thu, 9 December 2010 00:00:00 Researchers Draw High Resolution Map of Recombination Hotspots http://www.nigms.nih.gov/News/Results/20110404A.htm Wed, 6 April 2011 14:09:34 EST {9100B632-4AB3-4EC7-AB78-6BFA77365453} N/A Mon, 4 April 2011 00:00:00 Solution to Virus Structure Could Lead to Disease Treatments http://www.nigms.nih.gov/News/Results/020810.htm Tue, 16 February 2010 14:46:26 EST {914D424E-70B7-4A8E-A79E-E43B99EEFCD3} N/A Mon, 8 February 2010 00:00:00 Hydrogen Peroxide Marshals Immune System http://www.nigms.nih.gov/News/Results/060309b.htm Mon, 15 June 2009 10:56:03 EST {927A1059-9239-4A8A-8F33-C8EE811028D3} NIGMS-funded biologists have discovered that a burst of hydrogen peroxide could serve as a chemical signal marshalling healing cells to wounded tissue. N/A Wed, 3 June 2009 00:00:00 Understanding How Cells Establish Heterochromatin http://www.nigms.nih.gov/News/Results/040909.htm Fri, 17 April 2009 17:39:55 EST {92E0244D-A6D6-4BC6-B684-219C32B9EC3F} NIGMS-funded molecular biologists have found that the assembly of silent heterochromatin domains in DNA depends on the strength with which a protein binds to histones. N/A Thu, 9 April 2009 00:00:00 Newly Discovered Method of Gene Regulation Found From Yeast to Humans http://www.nigms.nih.gov/News/Results/030411b.htm Fri, 11 March 2011 14:52:14 EST {93050DA9-2440-40A7-8B76-93713B19EB42} ARRA Fri, 4 March 2011 00:00:00 Protein in Mosquitoes Metabolizes DDT http://www.nigms.nih.gov/News/Results/061608b.htm Tue, 1 July 2008 18:02:38 EST {933903C7-83D4-4C03-96A6-C5FA8F623FF0} NIGMS-funded researchers have identified a protein that allows some malaria-carrying mosquitoes to resist the pesticide DDT. N/A Mon, 16 June 2008 00:00:00 Researchers Turn Up Brightness on Fluorescent Probes http://www.nigms.nih.gov/News/Results/080910a.htm Tue, 17 August 2010 09:37:58 EST {934EC9C1-B2BC-443A-86BF-F2F3A7B5E4F2} ARRA Mon, 9 August 2010 00:00:00 Chemists Clarify Exactly How Antiviral Drugs Block Influenza Viruses From Spreading http://www.nigms.nih.gov/News/Results/020310a.htm Mon, 15 February 2010 17:28:27 EST {93699E1D-CB95-4363-8F99-43AC22F4EA21} N/A Wed, 3 February 2010 00:00:00 Compound May Treat Acute Diarrhea http://www.nigms.nih.gov/News/Results/061608.htm Fri, 27 June 2008 17:13:33 EST {93874064-F3CC-460F-8761-6F7135A39CAF} NIGMS-funded researchers have discovered a compound that decreases the fluid secretion caused by bacteria that trigger diarrhea. N/A Mon, 16 June 2008 00:00:00 Members of Katanin Enzyme Family Regulate Cell Movement http://www.nigms.nih.gov/News/Results/031711.htm Thu, 24 March 2011 11:15:58 EST {9460B6F7-8B02-40F4-B49F-C9596B9FB93F} N/A Thu, 17 March 2011 00:00:00 Structure Solved for Protein That Guides Proper Division of Chromosomes http://www.nigms.nih.gov/News/Results/091610.htm Tue, 21 September 2010 07:53:01 EST {949767EF-295C-4DA1-A9E9-9258ABFEE733} N/A Thu, 16 September 2010 00:00:00 Bacterial Toxin Closes Gate on Immune Response http://www.nigms.nih.gov/News/Results/02132008.htm Wed, 20 February 2008 16:07:05 EST {95DD23A2-4D04-4AF8-9283-8EDA5DAF593B} A toxin from the bacterium Staphylococcus aureus shuts down a type of ion channel key to mounting an immune response, according to a new NIGMS-supported study. N/A Wed, 13 February 2008 00:00:00 Gene-Transcription Machinery Poised for Action http://www.nigms.nih.gov/News/Results/072507b.htm Tue, 31 July 2007 14:20:03 EST {95F5B0F1-FB0A-428E-A38C-AC3D965924E9} NIGMS-funded researchers have shown that machinery for transcribing genes can be in place but held in check, allowing nearly instantaneous activation in response to vital needs. N/A Wed, 25 July 2007 00:00:00 How Closing Schools Might Affect a Flu Pandemic http://www.nigms.nih.gov/News/Results/040908.htm Wed, 23 April 2008 10:13:08 EST {96090916-9704-4572-B715-622828E4137D} NIGMS-funded researchers have calculated the impact of school closures on the spread of a future flu pandemic. N/A Wed, 9 April 2008 00:00:00 How Editing Error Leads to a Neurodegenerative Disease http://www.nigms.nih.gov/News/Results/012809a.htm Wed, 4 February 2009 11:10:18 EST {96C8755C-74B6-4949-8395-598DCE7F1C27} NIGMS-funded molecular biologists have explained how a gene mutation causes atypical RNA splicing that results in a devastating disease. N/A Wed, 28 January 2009 00:00:00 Scientists Unravel Clue in Cortisol Production http://www.nigms.nih.gov/News/Results/042407.htm Mon, 30 April 2007 13:43:19 EST {9729B3F5-81A9-47D1-87A2-048F0087B336} NIGMS-funded researchers have discovered an important step in the production of cortisol, a stress hormone with many and varied effects. N/A Tue, 24 April 2007 00:00:00 Refined NMR Techniques Show Structures of Membrane Proteins http://www.nigms.nih.gov/News/Results/081708.htm Mon, 16 March 2009 08:42:57 EST {975C5130-E7A3-422D-913C-9F0D1EF4DB55} NIGMS-funded chemists are developing techniques to reveal the structures of membrane proteins using NMR. N/A Sun, 17 August 2008 00:00:00 Researchers Develop First Method to Measure a Cell's Weight as It Grows http://www.nigms.nih.gov/News/Results/041210a.htm Wed, 21 April 2010 11:59:30 EST {97B089E2-CB27-470B-9075-DAB3E2700F37} N/A Mon, 12 April 2010 00:00:00 Molecular Motor Needs Two Water Molecules to Break Down ATP for Energy http://www.nigms.nih.gov/News/Results/030110a.htm Wed, 3 March 2010 16:11:04 EST {97D1EF74-87CB-4593-A521-C2D202B60325} N/A Mon, 1 March 2010 00:00:00 Now Playing—Cell Migration LIVE! http://www.nigms.nih.gov/News/Results/20070608.htm Thu, 28 June 2007 14:54:29 EST {9804913A-474E-45CC-AACF-EE076B0BE35D} NIGMS-supported researchers have found a way to directly observe cell migration—in real time and in living tissue. The advance could lead to strategies for controlling both normal growth and the spread of cancer. N/A Fri, 8 June 2007 00:00:00 Finding Challenges Timing of DNA Jumping http://www.nigms.nih.gov/News/Results/061109.htm Thu, 25 June 2009 14:41:28 EST {982025DF-8440-47EF-AF78-58ADBD1AEFBB} NIGMS-funded molecular biologists have discovered that transposons jump not during the formation of sperm and egg cells but during embryonic development. N/A Thu, 11 June 2009 00:00:00 Riboswitches Integrate Signals From the Cell http://www.nigms.nih.gov/News/Results/021311.htm Wed, 2 March 2011 15:27:46 EST {9880C9E4-387A-4194-B622-5F2F94784371} RNAandRNAinterference Sun, 13 February 2011 00:00:00 Gene Discovery Made Easier With New Networking Technique http://www.nigms.nih.gov/News/Results/20080129.htm Wed, 19 January 2011 13:06:13 EST {989972C0-B88E-4389-8629-03FA61282AC5} NIGMS-supported researchers have used a new gene networking model they developed to identify genes that regulate life span and affect tumor development in the nematode worm. N/A Tue, 29 January 2008 00:00:00 NMR Detects Dynamic Protein Interactions That Regulate Gene Expression http://www.nigms.nih.gov/News/Results/070910.htm Fri, 9 July 2010 12:55:30 EST {989B9E6F-D519-4B73-AE08-0A260E40B50A} N/A Fri, 9 July 2010 00:00:00 Dense Tissue Promotes Aggressive Cancers http://www.nigms.nih.gov/News/Results/082208.htm Fri, 5 September 2008 14:30:00 EST {98FA0796-B07E-41F4-B622-D56DD95E47A0} NIGMS-funded researchers have found that cancer cells in rigid surroundings are more invasive, perhaps explaining why breast cancer is more aggressive in some women. N/A Fri, 22 August 2008 00:00:00 Protein Competition Over an Enzyme Integrates Signals During Early Embryonic Development http://www.nigms.nih.gov/News/Results/030910a.htm Fri, 19 March 2010 14:45:27 EST {99047EDC-85C1-4B2E-99C5-75DCBE0E6FBE} N/A Tue, 9 March 2010 00:00:00 Ronin Keeps ES Cells' Potential http://www.nigms.nih.gov/News/Results/062708.htm Wed, 9 July 2008 12:14:58 EST {994936F5-62BA-4D89-8D09-AC260B040A7B} Researchers funded in part by NIH have discovered a protein they named Ronin that keeps embryonic stem cells undifferentiated. StemCellResearch Fri, 27 June 2008 00:00:00 New Insights on Cell Division http://www.nigms.nih.gov/News/Results/120408a.htm Wed, 10 December 2008 13:55:42 EST {994FC872-71FA-41E8-B9B1-B7A975CB02E6} NIGMS-funded researchers have discovered a mechanism critical to the pinching of cells in two when they divide. N/A Thu, 4 December 2008 00:00:00 Site of Alcohol Action in Brain http://www.nigms.nih.gov/News/Results/062809.htm Fri, 10 July 2009 14:20:58 EST {99991C31-D54B-43AA-B404-F256E9521512} An NIGMS-funded study reveals a site within a protein that interacts with alcohol, possibly leading to changes in brain cell function. N/A Sun, 28 June 2009 00:00:00 NIGMS Strategic Plan Reinforces Commitment to Investigator-Initiated Research http://www.nigms.nih.gov/News/Results/StrategicPlan01252008.htm Fri, 1 February 2008 14:10:47 EST {99B88104-CA5C-467F-815E-9ACF62E4AD45} NIGMS has issued Investing in Discovery, a strategic plan that will guide the Institute’s decision-making over the next 5 years. N/A Fri, 25 January 2008 00:00:00 Dangerous Stomach Bacterium Hosts Genetic Remnant of Life's Distant Past http://www.nigms.nih.gov/News/Results/20100812A.htm Wed, 18 August 2010 18:49:40 EST {9A019417-1FA8-4864-97C2-3D3A65A12775} N/A Thu, 12 August 2010 00:00:00 Genetic Data Combined With Archeology and Linguistics Clarify African History http://www.nigms.nih.gov/News/Results/052610a.htm Thu, 3 June 2010 13:55:40 EST {9A080D05-0333-45E6-B34D-1B352E202D58} N/A Wed, 26 May 2010 00:00:00 MicroRNAs Maintain Ovarian Stem Cells http://www.nigms.nih.gov/News/Results/021507a.htm Fri, 16 February 2007 14:19:32 EST {9A0A40CD-1220-410C-A8B9-7CD61EF4ED47} NIGMS-funded researchers have discovered that small RNA molecules control the renewal of stem cells in the Drosophila ovary. N/A Thu, 15 February 2007 00:00:00 A More Detailed View of Chromatin Structure http://www.nigms.nih.gov/News/Results/041608.htm Wed, 23 April 2008 10:13:57 EST {9A38FF9F-0907-48DE-9A3F-198FBBF7A269} NIGMS-funded researchers have developed a technique that reveals a sharper image of chromatin, the bundles of genetic material and protein that make up chromosomes. N/A Wed, 16 April 2008 00:00:00 Analysis Addresses When and Why Cells Decide to Divide http://www.nigms.nih.gov/News/Results/092310b.htm Fri, 24 September 2010 17:30:13 EST {9AD2084F-E723-4C85-9E5D-8484AEACDF90} ComplexBiologicalSystemsInitiatives Thu, 23 September 2010 00:00:00 Computer Tool Helps Spot Risky Mutations http://www.nigms.nih.gov/News/Results/021507b.htm Fri, 23 February 2007 11:53:50 EST {9B0ABCB9-8640-4B90-9EC8-519367D7EDAF} NIGMS-funded researchers have created a computer tool to help predict which genetic mutations might affect a person's risk for cancer. PharmacogeneticsResearchNetwork Thu, 15 February 2007 00:00:00 Two Molecules Found to Propel the Spread of Cancer Cells http://www.nigms.nih.gov/News/Results/20110407B.htm Wed, 13 April 2011 09:52:31 EST {9B8A6522-A58A-4891-80BD-F0CA4DE36BC5} GlueGrants Thu, 7 April 2011 00:00:00 Microfluidic Chip Shows How Cells Signal Each Other http://www.nigms.nih.gov/News/Results/022107.htm Wed, 28 February 2007 14:41:20 EST {9B8AE370-9D7D-4452-B27A-F7A4B0C3E78A} Using a biochemical version of a computer chip, NIGMS-funded researchers have shed light on the way cells send and receive signals through signal transduction, a process that goes awry in cancer and other illnesses. N/A Wed, 21 February 2007 00:00:00 Gene Networks Involved in Alcohol Dependency http://www.nigms.nih.gov/News/Results/110309b.htm Mon, 16 November 2009 19:10:44 EST {9BAB56C5-1F12-40E6-B705-A7E2C133F7D3} NIGMS-funded researchers have used drunken fruit flies to identify networks of genes--also present in humans--that play a role in drinking behavior. N/A Tue, 3 November 2009 00:00:00 Chemists Discover Proton Mechanism Used by Flu Virus to Infect Cells http://www.nigms.nih.gov/News/Results/102110b.htm Thu, 28 October 2010 17:23:41 EST {9BDC2EEE-DD88-4951-AF9F-921A7BD847DB} N/A Thu, 21 October 2010 00:00:00 Correcting a Splicing Defect May Help Patients http://www.nigms.nih.gov/News/Results/031207.htm Fri, 23 March 2007 12:58:15 EST {9BE0690E-F7AA-4356-8EDA-8E0BB3516C80} NIGMS-funded researchers have developed a way to correct an mRNA splicing defect that is found in people with spinal muscular atrophy. The method is ready to be tested in mice. N/A Mon, 12 March 2007 00:00:00 Poorly Understood Cell Plays Role in Immunity Against the Flu http://www.nigms.nih.gov/News/Results/032210a.htm Mon, 22 March 2010 15:54:31 EST {9C12FA66-E347-421E-8C9C-614AAC095D09} N/A Mon, 22 March 2010 00:00:00 Enzyme Could be Key to Treating Tuberculosis http://www.nigms.nih.gov/News/Results/100109a.htm Mon, 5 October 2009 12:38:24 EST {9C68376B-4246-4346-B880-996DFDD0BC22} NIGMS-funded researchers have identified an enzyme that helps tuberculosis bacteria resist humans' natural defense system. N/A Thu, 1 October 2009 00:00:00 New Details About a Gene Network Governing Metabolism http://www.nigms.nih.gov/News/Results/022208.htm Mon, 25 October 2010 13:15:11 EST {9CA99D28-223A-421E-B84C-5A6E1536C278} An NIGMS-funded study found an unexpected wrinkle in how yeast cells, through their genes, adjust their metabolism in response to changing food sources. N/A Fri, 22 February 2008 00:00:00 New Technique Reveals Protein Folding, Interaction http://www.nigms.nih.gov/News/Results/122308.htm Fri, 9 January 2009 17:32:08 EST {9CB9146C-4DF1-496F-AD58-F4A883445511} NIGMS-supported researchers have developed a computational method that predicts how bacterial proteins fold and interact. BioinformaticsAndComputationalBiology Tue, 23 December 2008 00:00:00 Translating Form into Function http://www.nigms.nih.gov/News/Results/20070701.htm Mon, 16 March 2009 08:45:45 EST {9CBF1820-CC3E-4D93-A732-60B81C4270F2} A team of NIGMS-supported researchers has for the first time determined an enzyme’s function from its structure. The strategy could become a potent tool for understanding how key enzymes work in the body. N/A Sun, 1 July 2007 00:00:00 Size of Protein Aggregates, Not Abundance, Drives Spread of Prion Disease http://www.nigms.nih.gov/News/Results/102810a.htm Wed, 3 November 2010 12:55:47 EST {9CEAF2DF-BD4C-4BA8-99EF-EB506185349A} N/A Thu, 28 October 2010 00:00:00 Structure of Important Neurological Receptor http://www.nigms.nih.gov/News/Results/100608.htm Thu, 23 October 2008 14:47:54 EST {9D96241E-F359-419D-BC92-FA4042AB9895} NIGMS-funded biologists have solved the structure of an adenosine receptor that could lead to drugs for neurological disorders. ProteinStructureInitiative Mon, 6 October 2008 00:00:00 Turning Up the Heat on Genetic Recoding http://www.nigms.nih.gov/News/Results/geneticrecord_090416_redirect.htm Fri, 8 May 2009 12:22:32 EST {9DB7CDFC-EB30-4D0C-A521-2D1CF046422A} By literally turning up the heat, a team of NIGMS-supported scientists has uncovered an RNA editing enzyme in an ancient heat-loving organism. N/A Thu, 30 April 2009 00:00:00 Enzyme That Destroys mRNA Can Also Protect It http://www.nigms.nih.gov/News/Results/011007.htm Wed, 24 January 2007 14:35:58 EST {9DC9C9FE-04B4-4EAE-B84F-D951995942FD} NIGMS-funded researchers have shown that an enzyme that can destroy mRNA to halt protein production can also shelter RNA under stress conditions, allowing quick resumption of protein production when the stress ends. N/A Wed, 10 January 2007 00:00:00 Mario R. Capecchi Wins 2007 Nobel Prize http://www.nigms.nih.gov/News/Results/10082007b.htm Thu, 20 May 2010 13:28:45 EST {9DD103A5-BFA0-451A-8A4D-6A8D3FB2C8BF} NIGMS grantee Mario R. Capecchi shares the 2007 Nobel Prize in physiology or medicine for pioneering work on gene targeting. Nobel Prize Mon, 8 October 2007 00:00:00 Signals from Newly Discovered "Instructor Cells" Turn Stem Cells' Progeny Cancerous http://www.nigms.nih.gov/News/Results/101910b.htm Tue, 26 October 2010 15:42:39 EST {9E2E3F2C-6E9D-48F8-B97B-1A8A5BB80892} N/A Tue, 19 October 2010 00:00:00 Two Views of a Giant Enzyme--High Resolution and In Action http://www.nigms.nih.gov/News/Results/080110c.htm Tue, 10 August 2010 12:43:59 EST {9E507F24-59CE-44B5-86CA-C5497EAA24CE} N/A Sun, 1 August 2010 00:00:00 Genetic Pathway Involved in Oxidative Stress, Disease http://www.nigms.nih.gov/News/Results/022008c.htm Thu, 28 February 2008 11:07:11 EST {9E6BF0B3-511C-4732-B89C-3490D046790A} NIGMS-funded researchers have discovered a genetic pathway that influences cells' response to oxidative stress, a process that contributes to a host of diseases. N/A Wed, 20 February 2008 00:00:00 Theory and Experiment to Explain Protein Folding http://www.nigms.nih.gov/News/Results/022309b.htm Wed, 4 March 2009 12:28:20 EST {9E874DF2-FA0C-4548-9762-10308CEF2D00} NIGMS-funded researchers have collaborated to study how amino acid chains fold into unique three-dimensional proteins. N/A Mon, 23 February 2009 00:00:00 How Bacteria Team Up to Form a Biofilm http://www.nigms.nih.gov/News/Results/032408.htm Tue, 1 April 2008 11:08:50 EST {9EEB3A42-F09D-4888-831F-5B43AC1A5FBE} NIGMS-funded researchers have identified a kind of bacterial signalling system that allows the formation of biofilms, which allow bacteria to evade antibiotics and the immune systems of their hosts. N/A Mon, 24 March 2008 00:00:00 Rho Keeps Bacterial Genome Tidy http://www.nigms.nih.gov/News/Results/05152008.htm Tue, 27 May 2008 14:55:36 EST {9F857A04-B276-492B-88CA-B48421A2D622} A new study led by NIGMS-supported researchers has revealed that the Rho protein maintains boundaries between genes in the bacterium. N/A Thu, 15 May 2008 00:00:00 Embryonic Stem Cell Culturing Grows From Art to Science http://www.nigms.nih.gov/News/Results/111410a.htm Fri, 19 November 2010 16:05:09 EST {9F92DC1F-F702-4EDB-987D-45BEC6EECD83} StemCellResearch Sun, 14 November 2010 00:00:00 Gene Networks and Sleep http://www.nigms.nih.gov/News/Results/022309.htm