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Protein Structure Initiative

Enabling High-Throughput Structural Biology and Structural Genomics

Comment on Potential New Resources for Protein Expression

We support a variety of resources for biomedical research, and we’re considering a new addition: one or more facilities for protein expression. These resources would offer protein expression expertise and high-throughput expression capability for the benefit of the entire research community. We’ve issued a request for information (RFI) seeking input on the needs within the biomedical research community for such resources and the types of protein expression services that would be most beneficial. To respond to the RFI, send an e-mail to NIGMSexpressionRFI@mail.nih.gov by May 15, 2015.

Protein Structure Initiative (PSI) 

The Protein Structure Initiative (PSI) began in 2000 with an initial goal to make the three-dimensional, atomic-level structures of most proteins easily obtainable from knowledge of their corresponding DNA sequences. During the current PSI:Biology phase, highly organized networks of investigators are applying the new paradigm of high-throughput structure determination, which was successfully developed during the earlier phases of the PSI, to study a broad range of important biological and biomedical problems.

Expected benefits from the PSI include: structural descriptions to help researchers discover the functions of proteins, design experiments and solve other key biomedical problems; faster identification of promising new structure-based medicines; better therapeutics for treating both genetic and infectious diseases; and development of technology and methodology for protein production and crystallography.

The PSI actively engages the scientific community in the selection of proteins for structure determination and is increasing its outreach, accessibility and impact on biomedical research via the PSI:Biology-Nature Structural Biology Knowledgebase Link to external Web site, a continually updated portal to PSI data, resources and latest developments. Biological material resources generated by the PSI are shared with the scientific community through the PSI:Biology Materials Repository Link to external Web site and through collaborations with PSI investigators.

Funding Opportunities

View PSI-related listings from the NIH Guide for Grants and Contracts, the official publication for NIH research grant policies, guidelines and funding opportunities.

Meetings

Find out about PSI meetings.

Reports

Read PSI meeting reports.

Contact Us

Reach PSI program staff.

Background Information

Discover more about the PSI and its history, including the pilot and production phases.

News

Read PSI announcements and results.

PSI:Biology

Learn about the next phase of the PSI.


This page last reviewed on April 23, 2015