Researchers Uncover New Target for Anticancer Drug Development  |
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| October 25, 2012 • University of Colorado at Boulder |
| Protein's Flexible Tail Helps Form Scaffold for Telomerase Assembly |
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| June 18, 2012 • University of California, Los Angeles |
| Roundworms Provide Tool for Studying How Cancers Override Cellular Growth Controls Based on Wearing Down Telomeres |
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| March 21, 2012 • Salk Institute for Biological Studies |
| How DNA Damage Checkpoint Enzymes Are Involved in Stable Maintenance of Telomeres |
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| November 23, 2011 • University of Illinois at Chicago |
| DNA Reshuffling in Worms Offers Insight on How Tumors Develop |
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| April 21, 2011 • University of North Carolina |
| Scientists Reveal a New Ending to an Old 'Tail' |
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| April 21, 2011 • Salk Institute |
| New 3-D Model of RNA 'Core Domain' of Enzyme Telomerase May Offer Clues to Cancer, Aging |
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| November 3, 2010 • UCLA Newsroom |
| Protein Shows Surprising Range of Functions |
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August 13, 2009 • University of Texas M. D. Anderson Cancer CenterA protein known to regulate gene expression also protects the tips of chromosomes and is involved in protein stability, NIGMS-funded researchers report. |
| Telomeres Resemble DNA Fragile Sites |
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July 9, 2009 • Rockefeller UniversityNew NIGMS-supported research suggests a striking similarity between telomeres and common fragile sites, parts of the genome where breaks tend to occur. |
| Cell Death and the Ends of Chromosomes |
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October 1, 2008 • University of UtahNIGMS-funded biologists have shown that losing just one telomere can lead to many abnormalities in a cell's chromosomes. |
| Twice the Telomere Options in Roundworms |
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March 6, 2008 • Salk InstituteNIGMS-funded researchers have discovered that C. elegans can cap their chromosomes with two different types of telomeres, a finding with implications for aging and cancer. |
| Mechanism Links Aging and Cancer |
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February 5, 2007 • Salk InstituteIn studying the chromosomes of patients with the premature aging disease Werner Syndrome, NIGMS-funded researchers have shown that rebuilding the chromosome tips blocks genetic damage associated with both aging and cancer. |
| NIGMS-Supported Research Garners Top U.S. Science Prize |
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September 18, 2006 • National Institute of General Medical SciencesThe 2006 Albert Lasker Award for Basic Medical Research went to Elizabeth Blackburn, Carol Greider, and Jack Szostak for their prediction and discovery of telomerase. Joseph Gall received a special achievement award for his pioneering work on chromosome structure and function, and for championing women in science. |
| Lasker Award for Special Achievement in Medical Science |
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September 17, 2006 • Carnegie InstitutionLong-time NIGMS grantee Joseph G. Gall has won a Lasker Award for his study of chromosome structure and function, his invention of an important technique, and his championing of women in science. |
| NIGMS Grantee Wins Lasker Award |
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September 17, 2006 • Johns Hopkins Medical InstitutionsNIGMS grantee Carol Greider was among the winners of this year's Lasker Award for her work on telomerase, the enzyme that maintains the ends of chromosomes. |
| Biochemists Uncover Structure of Major Piece of Telomerase |
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March 9, 2005 • University of California, Los AngelesNIGMS-funded biochemists have determined the three-dimensional structure of a major domain of telomerase, the enzyme that helps maintain telomeres—the small protective caps on the ends of chromosomes—allowing DNA ends to be copied completely when cells are replicated. |
| Psychological Stress and Disease: UCSF-led Study Suggests Connection |
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November 29, 2004 • University of California - San FranciscoIncreasing scientific evidence suggests that prolonged pshycological stress takes its toll on the body. Now, NIGMS-supported scientists report that psychological stress may exact its toll, at least in part, by affecting molecules believed to play a key role in cellular aging and possibly, disease. |