Thu, 20 August 2009 10:15:43 EST {9FB7B56A-EE8D-4F4F-86D0-593D43FD4FAD} Studying fruit flies, NIGMS-funded researchers have explored the genes underlying sleep. N/A Mon, 23 February 2009 00:00:00 New Members Appointed to NAGMS Council http://www.nigms.nih.gov/News/Results/07council.htm Thu, 7 August 2008 10:52:46 EST {A01AEEBB-2DE1-4847-911A-5B431D115A98} HHS Secretary Michael O. Leavitt has appointed three new members to the National Advisory General Medical Sciences Council. They are Clifford W. Houston, Ph.D., of the University of Texas Medical Branch, Galveston; Steven L. McKnight, Ph.D., of the University of Texas Southwestern Medical Center, Dallas; W. James Nelson, Ph.D., of Stanford University; and Timothy O’Leary, M.D., Ph.D., of the Department of Veterans Affairs. AdvisoryCouncil Tue, 30 January 2007 00:00:00 New Version of Medicine Fights Drug-Resistant Cancer http://www.nigms.nih.gov/News/Results/050107c.htm Thu, 10 May 2007 12:33:44 EST {A05B881D-9FF7-43DB-A372-889C6DC5A5AF} NIGMS-funded researchers have re-engineered the anti-cancer drug Gleevec so that it is effective against cancer cells that are resistant to the standard form of the drug. N/A Tue, 1 May 2007 00:00:00 Potential Approach to Treat Spinal Muscular Atrophy http://www.nigms.nih.gov/News/Results/040408b.htm Mon, 25 October 2010 13:18:29 EST {A0758A72-C901-41FE-A18F-2DE9D5E18E0B} NIGMS-funded researchers induced cells to replenish a protein without which there is damage to growing nerve cells and the muscles they control. N/A Fri, 4 April 2008 00:00:00 Different Pathways Govern Onset and Offset of Anesthesia http://www.nigms.nih.gov/News/Results/20080111.htm Tue, 22 January 2008 14:40:50 EST {A0838343-C043-480C-AEEA-39FF24DB65DB} A team of NIGMS-supported researchers has shown that the cellular pathway for emerging from general anesthesia is different from the one that drugs take to put patients to sleep. N/A Fri, 11 January 2008 00:00:00 Tumor Suppressor p53 Limits the Growth of Cells With Incorrect Numbers of Chromosomes http://www.nigms.nih.gov/News/Results/020110c.htm Thu, 4 February 2010 14:44:58 EST {A0E7D25C-BB86-4719-9F5E-2C7260EC43FE} N/A Mon, 1 February 2010 00:00:00 Antagonistic Genes Control Rice Growth http://www.nigms.nih.gov/News/Results/20091215.htm Tue, 29 December 2009 15:18:46 EST {A0FFBA6D-AF2E-476D-80B5-47F097FCA7D1} NIGMS-supported scientists have found that a plant steroid prompts two genes to battle each other—one suppresses the other to ensure that leaves grow normally in rice. N/A Tue, 15 December 2009 00:00:00 Researchers Inhibit Unusual Chemical Mechanism That Allows Malaria Parasites and Many Bacteria to Survive http://www.nigms.nih.gov/News/Results/021810d.htm Tue, 23 February 2010 14:48:53 EST {A100AA5F-A49B-4B81-8389-0934F0B254A7} N/A Thu, 18 February 2010 00:00:00 Genetic Variants Linked to Blood Pressure in African-Americans http://www.nigms.nih.gov/News/Results/20090716C.htm Mon, 27 July 2009 13:03:10 EST {A139FEEA-32D8-40AD-811D-BE76C8425EA2} A team of researchers partially supported by NIGMS report the discovery of five genetic variants related to blood pressure in African-Americans, findings that may provide new clues to treating and preventing hypertension. N/A Thu, 16 July 2009 00:00:00 Genes in High-Risk Childhood Leukemias http://www.nigms.nih.gov/News/Results/051909.htm Thu, 4 June 2009 14:24:14 EST {A1B13BCF-44F6-4CBF-B86F-50FC503485B1} NIGMS-funded researchers have discovered a new class of mutations linked to cases of childhood leukemia with a high risk of relapse and death. PharmacogeneticsResearchNetwork Tue, 19 May 2009 00:00:00 Cryptochrome Protein Links Light Signals to Circadian Rhythms http://www.nigms.nih.gov/News/Results/122910.htm Fri, 14 January 2011 13:00:20 EST {A1C11769-B5EF-4814-926A-7197FAEB1844} N/A Wed, 29 December 2010 00:00:00 New Technology Can Analyze Hundreds of Mutations at the Same Time http://www.nigms.nih.gov/News/Results/20110407C.htm Tue, 12 April 2011 16:13:49 EST {A2079F5F-99FC-44BB-9312-EB3626A5DFC1} N/A Thu, 7 April 2011 00:00:00 DNA Repair Protein Caught in Act of Molecular Theft http://www.nigms.nih.gov/News/Results/111010.htm Fri, 19 November 2010 16:04:49 EST {A235412D-929B-4D08-B3F4-388FE232F5FF} N/A Wed, 10 November 2010 00:00:00 Honey-Bee Study Suggests Nurture Alters Nature http://www.nigms.nih.gov/News/Results/20090817E.htm Mon, 24 August 2009 13:40:42 EST {A270DA6F-284F-418D-91F0-29D3EFE147E2} A new NIGMS-funded study in honey-bees lends support to the idea that nurture, an organism's environment, may ultimately influence nature, its genetic inheritance. N/A Mon, 17 August 2009 00:00:00 Stem Cells Used to Treat Disease in Mice http://www.nigms.nih.gov/News/Results/031107a.htm Mon, 20 October 2008 08:38:11 EST {A2D34F40-2F96-4846-BB2F-9D9F8C45E1B3} NIGMS-funded researchers have successfully used human embryonic stem cells to treat mice with a neurodegenerative disease related to Tay-Sachs, a lethal genetic disorder. StemCellResearch Sun, 11 March 2007 00:00:00 New Details About Telomerase Activity Suggest Pathway For Blocking It, Thwarting Cancer http://www.nigms.nih.gov/News/Results/021710.htm Mon, 22 February 2010 13:11:33 EST {A2D72D09-521B-4A75-8488-2BDDAFF5D3D9} N/A Wed, 17 February 2010 00:00:00 Cryptic Variations Caused By Genetic Errors Help Organisms Evolve http://www.nigms.nih.gov/News/Results/20110125A.htm Tue, 1 February 2011 16:53:34 EST {A2E45D6A-2BD7-49B1-B3EE-507781CC88C5} BioinformaticsAndComputationalBiology Tue, 25 January 2011 00:00:00 Eliminating Tumor Suppressor C/EBP Alpha Causes Liver Cancer http://www.nigms.nih.gov/News/Results/060110a.htm Fri, 11 June 2010 10:28:00 EST {A30BEB44-B163-4071-A534-0CB87C1AFDBC} N/A Tue, 1 June 2010 00:00:00 Team Wins Stimulus Funds for Nanoparticle Standardization http://www.nigms.nih.gov/News/Results/20091208A.htm Mon, 26 July 2010 10:35:58 EST {A32E34AF-B0CE-4AB1-9557-731FE100FBFF} A team of Texas scientists has been awarded a $3 million Grand Opportunity (GO) grant from NIGMS to advance the design of nanoparticles for medical applications. ARRA Tue, 8 December 2009 00:00:00 How a Cell's Mitotic Motors Organize Chromosomes for Division http://www.nigms.nih.gov/News/Results/13009b.htm Mon, 16 March 2009 09:23:29 EST {A367BDA9-FCFD-41E4-9058-BBF0D0F4D4E4} NIGMS-funded researchers have discovered which part of dynein takes charge of mitosis to keep chromosomes in order. N/A Fri, 30 January 2009 00:00:00 Researchers Harness the Power of Plants to Fight Hemophilia http://www.nigms.nih.gov/News/Results/20100330.htm Mon, 12 April 2010 15:44:49 EST {A3B4CBC8-3EBA-45EA-8500-4CA696AF1E9B} N/A Tue, 30 March 2010 00:00:00 Equation Shows How Cells Create Fly Eye http://www.nigms.nih.gov/News/Results/011108.htm Fri, 18 January 2008 17:38:34 EST {A4043465-51A5-4376-AF60-CDE486D9633D} A mathematician and biologist, funded by NIGMS, have created a mathematical model for how cells pack together to create the eyes of Drosophila. N/A Fri, 11 January 2008 00:00:00 Lipids Trigger Death of Brain Cells in Rare Disorder http://www.nigms.nih.gov/News/Results/20091112A.htm Thu, 19 November 2009 14:27:04 EST {A4646136-9FB3-411C-BD10-F9830D8F7F7A} NIGMS-supported scientists reveal new details linking lipid build-up with catastrophic calcium imbalance in brain cells of patients with rare, inherited disorder. N/A Thu, 12 November 2009 00:00:00 Genome Duplication Splits Plant Species http://www.nigms.nih.gov/News/Results/81209a.htm Tue, 18 August 2009 13:02:55 EST {A4DFFD8E-77F5-4E62-80A2-22A5D79A369A} NIGMS-funded scientists say that the acquisition of extra copies of chromosome sets drives speciation in plants more than previously supposed. N/A Wed, 12 August 2009 00:00:00 Nanopolymer Could Make Drug Testing Cheaper and Easier http://www.nigms.nih.gov/News/Results/031611b.htm Tue, 22 March 2011 12:06:44 EST {A4F7C332-8EED-4CDB-8DFA-436685A305A3} N/A Wed, 16 March 2011 00:00:00 Transparent Fish Show Spread of Breast Cancer http://www.nigms.nih.gov/News/Results/102207.htm Thu, 8 November 2007 15:30:37 EST {A515D0E1-43FA-419F-83EE-B96A3721B37D} NIGMS-funded researchers have used transparent zebrafish to view the spread of human breast cancer cells, leading them to two proteins important to metastasis. N/A Mon, 22 October 2007 00:00:00 Original Source of Malaria http://www.nigms.nih.gov/News/Results/080309.htm Thu, 13 August 2009 12:57:36 EST {A51A3E73-0302-4608-8767-0FC3BA81D071} NIGMS-funded researchers now believe that the original source of malignant malaria is a parasite found in chimps in equatorial Africa. N/A Mon, 3 August 2009 00:00:00 Mathematicians and Evolutionary Biologists Explain Dramatic Beak Shape Variation in Darwin's Finches http://www.nigms.nih.gov/News/Results/022210d.htm Mon, 1 March 2010 15:32:12 EST {A53E7B74-2CAA-4CAB-BC55-E5E0C233998E} N/A Mon, 22 February 2010 00:00:00 Engineers Build First-Ever Multi-Input Synthetic RNA Device http://www.nigms.nih.gov/News/Results/10172008.htm Mon, 3 November 2008 11:58:34 EST {A61827A4-595B-45EF-8ECE-5E5AD9248C70} NIGMS-supported engineers have created a synthetic RNA device that is capable of taking in and responding to more than one signal at a time. N/A Fri, 17 October 2008 00:00:00 "Network" Approach Identifies Possible Breast Cancer Gene http://www.nigms.nih.gov/News/Results/100907d.htm Thu, 11 October 2007 10:36:35 EST {A6A8DAC3-2D88-48BE-B15E-69D5497CF254} Using analytic methods and "data mining," NIGMS-funded researchers used known breast cancer genes to link a new gene to the disease. N/A Tue, 9 October 2007 00:00:00 The Connection Between Calorie Restriction and Longevity http://www.nigms.nih.gov/News/Results/092007c.htm Fri, 21 September 2007 16:00:23 EST {A6AF0C74-6912-4EB9-83A6-879480E811B0} With NIGMS support, researchers have discovered two genes that rev up and help protect cells from aging when faced with stresses such as caloric restriction. N/A Thu, 20 September 2007 00:00:00 Biologists Solve Vitamin Puzzle http://www.nigms.nih.gov/News/Results/032107b.htm Tue, 27 March 2007 12:54:48 EST {A718311A-2B3A-490F-A757-1723149E6FEE} NIGMS-funded researchers have discovered the final piece of the synthesis pathway for vitamin B12, the most chemically complex of all vitamins. N/A Wed, 21 March 2007 00:00:00 Gene Mobilizes Yeast Cells to Cooperate Against Threats http://www.nigms.nih.gov/News/Results/20081113.htm Mon, 16 March 2009 09:32:43 EST {A74FA35A-B6DB-43F1-B396-496B9C009353} A single gene drives yeast cells to cooperate in protecting themselves from stress, antibiotics, and other dangers, according to a new NIGMS-supported study. N/A Thu, 13 November 2008 00:00:00 Enzyme Actively Unwinds DNA During Gene Copying http://www.nigms.nih.gov/News/Results/20070702A.htm Thu, 12 July 2007 13:09:03 EST {A79A9613-FB88-4ADF-832C-3254737C18E8} A new NIGMS-supported study has found that an enzyme called helicase appears to separate the DNA strands during replication by exerting a force on the spot where the two intertwined strands fork away from each other. N/A Mon, 2 July 2007 00:00:00 Cancer-Fighting Role Discovered for Cells Lining Blood Vessels http://www.nigms.nih.gov/News/Results/012011a.htm Tue, 25 January 2011 16:19:16 EST {A801BDB4-E0C6-4BF5-B7A8-84D3CDE94EEA} N/A Thu, 20 January 2011 00:00:00 Scientists Uncover Pathway for Maintaining Cell’s Fuel Stores http://www.nigms.nih.gov/News/Results/20100727.htm Wed, 4 August 2010 13:52:00 EST {A80E9CA7-3E39-4614-B4D5-5843CCE914EC} N/A Tue, 27 July 2010 00:00:00 Cancer Cell ‘Bodyguard’ Turned Into Killer http://www.nigms.nih.gov/News/Results/20081124B.htm Mon, 1 December 2008 13:16:20 EST {A822C214-6A35-40A0-9D2E-0D15F571BD49} NIGMS-supported researchers have developed a peptide that converts the Bcl-2 protein from a cancer cell's friend to a foe. N/A Mon, 24 November 2008 00:00:00 How a Transcription Factor Controls Gene Expression http://www.nigms.nih.gov/News/Results/082707a.htm Tue, 28 August 2007 11:09:46 EST {A875BA02-BF26-4297-9EE7-FB5530B3F784} NIGMS-funded researchers have discovered how certain transcription factors work to regulate gene regulation. N/A Mon, 27 August 2007 00:00:00 Ricin's Deadly Action Revealed http://www.nigms.nih.gov/News/Results/080608a.htm Sat, 16 August 2008 16:31:19 EST {A8C67C73-17A4-4451-AF77-513CFFBC3539} NIGMS-funded researchers have developed a chemical probe that can detect the poison ricin, highlighting its damage to the body's protein-making machinery. N/A Wed, 6 August 2008 00:00:00 Technique Allows Efficient Production of Chemical Motif Found in Natural Molecules http://www.nigms.nih.gov/News/Results/052410a.htm Thu, 3 June 2010 12:18:56 EST {A8ED2B7A-2DDD-444B-A926-FEFFED743A31} ChemicalMethodologiesAndLibraryDevelopment Mon, 24 May 2010 00:00:00 Genetic Recombination Varies Among Individuals http://www.nigms.nih.gov/News/Results/20080131.htm Thu, 14 February 2008 10:21:17 EST {A941D273-E38C-45A7-9C45-5F321387EFCB} A new study supported by NIGMS has uncovered remarkably high levels of individual variation in recombination, the process by which parents pass on a mosaic-like mixture of their genes. N/A Thu, 31 January 2008 00:00:00 "Harmless" Viruses Could Lead to Cancer http://www.nigms.nih.gov/News/Results/022207b.htm Mon, 12 March 2007 23:34:08 EST {AA3C7186-BB2E-43E1-B469-000E842ADBD0} Viruses that fuse cells could lead to chromosomal instability and cancer, report NIGMS-funded researchers. N/A Thu, 22 February 2007 00:00:00 Folding of RNA Molecule Observed in Real Time http://www.nigms.nih.gov/News/Results/02132008A.htm Fri, 15 February 2008 14:54:05 EST {AA45ACA5-FA0D-4D00-9B0B-EA080EACCDB0} NIGMS-supported scientists have used a device called an optical trap to observe in real time the folding of a riboswitch, a type of RNA molecule. N/A Wed, 13 February 2008 00:00:00 Nicotine Has Dozens of Cellular Interactions http://www.nigms.nih.gov/News/Results/040309a.htm Tue, 14 April 2009 12:02:35 EST {AA6A6105-D9AC-4E5E-9BBF-2947133E166B} NIGMS-funded research suggests that nicotine may interfere with more processes in the body than previously thought. N/A Fri, 3 April 2009 00:00:00 Brain Tissue Reveals Possible Trigger for Schizophrenia http://www.nigms.nih.gov/News/Results/032807b.htm Wed, 25 April 2007 08:10:08 EST {AA7DDCAC-F44D-4DC2-BA80-0C49D59192E9} In studying the postmortem brain tissue of adults who had been diagnosed with schizophrenia, NIGMS-funded researchers found that levels of microRNAs were lower than normal. N/A Wed, 28 March 2007 00:00:00 Molecular Origins of Proportional Development http://www.nigms.nih.gov/News/Results/101308b.htm Tue, 4 November 2008 16:19:34 EST {AA9FE8B9-7037-4AAB-9791-AE519EDB30E8} NIGMS-funded developmental biologists have traced basic, molecular information on how different-sized animals develop bodies that are in proportion. N/A Mon, 13 October 2008 00:00:00 Silica Cages Help Anti-Cancer Antibodies Kill Tumors in Mice http://www.nigms.nih.gov/News/Results/052110a.htm Fri, 21 May 2010 17:11:18 EST {AB56516B-692E-4BE4-9086-4AC43E98A99B} N/A Fri, 21 May 2010 00:00:00 Enzyme Finds Gene Damage by Trying DNA on for Size http://www.nigms.nih.gov/News/Results/081907.htm Tue, 28 August 2007 11:06:52 EST {AB68B9CE-E7ED-4F69-849D-C99904656463} NIGMS-funded researchers have discovered how an enzyme scans the shape of DNA to find mismatched blocks. N/A Sun, 19 August 2007 00:00:00 Researchers Catch Evolution in the Act http://www.nigms.nih.gov/News/Results/01062009.htm Fri, 16 January 2009 15:26:53 EST {ABB5B946-0ADE-43C0-8466-A94BB07E2091} A team of NIGMS-supported biologists has discovered that two RNA polymerases found only in plants are specialized forms of an enzyme common to all eukaryotic organisms. RNAandRNAinterference Tue, 6 January 2009 00:00:00 NIH Grantee Wins 2010 Nobel Prize in Chemistry http://www.nigms.nih.gov/News/Results/nobelprize_101006c.htm Wed, 6 October 2010 16:43:21 EST {AC4F613E-3BA3-48A6-A103-6396D4D6262F} Nobel Prize Wed, 6 October 2010 00:00:00 Large Study Links Mutations to Leukemia http://www.nigms.nih.gov/News/Results/030707.htm Tue, 29 July 2008 13:47:50 EST {ACDB662C-0CAA-4340-AF8D-58F625576C30} NIGMS-funded researchers scanned 350,000 locations across the genome of 242 pediatric patients with acute lymphoblastic leukemia to identify new mutations that contribute to this common childhood cancer. PharmacogeneticsResearchNetwork Wed, 7 March 2007 00:00:00 Human Skin Harbors Unknown Bacteria http://www.nigms.nih.gov/News/Results/020507b.htm Fri, 9 February 2007 15:22:49 EST {ACF74507-6110-4322-A79D-A8CECA00F86E} Bacteria on the skin are more diverse than thought. Some species aren't even named, report NIGMS-funded researchers. N/A Mon, 5 February 2007 00:00:00 Device Measures Biofilm Mechanics http://www.nigms.nih.gov/News/Results/063009.htm Fri, 10 July 2009 14:27:12 EST {AD9317BF-E5EB-4E85-AC45-299BF0AA570F} NIGMS-funded researchres have devised a microscale tool to help understand the mechanical behavior of biofilms, the collective form of bacteria involved in most infectious diseases. N/A Tue, 30 June 2009 00:00:00 Bacterial Chemoreceptor Described http://www.nigms.nih.gov/News/Results/20090924A.htm Mon, 5 October 2009 12:34:28 EST {AD96B60B-8427-475C-B116-7A074C1EFEC0} A team of NIGMS-supported researchers has visualized the precise arrangement of chemoreceptors—the receptors that sense and respond to chemical stimuli—in bacteria. N/A Thu, 24 September 2009 00:00:00 MIDAS Maps Featured in Geography Highlights Book http://www.nigms.nih.gov/News/Results/072307.htm Fri, 27 July 2007 14:23:50 EST {AE213800-6489-4E22-A8C6-EDBDA3FA17B5} Maps developed as part of the Models of Infectious Disease Agent Study funded by NIGMS are being included in a book featuring the year's best examples of geographic information system cartography. ModelingInfectiousDiseases Mon, 23 July 2007 00:00:00 Circadian Clock Helps Time Behavior to Changes in Seasons http://www.nigms.nih.gov/News/Results/040507a.htm Thu, 19 April 2007 13:04:23 EST {AE23767E-FD9D-4BAD-A180-FF7555A21209} NIGMS-funded biologists have shown that circadian rhythms help insects adapt their behavior to the seasons. The findings may shed light on winter depression in people. N/A Thu, 5 April 2007 00:00:00 Multicellular Response is "All for One" http://www.nigms.nih.gov/News/Results/050808a.htm Mon, 12 May 2008 12:36:57 EST {AE97196F-ED85-45AD-AD73-A1B42F2771F3} Using C. elegans worms, NIGMS-funded researchers discovered that two specialized neurons sense temperature stress and organize an integrated response for the entire animal. N/A Thu, 8 May 2008 00:00:00 NAS Honors Four NIGMS Grantees http://www.nigms.nih.gov/News/Results/011707.htm Tue, 30 January 2007 12:12:49 EST {AEB62090-0C45-4C48-97C2-060A54067011} Among 18 individuals honored for major contributions to science, the National Academy of Sciences has recognized four NIGMS grantees: Barry Honig, Robert Bergman, Gregory Hannon and Richard Losick. N/A Wed, 17 January 2007 00:00:00 Method Interprets Data From Single-Cell Images to Identify Genetic Interaction in Biological Networks http://www.nigms.nih.gov/News/Results/020910.htm Wed, 17 February 2010 13:11:00 EST {AECE094E-7CF2-4779-ACF4-9263E29D95A4} N/A Tue, 9 February 2010 00:00:00 Role of Single-Stranded DNA-Binding Protein http://www.nigms.nih.gov/News/Results/102109b.htm Thu, 29 October 2009 15:54:18 EST {AF3D0D6E-4E26-49D1-ADE9-8323C6B0C916} An NIGMS-funded study finds that single-stranded DNA-binding protein plays a dynamic role and is critical to DNA repair. N/A Wed, 21 October 2009 00:00:00 Insulin Grown in Lettuce and Tobacco http://www.nigms.nih.gov/News/Results/073007a.htm Mon, 20 August 2007 17:12:26 EST {AF40CA8F-E4E5-43BB-A4B7-6DE3A12EF3B4} NIGMS-funded researchers have genetically engineered lettuce and tobacco plants to produce insulin. Freeze-dried powder from the resulting plants successfully treated diabetic mice. N/A Mon, 30 July 2007 00:00:00 Telomeres Resemble DNA Fragile Sites http://www.nigms.nih.gov/News/Results/20090709.htm Thu, 16 July 2009 15:30:40 EST {AFABFB4E-B596-43B7-B884-B7B8E82D7DBE} New NIGMS-supported research suggests a striking similarity between telomeres and common fragile sites, parts of the genome where breaks tend to occur. TelomeresAndTelomerase Thu, 9 July 2009 00:00:00 Structure of Dynamin Protein Helps Show How Vesicles Form From Cell Membranes http://www.nigms.nih.gov/News/Results/042810a.htm Thu, 6 May 2010 14:53:59 EST {AFAE78E1-4CF5-4851-A8DB-D364B68D9054} N/A Wed, 28 April 2010 00:00:00 Jumping Gene May Contribute to Aging Syndrome http://www.nigms.nih.gov/News/Results/032008b.htm Tue, 1 April 2008 09:18:40 EST {AFC46FFD-96EC-4E85-A19C-2245D995EB0B} NIGMS-funded researchers have discovered a transposon that has settled into a gene linked to Cockayne syndrome, which causes premature aging. N/A Thu, 20 March 2008 00:00:00 Structure of Pili Part, Linked to Diarrhea http://www.nigms.nih.gov/News/Results/060809c.htm Thu, 18 June 2009 15:26:47 EST {AFD4E730-F4C3-4FE4-9BEA-E9F06B47E90E} NIGMS-funded researchers have atomic resolution of a detail of the pili, which bacteria use to attach to host intestinal epithelia. N/A Mon, 8 June 2009 00:00:00 New Technology Promises to Help Drug Makers Go Green http://www.nigms.nih.gov/News/Results/20100616A.htm Tue, 22 June 2010 09:35:08 EST {AFF362A4-9F25-45CA-A79C-41893ACADF1E} ARRA Wed, 16 June 2010 00:00:00 Breaking Cholera's Lines of Communication http://www.nigms.nih.gov/News/Results/111407b.htm Mon, 26 November 2007 11:18:32 EST {B004B14D-54CB-4A3E-BD40-60BF3C1043D4} NIGMS-funded biologists have discovered a key mechanism for how cholera bacteria communicate, a finding that could lead to new antibiotics. N/A Wed, 14 November 2007 00:00:00 Snippet of RNA Helps Make Individuals Alike http://www.nigms.nih.gov/News/Results/050509a.htm Tue, 19 May 2009 14:38:21 EST {B03A0CF6-A419-4E9A-A473-8D02C6E44CC6} NIGMS-funded biologists have found that a microRNA is critical to the robustness of the molecular network that helps regulate uniformity. N/A Tue, 5 May 2009 00:00:00 Technology Illuminates Protein Interactions in Live Cells http://www.nigms.nih.gov/News/Results/110907.htm Thu, 15 November 2007 11:59:39 EST {B04A3CB6-1974-47A4-BAF8-7DCB323208CB} NIGMS-funded chemists have developed a tagging system that uses small, fluorescent probes to track proteins and their interactions in living cells. N/A Fri, 9 November 2007 00:00:00 Alzheimer’s Molecule Implicated in Nerve Cell Transport http://www.nigms.nih.gov/News/Results/20080117A.htm Mon, 28 January 2008 17:32:27 EST {B0BED10D-EA97-4B30-8EE8-65F489424B11} NIGMS-supported researchers have discovered that proteins carrying chemical cargo in nerve cells react differently when exposed to the tau protein, which plays an important role in Alzheimer’s disease. N/A Thu, 17 January 2008 00:00:00 Tiny Molecular Switch Turns On or Off Depending on Metallic Ions in Surroundings http://www.nigms.nih.gov/News/Results/041310a.htm Tue, 18 May 2010 15:19:44 EST {B1B0E00B-A2ED-455F-8C29-4F497073D0BC} ChemHealth Tue, 13 April 2010 00:00:00 Study Reveals Unexpected Link Between Nervous System and Innate Immunity http://www.nigms.nih.gov/News/Results/20110407D.htm Tue, 12 April 2011 16:13:08 EST {B2174708-E289-4303-97F2-93A72711501C} N/A Thu, 7 April 2011 00:00:00 Surprising Findings on How Plants Respond to Light Signals http://www.nigms.nih.gov/News/Results/121310c.htm Mon, 20 December 2010 16:53:23 EST {B23CA76B-6D2C-4218-8455-F802A817BF32} N/A Mon, 13 December 2010 00:00:00 Rapidly Evolving Genes and the Origin of Species http://www.nigms.nih.gov/News/Results/020609b.htm Fri, 13 February 2009 10:49:59 EST {B24F58DF-BB2D-4A5E-8204-CA03FDA9DAC4} NIGMS-funded researchers are exploring how rapidly evolving genes involved in the nuclear pore complex help one species split into two. N/A Fri, 6 February 2009 00:00:00 RNA Interacts With Promoters to Regulate Genes http://www.nigms.nih.gov/News/Results/070608.htm Wed, 16 July 2008 14:51:11 EST {B2AC81B9-D489-464A-8DE1-C43E82617FA2} NIGMS-funded researchers have discovered that RNA can interact with the non-coding part of a gene, apparently to regulate when it's turned on. N/A Sun, 6 July 2008 00:00:00 Tracking Paw Prints of Selective Breeding in Dogs http://www.nigms.nih.gov/News/Results/20100113.htm Mon, 25 January 2010 11:40:10 EST {B2D1FB99-35C4-44AB-9D77-A18F8119DD6E} NIGMS-supported researchers have identified 155 regions on the canine genome that appear to have been influenced by selective breeding. N/A Wed, 13 January 2010 00:00:00 'Cap' of Bundled Fibers Could Yield Clues to Disease http://www.nigms.nih.gov/News/Results/20091202A.htm Tue, 8 December 2009 16:19:45 EST {B32323D5-4E9A-457A-AD4F-7CC376B013FE} NIGMS-supported researchers have shown that a bundled "cap" of thread-like fibers holds the cell's nucleus, its genetic storehouse, in its proper place. N/A Wed, 2 December 2009 00:00:00 Simpler Chemical Synthesis Has Pharmaceutical Ramifications http://www.nigms.nih.gov/News/Results/031907b.htm Mon, 26 March 2007 11:57:47 EST {B337EE93-B22A-49EC-8D7D-1EB249945C78} NIGMS-funded chemists have developed a simpler way of synthesizing marine natural products, which could make synthesis of such substances more cost-effective for drug companies. N/A Mon, 19 March 2007 00:00:00 Newly Discovered Class of Compounds Could Lead to Drugs http://www.nigms.nih.gov/News/Results/030711a.htm Mon, 14 March 2011 15:26:35 EST {B36F6177-A33D-4A04-82BF-DFFC6389B44D} ChemHealth Mon, 7 March 2011 00:00:00 Ion Channels Caught in Opening Act http://www.nigms.nih.gov/News/Results/070908c.htm Wed, 23 July 2008 11:24:39 EST {B3A16D77-6184-45DE-888A-B96482B6B2C3} An NIGMS-funded study used unique methods to study how ion channels respond to voltage changes to open and close. N/A Wed, 9 July 2008 00:00:00 Bacterial Enzyme Could Be Target for Treating Cystic Fibrosis http://www.nigms.nih.gov/News/Results/041807.htm Tue, 24 April 2007 12:17:54 EST {B3B1A05E-FF0C-4BF4-8565-47BDF53BA1BB} NIGMS-funded researchers have discovered that an enzyme produced by lung-infecting bacteria further shuts down a protein that is defective in cystic fibrosis patients. Inhibitors of the enzyme could serve as drugs. N/A Wed, 18 April 2007 00:00:00 Logic of Sudoku Puzzles in Genome Sequencing http://www.nigms.nih.gov/News/Results/062509c.htm Fri, 3 July 2009 17:15:04 EST {B3C6FC4F-C59E-4243-A2D1-275961B061C5} NIGMS-supported researchers have devised a strategy that allows many thousands of DNA samples to be combined during sequencing. N/A Thu, 25 June 2009 00:00:00 New Targets for Histone-Modifying Enzymes http://www.nigms.nih.gov/News/Results/042708.htm Thu, 8 May 2008 15:14:50 EST {B42015C3-2A76-44E5-820F-80E4AD2F1EDA} NIGMS-funded researchers have discovered new molecular targets for an enzyme that modifies chromatin. N/A Sun, 27 April 2008 00:00:00 Light-Sensing Rhodopsin Molecules Also Sense Temperature http://www.nigms.nih.gov/News/Results/031011b.htm Thu, 17 March 2011 08:59:01 EST {B42DC5C5-D1BF-440A-83A2-8D39A15EA85D} N/A Thu, 10 March 2011 00:00:00 NIGMS Grant Supports Creation of Chicago Center for Systems Biology http://www.nigms.nih.gov/News/Results/09092008SysBio.htm Wed, 17 September 2008 13:00:27 EST {B433D692-A5C5-426D-A212-2D23FE776EF8} NIGMS funds the Chicago Center for Systems Biology as part of its national program to study complex biological systems. ComplexBiologicalSystemsInitiatives Tue, 9 September 2008 00:00:00 Protein Discovered to Shuttle RNA into Mitochondria http://www.nigms.nih.gov/News/Results/080510.htm Mon, 16 August 2010 17:39:25 EST {B4BE1DF4-7D4B-4111-8907-D36581D80142} N/A Thu, 5 August 2010 00:00:00 Bacteria Organize to Survive Stress http://www.nigms.nih.gov/News/Results/111307.htm Tue, 20 November 2007 13:27:47 EST {B4D5EA1C-5BEE-45C3-9861-A24E4FC542B6} Using innovative microfluidic devices, NIGMS-funded researchers are studying how bacteria organize into biofilms, which play a key role in a number of diseases. N/A Tue, 13 November 2007 00:00:00 How Animals Know It's Too Hot http://www.nigms.nih.gov/News/Results/072908.htm Thu, 7 August 2008 11:25:01 EST {B50AABE8-A671-4F34-9E0C-890244CA06D4} An NIGMS-funded study discovered how fruit flies sense small differences in temperature. N/A Tue, 29 July 2008 00:00:00 Genome Data Can be Used to Classify Cell Signaling Systems http://www.nigms.nih.gov/News/Results/070210.htm Sat, 17 July 2010 18:42:10 EST {B51C79D2-018F-40E3-9AE3-D92A37B8A4CD} N/A Fri, 2 July 2010 00:00:00 Two Non-Coding RNAs Trigger Formation of a Nuclear Subcompartment http://www.nigms.nih.gov/News/Results/122010a.htm Thu, 23 December 2010 17:03:46 EST {B547CA2F-412A-4EC6-A841-30D1DB68C770} N/A Mon, 20 December 2010 00:00:00 New Study Helps Explain Control of Key Step in Cell Division http://www.nigms.nih.gov/News/Results/20100615.htm Mon, 21 June 2010 12:45:31 EST {B5A86060-46BF-42AD-8648-E4E94FB572DF} N/A Tue, 15 June 2010 00:00:00 Anti-Aging Pathway Enhances Cell Stress Response http://www.nigms.nih.gov/News/Results/021909a.htm Wed, 25 February 2009 13:12:18 EST {B651F670-B197-4DDA-8595-41BB5BDA6865} An NIGMS-funded study found a new molecular relationship between a known anti-aging protein and how cells respond to stress. N/A Thu, 19 February 2009 00:00:00 Technique Probes Mechanism of DNA Enzyme http://www.nigms.nih.gov/News/Results/111207.htm Tue, 20 November 2007 13:26:23 EST {B66C5AD1-00FF-4986-83A7-BA00D11C0876} Using a sensitive measurement technique, NIGMS-funded researchers have shown that a DNA enzyme uses different mechanisms for different substrates. N/A Mon, 12 November 2007 00:00:00 Proteins in Nuclear Pore Complex Pull Double Duty Regulating the Activity of Genes http://www.nigms.nih.gov/News/Results/020410.htm Mon, 15 February 2010 17:28:53 EST {B6B08D89-4C81-4B77-87AF-432B974525A2} N/A Thu, 4 February 2010 00:00:00 On Switch Is Also an Off Switch http://www.nigms.nih.gov/News/Results/012110a.htm Fri, 29 January 2010 17:07:28 EST {B7A7142B-0893-43C5-B736-079279C6CA14} NIGMS-funded researchers discovered that a protein previously understood to activate inflammation also is needed to counter unabated inflammation. N/A Thu, 21 January 2010 00:00:00 DNA Palindromes and Disease http://www.nigms.nih.gov/News/Results/071408a.htm Wed, 30 July 2008 10:34:23 EST {B8246357-8BDE-42BB-9DAD-11EF93230B3D} NIGMS-funded biologists have found a link between DNA sequence palindromes and replication delays, which can trigger chromosome breaks. N/A Mon, 14 July 2008 00:00:00 Immune Responses to Mitochondria Help Explain Body's Inflammatory Response to Injury http://www.nigms.nih.gov/News/Results/030310a.htm Fri, 12 March 2010 16:23:29 EST {B862303C-8ED4-470D-8E38-A1431F39CAEA} N/A Wed, 3 March 2010 00:00:00 Dr. Venkatraman Ramakrishnan Wins 2009 Nobel Prize for Chemistry http://www.nigms.nih.gov/News/Results/nobel_20091007b.htm Wed, 21 October 2009 12:49:01 EST {B99D5CC2-74AB-4CBA-A8F1-83ED097792B8} NIGMS grantee Venkatraman Ramakrishnan of the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, is named a recipient of the 2009 Nobel Prize in chemistry. Nobel Prize Wed, 7 October 2009 00:00:00 Heart Rate Dynamics Differ in Premature Infants http://www.nigms.nih.gov/News/Results/042210c.htm Thu, 6 May 2010 14:53:39 EST {B9A80AB8-DA44-4C83-ADE0-A7DCC1F4B6BE} N/A Thu, 22 April 2010 00:00:00 Pivotal Hearing Structure Revealed http://www.nigms.nih.gov/News/Results/090507b.htm Fri, 21 September 2007 15:53:14 EST {B9D05E34-98D7-46E2-9EDF-A0F0DC1A88CD} A study supported in part by NIGMS shows that two key proteins join together at the precise location in the inner ear where energy of motion is turned into electrical impulses. N/A Wed, 5 September 2007 00:00:00 Human Neural Disorder Observed in Fruit Flies http://www.nigms.nih.gov/News/Results/20090624.htm Thu, 2 July 2009 14:34:07 EST {BA1764DC-096D-4139-BF53-AA1F9D238506} A team of NIGMS-funded scientists has created a genetically modified fruit fly that mimics key features of Charcot-Marie-Tooth disease. N/A Wed, 24 June 2009 00:00:00 The Scent of Soil http://www.nigms.nih.gov/News/Results/091607.htm Tue, 25 September 2007 10:07:01 EST {BA3E7BF3-4666-49D6-8632-D38574F12CF4} NIGMS-funded chemists have discovered how precisely the sweet smell of warm dirt is made. N/A Sun, 16 September 2007 00:00:00 MicroRNA Helps Prevent Tumors http://www.nigms.nih.gov/News/Results/022207a.htm Thu, 8 March 2007 14:35:06 EST {BAFC1CE5-5A36-4001-960F-C0B265778208} NIGMS-funded researchers have discovered that a microRNA directly regulates a gene implicated in human cancers, one of the first times an individual microRNA has been linked to a particular target in mammals. N/A Thu, 22 February 2007 00:00:00 Method Promises Routine Gene Modification http://www.nigms.nih.gov/News/Results/072408a.htm Tue, 5 August 2008 12:58:59 EST {BB0F362B-ECDD-42A5-8872-ABCFF52B2F1E} NIGMS-funded researchers have created a robust way to induce specific genome modifications in many types of cells. N/A Thu, 24 July 2008 00:00:00 New Type of Antibiotics Should Avoid Drug-Resistance http://www.nigms.nih.gov/News/Results/031209d.htm Wed, 25 March 2009 14:47:27 EST {BB4FA288-2865-4514-A91D-FC6911833F80} NIGMS-funded researchers are designing antibiotics that disrupt quorum sensing instead of killing bacteria. N/A Thu, 12 March 2009 00:00:00 Blocking Brain Enzyme Decreases Appetite http://www.nigms.nih.gov/News/Results/050608a.htm Thu, 15 May 2008 18:20:18 EST {BB5A3278-7B02-4472-8E1A-E3BF9B96877D} By blocking a brain enzyme in mice, NIGMS-funded researchers reduced the animals' appetite and their weight. N/A Tue, 6 May 2008 00:00:00 Study Sheds Light on 'Dark States' in DNA http://www.nigms.nih.gov/News/Results/010907.htm Thu, 18 January 2007 11:04:03 EST {BB6883F7-7043-4294-B64D-44F435A4BAA1} In an effort to understand how DNA resists damage from UV exposure, NIGMS-funded researchers have probed a state of DNA that appears able to dissipate energy it absorbs when bombarded by UV light. N/A Tue, 9 January 2007 00:00:00 Live Birth Enabled Adaptation to Ocean Life http://www.nigms.nih.gov/News/Results/20090914.htm Mon, 28 September 2009 09:33:09 EST {BBB0AC1B-B4C2-49FD-B5C5-603925C173F2} The transition from egg-laying to live-born young opened up evolutionary pathways that allowed ancient species to adapt to and thrive in open oceans, according to a new NIGMS-supported study. N/A Mon, 14 September 2009 00:00:00 Newly Discovered Genes Regulate Stem Cell Function http://www.nigms.nih.gov/News/Results/091708.htm Mon, 22 September 2008 14:47:30 EST {BC121053-A79A-4F5C-A061-B7068EE195FD} NIGMS-funded researchers have discovered genes in planaria flatworms that are also used in mammalian stem cell regulatory pathways. StemCellResearch Wed, 17 September 2008 00:00:00 Severity of H1N1 May Be Less Than Feared http://www.nigms.nih.gov/News/Results/20091207A.htm Tue, 15 December 2009 16:57:56 EST {BCA242AE-BA5A-42B0-8DF0-434EB61F5EF9} A new NIGMS-supported study projects that the severity of the H1N1 flu during the autumn-winter flu season in the U.S. will likely be less than previously feared. ModelingInfectiousDiseases Mon, 7 December 2009 00:00:00 Protein Contributes to Cancer Spread http://www.nigms.nih.gov/News/Results/120808b.htm Tue, 16 December 2008 16:12:04 EST {BD09E53D-5F8D-4384-86D9-1E21BD4FB4DD} NIGMS-funded researchers have identified a protein, called Menainv, that may be responsible for breast cancer metastasis. N/A Mon, 8 December 2008 00:00:00 Rod Cells in Retina Help Set Body's Internal Clocks http://www.nigms.nih.gov/News/Results/091310.htm Wed, 15 September 2010 14:24:12 EST {BD42A0EE-D526-4782-A1F1-CC0E13CC5434} N/A Mon, 13 September 2010 00:00:00 Model Reveals Strategy to Extend Flu Drug Effectiveness http://www.nigms.nih.gov/News/Results/20090430D.htm Thu, 3 June 2010 08:13:26 EST {BD62816F-E9FD-4BB5-87B9-8F4FCC3809BE} NIGMS-supported researchers have found that small stockpiles of a secondary flu medication—if used early in local outbreaks—could extend the effectiveness of primary drug stockpiles during a global influenza pandemic. ModelingInfectiousDiseases Thu, 30 April 2009 00:00:00 Mapping Cancer Genes in Yeast http://www.nigms.nih.gov/News/Results/20090727.htm Tue, 4 August 2009 14:45:37 EST {BD6F8B9D-999B-45EC-BAB5-7D160DF119CB} NIGMS-supported researchers have devised a scheme for identifying genes in yeast that could lead to the identification of new cancer genes in humans. N/A Mon, 27 July 2009 00:00:00 Balancing Act Between Regulators Ensures Roots and Shoots Stay Where They Belong http://www.nigms.nih.gov/News/Results/022810.htm Mon, 8 March 2010 15:51:17 EST {BD8715C1-033A-4722-88E7-7975D81FA0E2} N/A Sun, 28 February 2010 00:00:00 New Inroads in Understanding Circadian Rhythms http://www.nigms.nih.gov/News/Results/051509.htm Fri, 29 May 2009 12:13:14 EST {BDB8E059-02F4-4A26-A055-F8873DD72D6F} Two studies by NIGMS-funded researchers make new inroads into understanding the regulatory circuitry of cells' biological clock. N/A Fri, 15 May 2009 00:00:00 Why Humans Are More Sensitive Than Other Primates to Certain Viruses http://www.nigms.nih.gov/News/Results/20101216C.htm Wed, 22 December 2010 15:04:59 EST {BDCE87D4-E3F9-448F-A00F-B497BE95991C} N/A Thu, 16 December 2010 00:00:00 A Catalog of Mitochondrial Proteins http://www.nigms.nih.gov/News/Results/071008.htm Fri, 25 July 2008 15:53:58 EST {BDD9D24A-7ECC-4572-A432-29815A500245} An NIGMS-funded team has compiled a "parts list" for mitochondria, the cell's powerhouses, enhancing understanding of mitochondrial biology and disease. N/A Thu, 10 July 2008 00:00:00 Internal Clocks Help Hybrid Plants Grow Bigger http://www.nigms.nih.gov/News/Results/20081124.htm Mon, 16 March 2009 09:34:02 EST {BE210E15-8416-49BF-8FDD-B49F1DC3F94C} Hybrid plants grow bigger than their parents because many of their metabolism genes are more active during the day, report NIGMS-researchers. N/A Mon, 24 November 2008 00:00:00 Potential New Drug for Brain Diseases Helps Cells Get Rid of Bad Proteins http://www.nigms.nih.gov/News/Results/090810b.htm Mon, 13 September 2010 15:41:10 EST {BE4B71E0-90F2-4A7D-AF64-8267219D96B5} N/A Wed, 8 September 2010 00:00:00 New Insights into How the Ribosome Works http://www.nigms.nih.gov/News/Results/20091123A.htm Fri, 4 December 2009 14:19:08 EST {BE6542CB-5A34-4DAA-AB2D-BEA9897D1843} Two new NIGMS-supported studies reveal in unprecedented detail how the ribosome interacts with other molecules to assemble new proteins and guide them toward their destination. N/A Mon, 23 November 2009 00:00:00 Scientists Shed Light on How Neurons Interact http://www.nigms.nih.gov/News/Results/20091217.htm Wed, 6 January 2010 20:09:00 EST {BE6F7339-03E2-45EC-8F0B-84C09E8E8BFF} NIGMS-supported scientists have used light and genetic trickery to trace out neurons' ability to excite or inhibit one another, literally shedding new light on how neurons interact. N/A Thu, 17 December 2009 00:00:00 New Methods Streamline Chemical Synthesis http://www.nigms.nih.gov/News/Results/080207.htm Thu, 23 August 2007 11:15:16 EST {BE87E687-45FC-483A-9583-68A4026AE6DC} NIGMS-funded chemists have developed a more efficient way of making certain organic compounds, a method that could be applied to making drugs. N/A Thu, 2 August 2007 00:00:00 How Cholera Bacteria Use Energy http://www.nigms.nih.gov/News/Results/012907.htm Tue, 6 February 2007 14:34:30 EST {BEA8D73D-6047-4219-8716-DC966F8210B5} NIGMS-funded researchers have added key specifics to how V. cholerae process energy, offering a better understanding of the pathogen as well as insight about how cells transform energy. N/A Mon, 29 January 2007 00:00:00 A Drug-Dispensing Contact Lens http://www.nigms.nih.gov/News/Results/072109a.htm Thu, 30 July 2009 11:02:58 EST {BECF2356-5804-4371-976F-212AD47BF4DD} NIGMS-funded researchers have developed special contact lenses that gradually dispense a constant, adjustable amount of medication to the eye. N/A Tue, 21 July 2009 00:00:00 A Glimpse Into the Workings of Spliceosomes, Cells' RNA Editors http://www.nigms.nih.gov/News/Results/032110a.htm Fri, 2 April 2010 17:06:49 EST {BF455113-E28B-45BA-B58E-480BD8A6CED4} N/A Sun, 21 March 2010 00:00:00 Study Reveals That DNA Can Fine-Tune the Activity of Certain Gene Regulators http://www.nigms.nih.gov/News/Results/20110410A.htm Wed, 13 April 2011 12:34:11 EST {BF6359EA-CAD6-4210-827B-20AB04DB1D4E} N/A Sun, 10 April 2011 00:00:00 Scientists See DNA Get "Sunburned" http://www.nigms.nih.gov/News/Results/020107b.htm Tue, 6 February 2007 14:45:46 EST {BFDE18F2-1685-44B7-81A8-C1AE45A187FA} NIGMS-funded researchers have observed DNA being damaged by ultraviolet light and discovered that the most common damaging chemical reaction happens in less than a picosecond. N/A Thu, 1 February 2007 00:00:00 DNA "Tattoos" Mark Stem Cells in Planarians http://www.nigms.nih.gov/News/Results/091108.htm Fri, 19 September 2008 15:52:46 EST {C0193A01-B1D9-455A-8D73-3CABCAED6014} NIGMS-funded researchers have used synthetic molecules to mark the DNA of planarians, a kind of regenerating worm that could serve as a model for stem cell biology. StemCellResearch Thu, 11 September 2008 00:00:00 Fluorescence Imaging Technique Gives View of Receptors in Central Nervous System http://www.nigms.nih.gov/News/Results/020711a.htm Fri, 11 February 2011 15:07:33 EST {C0D48FB7-619F-4FA3-85F7-EBB7005193FA} CellularImaging Mon, 7 February 2011 00:00:00 Why Males Evolve More Quickly http://www.nigms.nih.gov/News/Results/111407a.htm Fri, 23 November 2007 13:37:52 EST {C0E2ED1A-AA16-4F83-BDAA-FC9FDA94ACB3} The fact that males have a single X chromosome could account for faster evolution in males throughout their genomes, report NIGMS-funded biologists. N/A Wed, 14 November 2007 00:00:00 Heritable Individuality May Lie Not in Genes But in Gene-Controlling Regions http://www.nigms.nih.gov/News/Results/031810a.htm Thu, 25 March 2010 17:02:00 EST {C0E58B80-647C-4346-AD2E-17A38688EC49} N/A Thu, 18 March 2010 00:00:00 The Textures of the Surfaces Where Stem Cells Grow Affect How They Develop http://www.nigms.nih.gov/News/Results/080110b.htm Mon, 9 August 2010 16:57:07 EST {C0F161D3-DFA0-4D1F-B89A-4A8CCCF03450} StemCellResearch Sun, 1 August 2010 00:00:00 Actin Keeps Things Moving in Cells http://www.nigms.nih.gov/News/Results/20091217B.htm Mon, 4 January 2010 15:53:00 EST {C1125F3F-CACF-4E36-8D76-8C3BFB1C4CCA} Using new technology they developed, NIGMS-supported chemists have captured what they describe as well-orchestrated, actin-driven, mitochondrial movement within a single cell. N/A Thu, 17 December 2009 00:00:00 Explanation for Chromosome Instability in Cancer Disproven http://www.nigms.nih.gov/News/Results/060709.htm Tue, 16 June 2009 15:32:54 EST {C2D21692-C159-4E7E-9994-9B2DAFFD5E3B} An NIGMS-funded study disproves a longstanding theory about why cancer cells often have too many or too few chromosomes. N/A Sun, 7 June 2009 00:00:00 Variations in Genes Linked to Toxicity of Leukemia Therapy http://www.nigms.nih.gov/News/Results/051107b.htm Tue, 29 July 2008 13:49:27 EST {C30CD71A-F0C4-4BF0-974F-4867774151F8} An NIGMS-funded study has discovered variations in certain genes that make some children with leukemia susceptible to toxic side effects from common chemotherapy drugs. PharmacogeneticsResearchNetwork Fri, 11 May 2007 00:00:00 Bacteria Control How Infectious They Become http://www.nigms.nih.gov/News/Results/041207.htm Mon, 23 April 2007 11:38:46 EST {C3ACBDC1-814A-40B5-A690-4653F2F50224} NIGMS-funded researchers have determined the structure of a protein that appears to make a wide range of microbes infectious. N/A Thu, 12 April 2007 00:00:00 "Cap" of mRNA Enforces Proper Behavior in Protein Production http://www.nigms.nih.gov/News/Results/101410d.htm Fri, 22 October 2010 14:45:34 EST {C3DC605E-A23E-497A-A2DC-569E746C731D} N/A Thu, 14 October 2010 00:00:00 Strain Spread by the Fur Trade Reveals Stealthy Approach of Tuberculosis http://www.nigms.nih.gov/News/Results/20110407E.htm Wed, 13 April 2011 12:32:24 EST {C4462CFB-3A96-4FBB-9DCC-A0699A6CC83E} N/A Thu, 7 April 2011 00:00:00 Faulty Export May Damage Cilia in Rare Disease http://www.nigms.nih.gov/News/Results/20091228.htm Wed, 13 January 2010 15:00:12 EST {C44DD472-14B3-40CF-A53A-5C22941B26EB} A protein complex mutated in a rare human disease, Bardet-Biedl syndrome, removes excess signaling molecules to prevent them from damaging cilia, according to an NIGMS-supported study. N/A Mon, 28 December 2009 00:00:00 Scientists Link Genetic Marker to Aggressiveness of Cancer http://www.nigms.nih.gov/News/Results/20070625.htm Tue, 3 July 2007 17:30:08 EST {C4597BB4-36E6-4910-8C07-ECE8BF1DA68F} Levels of a small non-coding RNA molecule called let-7 appear to define different stages of cancer better than some of the "classical" markers for tumor progression, report a team of NIGMS-supported researchers. N/A Mon, 25 June 2007 00:00:00 New Approach for Drugs Against Colon Cancer http://www.nigms.nih.gov/News/Results/111910b.htm Fri, 19 November 2010 16:19:38 EST {C49A9837-7DA3-458E-9F9E-2688C0A85C27} N/A Fri, 19 November 2010 00:00:00 Bird Embryos Provide a Model for Studying Movement of Cells as a Sheet http://www.nigms.nih.gov/News/Results/032311c.htm Wed, 30 March 2011 15:26:58 EST {C4DF762B-7424-4FC1-A67B-9E5624605578} N/A Wed, 23 March 2011 00:00:00 A Role for Transposons http://www.nigms.nih.gov/News/Results/052009.htm Mon, 8 June 2009 14:22:36 EST {C5049F86-17EA-4A56-B002-74729FA7BD03} An NIGMS-funded study has found that transposon sequences thought of as "junk DNA" spur useful rearrangement of the genome. N/A Wed, 20 May 2009 00:00:00 Fluorescence Technique Studies Dynamics of Large Protein Complexes in Real Time http://www.nigms.nih.gov/News/Results/092110.htm Fri, 24 September 2010 17:22:21 EST {C5153706-362D-4878-B431-D34FE555F21D} CellularImaging Tue, 21 September 2010 00:00:00 Unusual Plant Gene Disrupts Fertilization http://www.nigms.nih.gov/News/Results/122007c.htm Mon, 7 January 2008 08:42:15 EST {C51BE789-88DB-4E79-A95F-BDA0A035ECC4} NIGMS-funded biologists have discovered a gene in plants that disrupts fertilization only when the gene is mutated in both female and male reproductive cells. N/A Thu, 20 December 2007 00:00:00 Structure Related to Chemotherapy Resistance http://www.nigms.nih.gov/News/Results/032609a.htm Fri, 3 April 2009 17:57:49 EST {C5261F19-CFE7-4333-9FA4-87296A9F6AB2} NIGMS-funded researchers have solved the structure of a protein that keeps many drugs out of cells and can make cancer cells resistant to chemotherapy. N/A Thu, 26 March 2009 00:00:00 Ratchet-Like Mutations Make Evolution Irreversible http://www.nigms.nih.gov/News/Results/20090923.htm Fri, 2 October 2009 11:55:42 EST {C5330D0B-5A58-4AB5-8F1E-6B2DC85535B3} An NIGMS-supported research team has found that evolution can never go backwards because the paths to the genes once present in our ancestors are forever blocked. N/A Wed, 23 September 2009 00:00:00 Enzyme Structure Reveals New Drug Targets for Cancer and Other Diseases http://www.nigms.nih.gov/News/Results/NIGMS02142008.htm Thu, 21 February 2008 13:52:01 EST {C5754FF1-7911-49C3-9F36-C0983E5A5021} NIGMS-funded scientists now have a clearer understanding of how a key protein (p300/CBP) controls gene activity and how mutations in the protein may cause disease. The work could provide new avenues to design drugs aimed at cancer, diabetes, HIV, and heart disease. N/A Thu, 14 February 2008 00:00:00 Seams in HIV Coat Could Lead to New Drugs http://www.nigms.nih.gov/News/Results/20091112.htm Thu, 19 November 2009 14:22:37 EST {C57AF639-F8FF-4EF3-9D60-ED6FC0D26469} NIGMS-supported structural biologists have identified functionally important ‘seams’ within the coat that surrounds the HIV genome. ProteinStructureInitiative Thu, 12 November 2009 00:00:00 Defective Signaling Pathway Accounts for Some of the Disease Symptoms in Cystic Fibrosis http://www.nigms.nih.gov/News/Results/021410b.htm Thu, 18 February 2010 18:58:42 EST {C5B00220-D91E-407F-A9BD-83214326F5FB} N/A Sun, 14 February 2010 00:00:00 Grant Will Help Improve Diversity in the Scientific Workforce http://www.nigms.nih.gov/News/Results/102710d.htm Tue, 2 November 2010 16:56:23 EST {C65BE4ED-8AA0-4A85-91D8-6DC38DA025B9} ARRA Wed, 27 October 2010 00:00:00 Scientists Reveal the Hidden Lives of Proteins http://www.nigms.nih.gov/News/Results/20091202C.htm Tue, 8 December 2009 15:54:27 EST {C68F7051-C61E-4FBB-AB91-D939D8FD38C1} A new NIGMS-supported study has shown that the rare, or ‘hidden’, structures of proteins collectively contribute to enzyme catalysis. N/A Wed, 2 December 2009 00:00:00 Innovative Imaging Technique Reveals Molecular Details http://www.nigms.nih.gov/News/Results/092508.htm Mon, 16 March 2009 09:40:19 EST {C6BC96CD-820D-468C-B78D-9B1BF98FF459} NIGMS-funded researchers are developing new tools based on mass spectrometry to visualize things like tissue slices or organisms in biofilms. N/A Thu, 25 September 2008 00:00:00 Cancer Gene Activity Tuned to Environmental Cues By a “Dimmer Switch” http://www.nigms.nih.gov/News/Results/20100816.htm Fri, 20 August 2010 15:11:03 EST {C715180A-F228-4187-8271-982DB4703036} N/A Mon, 16 August 2010 00:00:00 Competition Helps Control Protein Destruction http://www.nigms.nih.gov/News/Results/20090911.htm Tue, 22 September 2009 17:10:54 EST {C760D8F6-1296-4F1E-8F4E-91C3AF63D1E3} NIGMS-supported researchers have illuminated how competition between proteins enhances combinatorial diversity during ubiquitination, the process that marks proteins for destruction. N/A Fri, 11 September 2009 00:00:00 Scientists Present New Insights on Bacterial Decision-Making http://www.nigms.nih.gov/News/Results/20081121A.htm Mon, 16 March 2009 09:37:13 EST {C787AE5C-980E-4F8B-B82E-66F1F0F4EC49} NIGMS-supported biochemists have answered a fundamental question about how a key class of bacterial proteins binds DNA and controls a variety of functions. N/A Fri, 21 November 2008 00:00:00 Proteins Moonlight to Control Genes http://www.nigms.nih.gov/News/Results/102909b.htm Thu, 12 November 2009 19:53:17 EST {C79C23C5-81C9-4427-BC47-813516C85F7F} An NIGMS-funded study has uncovered more than 300 proteins that appear to control gene expression as well as perform other roles in cells. N/A Thu, 29 October 2009 00:00:00 Structure Sheds Light on How Sugar Gets Into Cells http://www.nigms.nih.gov/News/Results/20110406A.htm Tue, 12 April 2011 16:09:55 EST {C7E22F7E-E0E9-46AF-B173-5F26F7B608A2} ProteinStructureInitiative Wed, 6 April 2011 00:00:00 ARRA Funds Research on How Saturated Fats Cause Disease http://www.nigms.nih.gov/News/Results/20091221.htm Mon, 21 December 2009 15:14:22 EST {C93FFD86-3B6B-41FB-AB58-ADDE7B599C32} An ARRA-funded award will advance the research of a University of Nebraska scientist seeking to understand the molecular basis of the disease-causing effects of saturated fats. ARRA Mon, 21 December 2009 00:00:00 Light-Activated Lock Could be Placed in Drugs http://www.nigms.nih.gov/News/Results/033009c.htm Sat, 11 April 2009 20:19:16 EST {C95C996D-BAFD-4FED-A374-F6AD4AA2B82C} NIGMS-funded chemists have designed a lock-like molecule that clasps or unclasps based on exposure to light. N/A Mon, 30 March 2009 00:00:00 Inside-Out Mechanism Pushes Chromosomes Apart During Egg Cell Formation http://www.nigms.nih.gov/News/Results/20100822.htm Fri, 27 August 2010 11:51:37 EST {C9D4C119-7BA5-4BB0-8616-AD0BB51C2424} N/A Sun, 22 August 2010 00:00:00 Protein "Shocks" Evolution Into Action http://www.nigms.nih.gov/News/Results/022308.htm Fri, 29 February 2008 15:30:49 EST {CA95F523-0E26-45EC-8699-A1355BB3BFB9} A heat shock protein could act as a key pivot on which evolution acts, report NIGMS-funded researchers. N/A Sat, 23 February 2008 00:00:00 Autoimmune Response Could Be a Step in Speciation http://www.nigms.nih.gov/News/Results/090407a.htm Tue, 18 September 2007 09:18:11 EST {CAD64907-F4CB-4299-8E04-86CCB410C2A9} Incompatibilities in the genetic codes of two parents can make it impossible for them to breed, report NIGMS-funded researchers who worked on plants but suspect that the same is true in animals. N/A Tue, 4 September 2007 00:00:00 Researchers Awarded $33.9 Million Grant to Study Enzyme Functions http://www.nigms.nih.gov/News/Results/gluegrant_052010.htm Mon, 24 May 2010 10:15:25 EST {CADBAB98-39A1-4ED7-863D-FE3C22E2D437} GlueGrants Thu, 20 May 2010 00:00:00 Altered Protein Structure Linked to Autism http://www.nigms.nih.gov/News/Results/20070612.htm Mon, 2 July 2007 17:07:53 EST {CAEB228E-17D0-47A7-9C42-0BBF926E34A4} NIGMS-supported researchers have discovered how particular genetic mutations affect the structure of a protein complex implicated in autism. The findings may help scientists better understand the underpinnings of autism and related disorders. N/A Tue, 12 June 2007 00:00:00 The Mechanism of Chromosome Separation in Dividing Cells http://www.nigms.nih.gov/News/Results/030609.htm Mon, 16 March 2009 11:25:32 EST {CB244A2C-47B6-43F7-914E-7F81812D1387} An NIGMS-funded study has shed light on how kinetochores, which control chromosome movement during cell division, can be both strong and dynamic. N/A Fri, 6 March 2009 00:00:00 X Chromosome Drives Speciation http://www.nigms.nih.gov/News/Results/101707.htm Fri, 2 November 2007 13:35:32 EST {CB3978FF-BFA1-40E5-8377-83DEBE552724} NIGMS-funded biologists have shown that the X chromosome is a hotspot for genes that cause infertility in hybrid males, acting as a wedge between newly formed species. N/A Wed, 17 October 2007 00:00:00 New Clue to Stopping Breast Cancer Spread http://www.nigms.nih.gov/News/Results/20081117A.htm Wed, 17 December 2008 09:39:03 EST {CB55336F-1322-4B3A-BA02-CCDB64563EEB} A team of NIGMS-supported scientists has reduced the ability of breast cancer cells to migrate by knocking down levels of a protein called palladin. N/A Mon, 17 November 2008 00:00:00 New Tagging Technique Shows Protein Interactions in Living Cells http://www.nigms.nih.gov/News/Results/080310.htm Wed, 11 August 2010 09:58:37 EST {CBAB4D77-B782-4EB6-A02A-F9FC38959F13} CellularImaging Tue, 3 August 2010 00:00:00 Research in Plants Shows That MicroRNAs Regulate Genes on a Broad Scale Across Cells http://www.nigms.nih.gov/News/Results/042110d.htm Thu, 29 April 2010 14:49:32 EST {CBD20D0E-3B5E-4866-8008-1BB9B1866F76} N/A Wed, 21 April 2010 00:00:00 Messenger RNAs Are Lost in Translation http://www.nigms.nih.gov/News/Results/20090823.htm Wed, 9 September 2009 14:52:46 EST {CC3B4B63-577D-4CA3-9B2A-9C706A5392A3} New NIGMS-supported research demonstrates that mRNA decay takes place while mRNAs are associated with actively translating ribosomes. N/A Sun, 23 August 2009 00:00:00 Computational Research Uncovers Clue to Molecular Evolution http://www.nigms.nih.gov/News/Results/091008.htm Wed, 17 September 2008 13:56:39 EST {CC7199F7-31F3-4CB6-9E3F-6B5CE231B2B3} NIGMS-funded researchers have discovered intriguing details about how an enzyme may have evolved. N/A Wed, 10 September 2008 00:00:00 A Step Forward in Understanding Cell Division http://www.nigms.nih.gov/News/Results/020909a.htm Wed, 18 February 2009 16:33:36 EST {CCFE0BB3-DFB7-4244-94C0-8D3B47F64C08} NIGMS-funded researchers have discovered that the proteins dynein and Nudel are essential for regulating the assembly of the spindle matrix. N/A Mon, 9 February 2009 00:00:00 Molecular Analysis Supports T. Rex Link to Birds http://www.nigms.nih.gov/News/Results/042408.htm Tue, 6 May 2008 11:48:46 EST {CD283024-C2F2-4602-97A3-3C920C083E20} Researchers supported in part by NIGMS sequenced collagen protein to analyze the ancestry of Tyrannosaurus rex, finding the dinosaurs to be closer to birds than reptiles. N/A Thu, 24 April 2008 00:00:00 Tools Used to Decipher 'Histone Code' May Be Faulty http://www.nigms.nih.gov/News/Results/20101216A.htm Wed, 22 December 2010 15:04:33 EST {CD7218D7-506A-4DE4-8D2B-C81AB959921B} N/A Thu, 16 December 2010 00:00:00 Common Drug Can Treat Opioid Addiction http://www.nigms.nih.gov/News/Results/021709d.htm Wed, 4 March 2009 12:35:45 EST {CD96FB01-5752-49A1-B08B-80BF473B9DC3} NIGMS-funded researchers have found that a drug approved to treat nausea can treat opioid withdrawal. N/A Tue, 17 February 2009 00:00:00 Scientists Shed Light on How DNA Is Unwound http://www.nigms.nih.gov/News/Results/20081124A.htm Mon, 16 March 2009 09:34:37 EST {CE1FFCDE-35D7-4130-A3AB-D209817B9BA9} NIGMS-supported researchers have figured out how a molecular machine unwinds DNA tangles so that the genetic information can be read and used. N/A Mon, 24 November 2008 00:00:00 Molecular Image of System That Moves Electrons Between Proteins in Cells http://www.nigms.nih.gov/News/Results/031110a.htm Mon, 22 March 2010 15:51:50 EST {CE3A0F00-21AB-4EC4-8078-FA53983C569D} N/A Thu, 11 March 2010 00:00:00 New NIGMS ‘Glue Grant’ Takes Aim at Unknown Enzymes http://www.nigms.nih.gov/News/Results/gluegrant_051510.htm Fri, 28 May 2010 14:06:52 EST {CED79837-E492-4854-A55D-F8D90C60A62C} GlueGrants Thu, 20 May 2010 00:00:00 Identical Genes Behave Differently in Mouse and Human http://www.nigms.nih.gov/News/Results/05062008A.htm Fri, 16 May 2008 11:49:05 EST {CF24BB2B-C2C8-4A37-844A-BDCF34EF2623} While mice and humans are closely related at the genetic level, mice can live without certain genes that are essential to humans, according to a new NIGMS-supported study. N/A Tue, 6 May 2008 00:00:00 Molecular Mimicry That Protects Genome Integrity http://www.nigms.nih.gov/News/Results/041309.htm Tue, 21 April 2009 16:47:05 EST {CF25350C-43D1-4D7B-B6BB-82242AAE62CC} An NIGMS-funded study draws parallels between a DNA repair factor and a ubiquitin-like modifier that are both essential for genome stability. N/A Mon, 13 April 2009 00:00:00 U.S. Obesity Rate Will Reach 42% Before Hitting Plateau http://www.nigms.nih.gov/News/Results/20101104.htm Tue, 9 November 2010 14:29:28 EST {CF5DCE84-71BD-4340-96DE-396F9CEA7F9E} N/A Thu, 4 November 2010 00:00:00 No Sex, But Plenty of Gene Transfer http://www.nigms.nih.gov/News/Results/05292008A.htm Fri, 6 June 2008 16:51:10 EST {CF842A7B-5463-4310-8FB5-E2BF6E10F181} NIGMS-supported scientists have uncovered evidence for massive horizontal gene transfer in the bdelloid rotifer, a microscopic, asexual, freshwater animal. N/A Thu, 29 May 2008 00:00:00 Tethered Protein Provides Answers http://www.nigms.nih.gov/News/Results/20090922.htm Fri, 2 October 2009 11:55:22 EST {CFB68B63-9E0C-4089-B0F6-018C3306238A} Using a DNA-binding protein called the lac repressor, NIGMS-supported biologists have answered some long-sought questions about DNA looping. N/A Tue, 22 September 2009 00:00:00 First 3-D View of Anti-Cancer Agent http://www.nigms.nih.gov/News/Results/031808.htm Thu, 27 March 2008 10:32:07 EST {CFD427E7-DACC-4ACE-8796-DFE682608926} An NIGMS-funded study shows how bleomycin, an established chemotherapy agent, binds to DNA, a finding that may help in the development of future cancer drugs. N/A Tue, 18 March 2008 00:00:00 Structure of DNA Repair Proteins http://www.nigms.nih.gov/News/Results/042308.htm Mon, 5 May 2008 14:07:01 EST {CFDD7BAB-E49F-49F3-A3E1-EE7E0ADB1947} NIGMS-funded researchers have determined the atomic structures of DNA-repair proteins that repair damage caused by certain cancer treatments. N/A Wed, 23 April 2008 00:00:00 Chromatin Regulatory Proteins Have an Additional, Unique Function in Embryonic Stem Cells http://www.nigms.nih.gov/News/Results/022210c.htm Fri, 26 February 2010 16:11:10 EST {CFEF7D3E-230B-4818-960D-986D7BA9E3BA} StemCellResearch Mon, 22 February 2010 00:00:00 Scientists Discover How Chemical Repellants Trip Up Insects http://www.nigms.nih.gov/News/Results/20100825B.htm Wed, 1 September 2010 15:02:00 EST {D047987C-56AB-4032-BE98-B65D718EFD1A} ChemHealth Wed, 25 August 2010 00:00:00 Scientists Unravel Bacterial Communication Pathways http://www.nigms.nih.gov/News/Results/06122008.htm Fri, 27 June 2008 17:13:18 EST {D0E1928B-28D4-4E3B-AEDA-697037A3E3DA} A team of NIGMS-supported researchers has figured out how bacteria ensure that they respond correctly to hundreds of incoming signals from their environment. ComplexBiologicalSystemsInitiatives Thu, 12 June 2008 00:00:00 Common Cellular "Chaperone" Found to Loosen Rather Than Fold Proteins http://www.nigms.nih.gov/News/Results/20110403.htm Thu, 7 April 2011 18:54:38 EST {D10EF700-5345-417C-A8A0-3DDC776FB2B9} N/A Sun, 3 April 2011 00:00:00 Scientists Guide Human Skin Cells to Embryonic State http://www.nigms.nih.gov/News/Results/112007.htm Mon, 20 October 2008 08:37:43 EST {D17CCC87-4C4F-4572-BCC7-99DB07B3D410} NIGMS-funded researchers report the genetic reprogramming of human skin cells to create cells indistinguishable from embryonic stem cells, an accomplishment that should speed up stem cell research and remove ethical and legal constraints to their use. StemCellResearch Tue, 20 November 2007 00:00:00 Blocking the Immune Cell Rush Behind Deadly Sepsis http://www.nigms.nih.gov/News/Results/022409.htm Fri, 6 March 2009 14:45:46 EST {D1898DC9-40A1-4C04-9753-2D743AF4CAE8} A study supported in part by NIGMS suggests improvements to treating sepsis, which would be more effective and not lead to internal bleeding. N/A Tue, 24 February 2009 00:00:00 A Laser Beam Can Make a Cluster of Fruit Fly Cells Turn in Unison http://www.nigms.nih.gov/News/Results/061710.htm Fri, 25 June 2010 18:21:52 EST {D1EEE56E-E11B-4DCF-A48A-F3C0A517C934} N/A Thu, 17 June 2010 00:00:00 Small Molecule Attacks Amyloid Fibers http://www.nigms.nih.gov/News/Results/05162008.htm Tue, 27 May 2008 14:56:33 EST {D35079E7-06E2-4A4C-8A56-6DA20ECEC709} NIGMS-supported researchers have shown how a small molecule selectively takes apart abnormally folded protein fibers connected to Alzheimer's disease and prion diseases. N/A Fri, 16 May 2008 00:00:00 Modeling Could Improve Antibody Drugs http://www.nigms.nih.gov/News/Results/092307.htm Thu, 4 October 2007 13:07:37 EST {D35EBE81-4202-42ED-9F15-45B1C0A87097} Computer modeling developed by NIGMS-funded researchers could build more effective drugs based on antibodies, large immune molecules that bind to a wide range of targets. N/A Sun, 23 September 2007 00:00:00 Scientists Shed Light on DNA Repair Mechanism http://www.nigms.nih.gov/News/Results/20090716A.htm Wed, 22 July 2009 23:10:42 EST {D37619A1-CCF3-495C-8871-58034B1F5C44} A new NIGMS-supported study that sheds light on a DNA repair process could lead to new ways to enhance the effectiveness of cancer medicines. N/A Thu, 16 July 2009 00:00:00 New Tool Probes Cellular Oxidative Stress http://www.nigms.nih.gov/News/Results/02152008.htm Tue, 26 February 2008 10:40:52 EST {D3B77DA8-6F03-481E-9CD2-CF2893EBB742} Scientists supported by NIGMS have developed a new method to observe how oxidative stress affects the major building blocks of a cell, the proteins. N/A Wed, 20 February 2008 00:00:00 Biologists Isolate Genes That Regulate the Link Between Sleep and Feeding http://www.nigms.nih.gov/News/Results/20100610.htm Wed, 16 June 2010 18:11:58 EST {D3F0E067-BD4A-4FBC-9705-FC6D43651355} N/A Thu, 10 June 2010 00:00:00 How Plants Step Out of the Shade http://www.nigms.nih.gov/News/Results/040308.htm Fri, 11 April 2008 12:34:02 EST {D41C2370-196A-4E39-9BB2-3B58FEAB4C3D} An NIGMS-funded study has clarified the molecular steps that allow a plant to stretch out of the shade toward the sun. N/A Thu, 3 April 2008 00:00:00 Scientists Use Engineering Approach to Study Biological Pathways http://www.nigms.nih.gov/News/Results/20080206.htm Thu, 14 February 2008 10:41:02 EST {D4447782-C42C-48AB-B28F-ABDEC6A66C92} An NIGMS-supported team of scientists has analyzed a complex biological system by treating it as a “black box,” an approach commonly used in engineering disciplines. N/A Wed, 6 February 2008 00:00:00 Image Library Features Scientific Images of Cells and Their Constituents http://www.nigms.nih.gov/News/Results/121310a.htm Mon, 20 December 2010 14:17:14 EST {D44957F7-4E31-4FD6-8C17-5D7A34F0C315} ARRA Mon, 13 December 2010 00:00:00 Protein Protects Brain Against Lead, Liver Disease http://www.nigms.nih.gov/News/Results/120607b.htm Thu, 13 December 2007 12:00:20 EST {D44CEC75-D579-4E13-985B-BD5E9F3738AE} Using mice, NIGMS-funded researchers discovered that a protein (PEPT2) protects brains from lead poisoning and liver diseases with neurological effects. N/A Thu, 6 December 2007 00:00:00 Acetaminophen Helps Prevent Kidney Damage After Severe Muscle Injuries http://www.nigms.nih.gov/News/Results/020110b.htm Fri, 5 February 2010 12:41:04 EST {D488EF5A-312D-4CCD-8978-0E2D2721B59D} N/A Mon, 1 February 2010 00:00:00 Scientists Create Energy-Burning Brown Fat http://www.nigms.nih.gov/News/Results/20090729.htm Wed, 5 August 2009 14:49:41 EST {D4A6AA52-EBF2-4527-A98D-10EB2F98397D} NIGMS-supported researchers have shown that they can engineer mouse and human cells to produce brown fat, a natural type of fat that counteracts obesity. N/A Wed, 29 July 2009 00:00:00 Developmental Genes Have More Than One Way to Stop http://www.nigms.nih.gov/News/Results/022411.htm Fri, 4 March 2011 16:13:24 EST {D4CDBB99-8A9A-4047-B185-E5D6B489FFA8} N/A Thu, 24 February 2011 00:00:00 Folate Mystery Finally Solved http://www.nigms.nih.gov/News/Results/082207a.htm Tue, 28 August 2007 14:52:44 EST {D56E2947-CABD-40CB-8893-26E19F2C5CED} NIGMS-funded researchers unexpectedly discovered a long-sought enzyme involved in folate synthesis, which could serve as a target for antibacterial drugs. N/A Wed, 22 August 2007 00:00:00 Short RNAs Show a Long History http://www.nigms.nih.gov/News/Results/100108a.htm Fri, 10 October 2008 15:55:59 EST {D5798CF2-B408-4C37-AAAE-E3008C1A43C8} NIGMS-funded researchers have discovered that microRNAs, which help regulate genes, have been around since the earliest of animal lineages. RNAandRNAinterference Wed, 1 October 2008 00:00:00 Pinch Helps Bacteria Divide http://www.nigms.nih.gov/News/Results/101107a.htm Wed, 31 October 2007 11:26:24 EST {D5C75D0B-D825-4960-B045-16C9ECD71173} NIGMS-funded engineers have shed light on how rod-shaped bacteria like E. coli divide by having a structure called a Z-ring pinch through their bodies. N/A Thu, 11 October 2007 00:00:00 How Molecular Muscles Pinch Cells in Two http://www.nigms.nih.gov/News/Results/121407b.htm Sat, 22 December 2007 13:05:18 EST {D605CBA3-376C-436C-867D-DAF6BD4A7791} Observing live cells, NIGMS-funded researchers have studied how cells assemble contractile rings during cell division. N/A Fri, 14 December 2007 00:00:00 Structure of HIV's Shell http://www.nigms.nih.gov/News/Results/061509.htm Fri, 26 June 2009 16:26:00 EST {D60C4ECB-6B09-4EC1-A456-DB537DE4E328} An NIGMS-funded study has provided a close-up look at the hexagonal protein building blocks that make up the HIV capsid. ProteinStructureInitiative Mon, 15 June 2009 00:00:00 Macrophages Hook and Reel in Invading Bacteria Through a Protein That Serves as First Line of Defense http://www.nigms.nih.gov/News/Results/021710b.htm Fri, 19 February 2010 12:45:02 EST {D62AEF0D-2CE8-4030-8D62-C4B796967014} N/A Wed, 17 February 2010 00:00:00 Why Small Dogs Are Small http://www.nigms.nih.gov/News/Results/040507b.htm Fri, 20 April 2007 12:34:01 EST {D6CF3CFD-C882-47DB-844A-ED559B56B612} A difference in the regulatory sequence for a single gene ensures that small breeds of dog stay small, report NIGMS-funded researchers. N/A Thu, 5 April 2007 00:00:00 Cilia Go With the Flow http://www.nigms.nih.gov/News/Results/042207b.htm Thu, 26 April 2007 12:28:00 EST {D706335F-31AF-42DF-BF2B-8F4861A05F9C} NIGMS-funded biologists have discovered a two-step mechanism that ensures that cilia, tiny hair-like structures in airways and other parts of the body, beat in unison. Misalignment of cilia results in a number of diseases. N/A Sun, 22 April 2007 00:00:00 Inherited Factors Linked to Risk of Childhood Cancer http://www.nigms.nih.gov/News/Results/20090816.htm Thu, 20 August 2009 18:52:42 EST {D79B8E03-0C95-4BA0-82AB-5B27AA0C8C4D} NIGMS-supported scientists have identified inherited variations in two genes that account for 37 percent of childhood acute lymphoblastic leukemia, including a gene that may help predict drug response. PharmacogeneticsResearchNetwork Sun, 16 August 2009 00:00:00 Atomic Properties Make Gold a Unique Catalyst http://www.nigms.nih.gov/News/Results/032207.htm Thu, 29 March 2007 11:31:13 EST {D7C6F0FF-1E53-4173-9AE5-8084114A1133} NIGMS-funded researchers explain why gold is an excellent and versatile catalyst in reactions that create organic molecules. Gold catalysis is increasingly being used in the pharmaceutical industry. N/A Thu, 22 March 2007 00:00:00 How the Protein Alphabet Can Evolve http://www.nigms.nih.gov/News/Results/012709.htm Fri, 30 January 2009 11:50:00 EST {D846FF5F-9721-437A-9A2C-39014AB5FB39} NIGMS-funded researchers have demonstrated how a rare and relatively new amino acid was incorporated into the menu for protein synthesis. N/A Tue, 27 January 2009 00:00:00 How Embryos Regulate Levels of Vitamin A Derivative http://www.nigms.nih.gov/News/Results/111907b.htm Tue, 27 November 2007 14:40:46 EST {D9682B18-6977-48CE-8FF8-2F44166B58C4} NIGMS-funded research shows how embryonic cells may regulate levels of retinoic acid, a signal that controls the development of many body parts. N/A Mon, 19 November 2007 00:00:00 Researchers Unravel Mystery of DNA Conformation http://www.nigms.nih.gov/News/Results/20090713A.htm Fri, 17 July 2009 12:28:53 EST {D997F479-7796-47ED-8DA4-813BC380AB8A} A team of NIGMS-supported researchers has found that under- or overwinding DNA induces structural changes that expose the sequence of bases within the molecule. N/A Mon, 13 July 2009 00:00:00 Distinct Mechanisms Underlie Nuclear Pore Formation at Different Cell Cycle Stages http://www.nigms.nih.gov/News/Results/20100610B.htm Tue, 15 June 2010 17:45:58 EST {D9D61B24-15A3-4DC3-8B53-7455558B80B6} N/A Thu, 10 June 2010 00:00:00 Structure of Flu Protein Gives Clues About Pandemics http://www.nigms.nih.gov/News/Results/101507.htm Fri, 2 November 2007 13:34:38 EST {D9E35B4E-FFB6-461E-BDCA-F26E86DDC028} By comparing surface proteins of flu strains, NIGMS-funded researchers have identified structural elements that may allow avian flu to infect humans. N/A Mon, 15 October 2007 00:00:00 New Insight Into Adaptive Ability of Cells http://www.nigms.nih.gov/News/Results/20081126.htm Mon, 16 March 2009 09:31:28 EST {DBC09E99-0D81-4620-A6EF-A1E59142EA1C} A new NIGMS-supported study sheds light on how cells adapt to disruptions in cell division—findings that may help explain how cancer cells elude the body's defenses. N/A Wed, 26 November 2008 00:00:00 Nanoparticles Could Target and Destroy Tumors http://www.nigms.nih.gov/News/Results/20090616.htm Fri, 26 June 2009 16:27:04 EST {DBDBC78C-B580-49D7-AA86-216F327762B0} Nanoparticles specially engineered by a team of NIGMS-supported researchers could someday target and destroy tumors, sparing patients from toxic, whole-body chemotherapies. N/A Tue, 16 June 2009 00:00:00 Structure of Bacterial Switch Could Lead to New Antibiotics http://www.nigms.nih.gov/News/Results/041709b.htm Fri, 1 May 2009 15:29:33 EST {DC1BE14B-4B66-4D0A-83E7-7778EBECA1B3} NIGMS-funded biochemists have determined the structure of a key genetic mechanism in bacteria that could lead to a new class of antibiotics. N/A Fri, 17 April 2009 00:00:00 Structural Changes in Protein Control Biological Clock in Bacteria, Determining When Cells Divide http://www.nigms.nih.gov/News/Results/021110b.htm Tue, 23 February 2010 14:46:00 EST {DC349727-4FCE-492A-BF02-7B9739E536BB} ARRA Thu, 18 February 2010 00:00:00 New Test Can Predict HIV Drug Resistance http://www.nigms.nih.gov/News/Results/010707.htm Wed, 17 January 2007 12:57:19 EST {DC38D37B-FA85-41B8-AEE1-4CCE712CAECE} NIGMS-funded researchers have developed a sensitive test for identifying drug-resistant strains of HIV in a patient's bloodstream. The test also has the potential to detect mutations conferring drug resistance in other infectious agents. N/A Sun, 7 January 2007 00:00:00 Systems Approach Sheds Light on Insulin Resistance http://www.nigms.nih.gov/News/Results/20091123.htm Tue, 24 November 2009 16:53:57 EST {DC3F4D5B-ADAE-4EB7-8D9F-1C18790A6D51} NIGMS-supported researchers have provided the sharpest-yet picture of how core biochemical pathways are altered in people who have insulin resistance. ComplexBiologicalSystemsInitiatives Mon, 23 November 2009 00:00:00 A Natural Editing Process Redirects microRNAs http://www.nigms.nih.gov/News/Results/022207.htm Tue, 6 March 2007 15:27:59 EST {DC637566-7822-45E2-8E9E-D4B49F284543} NIGMS-funded researchers have shown that editing the sequence of microRNAs--tiny molecules that are increasingly known for their role in regulating the genome--can change the genes they target, with physiologic consequences. N/A Thu, 22 February 2007 00:00:00 "GO" Grant to Study Personalized Medicine http://www.nigms.nih.gov/News/Results/101609.htm Fri, 16 October 2009 17:13:40 EST {DC945550-8ADD-40E4-8175-8BB63402A40E} An NIGMS Grand Opportunities stimulus grant will support a study on whether genetic information in existing electronic medical records can be used to make drug administration safer. ARRA Fri, 16 October 2009 00:00:00 Factor Regulates Length of Actin Filaments http://www.nigms.nih.gov/News/Results/021809.htm Tue, 24 February 2009 14:38:02 EST {DCFD2CA8-E5ED-40FD-AAC2-41F1E9E4393E} NIGMS-funded researchers discovered that a protein regulates the length of actin filaments, which make up part of the cytoskeleton and are important for transport and cell division. N/A Wed, 18 February 2009 00:00:00 Soft Medium Provides Cheaper Way to Grow Stem Cells http://www.nigms.nih.gov/News/Results/20101215B.htm Mon, 20 December 2010 16:54:43 EST {DD15FC4D-ACEF-4BE8-A725-7507DF7EB057} StemCellResearch Wed, 15 December 2010 00:00:00 Genes Stay Put For Transcription http://www.nigms.nih.gov/News/Results/010108.htm Wed, 16 January 2008 12:16:35 EST {DD581F74-1D51-4662-A90D-9CB584334A06} NIGMS-funded researchers have evidence that transcription machinery moves to genes instead of genes having to move to specific locations in the nuclei to be expressed. N/A Tue, 8 January 2008 00:00:00 Body Clock Regulates Metabolism http://www.nigms.nih.gov/News/Results/031209b.htm Fri, 20 March 2009 10:45:01 EST {DD84C398-16F7-4111-9E85-B2B6AE40AFDA} NIGMS-funded researchers have discovered how circadian rhythms regulate energy levels in cells. N/A Thu, 12 March 2009 00:00:00 Motor Protein Helps Choreograph Dance of Chromosomes http://www.nigms.nih.gov/News/Results/05132008.htm Wed, 21 May 2008 17:34:21 EST {DD8E7BFF-04C6-42D9-AE43-C8B26D9BDBBA} In a new NIGMS-supported study, researchers report on how a key motor protein orchestrates chromosome movements at a critical stage of cell division. N/A Tue, 13 May 2008 00:00:00 Chemists Use 'Green Chemistry' to Produce Widely Used Compound http://www.nigms.nih.gov/News/Results/06122008A.htm Thu, 26 June 2008 13:59:39 EST {DDA142E8-EA88-4264-9CBD-466E91B09C06} NIGMS-supported chemists have discovered an inexpensive, clean and quick way to prepare amines, compounds that are used widely in industry. ChemicalMethodologiesAndLibraryDevelopment Thu, 12 June 2008 00:00:00 Gene Involved in Male Infertility Identified http://www.nigms.nih.gov/News/Results/03142008A.htm Tue, 25 March 2008 10:29:10 EST {DDB71303-ABCF-43CD-8CD7-81F1D8EBBFE7} A team of NIGMS-supported scientists has identified an X chromosome gene involved in meiosis that when disrupted renders male mice sterile and female mice less fecund. N/A Fri, 14 March 2008 00:00:00 Protein By Design http://www.nigms.nih.gov/News/Results/032309b.htm Wed, 1 April 2009 11:38:02 EST {DDB76D17-360F-4D96-9870-6C7AA5C9C4AD} NIGMS-funded biochemists built a functioning protein from scratch, that is, without working from an existing scaffold from nature. N/A Mon, 23 March 2009 00:00:00 Potential Anthrax Vaccine and Antitoxin In One http://www.nigms.nih.gov/News/Results/100407.htm Tue, 9 October 2007 15:40:23 EST {DDC83CF8-D31D-4D7A-8CB0-CF9D5B8F0E38} NIGMS-funded researchers have discovered an agent that protects rats against anthrax by neutralizing its toxin and also providing immunity. N/A Thu, 4 October 2007 00:00:00 Copper-Free Click Chemistry Used in Mice http://www.nigms.nih.gov/News/Results/20100118.htm Tue, 26 January 2010 15:50:00 EST {DE34C7A9-8360-42E3-8642-25B36272D39B} NIGMS-supported researchers have crafted a unique copper-free version of click chemistry to create biomolecular probes for in vivo studies of live mice. ChemHealth Mon, 18 January 2010 00:00:00 Structure Formed by Strep Protein Can Trigger Toxic Shock http://www.nigms.nih.gov/News/Results/20110406.htm Mon, 11 April 2011 17:13:39 EST {DEA72281-B478-4CA2-B9F9-C43F9E2E4D99} N/A Wed, 6 April 2011 00:00:00 Studies of Yeast Spore Formation Uncover Possible Sources of Male Infertility http://www.nigms.nih.gov/News/Results/20100825.htm Tue, 31 August 2010 13:23:57 EST {DEDF00D1-96E7-4236-ADFC-8405EA6F3D5C} N/A Wed, 25 August 2010 00:00:00 Cells Change Shape to Fit the Situation http://www.nigms.nih.gov/News/Results/20081121.htm Mon, 16 March 2009 09:32:06 EST {DEEEA721-CB8A-4551-BB89-B04AF4CEB807} As cells bend, they reorganize their internal scaffolding, and as they reorganize the scaffolding, the cells further adjust their shape, according to a new NIGMS-supported study. N/A Fri, 21 November 2008 00:00:00 Structure Shows How Chemical Switch Works http://www.nigms.nih.gov/News/Results/011607a.htm Mon, 29 January 2007 14:08:01 EST {DF0B6EE2-1D6F-4204-8903-9B3CB8BBF194} NIGMS-funded researchers have discovered how a simple thioester bond acts like a switch to trigger key reactions inside cells, such as allowing them to multiply. N/A Tue, 16 January 2007 00:00:00 Primitive Bacterial Immune System Co-opts the DNA of Enemy Viruses http://www.nigms.nih.gov/News/Results/122310c.htm Tue, 4 January 2011 15:37:42 EST {DF1E9619-969D-40AA-8EFF-9D94A3544837} N/A Thu, 23 December 2010 00:00:00 Ulcer Germ May Protect Kids From Asthma http://www.nigms.nih.gov/News/Results/042307b.htm Mon, 30 April 2007 12:53:19 EST {DF50E973-D05F-4535-B882-179B5D138AA0} People with a virulent strain of H. pylori, the bacterium that causes stomach cancer and peptic ulcers, appear less likely to have had asthma and allergies in their youth. N/A Mon, 23 April 2007 00:00:00 Inconspicuous Hosts for Lyme Disease http://www.nigms.nih.gov/News/Results/112907.htm Mon, 10 December 2007 16:25:43 EST {DF6D00E5-2505-4C4C-8941-442400442E83} NIGMS-funded researchers have shown that chipmunks and two types of shrews, not just mice, are the main animal reservoirs for lyme disease. N/A Thu, 29 November 2007 00:00:00 How Regulating Alternative Splicing Affects Immune Response http://www.nigms.nih.gov/News/Results/101510.htm Fri, 22 October 2010 14:45:59 EST {DF70B83F-EE59-4210-9B62-4AB2141C976C} N/A Fri, 15 October 2010 00:00:00 New Way Ubiquitin Affects Transcription Machinery http://www.nigms.nih.gov/News/Results/121708.htm Fri, 19 December 2008 10:15:05 EST {DFBB25B0-D11A-4BAE-9C6B-8C8C30FB7453} NIGMS-funded researchers are deepening their grasp of how adding ubiquitin tags affects transcription. N/A Wed, 17 December 2008 00:00:00 Patient’s Whole Genome Reveals Risk of Diseases and Adverse Drug Responses http://www.nigms.nih.gov/News/Results/genomemedia_042910.htm Tue, 18 May 2010 10:25:20 EST {DFDB73D0-19F1-4EBE-BD77-EDC598D789B1} PharmacogeneticsResearchNetwork Thu, 29 April 2010 00:00:00 A Single Mutation Could Let H1N1 Flu Virus Spread Much More Easily http://www.nigms.nih.gov/News/Results/030911.htm Tue, 15 March 2011 14:32:07 EST {DFE223F0-7FAE-4A80-BB04-2CD849ECE8C9} N/A Wed, 9 March 2011 00:00:00 Nanotechnology Shows Cancer Cells "Feel" Softer http://www.nigms.nih.gov/News/Results/120207.htm Thu, 13 December 2007 09:40:32 EST {E092BE3D-34E1-4744-8B36-A994CF4F117A} Using nanotechnology that measures the softness of cells, NIGMS-funded researchers showed that metastatic cancer cells feel different from normal cells. N/A Sun, 2 December 2007 00:00:00 Unraveling the Secrets of Red Tide http://www.nigms.nih.gov/News/Results/083007c.htm Thu, 6 September 2007 11:51:45 EST {E0973E67-F2B1-4A92-AD15-5560D4C821FD} An NIGMS-funded study shows how tiny marine organisms likely produce red tide toxin. N/A Thu, 30 August 2007 00:00:00 Study Uncovers Light and Temperature Driven Genes in Worms http://www.nigms.nih.gov/News/Results/20101216B.htm Tue, 21 December 2010 14:40:57 EST {E0DFF4FB-01AF-40F6-A229-0D75AA3FF1F2} ModelOrganisms Thu, 16 December 2010 00:00:00 New Method Produces "Libraries" of Important Carbohydrate Molecules http://www.nigms.nih.gov/News/Results/052310a.htm Tue, 1 June 2010 14:43:19 EST {E0FA447A-B111-41CD-8BD1-166E37C1B81A} ChemicalMethodologiesAndLibraryDevelopment Sun, 23 May 2010 00:00:00 Discovery Shows How to Disable a Protein That Often Thwarts Chemotherapy http://www.nigms.nih.gov/News/Results/062010.htm Fri, 25 June 2010 18:22:34 EST {E10C20A1-EE3A-4294-B962-248CC1FBF556} N/A Sun, 20 June 2010 00:00:00 Technique for Solving Protein Structures May Lead to Better Antibiotics http://www.nigms.nih.gov/News/Results/100108b.htm Fri, 10 October 2008 15:55:01 EST {E11B0B90-332C-42BC-87F8-8A624FE4165B} Using NMR to solve the structure of an integral membrane protein, NIGMS-funded researchers have paved the way to creating better antibiotics. StructuralBiology Wed, 1 October 2008 00:00:00 Study Proves that Tainted Heparin Caused Reactions http://www.nigms.nih.gov/News/Results/120308b.htm Wed, 17 December 2008 09:25:17 EST {E198EF14-E19E-45E8-A64C-18277F2C4B09} An NIGMS-funded study provides epidemiological evidence confirming that a contaminant in batches of heparin caused severe allergic reactions. N/A Wed, 3 December 2008 00:00:00 Enzyme Structure Could Lead to New Drugs for Sleeping Sickness http://www.nigms.nih.gov/News/Results/20100115.htm Mon, 25 January 2010 11:40:35 EST {E1B4664B-6326-4633-AE3A-D81FF5282B20} NIGMS-supported scientists have determined the structure of an enzyme essential to the survival of the protozoan parasites that cause sleeping sickness, Chagas disease and leishmaniasis. N/A Fri, 15 January 2010 00:00:00 Imaging Method Selectively Reveals Dead and Dying Cells in Living Animals http://www.nigms.nih.gov/News/Results/012910a.htm Thu, 4 February 2010 14:43:29 EST {E21ED1D7-F088-4B99-BF3E-7563DA84AF00} N/A Fri, 29 January 2010 00:00:00 Computer Program Simulates Protein Folding Faster, Helping Accuracy http://www.nigms.nih.gov/News/Results/070610.htm Mon, 19 July 2010 14:32:35 EST {E28A2560-52DF-4A33-8927-B9635CE20E4F} ComputingLife Tue, 6 July 2010 00:00:00 Leprosy Medicine Holds Promise for Autoimmune Diseases http://www.nigms.nih.gov/News/Results/13009c.htm Tue, 10 February 2009 13:26:43 EST {E294B0DF-B661-44B9-96B8-719DF7C1D56F} NIGMS-funded researchers have found that a drug with a long history holds promise as a therapy for multiple sclerosis and other autoimmune diseases. N/A Fri, 30 January 2009 00:00:00 Embryology Study Offers Clues to Birth Defects http://www.nigms.nih.gov/News/Results/060909.htm Wed, 24 June 2009 17:33:31 EST {E2A391CF-D602-4146-B822-0DD5F4CAA157} An NIGMS-funded study has clarified the role that retinoic acid plays in limb development. N/A Tue, 9 June 2009 00:00:00 Journal Devotes Issue to Research from Protein Structure Initiative Center http://www.nigms.nih.gov/News/Results/102110a.htm Wed, 27 October 2010 15:35:58 EST {E2D158A0-8671-45DE-9CE3-C2C63497E8F1} ProteinStructureInitiative Thu, 21 October 2010 00:00:00 Scientists Guide Immune Cells with Light and Microparticles http://www.nigms.nih.gov/News/Results/20091115.htm Mon, 16 November 2009 18:58:16 EST {E2FFED68-A6BE-4C0A-92AF-7F7EC0A46CD8} A team of scientists partly supported by NIGMS has developed a new approach to studying how immune cells chase down bacteria in our bodies. N/A Sun, 15 November 2009 00:00:00 Fast, Affordable Tool For Finding Gene Switches http://www.nigms.nih.gov/News/Results/051809b.htm Fri, 29 May 2009 12:20:32 EST {E3491168-58FA-4E95-86AE-19E8DF26EA8F} NIGMS-funded researchers have created a method for quickly identifying large numbers of short hairpin RNA sequences in human genes. N/A Mon, 18 May 2009 00:00:00 Newly Discovered Molecule Has Potent Effect on Biological Clock http://www.nigms.nih.gov/News/Results/20101214.htm Mon, 20 December 2010 14:07:42 EST {E34A70A5-610A-4B60-8C65-30BBC47FA33D} N/A Tue, 14 December 2010 00:00:00 Knowing When to Divide http://www.nigms.nih.gov/News/Results/073007b.htm Fri, 17 August 2007 14:35:07 EST {E35D464E-753A-4AE1-AC38-6804C844AF71} NIGMS-funded biologists identified a metabolic sensor that links cell division and cell size in bacteria with food availability. N/A Mon, 30 July 2007 00:00:00 Scientists Make Fundamental Discovery About Gene Expression in Bacteria http://www.nigms.nih.gov/News/Results/042210a.htm Sat, 1 May 2010 21:09:49 EST {E3E90126-8627-4A83-B3E6-74EEDBD6EC95} N/A Thu, 22 April 2010 00:00:00 Protein Plays Dual Role in Sepsis, Promoting Both Cell Death and Survival http://www.nigms.nih.gov/News/Results/020211.htm Fri, 4 February 2011 15:20:14 EST {E41C723C-1089-427D-A81E-74E5061FC62D} N/A Wed, 2 February 2011 00:00:00 Gene Linked to Cancer Remodels Chromatin http://www.nigms.nih.gov/News/Results/080709.htm Tue, 18 August 2009 13:04:43 EST {E472899E-2A51-46FF-BB22-8C2D173229CD} NIGMS-funded researchers have discovered a function for a gene that is expressed highly in certain cancers. N/A Fri, 7 August 2009 00:00:00 NIGMS Grantees Win Nobel Prize for Studies of the Structure and Function of the Ribosome http://www.nigms.nih.gov/News/Results/nobel_20091007.htm Fri, 9 October 2009 11:05:56 EST {E4B9D328-CE3F-4846-ABFE-61BFEF2F3CCC} The 2009 Nobel Prize in chemistry is awarded to three NIGMS grantees for studies of the structure and function of the ribosome. The winners are Venkatraman Ramakrishnan, Thomas A. Steitz and Ada E. Yonath. Nobel Prize Wed, 7 October 2009 00:00:00 Theory Predicts Protein Association Rates http://www.nigms.nih.gov/News/Results/021407.htm Tue, 20 February 2007 13:17:04 EST {E4BDC6E0-2E99-4C81-BEED-6D68A5C1A391} NIGMS-funded researchers have put forth a new theory that accurately predicts the rate at which different proteins associate together--a crucial step in a wide range of biological processes. N/A Wed, 14 February 2007 00:00:00 Cancer's Break-In Tools Possibly Identified http://www.nigms.nih.gov/News/Results/20090817A.htm Mon, 24 August 2009 13:50:35 EST {E4CB7E4A-09AE-4F90-A974-29C0DD50C028} A team of NIGMS-supported scientists has uncovered new clues into cancer's deadliest behavior—its ability to put down roots in new tissues after spreading throughout the body. N/A Mon, 17 August 2009 00:00:00 Biologists Decipher Molecular Code That Regulates Neuronal Excitability http://www.nigms.nih.gov/News/Results/032111.htm Tue, 29 March 2011 11:55:34 EST {E4F0A325-26B1-4FEB-A2BC-BE979B9D92C5} N/A Mon, 21 March 2011 00:00:00 DNA Replication Recruits Proteins to Lesions http://www.nigms.nih.gov/News/Results/091009d.htm Mon, 21 September 2009 13:32:59 EST {E58DE4E5-2B6A-42B9-B39A-C9CA61DC0D8E} NIGMS-funded researchers have found that certain disease-related proteins are present at DNA damage sites only when DNA replicates. N/A Thu, 10 September 2009 00:00:00 H1N1 Used a New Strategy to Cross to Humans http://www.nigms.nih.gov/News/Results/20091208.htm Wed, 16 December 2009 16:31:29 EST {E58F61A4-76AD-47AA-A822-276CDF0FBE21} The 2009 H1N1 influenza virus used a new strategy to cross from birds into humans, a warning that it has more than one trick up its sleeve to jump the species barrier, according to a new NIGMS-supported report. N/A Tue, 8 December 2009 00:00:00 Pulling Protein's Tail Curtails Cancer http://www.nigms.nih.gov/News/Results/123008.htm Mon, 12 January 2009 14:27:07 EST {E5AE6E49-AA28-4F77-976C-0F303EE43DD5} NIGMS-funded researchers discovered that removing the tail of a tumor suppressor called PTEN activated the protein, which is often inactive in cancer cells. N/A Tue, 30 December 2008 00:00:00 NIGMS Grantee Honored with Nobel Prize in Chemistry http://www.nigms.nih.gov/News/Results/nobelprize_101006.htm Thu, 10 February 2011 13:50:46 EST {E60A713C-E962-4C50-BF16-892ABD80331C} Nobel Prize Wed, 6 October 2010 00:00:00 Cell Type-Specific Signaling in Tumor Development http://www.nigms.nih.gov/News/Results/040609a.htm Tue, 14 April 2009 12:02:58 EST {E6176EF1-3FD2-4FF1-A2C7-BF7979A51235} NIGMS-funded biochemists have discovered mechanisms behind two key checkpoints in cell development that are related to tumor growth. N/A Mon, 6 April 2009 00:00:00 Researchers Track Disease-Spreading Interactions in a High School Population http://www.nigms.nih.gov/News/Results/121310b.htm Thu, 16 December 2010 18:23:21 EST {E6337A21-B90C-4DAB-9EA2-36124C21F334} N/A Mon, 13 December 2010 00:00:00 A Dead Gene Comes Back to Life http://www.nigms.nih.gov/News/Results/030509.htm Mon, 16 March 2009 11:22:21 EST {E633F185-04C9-4BFD-890D-849BDF07FB9E} NIGMS-funded researchers have discovered that a gene remnant was resurrected during human evolution. N/A Thu, 5 March 2009 00:00:00 Test May Predict Spread of Breast Cancer http://www.nigms.nih.gov/News/Results/032409.htm Fri, 3 April 2009 18:00:51 EST {E6716179-2350-4A56-8672-118465AD03E7} A study funded partly by NIGMS has produced a test that could help doctors identify which breast cancer patients should receive aggressive therapy. N/A Fri, 27 March 2009 00:00:00 NMR Helps Researchers Take Flexibility of Molecules Into Account When Designing Drugs http://www.nigms.nih.gov/News/Results/051910a.htm Mon, 24 May 2010 15:40:56 EST {E671C6C0-E4B7-46FD-B536-51B131BF23F1} SingleMoleculeDetectionAndManipulation Wed, 19 May 2010 00:00:00 Technique Helps Adult Stem Cells Grow http://www.nigms.nih.gov/News/Results/022707.htm Mon, 12 March 2007 23:34:36 EST {E679789F-FAA6-4B58-AEDC-F8C1752187C6} NIGMS-funded bioengineers have developed a technique using a growth factor and a ceramic and polymer scaffold to encourage the survival and growth of adult stem cells. N/A Tue, 27 February 2007 00:00:00 Chemists Create a Nanoscale Assembly Line With DNA Machines Working in Tandem http://www.nigms.nih.gov/News/Results/051210a.htm Tue, 18 May 2010 14:50:33 EST {E6B1D346-9D9B-45DF-914A-47C183629D32} N/A Wed, 12 May 2010 00:00:00 $22.5 Million Grant Funds International Study of Membrane Proteins http://www.nigms.nih.gov/News/Results/20100810B.htm Tue, 10 August 2010 16:04:35 EST {E70934DC-ACCC-4F85-B58F-5A930F76C26A} GlueGrants Tue, 10 August 2010 00:00:00 Atomic Structure Reveals Membrane Protein That Closes Stomata of Plants http://www.nigms.nih.gov/News/Results/102710b.htm Sun, 31 October 2010 12:47:58 EST {E7419625-2668-4FD2-ABBB-117777915D7E} ProteinStructureInitiative Wed, 27 October 2010 00:00:00 Five NIH Leaders Elected to the Institute of Medicine http://www.nigms.nih.gov/News/Results/nihleaders_101011.htm Fri, 15 October 2010 16:13:08 EST {E7671C08-9746-4AB2-AA23-86BC2F357976} N/A Mon, 11 October 2010 00:00:00 Gatekeepers to the Nucleus Implicated in Aging http://www.nigms.nih.gov/News/Results/012209.htm Thu, 29 January 2009 16:48:48 EST {E7D2747A-1BDC-42A0-B944-8B2397372DB7} NIGMS-funded researchers have discovered that cells do not replace or repair the core structure of nuclear pores, which become leaky over time. N/A Thu, 22 January 2009 00:00:00 DNA Repair Link to Cancer http://www.nigms.nih.gov/News/Results/20091203.htm Fri, 11 December 2009 10:12:37 EST {E7D89DEC-3617-4354-AB4B-ACE26620ED0C} A new NIGMS-supported study has shown that a protein that copies DNA also plays a vital role in repairing DNA breaks, shedding light on how cells become cancerous. N/A Thu, 3 December 2009 00:00:00 Errant Jumping Genes Provide Raw Material for Human Evolution http://www.nigms.nih.gov/News/Results/060110b.htm Wed, 9 June 2010 17:47:45 EST {E7F0393A-EF3A-4DD3-964B-1B8579F97BCE} N/A Tue, 1 June 2010 00:00:00 Genome of Malaria Species Decoded http://www.nigms.nih.gov/News/Results/100808.htm Fri, 10 October 2008 16:04:40 EST {E8017D29-87B3-406D-B307-E2B33F24302D} A parasitologist funded by NIGMS headed a team of researchers that has decoded the genome of the parasite that causes 40 percent of malaria infections. N/A Wed, 8 October 2008 00:00:00 Genetics Supports Single Migration Across Bering Strait http://www.nigms.nih.gov/News/Results/112707.htm Mon, 3 December 2007 13:49:39 EST {E805D248-466C-4B7F-86B5-DB5D5933B19A} New genetic evidence, uncovered with NIGMS funding, supports the notion that Native Americans descended from a small number of people crossing once from Asia across the Bering Strait. N/A Tue, 27 November 2007 00:00:00 Structure of Signal That Controls DNA Packaging Could Lead to Way to Combat Cancer http://www.nigms.nih.gov/News/Results/020811b.htm Fri, 11 February 2011 15:07:59 EST {E828CE38-5BFC-4C6C-A736-461BA3CE24F5} N/A Tue, 8 February 2011 00:00:00 Insights on the Regulation of Histone Levels http://www.nigms.nih.gov/News/Results/100709f.htm Thu, 8 October 2009 14:35:52 EST {E840570D-4AFF-44CE-85AD-17813B18E0AD} NIGMS-funded biologists have shed light on the regulation of histones, the proteins that package DNA into chromosomes. N/A Wed, 7 October 2009 00:00:00 Stem Cells From Humans Repair Damage in Rat Hearts http://www.nigms.nih.gov/News/Results/082607.htm Sat, 1 September 2007 09:42:38 EST {E84316F1-C7EC-433E-AFC3-560BD9ACDC3E} A study funded partly by NIGMS shows that human heart muscle cells derived from embryonic stems cells can repair rat hearts damaged by heart attack. N/A Sun, 26 August 2007 00:00:00 Blocking a Specific Enzyme Could Protect Lungs From Inflammation Damage http://www.nigms.nih.gov/News/Results/010411a.htm Tue, 18 January 2011 18:16:00 EST {E85E209C-613C-4691-8559-A98A17AF212B} N/A Tue, 4 January 2011 00:00:00 Key Molecule Lets Microbes Produce Greenhouse Gases http://www.nigms.nih.gov/News/Results/070708.htm Wed, 16 July 2008 14:51:37 EST {E86C52CC-128D-4381-A8F2-8E9A8BCF1F95} A 12-year effort funded by NIGMS sheds light on how microbes produce carbon dioxide and methane, offering insights for improving industrial processes. N/A Mon, 7 July 2008 00:00:00 Structure Study Dissects How Nitric Oxide Attacks Proteins http://www.nigms.nih.gov/News/Results/120710.htm Mon, 13 December 2010 15:38:09 EST {E873DDB2-7559-49A3-BAEE-3EF033BB11DC} N/A Tue, 7 December 2010 00:00:00 How ZIP Proteins Allow Zinc Into Cells http://www.nigms.nih.gov/News/Results/112210.htm Thu, 2 December 2010 15:29:20 EST {E88D4DFA-6B57-41A3-A373-B27F4F0BA425} N/A Mon, 22 November 2010 00:00:00 Assembly Line Makes Cell-Like Structures From Simple Starting Materials http://www.nigms.nih.gov/News/Results/030311.htm Fri, 11 March 2011 14:51:12 EST {E8C060F0-4BAB-42D7-B30C-7EC7981B876F} N/A Thu, 3 March 2011 00:00:00 Chemical Model May Help Explain How Life Arose http://www.nigms.nih.gov/News/Results/20070608A.htm Thu, 21 June 2007 18:11:28 EST {E9285118-D36B-4BE7-BFF9-707A994599C6} NIGMS-supported scientists have developed a model explaining how simple chemical and physical processes may have laid the foundation for life. N/A Fri, 8 June 2007 00:00:00 Seeing Enzymes in Real Time http://www.nigms.nih.gov/News/Results/121107a.htm Thu, 13 December 2007 09:34:27 EST {E9A10F0D-00A4-4659-A087-11D7799F0195} NIGMS-funded researchers were able to watch an enzyme as it changed shape in the absence of a substrate. N/A Tue, 11 December 2007 00:00:00 Two Steps to Filtering the Evolution of Genes http://www.nigms.nih.gov/News/Results/030507.htm Tue, 13 March 2007 14:11:22 EST {E9A9BB1B-63C7-4FD1-8DE7-34B9C4ACC5BD} Before a beneficial mutation can take its place in the human genome, it has to pass through a two-step screening process, say NIGMS-funded researchers. If a radical change survives initially, it is likely to spread quickly. N/A Mon, 5 March 2007 00:00:00 Cooling Down Enzyme and Probing With Lasers Allows Researchers to Track Reaction Progress http://www.nigms.nih.gov/News/Results/022510.htm Tue, 2 March 2010 15:43:56 EST {E9EFF4D6-5865-4C34-96A3-3E4B0D1E774A} N/A Thu, 25 February 2010 00:00:00 New Insights on How Sugar Controls Cell Growth http://www.nigms.nih.gov/News/Results/20090817D.htm Mon, 24 August 2009 13:49:18 EST {EAF355DA-C09D-4934-8E1D-2C9BF5481FC4} New NIGMS-supported research helps show how sugar contributes to cell growth, and how it might be stopped to control tumors. N/A Mon, 17 August 2009 00:00:00 Fuzzy Logic Reveals Cells' Workings http://www.nigms.nih.gov/News/Results/040309.htm Sat, 11 April 2009 20:14:48 EST {EB59CB3F-02D2-46DB-A8F6-F1E87955C34C} NIGMS-funded biological engineers have used a "fuzzy logic" approach to model information networks in cells. ComplexBiologicalSystemsInitiatives Fri, 3 April 2009 00:00:00 Cell Division Mechanism May Shed Light on Cancer http://www.nigms.nih.gov/News/Results/20090817B.htm Thu, 20 August 2009 18:54:07 EST {EB614D35-D101-4922-82B0-6401C583170E} A team supported by NIGMS describes a molecular scaffold that ensures a critical step in cell division: equal distribution of genetic material between two daughter cells. N/A Mon, 17 August 2009 00:00:00 Structure of Telomerase’s RNA Core Domain Offers Clues to Cancer and Aging http://www.nigms.nih.gov/News/Results/20101103A.htm Mon, 8 November 2010 17:20:23 EST {EB96FBA4-1469-4616-B8D7-92CBB2EB43CB} ARRA Wed, 3 November 2010 00:00:00 Block in Cell Division Could Help Explain Cell Death in Diseases Like Huntington’s http://www.nigms.nih.gov/News/Results/20110411A.htm Thu, 21 April 2011 15:30:14 EST {EBC631AD-6B73-4066-A395-8D6671884CA8} N/A Mon, 11 April 2011 00:00:00 Human Skin Cells Reprogrammed To Produce Insulin http://www.nigms.nih.gov/News/Results/091708a.htm Wed, 5 November 2008 13:45:19 EST {EBD70768-CFCB-4AA3-B3EE-2BD46611D90B} NIGMS-funded researchers transformed human skin cells into pluripotent stem cells and then to cells that can make the hormone insulin. StemCellResearch Wed, 17 September 2008 00:00:00 Science Academy Elects 13 NIGMS Grantees http://www.nigms.nih.gov/News/Results/050107.htm Mon, 7 May 2007 11:39:07 EST {EC2CCCEC-B8F3-4946-9801-479AEFDD2DD2} The National Academy of Sciences elected 72 new members for distinguished and continuing achievements in original research. Thirteen are NIGMS-funded scientists: David Agard, Victor Ambros, Tania Baker, Steven Block, Jeffery Dangl, Mark Estelle, Michael Fayer, Laura Kiessling, Stephen Kowalczykowski, Christopher Miller, William Moerner, Vern Schramm, and Michael Young. N/A Tue, 1 May 2007 00:00:00 Model Suggests How Cholesterol Interacts With Important Proteins http://www.nigms.nih.gov/News/Results/092608b.htm Mon, 29 September 2008 12:18:52 EST {EC683F16-720F-4C62-B66F-1E33BEC4FD5C} NIGMS-funded researchers have clarified how cholesterol interacts with neurotransmitter receptors involved in inflammation and a range of diseases. N/A Fri, 26 September 2008 00:00:00 Acetylation Regulates Fidelity of DNA Replication and Repair http://www.nigms.nih.gov/News/Results/031811.htm Thu, 24 March 2011 15:06:28 EST {EC6CAC59-0980-40EA-9330-FCEA38DC6CD1} N/A Fri, 18 March 2011 00:00:00 Federal Funds Support Malaria Research http://www.nigms.nih.gov/News/Results/110509b.htm Fri, 6 November 2009 16:13:19 EST {ED0F32EA-EA9E-483B-9598-F0A0C286920D} NIGMS has issued a supplement grant to a researcher who is studying how the malaria parasite evolved resistance to the medication chloroquine. ARRA Thu, 5 November 2009 00:00:00 Researchers Uncover Nerve Cell Signaling Gene http://www.nigms.nih.gov/News/Results/20090921A.htm Tue, 29 September 2009 19:11:40 EST {ED13D2B9-E7D0-4868-82E8-8FC6E0251EA1} A team of NIGMS-supported researchers has found that a particular gene—known as Rab2—is critical for nerve cells to make and package signals that mediate communication between neurons. N/A Mon, 21 September 2009 00:00:00 Yellowstone Alga Detoxifies Arsenic http://www.nigms.nih.gov/News/Results/031009.htm Tue, 17 March 2009 15:45:31 EST {ED546CE8-6034-42F4-B3BA-CEDA2539A5FB} NIGMS-funded researchers have discovered that a species of algae that grows in hot, acidic environments chemically modifies arsenic to make it less toxic. N/A Tue, 10 March 2009 00:00:00 Study May Shed Light on Mitochondrial Diseases http://www.nigms.nih.gov/News/Results/20090924.htm Mon, 5 October 2009 11:58:35 EST {ED612D39-EC96-4B1A-B9DD-D1886E4C2D80} Using genetic engineering, NIGMS-supported researchers have examined the roles of individual genes in the production of energy within mitochondria. N/A Thu, 24 September 2009 00:00:00 HHS Unveils Two New Efforts to Advance Pandemic Flu Preparedness http://www.nigms.nih.gov/News/Results/020107.htm Thu, 6 August 2009 13:18:32 EST {ED89BAAD-0B30-4F9E-A17A-758FC191C15B} Researchers involved in the NIGMS Models of Infectious Disease Agent Study contributed to interim guidance for slowing a pandemic flu outbreak. ModelingInfectiousDiseases Thu, 1 February 2007 00:00:00 Almost 600 Kinds of Fat Found Circulating in Human Blood http://www.nigms.nih.gov/News/Results/101410b.htm Fri, 22 October 2010 14:45:11 EST {EE64FAE2-42AC-4D2F-AAEA-99903863574E} GlueGrants Thu, 14 October 2010 00:00:00 Selenium Supplements May Not be Useful http://www.nigms.nih.gov/News/Results/040408c.htm Fri, 11 April 2008 12:39:45 EST {EEA21D46-1D34-4579-A079-D51AD46139F5} By conducting a genetic analysis in a broad range of animals, NIGMS-funded researchers suggest that mammals may need little selenium. N/A Fri, 4 April 2008 00:00:00 Researchers Find Protein Domain To Serve as Cancer Drug Target http://www.nigms.nih.gov/News/Results/021709b.htm Fri, 20 February 2009 13:43:24 EST {EEDF8D06-0DFD-460E-8690-66BBD82DAF6F} NIGMS-funded researchers have found that drugs that inactivate a specific part of matrix metalloproteinases may target tumors without damaging side effects. N/A Tue, 17 February 2009 00:00:00 Missing Piece of Plant Clock Found http://www.nigms.nih.gov/News/Results/031209a.htm Fri, 20 March 2009 10:32:24 EST {EF55922E-14BB-4EBF-9897-4D220CA42472} NIGMS-funded researchers have identified a key protein that links the morning and evening components of the daily biological clock of plants. N/A Thu, 12 March 2009 00:00:00 Protein Compass Guides Amoebas Toward Their Prey http://www.nigms.nih.gov/News/Results/10232008.htm Mon, 16 March 2009 09:33:04 EST {EF6D7FD7-106B-41C2-B81F-0853F7D038FD} Amoebas glide toward their prey with the help of a protein switch that controls a molecular compass, according to a new NIGMS-supported study. N/A Thu, 23 October 2008 00:00:00 Evolution of Sex in Weeds http://www.nigms.nih.gov/News/Results/080707.htm Wed, 8 August 2007 12:12:57 EST {F018CA3D-D4F6-4ED6-8FE2-05D99F269D38} Weeds started reproducing by self-pollination longer ago than previously thought, and only occasionally reproduce sexually, report NIGMS-funded researchers. N/A Tue, 7 August 2007 00:00:00 Multicenter Sepsis Study Shows Greater Risk of Death in Pneumonia Patients With Kidney Injury http://www.nigms.nih.gov/News/Results/030210a.htm Tue, 9 March 2010 14:38:26 EST {F023FBA5-E237-451A-8587-995910BCA787} N/A Tue, 2 March 2010 00:00:00 New ‘GATE’ Computer Program Helps Biologists Visualize and Interact with Experimental Data http://www.nigms.nih.gov/News/Results/sysbio_021610.htm Fri, 26 February 2010 16:09:44 EST {F0879A7E-FA05-4F59-A4B0-ED036E672EEE} ComplexBiologicalSystemsInitiatives Tue, 16 February 2010 00:00:00 Protein Disposal Components Linked to Cancer http://www.nigms.nih.gov/News/Results/072408b.htm Tue, 5 August 2008 12:56:02 EST {F0A3FDE5-A104-4B1F-8E45-A8235A1B50F6} An NIGMS-funded study has identified a new pathway that responds to DNA damage. N/A Thu, 24 July 2008 00:00:00 Structure of Bacterial Protein Involved in Iron Metabolism http://www.nigms.nih.gov/News/Results/071307.htm Mon, 23 July 2007 10:00:21 EST {F0C1E881-B905-41F0-921D-63EDD6AD5188} NIGMS-funded scientists have solved the structure of a novel protein that is present in many bacteria, including the most persistent pathogen in cystic fibrosis patients. N/A Fri, 13 July 2007 00:00:00 Study Explains Spread of 1918 Flu http://www.nigms.nih.gov/News/Results/021808.htm Mon, 25 February 2008 10:51:12 EST {F0CBF78D-2B66-460B-B44E-B29FA4ADD0C7} Two mutations in a surface molecule of the 1918 pandemic flu strain dramatically changed the affinity of the virus to human receptors, reports an NIGMS-funded study. N/A Mon, 18 February 2008 00:00:00 Species Risk Extinction Beyond Mutation "Speed Limit" http://www.nigms.nih.gov/News/Results/100107b.htm Mon, 8 October 2007 07:58:24 EST {F0EF4822-79A5-43A7-9397-8572AFF35641} NIGMS-funded researchers calculate that most organisms must have less than 6 mutations in their genome per generation for a species to survive. N/A Mon, 1 October 2007 00:00:00 Secret to Healing Chronic Wounds Might Lie in Tiny Pieces of Silent RNA http://www.nigms.nih.gov/News/Results/032210b.htm Tue, 6 April 2010 19:02:42 EST {F11445FF-C51A-4CAA-AFEF-FB828DCC1D40} TraumaBurnPerioperativeInjuryAndWoundHealing Mon, 22 March 2010 00:00:00 Protein Predicts Survival in Pediatric Septic Shock http://www.nigms.nih.gov/News/Results/080108.htm Mon, 16 March 2009 09:45:54 EST {F1F29B77-00BF-48A7-8585-A7F7A6340E90} An NIGMS-funded study shows that levels of the protein interleukin-8 in the blood are linked to children's risk for death from septic shock. N/A Fri, 1 August 2008 00:00:00 Algae Point to Possible Malaria Vaccine http://www.nigms.nih.gov/News/Results/032508.htm Thu, 3 April 2008 10:02:30 EST {F202DB85-A8B6-4511-9E38-AF832E28FBF0} An NIGMS-funded study of reproduction in a harmless type of algae revealed a mechanism similar to that used by the malaria parasite. N/A Tue, 25 March 2008 00:00:00 Genome-Wide Analysis of Insertions and Deletions http://www.nigms.nih.gov/News/Results/070109.htm Fri, 10 July 2009 14:28:34 EST {F238097B-C5EE-4440-99C8-1FAD6FFCD7A5} An NIGMS-funded study sheds light on the processes that lead to insertion and deletion mutations, which cause many inherited diseases. BioinformaticsAndComputationalBiology Wed, 1 July 2009 00:00:00 Genome-Wide Insights Into Human Populations http://www.nigms.nih.gov/News/Results/051409a.htm Tue, 26 May 2009 12:38:08 EST {F254A12D-D4FF-4BD9-8F3C-CA408059B01F} NIGMS-funded researchers examined 650,000 variable sites in the genome among a broad group of the world's population. N/A Thu, 14 May 2009 00:00:00 Learning to Bust Drug-Resistant Bugs http://www.nigms.nih.gov/News/Results/100109c.htm Mon, 5 October 2009 12:35:55 EST {F2599C30-687D-409C-8813-0248DD9388AF} NIGMS grantee Scott Singleton is studying the basic biology of bacterial drug resistance, work that could lead to new strategies to combat this health issue. N/A Thu, 1 October 2009 00:00:00 Genomic Exchanges Linked to Flu Epidemics http://www.nigms.nih.gov/News/Results/030408.htm Mon, 10 March 2008 14:10:04 EST {F30D16F0-7E26-4F13-9118-ECB72C07F9FF} An NIGMS-funded study reports that the swapping of genetic material between closely related flu strains--not just ones infecting different species--can trigger epidemics. N/A Tue, 4 March 2008 00:00:00 Computer Algorithm Helps Reveal Genetic Basis for Disease Through Other Organisms http://www.nigms.nih.gov/News/Results/041310b.htm Mon, 19 April 2010 15:24:01 EST {F34A54B6-BC5B-425D-98FB-0170D5C2A3A8} N/A Tue, 13 April 2010 00:00:00 Stimulus Grants Support Bioinformatics Projects http://www.nigms.nih.gov/News/Results/102309a.htm Mon, 26 July 2010 10:37:49 EST {F35BF802-E3FD-4451-99A4-0292E8644FBD} NIGMS is funding a relatively large number of bioinformatics-related projects with stimulus grants. ARRA Fri, 23 October 2009 00:00:00 How Hepatitis C Protein Unwinds DNA http://www.nigms.nih.gov/News/Results/072607a.htm Wed, 28 November 2007 08:55:06 EST {F3F359BD-A8BC-4C70-98FB-412A87809C13} NIGMS-funded researchers have new insights about the workings of hepatitis C helicase, a protein that unwinds DNA in preparation for copying. N/A Thu, 26 July 2007 00:00:00 Researchers Describe Structure of Key Pump That Bacteria Use to Resist Drugs http://www.nigms.nih.gov/News/Results/022311.htm Fri, 4 March 2011 16:12:42 EST {F4012105-793F-4084-BCC0-62DC9B5BC1CD} N/A Wed, 23 February 2011 00:00:00 Human Immune Response to Viral RNA http://www.nigms.nih.gov/News/Results/080409b.htm Fri, 14 August 2009 14:01:34 EST {F42F7EBD-7D51-4766-840B-11844745F1A8} An NIGMS-funded study shows that an enzyme in our immune system may recognize the presence of certain types of viral RNA. N/A Tue, 4 August 2009 00:00:00 Statistical Technique Finds Gene Regulation Sites http://www.nigms.nih.gov/News/Results/111909a.htm Tue, 1 December 2009 11:42:50 EST {F44EF00F-498C-4B2B-85B2-7516CB0A83CC} NIGMS-funded computer scientists have discovered a way to scan the genome for regions involved in gene regulation without prior knowledge of transcription factors. BioinformaticsAndComputationalBiology Thu, 19 November 2009 00:00:00 HIV Entry of Cells Offers Drug Target http://www.nigms.nih.gov/News/Results/043009c.htm Fri, 8 May 2009 12:17:55 EST {F45DB4B1-7046-4B3F-9ED9-0765ED148750} NIGMS-funded researchers have discovered that HIV primarily enters cells via endosomes, suggesting that new drugs could inhibit that process. N/A Thu, 30 April 2009 00:00:00 Keeping Proteins Folded is Critical to Successful Adaptation in Microbes http://www.nigms.nih.gov/News/Results/20100825C.htm Mon, 30 August 2010 14:11:43 EST {F46574D3-2A77-4BA8-82FC-36AA7D934CC5} N/A Wed, 25 August 2010 00:00:00 Scientists Explore Factors Contributing to DNA Mutations http://www.nigms.nih.gov/News/Results/20080128.htm Mon, 25 October 2010 13:37:14 EST {F49F6AFD-2F5A-4117-BFC7-D652D66DCC79} A team of NIGMS-supported researchers has conducted a genome-wide study comparing the relative importance of factors that contribute to DNA mutations, which are implicated in cancer and other diseases. N/A Mon, 28 January 2008 00:00:00 Stimulus Grant Funds Stem Cell Research http://www.nigms.nih.gov/News/Results/102909a.htm Mon, 7 December 2009 12:54:09 EST {F4A10601-9B54-40D3-8B39-4CAF507AB7A6} NIGMS has issued a $600,000 grant to accelerate research into induced pluripotent stem cells, which can be reprogrammed into virtually any cell type. ARRA Thu, 29 October 2009 00:00:00 Method to Attach Chemical Group Could Expedite Development of Medicines http://www.nigms.nih.gov/News/Results/062510a.htm Sat, 3 July 2010 12:12:42 EST {F5608994-E196-4B30-9134-1B1B8DEF6D8E} ChemHealth Fri, 25 June 2010 00:00:00 Finding May Expedite Cholesterol Drug Production http://www.nigms.nih.gov/News/Results/110309c.htm Mon, 16 November 2009 19:09:09 EST {F5CB24F5-38B7-4FCC-B60B-ADCD659B75B5} Researchers funded by NIGMS have successfully reconstituted the enzyme responsible for producing the blockbuster cholesterol-lowering drug lovastatin. N/A Tue, 3 November 2009 00:00:00 Bioengineers Fill Holes in Science of Cellular Self-Organization http://www.nigms.nih.gov/News/Results/100608b.htm Thu, 23 October 2008 14:40:20 EST {F60FB430-54BC-4E4C-9F70-AC720F2BD052} NIGMS-funded bioengineers are developing models for how cell populations order themselves. BioinformaticsAndComputationalBiology Mon, 6 October 2008 00:00:00 Atomic Structure Reveals How RCC1 Recognizes the Nucleosome/DNA Complex http://www.nigms.nih.gov/News/Results/20100825A.htm Mon, 30 August 2010 14:11:46 EST {F6B06ADF-B876-4054-9B39-2B142EA1CDC4} N/A Wed, 25 August 2010 00:00:00 Genome of Freshwater Crustacean Shows More Genes Than in Any Other Animal http://www.nigms.nih.gov/News/Results/020311b.htm Mon, 7 February 2011 14:40:34 EST {F7299B86-A6E0-46E1-8381-7FC38A5C0D44} N/A Thu, 3 February 2011 00:00:00 New Genetic Link to Crohn’s Disease http://www.nigms.nih.gov/News/Results/20090708.htm Thu, 16 July 2009 15:14:29 EST {F7381525-3364-4722-8DC5-B031755AE335} NIGMS-supported researchers have identified a novel link between ITCH, a gene known to regulate inflammation, and NOD2, a Crohn's Disease susceptibility gene. N/A Wed, 8 July 2009 00:00:00 Computational Model Helps Identify Significance of Variations Between Genomes http://www.nigms.nih.gov/News/Results/033111a.htm Fri, 8 April 2011 10:51:16 EST {F766CEDA-5977-4168-9D58-068A1FA72AA4} N/A Thu, 31 March 2011 00:00:00 Overexcited Neurons Can Damage Cells http://www.nigms.nih.gov/News/Results/121707.htm Thu, 3 January 2008 11:25:33 EST {F78E695D-BCB5-412D-8478-83AA8956DF75} Excessive neuronal signaling can damage proteins in target cells, similar to the effects of exposure to nicotine or a pesticide, report NIGMS-funded researchers. N/A Mon, 17 December 2007 00:00:00 A Molecular Link Between Inflammation and Cancer http://www.nigms.nih.gov/News/Results/012507a.htm Thu, 1 February 2007 11:28:06 EST {F7D6D9BA-E281-4D98-B460-1C07038CE8DF} NIGMS-supported researchers have discovered a molecular mechanism linking inflammation and cancer. The levels of a protein called p100 increase in response to inflammation, but p100 is also used in certain steps in development. N/A Thu, 25 January 2007 00:00:00 Gene Linked to Lupus http://www.nigms.nih.gov/News/Results/072907b.htm Wed, 15 August 2007 09:48:12 EST {F8673DD3-D560-4066-A133-AB9AB0C87933} With NIGMS funding, researchers have discovered a gene linked to lupus. The encoded protein disassembles DNA. N/A Sun, 29 July 2007 00:00:00 Wider Vaccination Could Slow Flu Evolution http://www.nigms.nih.gov/News/Results/103009b.htm Thu, 12 November 2009 19:54:50 EST {F874E20B-5744-4655-9AC6-A9A6DF443693} An NIGMS-funded study suggests that vaccinating more people would slow the evolution of seasonal flu viruses, making vaccines more effective. N/A Fri, 30 October 2009 00:00:00 Virus Mimics Human Protein http://www.nigms.nih.gov/News/Results/050808b.htm Fri, 16 May 2008 12:39:43 EST {F8EC229A-7633-4908-9D1D-5B8A6BA92770} An NIGMS-funded study has discovered that human cytomegalovirus can mimic a common regulatory protein to hijack normal cell division machinery. N/A Thu, 8 May 2008 00:00:00 The Uncharted Arena of Human-Only Genes http://www.nigms.nih.gov/News/Results/032108.htm Tue, 1 April 2008 11:07:31 EST {F90C669E-1E20-47CB-8D69-4165A1858852} An NIGMS-funded study produced the first detailed analysis of one of the few genes found only in hominoids. N/A Fri, 21 March 2008 00:00:00 Lab-on-a-Chip Promises to Speed Proteomics Research http://www.nigms.nih.gov/News/Results/050207c.htm Tue, 8 May 2007 14:10:49 EST {F9282915-A538-4826-BD79-0D8D2620BCEF} NIGMS-funded researchers have developed lab-on-a-chip technology that could be integrated with mass spectrometry to allow large-scale proteomics research. N/A Wed, 2 May 2007 00:00:00 Soil Bacterium Only Cooperates With Close Kin http://www.nigms.nih.gov/News/Results/20100107A.htm Tue, 19 January 2010 17:20:26 EST {FA1EA860-C108-4CDF-826F-66B3E23716E7} A bacterial species that depends on cooperation to survive is discriminating when it comes to the company it keeps, according to an NIGMS-supported study. N/A Thu, 7 January 2010 00:00:00 Switch Regulates Trafficking Within Cells http://www.nigms.nih.gov/News/Results/121007.htm Wed, 12 December 2007 12:12:01 EST {FA3D67BD-03EC-4CD8-AC1A-3D85D7132B0A} NIGMS-funded researchers have discovered a molecular "switch" in epithelial cells that selects from motor proteins called kinesins to traffic materials to the cell surface. N/A Mon, 10 December 2007 00:00:00 Genetic Switch Helps Cilia Beat Path to Asymmetry http://www.nigms.nih.gov/News/Results/20081116.htm Mon, 24 November 2008 20:33:38 EST {FA756FCA-082B-4E58-80EF-F0B68433E71E} A new NIGMS-supported study reveals how a genetic switch known as FoxJ1 helps developing embryos tell their left from their right. N/A Sun, 16 November 2008 00:00:00 Tighter Ethics Rules Have Reduced Industrial Relationship of NIH Scientists http://www.nigms.nih.gov/News/Results/102810c.htm Mon, 1 November 2010 15:51:06 EST {FA9D782A-079E-4C5D-B8B5-5E5529879098} N/A Thu, 28 October 2010 00:00:00 The Secrets of Gene Regulatory Networks http://www.nigms.nih.gov/News/Results/020309a.htm Tue, 10 February 2009 13:31:35 EST {FAA599A0-2C9F-4FE1-93F2-4C221A6BD5F2} A set of studies funded in part by NIGMS sheds light on the complex networks of gene interactions that guide the development of different species. N/A Tue, 3 February 2009 00:00:00 Study Helps Explain How Calorie Restriction Delays Aging http://www.nigms.nih.gov/News/Results/111810a.htm Fri, 26 November 2010 17:15:46 EST {FAFEF84B-FD57-4BF1-88B2-677CADC2124B} N/A Thu, 18 November 2010 00:00:00 Proteins in Intestines Can Kill Bacteria That Have Human Blood Type Molecules on Their Surfaces http://www.nigms.nih.gov/News/Results/021410.htm Thu, 18 February 2010 18:58:10 EST {FB2432F0-BD19-4317-8C74-34FA102A0B69} N/A Sun, 14 February 2010 00:00:00 Scientists Crack Mystery of Protein's Dual Function http://www.nigms.nih.gov/News/Results/20091213A.htm Tue, 22 December 2009 19:48:49 EST {FB84469E-F892-43A1-96E8-2A75EE5BE422} NIGMS-supported researchers have solved a 10-year-old mystery of how a single protein from an ancient family of enzymes can have two completely distinct roles in the body. N/A Sun, 13 December 2009 00:00:00 Structure Reveals How Anti-Cancer Drug Works http://www.nigms.nih.gov/News/Results/20091126.htm Mon, 7 December 2009 17:54:42 EST {FBA000E1-BE36-40D2-99EE-6634DF45A22F} A new NIGMS-supported study has uncovered the three-dimensional structure of the copper sequestering drug, tetrathiomolybdate, changing our view of how the drug works. MetalsInMedicine Thu, 26 November 2009 00:00:00 Protein That Regulates Biological Clock Linked to Diabetes http://www.nigms.nih.gov/News/Results/091910b.htm Tue, 21 September 2010 21:45:14 EST {FBDC9468-DF66-4553-B347-42F46CDF361A} N/A Sun, 19 September 2010 00:00:00 Biochemists Develop New Way to Prevent Oxidative Damage to Cells http://www.nigms.nih.gov/News/Results/120110c.htm Mon, 6 December 2010 15:23:00 EST {FBE0F14C-0F75-4D5D-B5FE-BCB4B1981E59} N/A Wed, 1 December 2010 00:00:00 Nanotechnology To Detect Gene Expression http://www.nigms.nih.gov/News/Results/011008b.htm Fri, 18 January 2008 17:33:47 EST {FC66702D-2E9D-406A-AFB1-48BD67FE65E9} Using self-assembled DNA nanostructures, NIGMS-funded researchers are developing new and sensititve ways to detect gene expression. N/A Thu, 10 January 2008 00:00:00 Genomes Can Be Used to Study Ecological Adaptation http://www.nigms.nih.gov/News/Results/013111a.htm Thu, 3 February 2011 15:38:28 EST {FC8475DE-5473-461B-B7A1-0A915D234104} N/A Mon, 31 January 2011 00:00:00 Unzipping Molecules to Understand DNA Packing http://www.nigms.nih.gov/News/Results/012809b.htm Wed, 4 February 2009 11:05:58 EST {FC918604-9809-4CC8-B581-24A422D99AAE} NIGMS-funded researchers used an optical trap to unwrap strands of DNA from their histone cores to understand this important interaction. N/A Wed, 28 January 2009 00:00:00 How a "Wimpy" Protein Motor Gains Strength From Other Proteins http://www.nigms.nih.gov/News/Results/041510.htm Fri, 23 April 2010 13:34:14 EST {FCBC704D-FBCA-4F94-BAA8-9AD80CC1999A} N/A Thu, 15 April 2010 00:00:00 MicroRNAs From Epstein-Barr Virus Allow Evasion of Immune System http://www.nigms.nih.gov/News/Results/102510.htm Thu, 28 October 2010 17:24:25 EST {FD049205-1B27-49C9-8E0F-EC0CBBD1DE15} N/A Mon, 25 October 2010 00:00:00 Scientists Determine Protein Structure Key to Huntington's Disease http://www.nigms.nih.gov/News/Results/20080204.htm Thu, 14 February 2008 10:37:57 EST {FD42CA7D-C40D-499D-9CEE-58DB8D058A14} NIGMS-supported scientists have determined the structure of a key part of HIP1, a protein that is implicated in Huntington's disease. N/A Mon, 4 February 2008 00:00:00 Grant to Advance the Use of Simulations in Drug Discovery http://www.nigms.nih.gov/News/Results/111610b.htm Fri, 19 November 2010 16:08:52 EST {FD64AB8E-D61E-46AA-8320-354F4005FFE1} N/A Tue, 16 November 2010 00:00:00 Mathematical Model of Inflammatory Bowel Disease Allows In Silico Research http://www.nigms.nih.gov/News/Results/072210b.htm Fri, 23 July 2010 11:26:38 EST {FDB1C6B4-2B59-4696-91E4-0404362122BF} N/A Thu, 22 July 2010 00:00:00 Precise Switches Turn Genes Off in Response to UV Light http://www.nigms.nih.gov/News/Results/102810b.htm Thu, 28 October 2010 17:31:48 EST {FDEE8181-059A-4160-AF07-C74BFB8BE30D} N/A Thu, 28 October 2010 00:00:00 PGRN Researchers Question Need for Genetic Tests in All Cases http://www.nigms.nih.gov/News/Results/082807b.htm Tue, 4 September 2007 14:00:32 EST {FE1FB554-4B45-485E-8952-114460E380C4} People taking low doses of the cancer drug irinotecan need not undergo genetic testing first, say NIGMS-funded researchers. PharmacogeneticsResearchNetwork Tue, 28 August 2007 00:00:00 Networks Between Cells Vital to Circadian Rhythm http://www.nigms.nih.gov/News/Results/050307.htm Mon, 14 May 2007 14:48:27 EST {FE27C4CE-87DC-47AB-B7A1-2C75D90CDE58} NIGMS-funded biologists have discovered previously overlooked mechanisms for sustaining circadian rhythm in cells. N/A Thu, 3 May 2007 00:00:00 Gene Variant Linked to Effectiveness of Plavix http://www.nigms.nih.gov/News/Results/20090825.htm Thu, 10 September 2009 13:14:59 EST {FE2826FA-92EE-4AEC-9CBB-89657EF91F15} NIGMS-supported researchers have identified a common gene variant carried by as many as a third of the population that plays a major role in determining why some people do not respond to an anti-clotting medication, Plavix. PharmacogeneticsResearchNetwork Tue, 25 August 2009 00:00:00 Cancer-Prevention Protein Found to Play a Role in Egg and Sperm Formation http://www.nigms.nih.gov/News/Results/20100610C.htm Mon, 14 June 2010 11:59:28 EST {FE66E321-7F82-4A10-B2FE-69A5F58CD42C} N/A Thu, 10 June 2010 00:00:00 How Heart Protein Works http://www.nigms.nih.gov/News/Results/041008.htm Fri, 18 April 2008 12:17:04 EST {FEAEDC53-E676-448F-9C50-CACD7DDF3CD4} An NIGMS-funded study has discovered how a protein called leiomodin directs the assembly of actin to allow the pumping of the heart. N/A Thu, 10 April 2008 00:00:00 Grantee Carolyn Bertozzi Wins Lemelson-MIT Innovation Prize http://www.nigms.nih.gov/News/Results/060210.htm Fri, 11 June 2010 19:04:42 EST {FEB328EC-AA2B-480A-9B53-5F38DB8B7495} N/A Wed, 2 June 2010 00:00:00 New Catalytic Process Could Help Produce Drugs With Less Chemical Waste http://www.nigms.nih.gov/News/Results/20100727A.htm Tue, 3 August 2010 11:30:15 EST {FF3BBFAD-A50E-4872-8166-0E94F8EE9D80} ChemHealth Tue, 27 July 2010 00:00:00 Evolution of Human Complexity http://www.nigms.nih.gov/News/Results/110309d.htm Thu, 12 November 2009 19:56:27 EST {FF68BB06-6856-4500-A20A-38852B9401F6} An NIGMS-funded analysis of thousands of genes and proteins shows that humans are complex, in part, because of the way we evolved to cope with redundancies among duplicate genes. N/A Tue, 3 November 2009 00:00:00 Conserved Molecules Maintain Energy Balance http://www.nigms.nih.gov/News/Results/050708a.htm Thu, 15 May 2008 18:19:26 EST {FF886C45-E8CC-47C2-AE17-3C2288B7D184} Using fruit flies, NIGMS-funded researchers studied molecules that have a role in maintaining energy balance in humans as well. N/A Wed, 7 May 2008 00:00:00 Recombinant DNA Technology Produces Absorbable Suture http://www.nigms.nih.gov/News/Results/021207.htm Fri, 23 February 2007 11:53:19 EST {FF97EB3F-617E-4372-9C00-08BCA035BCDA} With funding from an NIGMS small business research grant, Tepha, Inc. has developed an FDA-approved absorbable polymer suture manufactured using genetically engineered bacteria. N/A Mon, 12 February 2007 00:00:00 Stem Cells for First Time Used to Create Abnormal Heart Cells for Study of Cardiomyopathy http://www.nigms.nih.gov/News/Results/20100609.htm Mon, 14 June 2010 11:31:13 EST {FF9A77F5-CF6B-4E65-8F35-92F5F6FA35EF} StemCellResearch Wed, 9 June 2010 00:00:00 Genetic Clockmakers Craft Bacterial Timepiece http://www.nigms.nih.gov/News/Results/10292008.htm Mon, 16 March 2009 09:37:45 EST {FFFD0D0F-6F9E-482B-AFF9-0775DE9EEBB7} NIGMS-supported bioengineers have created the first stable, fast and programmable genetic clock that reliably keeps time by the blinking of fluorescent proteins inside E. coli cells. N/A Wed, 29 October 2008 00:00:00